Gene: ERGIC1

57222
AMCN|ERGIC-32|ERGIC32|NET24
endoplasmic reticulum-golgi intermediate compartment 1
protein-coding
5q35.1
Ensembl:ENSG00000113719 MIM:617946 Vega:OTTHUMG00000130520 UniprotKB:Q969X5
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.690e-1 (AD)  8.482e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13176814chr5:172864246 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07496207chr5:172280684ERGIC18.690e-8Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAF70.911
SRF0.907
BAHD10.904
CSNK1D0.896
LASP10.895
RNF400.895
GID80.891
MLEC0.891
TNFAIP10.89
U2AF20.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.738
OR4F29-0.671
CTNNA3-0.347
OR6C74-0.337
TNFRSF13B-0.29
C5orf64-0.281
CDNF-0.263
PDE11A-0.256
CLEC6A-0.245
TRPV5-0.243

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the methylation of ERGIC1 gene25304211
C015001arsenitearsenite results in decreased methylation of ERGIC1 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ERGIC1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ERGIC1 mRNA19770486
C006780bisphenol Abisphenol A affects the expression of ERGIC1 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of ERGIC1 protein28903499
D002065BuspironeBuspirone results in decreased expression of ERGIC1 mRNA24136188
D002090ButyrophenonesERGIC1 gene SNP affects the susceptibility to Butyrophenones analog25622337
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ERGIC1 protein24527689
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ERGIC1 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ERGIC1 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of ERGIC1 mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased expression of ERGIC1 mRNA19320972
D016572CyclosporineCyclosporine results in decreased expression of ERGIC1 mRNA25562108
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ERGIC1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ERGIC1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ERGIC1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ERGIC1 mRNA23649840
D017313FenretinideFenretinide results in increased expression of ERGIC1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ERGIC1 mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ERGIC1 mRNA21179406
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERGIC1 protein18951874
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ERGIC1 mRNA23086925
C410337K 7174K 7174 results in decreased expression of ERGIC1 mRNA24086573
D064704LevofloxacinLevofloxacin results in decreased expression of ERGIC1 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ERGIC1 gene20938992
D008727MethotrexateMethotrexate results in increased expression of ERGIC1 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ERGIC1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ERGIC1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ERGIC1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ERGIC1 mRNA"25554681
C006253pirinixic acidpirinixic acid results in decreased expression of ERGIC1 mRNA19162173
C005556propionaldehydepropionaldehyde results in increased expression of ERGIC1 mRNA26079696
D013629TamoxifenTamoxifen affects the expression of ERGIC1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ERGIC1 mRNA21570461
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERGIC1 protein18951874
D013849ThimerosalThimerosal results in decreased expression of ERGIC1 mRNA27188386
C009495titanium dioxidetitanium dioxide results in increased expression of ERGIC1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ERGIC1 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of ERGIC1 mRNA"26179874
C080163trovafloxacintrovafloxacin results in decreased expression of ERGIC1 mRNA24136188
D017973Tungsten CompoundsTungsten Compounds results in increased expression of ERGIC1 mRNA28666766
D014520UrethaneUrethane results in decreased expression of ERGIC1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ERGIC1 mRNA23179753|2915479

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15308636  
GO ID GO Term Qualifier Evidence PubMed
GO:0006888ER to Golgi vesicle-mediated transport-IBA21873635  
GO:0006888ER to Golgi vesicle-mediated transport-IDA15308636  
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IBA21873635  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IDA15308636  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal