Gene: VANGL2

57216
LPP1|LTAP|STB1|STBM|STBM1
VANGL planar cell polarity protein 2
protein-coding
1q23.2
Ensembl:ENSG00000162738 MIM:600533 Vega:OTTHUMG00000033122 UniprotKB:Q9ULK5
NG_023420.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.455e-1 (AD)  3.349e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DPY19L30.867
USP30.864
AASS0.855
DHTKD10.851
CPNE30.837
TEAD10.837
FERMT20.831
CAPN20.83
DDR10.827
SLC44A20.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHO-0.424
RTP1-0.416
ABCC12-0.413
ANKRD34C-0.393
AGMAT-0.391
FBLN7-0.383
ADRA1D-0.383
LRRC38-0.381
CALHM1-0.381
TYRP1-0.381

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0415944-nonylphenol4-nonylphenol results in increased expression of VANGL2 mRNA17912697
D000452AldrinAldrin results in increased expression of VANGL2 mRNA18579281
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of VANGL2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VANGL2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VANGL2 mRNA21569818|2222880
D004958EstradiolEstradiol results in increased expression of VANGL2 mRNA17912697
C006780bisphenol Abisphenol A results in increased expression of VANGL2 mRNA17912697
C006780bisphenol Abisphenol A affects the expression of VANGL2 mRNA21786754
D004390ChlorpyrifosChlorpyrifos results in increased expression of VANGL2 mRNA21356183
D003300CopperCopper deficiency results in increased expression of VANGL2 mRNA26033743
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of VANGL2 mRNA24317228
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of VANGL2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of VANGL2 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of VANGL2 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of VANGL2 mRNA26033743
D004221DisulfiramDisulfiram results in decreased expression of VANGL2 mRNA20530235
D004237DiuronDiuron results in increased expression of VANGL2 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of VANGL2 mRNA17912697
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of VANGL2 mRNA23649840
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of VANGL2 mRNA]15016801
D005557FormaldehydeFormaldehyde results in increased expression of VANGL2 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of VANGL2 mRNA19167457
C039281furanfuran results in increased methylation of VANGL2 gene22079235
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of VANGL2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of VANGL2 mRNA26752646
D007854LeadLead affects the expression of VANGL2 mRNA28903495
D008727MethotrexateMethotrexate results in increased expression of VANGL2 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of VANGL2 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of VANGL2 mRNA23649840
C028007nickel monoxidenickel monoxide results in decreased expression of VANGL2 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of VANGL2 mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of VANGL2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of VANGL2 mRNA24780913
D012999SomanSoman results in decreased expression of VANGL2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VANGL2 mRNA21570461
D013893ThiramThiram results in decreased expression of VANGL2 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of VANGL2 mRNA27760801
C024746tobacco tartobacco tar results in decreased expression of VANGL2 mRNA19559774
D014635Valproic AcidValproic Acid affects the expression of VANGL2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of VANGL2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of VANGL2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of VANGL2 mRNA21427059
D014752Vinyl ChlorideVinyl Chloride results in increased expression of VANGL2 mRNA18579281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22610794  28330616  
GO ID GO Term Qualifier Evidence PubMed
GO:0001736establishment of planar polarity-ISS-  
GO:0001843neural tube closure-ISS-  
GO:0001942hair follicle development-IEA-  
GO:0001947heart looping-ISS-  
GO:0003149membranous septum morphogenesis-IEA-  
GO:0003150muscular septum morphogenesis-IEA-  
GO:0003402planar cell polarity pathway involved in axis elongation-IEA-  
GO:0007266Rho protein signal transduction-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0015012heparan sulfate proteoglycan biosynthetic process-IEA-  
GO:0022007convergent extension involved in neural plate elongation-IEA-  
GO:0030111regulation of Wnt signaling pathway-IEA-  
GO:0032835glomerulus development-IEA-  
GO:0032956regulation of actin cytoskeleton organization-IEA-  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0035787cell migration involved in kidney development-ISS-  
GO:0036342post-anal tail morphogenesis-IEA-  
GO:0036514dopaminergic neuron axon guidance-IEA-  
GO:0036515serotonergic neuron axon guidance-IEA-  
GO:0042060wound healing-IEA-  
GO:0043507positive regulation of JUN kinase activity-IEA-  
GO:0045176apical protein localization-ISS-  
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity-IEA-  
GO:0048103somatic stem cell division-IEA-  
GO:0048105establishment of body hair planar orientation-IEA-  
GO:0048546digestive tract morphogenesis-IEA-  
GO:0060028convergent extension involved in axis elongation-IEA-  
GO:0060122inner ear receptor cell stereocilium organization-IEA-  
GO:0060488orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis-IEA-  
GO:0060489planar dichotomous subdivision of terminal units involved in lung branching morphogenesis-IEA-  
GO:0060490lateral sprouting involved in lung morphogenesis-IEA-  
GO:0060993kidney morphogenesis-IEA-  
GO:0061346planar cell polarity pathway involved in heart morphogenesis-IEA-  
GO:0090103cochlea morphogenesis-IEA-  
GO:0090177establishment of planar polarity involved in neural tube closure-IEA-  
GO:0090179planar cell polarity pathway involved in neural tube closure-IEA-  
GO:1904938planar cell polarity pathway involved in axon guidance-IEA-  
GO:1905515non-motile cilium assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-ISS-  
GO:0016021integral component of membrane-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-ISS-  
GO:0016328lateral plasma membrane-ISS-  
GO:0030134COPII-coated ER to Golgi transport vesicle-IEA-  
GO:0060187cell pole-IEA-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-195721Signaling by WNTIEA
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-4086400PCP/CE pathwayIEA
R-HSA-4608870Asymmetric localization of PCP proteinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28237967Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. (2017 Apr 1)Poobalasingam TDis Model Mech