Gene info: ID 5724

Gene: PTAFR

GENE ID: 5724

Synonyms: PAFR

Description: platelet activating factor receptor

Gene type: protein-coding

Location: 1p35.3

dbXrefs: Ensembl:ENSG00000169403 MIM:173393 Vega:OTTHUMG00000003953 UniprotKB:P25105

RefSeq: NG_029815.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.370e-1 (AD) 3.455e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg20460771	chr1:28521540	PTAFR		9.760e-9	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LPAR5	0.93
SYK	0.916
MILR1	0.915
SASH3	0.915
MYO1F	0.909
SLC7A7	0.909
CD33	0.908
TLR7	0.908
TNFAIP8L2	0.903
CD37	0.903

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZSCAN1	-0.404
ATP2C2	-0.4
TMEM191C	-0.394
KRTAP5-7	-0.385
ATOH7	-0.384
ST6GAL2	-0.376
KREMEN2	-0.372
KCNIP3	-0.362
BDH1	-0.361
KCNK4	-0.358

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02261	Platelet Activating Factor	Small Molecule	74389-68-7	Experimental	Target
DB09166	Etizolam	Small Molecule	40054-69-1	Approved	Target
DB11614	Rupatadine	Small Molecule	158876-82-5	Approved	Target

ID	Drug Name	Action	PubMed
C053479	1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine	Arachidonic Acid inhibits the reaction [1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine results in increased expression of PTAFR mRNA]	17515866
C053479	1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine	Docosahexaenoic Acids inhibits the reaction [1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine results in increased expression of PTAFR mRNA]	17515866
C400184	1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine	1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine binds to PTAFR protein	16386258
C400184	1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine	1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	16386258
C003898	2-anisidine	2-anisidine affects the expression of PTAFR mRNA	28089782
C065776	3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one	"3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one binds to and results in decreased activity of PTAFR protein"	10087035
C095427	A 86929	A 86929 binds to PTAFR protein	8558425
D000082	Acetaminophen	Acetaminophen results in increased expression of PTAFR mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of PTAFR mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of PTAFR mRNA	17585979
D020106	Acrylamide	Acrylamide results in decreased expression of PTAFR mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PTAFR mRNA	21641981\|2210060
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of PTAFR gene	27153756
D000420	Albuterol	Albuterol results in increased expression of PTAFR protein	18362475
D015081	2-Naphthylamine	2-Naphthylamine results in decreased expression of PTAFR mRNA	18247414
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PTAFR mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PTAFR mRNA	24449571
D001060	Aporphines	Aporphines inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11488464
D016718	Arachidonic Acid	Arachidonic Acid inhibits the reaction [1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine results in increased expression of PTAFR mRNA]	17515866
D016718	Arachidonic Acid	[Docosahexaenoic Acids co-treated with Arachidonic Acid] affects the expression of PTAFR mRNA	17515866
D001194	Asbestos	Asbestos results in increased expression of PTAFR mRNA	22398240
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PTAFR mRNA	18247414
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PTAFR mRNA	21871943
C063964	bepafant	bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]	9065783
C063964	bepafant	bepafant binds to and results in decreased activity of PTAFR protein	21432021
C063964	bepafant	bepafant results in decreased activity of PTAFR protein	16386349
D004958	Estradiol	Estradiol affects the expression of PTAFR mRNA	21826169
C006780	bisphenol A	bisphenol A affects the expression of PTAFR mRNA	21826169
C006780	bisphenol A	bisphenol A results in increased expression of PTAFR mRNA	25181051
C066686	BN 50730	BN 50730 binds to and results in decreased activity of PTAFR protein	11529688
C066686	BN 50730	BN 50730 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
C064509	BN 50739	BN 50739 binds to and results in decreased activity of PTAFR protein	11529688\|9599246
C064509	BN 50739	BN 50739 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
C064509	BN 50739	BN 50739 binds to and results in decreased activity of PTAFR protein	21432021
C506830	boldine methine	boldine methine results in decreased activity of PTAFR protein	15944212
D002104	Cadmium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of PTAFR mRNA	21481475
D002118	Calcium	RGS4 protein inhibits the reaction [PTAFR protein affects the localization of and affects the abundance of Calcium]	11297424
D002251	Carbon Tetrachloride	Carbon Tetrachloride promotes the reaction [Platelet Activating Factor binds to PTAFR protein]	18205269
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased activity of PTAFR protein	12873816\|1652118
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PTAFR mRNA	12873816\|1292162
C078669	cedrol	cedrol inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11488464
D002713	Chlorine	Chlorine results in increased expression of PTAFR mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of PTAFR mRNA	18636392
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTAFR mRNA	20938992
C112433	CMI 392	CMI 392 binds to and results in decreased activity of PTAFR protein	11529688\|9599246
C112433	CMI 392	CMI 392 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
D003471	Cuprizone	Cuprizone results in increased expression of PTAFR mRNA	27523638
D003703	Demecolcine	Demecolcine results in increased expression of PTAFR mRNA	23649840
D003907	Dexamethasone	Dexamethasone results in decreased expression of PTAFR mRNA	10447766
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of PTAFR mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of PTAFR mRNA	27392435
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of PTAFR mRNA	25380136
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids affects the expression of PTAFR mRNA	17515866
D004281	Docosahexaenoic Acids	[Docosahexaenoic Acids co-treated with Arachidonic Acid] affects the expression of PTAFR mRNA	17515866
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids inhibits the reaction [1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine results in increased expression of PTAFR mRNA]	17515866
