Gene: PTCH1

5727
BCNS|NBCCS|PTC|PTC1|PTCH
patched 1
protein-coding
9q22.32
Ensembl:ENSG00000185920 MIM:601309 Vega:OTTHUMG00000020280 UniprotKB:Q13635
NG_007664.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.749e-1 (AD)  4.474e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00638945chr9:98266643PTCH1Promoter3.632e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLITRK20.819
ZHX30.818
ADCYAP1R10.81
DAG10.806
HEPACAM0.803
SALL20.802
CADM10.796
CDH200.792
EGFR0.791
AHCYL20.791

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.401
OR4F29-0.361
GSDMA-0.352
C2orf83-0.35
CD244-0.342
GADL1-0.336
KLK8-0.322
SULT1E1-0.321
FCER2-0.32
NOX4-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0889691,4-diaminocyclohexane"1,4-diaminocyclohexane analog results in increased expression of PTCH1 mRNA"24973920
C0889691,4-diaminocyclohexane"BRD4 mutant form inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of PTCH1 mRNA]"24973920
C0889691,4-diaminocyclohexane"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of PTCH1 mRNA]"24973920
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PTCH1 mRNA"19114083
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of PTCH1 mRNA"17109907
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PTCH1 mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of PTCH1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of PTCH1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PTCH1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTCH1 mRNA16483693
D000728AndrogensAndrogens deficiency results in increased expression of PTCH1 mRNA26710974
D000728Androgens[mono-(2-ethylhexyl)phthalate co-treated with Androgens deficiency] results in increased expression of PTCH1 mRNA26710974
D001151ArsenicArsenic affects the methylation of PTCH1 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of PTCH1 mRNA23861973|2468527
C006632arsenic trioxidearsenic trioxide results in decreased expression of PTCH1 mRNA21183792
C015001arsenitearsenite results in increased methylation of PTCH1 promoter23974009
D001379AzathioprineAzathioprine affects the mutagenesis of PTCH1 gene18854826
C547126AZM551248AZM551248 results in decreased expression of PTCH1 mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of PTCH1 mRNA23656298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTCH1 mRNA"19150397
D004958Estradiol[Estradiol co-treated with IGF1 protein] results in increased expression of PTCH1 mRNA22811575
D004958EstradiolEstradiol affects the expression of PTCH1 mRNA23557687
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PTCH1 mRNA22958837
D004958EstradiolEstradiol results in decreased expression of PTCH1 mRNA25210133
D004958EstradiolEstradiol results in decreased expression of PTCH1 mRNA15328011
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PTCH1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTCH1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PTCH1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PTCH1 mRNA26079696
C028031cadmium acetatecadmium acetate results in decreased expression of PTCH1 mRNA23124188
C028031cadmium acetatecadmium acetate results in decreased expression of PTCH1 protein23124188
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PTCH1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PTCH1 mRNA27590029
D002251Carbon TetrachlorideColforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTCH1 mRNA]27590029
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PTCH1 gene20938992
D005576ColforsinColforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTCH1 mRNA]27590029
C038459curdlancurdlan results in decreased expression of PTCH1 mRNA23543010
C000541cyclopaminecyclopamine results in decreased expression of PTCH1 mRNA26710974
C000541cyclopaminemono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in decreased expression of PTCH1 mRNA]26710974
C000541cyclopaminecyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein]27481074
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]21110116
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]21110116
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 protein]21110116
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PTCH1 mRNA24317228
C014347decitabine[[decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP protein] which affects the expression of PTCH1 mRNA18559595
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of PTCH1 mRNA]21095227
C014347decitabine[decitabine co-treated with Valproic Acid] results in increased expression of PTCH1 mRNA19155313
C014347decitabinedecitabine results in decreased methylation of PTCH1 promoter19155313
C014347decitabinedecitabine results in increased expression of PTCH1 mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PTCH1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTCH1 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of PTCH1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTCH1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTCH1 mRNA19464577
D002945CisplatinCisplatin results in decreased expression of PTCH1 mRNA27392435
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of PTCH1 mRNA25386960
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PTCH1 mRNA28123099
C089799diheptyl phthalatediheptyl phthalate results in decreased expression of PTCH1 mRNA22112501
C118739entinostatentinostat results in decreased expression of PTCH1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
D000431EthanolPTCH1 gene affects the reaction [CDON gene mutant form results in increased susceptibility to Ethanol]24244464
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PTCH1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTCH1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PTCH1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PTCH1 mRNA17109907
