| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| MAGEB6 | 0.86 |
| CDY2A | 0.852 |
| OR5F1 | 0.852 |
| TSPY3 | 0.852 |
| OR5M1 | 0.852 |
| OR5T2 | 0.852 |
| KRTAP6-2 | 0.852 |
| KRTAP27-1 | 0.852 |
| OR5W2 | 0.852 |
| MAGEB5 | 0.852 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| GSTT1 | -0.209 |
| SFTPC | -0.204 |
| RGS9BP | -0.204 |
| FAM43B | -0.201 |
| SLC1A4 | -0.2 |
| BGLAP | -0.199 |
| PCDH9 | -0.199 |
| HDAC11 | -0.198 |
| FUT9 | -0.197 |
| DBP | -0.195 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C047832 | 4-((diethylamino)sulfonyl)benzoic acid | 4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein] | 21629661 |
| D017638 | Asbestos, Crocidolite | "Asbestos, Crocidolite affects the expression of TAS2R38 mRNA" | 17331233 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of TAS2R38 mRNA | 25181051 |
| D010670 | Phenylthiourea | 4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein] | 21629661 |
| D010670 | Phenylthiourea | Phenylthiourea affects the activity of TAS2R38 | 22384968 |
| D010670 | Phenylthiourea | Phenylthiourea results in increased activity of TAS2R38 protein | 21629661 |
| D010670 | Phenylthiourea | Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein] | 21629661 |
| D010670 | Phenylthiourea | TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea | 17684414 |
| D010670 | Phenylthiourea | Phenylthiourea binds to TAS2R38 protein | 22312435 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of TAS2R38 mRNA | 23557933 |
| D011339 | Probenecid | Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein] | 21629661 |
| D011339 | Probenecid | Probenecid inhibits the reaction [Propylthiouracil results in increased activity of TAS2R38 protein] | 21629661 |
| D011339 | Probenecid | Probenecid results in decreased activity of TAS2R38 protein | 21629661 |
| D011441 | Propylthiouracil | Probenecid inhibits the reaction [Propylthiouracil results in increased activity of TAS2R38 protein] | 21629661 |
| D011441 | Propylthiouracil | Propylthiouracil affects the activity of TAS2R38 | 22384968 |
| D011441 | Propylthiouracil | Propylthiouracil results in increased activity of TAS2R38 protein | 21629661 |
| D011441 | Propylthiouracil | TAS2R38 gene polymorphism affects the susceptibility to Propylthiouracil | 17684414|2231243 |
| D011441 | Propylthiouracil | Propylthiouracil binds to TAS2R38 protein | 22312435 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | - | IEA | - |
| GO:0033038 | bitter taste receptor activity | - | IBA | 21873635 |
| GO:0033038 | bitter taste receptor activity | - | IDA | 20022913 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | - | IBA | 21873635 |
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | - | IDA | 20022913 |
| GO:0007186 | G-protein coupled receptor signaling pathway | - | TAS | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005886 | plasma membrane | - | IDA | 12379855 |
| GO:0005886 | plasma membrane | - | TAS | - |
| GO:0016021 | integral component of membrane | - | IBA | 21873635 |
| GO:0016021 | integral component of membrane | - | IC | 20022913 |
| KEGG ID | KEGG Term |
|---|---|
| hsa04742 | Taste transduction |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-162582 | Signal Transduction | TAS |
| R-HSA-372790 | Signaling by GPCR | TAS |
| R-HSA-388396 | GPCR downstream signalling | TAS |
| R-HSA-418594 | G alpha (i) signalling events | TAS |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | TAS |
| R-HSA-500792 | GPCR ligand binding | TAS |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 23632915 | Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception. (2013 Jul) | Behrens M | Chem Senses |
| 21092367 | Genetic variation in taste perception: does it have a role in healthy eating? (2011 Feb) | Feeney E | Proc Nutr Soc |
| 21338274 | Genetic variation in the hTAS2R38 taste receptor and brassica vegetable intake. (2011 Jul) | Gorovic N | Scand J Clin Lab Invest |
| 18524836 | Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. (2008 Sep) | Mangold JE | J Med Genet |
| 23821729 | Factors related to fungiform papillae density: the beaver dam offspring study. (2013 Oct) | Fischer ME | Chem Senses |
| 20714161 | Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. (2010) | Mustavich LF | Hum Hered |
| 27059147 | Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits. (2016 Jul) | Ortega FJ | Mol Nutr Food Res |
| 25832883 | Genetic Vulnerability to Menthol Cigarette Preference in Women. (2015 Dec) | Oncken C | Nicotine Tob Res |
| 24312479 | TAS2R38 and its influence on smoking behavior and glucose homeostasis in the German Sorbs. (2013) | Keller M | PLoS One |
| 17250611 | Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. (2007 Feb) | Wang JC | Alcohol Clin Exp Res |
| 24302675 | The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. (2014 Jan) | Adappa ND | Int Forum Allergy Rhinol |