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PTAFR mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PTAFR mRNA	23550701
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of PTAFR mRNA	23649840
D005419	Flavonoids	Flavonoids results in increased expression of PTAFR mRNA	18035473
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTAFR mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of PTAFR mRNA	23649840
D009240	N-Formylmethionine Leucyl-Phenylalanine	PTAFR protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]	11116075
D007213	Indomethacin	Indomethacin results in decreased expression of PTAFR mRNA	9065783
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTAFR mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of PTAFR mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PTAFR mRNA	21949397
C054893	L 659989	L 659989 binds to and results in decreased activity of PTAFR protein	7644563
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTAFR mRNA"	21432021
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PTAFR mRNA	9065783
C040527	lipoxin A4	[WEB 2086 binds to and results in decreased activity of PTAFR protein] which results in decreased susceptibility to lipoxin A4	7602232
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTAFR mRNA	20938992
C071469	MK 287	MK 287 binds to and results in decreased activity of PTAFR protein	11529688\|9599246
C071469	MK 287	MK 287 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PTAFR mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PTAFR mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of PTAFR mRNA	25380136
D009532	Nickel	Nickel results in increased expression of PTAFR mRNA	24768652
D009538	Nicotine	Nicotine results in decreased expression of PTAFR mRNA	18247414
D009538	Nicotine	Nicotine results in increased expression of PTAFR mRNA	23825647
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of PTAFR mRNA	18636392
D052638	Particulate Matter	Particulate Matter results in increased expression of PTAFR mRNA	16504425
C031181	phenanthrene	phenanthrene analog inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11488464
D010716	Phosphatidylinositols	RGS4 protein inhibits the reaction [PTAFR protein results in increased hydrolysis of Phosphatidylinositols]	11297424
D010972	Platelet Activating Factor	1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	16386258
D010972	Platelet Activating Factor	BN 50730 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
D010972	Platelet Activating Factor	BN 50739 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
D010972	Platelet Activating Factor	CMI 392 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
D010972	Platelet Activating Factor	MK 287 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
D010972	Platelet Activating Factor	Platelet Activating Factor binds to PTAFR protein	11529688\|1638625
D010972	Platelet Activating Factor	Platelet Activating Factor results in increased expression of PTAFR mRNA	16386258
D010972	Platelet Activating Factor	zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
D010972	Platelet Activating Factor	Aporphines inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11488464
D010972	Platelet Activating Factor	cedrol inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11488464
D010972	Platelet Activating Factor	phenanthrene analog inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11488464
D010972	Platelet Activating Factor	bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]	9065783
D010972	Platelet Activating Factor	Carbon Tetrachloride promotes the reaction [Platelet Activating Factor binds to PTAFR protein]	18205269
D010972	Platelet Activating Factor	Platelet Activating Factor results in increased expression of PTAFR mRNA	10447766\|9065783
D010972	Platelet Activating Factor	Platelet Activating Factor results in increased phosphorylation of PTAFR protein	11297424
D010972	Platelet Activating Factor	RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]	11297424
D010972	Platelet Activating Factor	TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]	9065783
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PTAFR mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of PTAFR mRNA	22079256
C071318	Ro 24-4736	Ro 24-4736 binds to and results in decreased activity of PTAFR protein	9593866
D012643	Selenium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of PTAFR mRNA	21481475
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of PTAFR mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of PTAFR mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of PTAFR mRNA	21602193\|2243100
D019821	Simvastatin	Simvastatin results in decreased expression of PTAFR mRNA	16414398
C049411	stephenanthrine	stephenanthrine results in decreased activity of PTAFR protein	14559857
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTAFR mRNA	25613284
D013755	Tetradecanoylphorbol Acetate	RGS4 protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PTAFR protein]	11297424
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of PTAFR protein	11297424
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of PTAFR mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of PTAFR gene	26756918
C012589	trichostatin A	trichostatin A results in decreased expression of PTAFR mRNA	15901671
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of PTAFR mRNA	29024780
C488565	uvariopsine	uvariopsine results in decreased activity of PTAFR protein	14559857
D014635	Valproic Acid	Valproic Acid results in increased methylation of PTAFR gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of PTAFR mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of PTAFR mRNA	16504425
D014750	Vincristine	Vincristine results in increased expression of PTAFR mRNA	23649840
C052518	WEB 2086	WEB 2086 binds to and results in decreased activity of PTAFR protein	8666909
C052518	WEB 2086	[WEB 2086 binds to and results in decreased activity of PTAFR protein] which results in decreased susceptibility to lipoxin A4	7602232
C052518	WEB 2086	WEB 2086 binds to and results in decreased activity of PTAFR protein	11479258\|7602232
C063449	zileuton	zileuton binds to and results in decreased activity of PTAFR protein	11529688
C063449	zileuton	zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]	11529688
C031238	zinc sulfide	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of PTAFR mRNA	21481475