D004997Ethinyl Estradiolfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of PTCH1 mRNA]17109907
D005419FlavonoidsFlavonoids results in decreased expression of PTCH1 mRNA18035473
D005472FluorouracilFluorouracil affects the localization of PTCH1 protein18776995
D005472Fluorouracil[Fluorouracil co-treated with irinotecan] results in increased expression of PTCH1 mRNA16391804
D005472FluorouracilFluorouracil results in decreased expression of PTCH1 mRNA18776995
D005472FluorouracilFluorouracil results in decreased expression of PTCH1 protein18776995|2519061
D005472FluorouracilGLI1 protein inhibits the reaction [Fluorouracil affects the localization of PTCH1 protein]18776995
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PTCH1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of PTCH1 mRNA20655997
C070081fulvestrantfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of PTCH1 mRNA]17109907
C056507gemcitabinegemcitabine affects the expression of PTCH1 mRNA20103597
D005947Glucosecyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein]27481074
D005947Glucose[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein27481074
D005947GlucoseSHH protein affects the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein]27481074
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of PTCH1 mRNA22634610
C538724HhAntag691HhAntag691 results in decreased expression of PTCH1 mRNA22087285
C538724HhAntag691GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]27585885
C538724HhAntag691HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]27585885
C538724HhAntag691HhAntag691 results in decreased expression of PTCH1 mRNA24973920
D017313FenretinideFenretinide results in decreased expression of PTCH1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PTCH1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTCH1 mRNA28628672
C051890irinotecan[Fluorouracil co-treated with irinotecan] results in increased expression of PTCH1 mRNA16391804
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PTCH1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTCH1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PTCH1 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PTCH1 mRNA24973920
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of PTCH1 mRNA]"24973920
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PTCH1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTCH1 mRNA12057914
D008070LipopolysaccharidesPTCH1 protein results in decreased susceptibility to Lipopolysaccharides21131441
D008070Lipopolysaccharidescyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]21110116
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PTCH1 mRNA21110116
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PTCH1 protein21110116
D008070LipopolysaccharidesSHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]21110116
D008070LipopolysaccharidesSHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 protein]21110116
D008555MelittenMelitten results in increased expression of PTCH1 protein26189965
D008627Mercuric ChlorideMercuric Chloride affects the expression of PTCH1 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PTCH1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PTCH1 mRNA26011545
C016599mono-(2-ethylhexyl)phthalate[mono-(2-ethylhexyl)phthalate co-treated with Androgens deficiency] results in increased expression of PTCH1 mRNA26710974
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in decreased expression of PTCH1 mRNA]26710974
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PTCH1 mRNA26710974
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PTCH1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PTCH1 mRNA"21624382|2555468
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTCH1 mRNA"25554681
D010100Oxygencyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein]27481074
D010100Oxygen[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein27481074
D010100OxygenSHH protein affects the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein]27481074
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PTCH1 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of PTCH1 mRNA16141649
C006253pirinixic acidpirinixic acid results in decreased expression of PTCH1 mRNA18445702|2081375
D010936Plant ExtractsPlant Extracts affects the expression of PTCH1 mRNA12878215
D059808PolyphenolsPolyphenols results in decreased expression of PTCH1 mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PTCH1 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PTCH1 mRNA22958837
D011441PropylthiouracilPropylthiouracil results in decreased expression of PTCH1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PTCH1 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of PTCH122301921
C059514resveratrolresveratrol results in decreased expression of PTCH1 protein25190613
C059514resveratrolresveratrol results in increased expression of PTCH1 mRNA20878097
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PTCH1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PTCH1 mRNA19073995
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of PTCH1 mRNA]21095227
C017947sodium arsenitesodium arsenite results in increased expression of PTCH1 mRNA20179202
D013629TamoxifenTamoxifen affects the expression of PTCH1 mRNA17555576
D013739TestosteroneTestosterone results in increased expression of PTCH1 mRNA19693291
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PTCH1 mRNA25172293
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PTCH1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTCH1 mRNA17337447|1879615
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTCH1 mRNA22298810
C009495titanium dioxidetitanium dioxide results in increased expression of PTCH1 mRNA29128614
D014212TretinoinTretinoin results in decreased expression of PTCH1 mRNA9224671
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of PTCH1 mRNA17085092
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PTCH1 mRNA22723015|2493525
C057693troglitazonetroglitazone results in decreased expression of PTCH1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PTCH1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PTCH1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of PTCH1 mRNA19101580
D014635Valproic Acid[decitabine co-treated with Valproic Acid] results in increased expression of PTCH1 mRNA19155313
D014635Valproic AcidValproic Acid results in increased expression of PTCH1 mRNA24896083
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTCH1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of PTCH1 mRNA19421011|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005113patched binding-IEA-  
GO:0005119smoothened binding-IBA21873635  
GO:0005119smoothened binding-IPI9811851  11278759  
GO:0005515protein binding-IPI19502428  19561609  25283809  
GO:0008158hedgehog receptor activity-IBA21873635  
GO:0008158hedgehog receptor activity-IEA-  
GO:0008201heparin binding-IEA-  
GO:0015485cholesterol binding-IDA21931618  
GO:0030332cyclin binding-IPI11331587  
GO:0044877protein-containing complex binding-IEA-  
GO:0097108hedgehog family protein binding-IBA21873635  
GO:0097108hedgehog family protein binding-IPI9811851  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP16229683  
GO:0001658branching involved in ureteric bud morphogenesis-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0001709cell fate determination-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0003007heart morphogenesis-IEA-  
GO:0007224smoothened signaling pathway-IBA21873635  
GO:0007224smoothened signaling pathway-IEP17850284  
GO:0007224smoothened signaling pathway-ISS-  
GO:0007346regulation of mitotic cell cycle-IEA-  
GO:0007420brain development-ISS-  
GO:0008589regulation of smoothened signaling pathway-ISS-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0009887animal organ morphogenesis-ISS-  
GO:0009953dorsal/ventral pattern formation-ISS-  
GO:0009957epidermal cell fate specification-IEA-  
GO:0010157response to chlorate-IEA-  
GO:0010875positive regulation of cholesterol efflux-IDA21931618  
GO:0016485protein processing-ISS-  
GO:0021522spinal cord motor neuron differentiation-IEA-  
GO:0021532neural tube patterning-IMP8681379  
GO:0021997neural plate axis specification-ISS-  
GO:0030326embryonic limb morphogenesis-ISS-  
GO:0030850prostate gland development-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032526response to retinoic acid-IEA-  
GO:0032880regulation of protein localization-IEA-  
GO:0035108limb morphogenesis-IMP8681379  
GO:0035137hindlimb morphogenesis-IEA-  
GO:0040015negative regulation of multicellular organism growth-ISS-  
GO:0042493response to drug-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0043433negative regulation of DNA-binding transcription factor activity-IMP16229683  
GO:0043616keratinocyte proliferation-IEA-  
GO:0045606positive regulation of epidermal cell differentiation-IEA-  
GO:0045668negative regulation of osteoblast differentiation-IMP16229683  
GO:0045879negative regulation of smoothened signaling pathway-ISS-  
GO:0045879negative regulation of smoothened signaling pathway-TAS11001584  
GO:0045893positive regulation of transcription, DNA-templated-IEA-  
GO:0048568embryonic organ development-IEA-  
GO:0050680negative regulation of epithelial cell proliferation-IEA-  
GO:0051782negative regulation of cell division-IEA-  
GO:0060037pharyngeal system development-IMP8681379  8981943  
GO:0060603mammary gland duct morphogenesis-IEA-  
GO:0060644mammary gland epithelial cell differentiation-IEA-  
GO:0060831smoothened signaling pathway involved in dorsal/ventral neural tube patterning-IEA-  
GO:0061005cell differentiation involved in kidney development-IEA-  
GO:0061053somite development-IMP8681379  
GO:0071397cellular response to cholesterol-IMP11278759  
GO:0071397cellular response to cholesterol-ISS-  
GO:0071679commissural neuron axon guidance-IEA-  
GO:0072001renal system development-IEP17850284  
GO:0072203cell proliferation involved in metanephros development-IEA-  
GO:0072659protein localization to plasma membrane-IDA11278759  
GO:0097421liver regeneration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005794Golgi apparatuscolocalizes_withIDA11278759  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA11278759  12635140  
GO:0005901caveola-IDA11278759  
GO:0014069postsynaptic density-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030496midbody-IEA-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA11278759  
GO:0044294dendritic growth cone-IEA-  
GO:0044295axonal growth cone-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA11278759  
GO:0060170ciliary membrane-TAS-  
KEGG ID KEGG Term
hsa04340Hedgehog signaling pathway
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-373080Class B/2 (Secretin family receptors)IEA
R-HSA-500792GPCR ligand bindingIEA
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5632681Ligand-receptor interactionsTAS
R-HSA-5632681Ligand-receptor interactionsIEA
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5632684Hedgehog 'on' stateIEA
R-HSA-5635838Activation of SMOTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21636545Cancer interception. (2011 Jun)Blackburn EHCancer Prev Res (Phila)
21889114Association of copy number loss of CDKN2B and PTCH1 with poor overall survival in patients with pulmonary squamous cell carcinoma. (2011 Sep)Zhao YClin Lung Cancer
25839328Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. (2015 Apr 2)Zhang LAm J Hum Genet