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001530	lipopolysaccharide binding	-	IEA	-
GO:0001875	lipopolysaccharide receptor activity	-	IEA	-
GO:0004930	G-protein coupled receptor activity	-	TAS	1322356
GO:0004992	platelet activating factor receptor activity	-	IDA	1281995 1656963 1657923
GO:0005543	phospholipid binding	-	IDA	1656963 1657923
GO:0045028	G-protein coupled purinergic nucleotide receptor activity	-	IBA	21873635
GO:0051019	mitogen-activated protein kinase binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001816	cytokine production	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006935	chemotaxis	-	IEA	-
GO:0006954	inflammatory response	-	IEA	-
GO:0006955	immune response	-	TAS	8892648
GO:0007186	G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	IMP	1657923
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007567	parturition	-	IEA	-
GO:0009609	response to symbiotic bacterium	-	IEA	-
GO:0010863	positive regulation of phospholipase C activity	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0031663	lipopolysaccharide-mediated signaling pathway	-	IEA	-
GO:0032760	positive regulation of tumor necrosis factor production	-	IEA	-
GO:0032959	inositol trisphosphate biosynthetic process	-	IEA	-
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043315	positive regulation of neutrophil degranulation	-	IEA	-
GO:0045056	transcytosis	-	IEA	-
GO:0045410	positive regulation of interleukin-6 biosynthetic process	-	IEA	-
GO:0045727	positive regulation of translation	-	IEA	-
GO:0045776	negative regulation of blood pressure	-	IEA	-
GO:0045907	positive regulation of vasoconstriction	-	IEA	-
GO:0048015	phosphatidylinositol-mediated signaling	-	IDA	1657923
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	-
GO:0060732	positive regulation of inositol phosphate biosynthetic process	-	IEA	-
GO:0071258	cellular response to gravity	-	IEA	-
GO:0071320	cellular response to cAMP	-	IEA	-
GO:0071398	cellular response to fatty acid	-	IEA	-
GO:0071548	response to dexamethasone	-	IEA	-
GO:0097755	positive regulation of blood vessel diameter	-	IEA	-
GO:1902943	positive regulation of voltage-gated chloride channel activity	-	IEA	-
GO:1903238	positive regulation of leukocyte tethering or rolling	-	IEA	-
GO:1904058	positive regulation of sensory perception of pain	-	IEA	-
GO:1904300	positive regulation of transcytosis	-	IEA	-
GO:1904303	positive regulation of maternal process involved in parturition	-	IEA	-
GO:1904306	positive regulation of gastro-intestinal system smooth muscle contraction	-	IEA	-
GO:1904317	cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	8168510
GO:0016020	membrane	-	IDA	1374385
GO:0016021	integral component of membrane	-	NAS	1281995 1656963
GO:0030667	secretory granule membrane	-	TAS	-
GO:0070821	tertiary granule membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa05150	Staphylococcus aureus infection

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-877300	Interferon gamma signaling	TAS
R-HSA-913531	Interferon Signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26756918	Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population. (2016 Jul)	Zhu X	Environ Health Perspect
28585144	Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer. (2017 Jun)	Zhang C	J Huazhong Univ Sci Technolog Med Sci