Gene info: ID 57282

Gene: SLC4A10

GENE ID: 57282

Synonyms: NBCn2|NCBE

Description: solute carrier family 4 member 10

Gene type: protein-coding

Location: 2q24.2

dbXrefs: Ensembl:ENSG00000144290 MIM:605556 Vega:OTTHUMG00000153938 UniprotKB:Q6U841

RefSeq: NG_021401.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.320e-1 (AD) 4.860e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs16846221	chr2:161963710 (GRCh38.p7)	G>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg16640027	chr2:162480963	SLC4A10	Promoter	1.791e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FRMPD4	0.979
MYT1L	0.977
GABRG2	0.976
CLVS2	0.975
OLFM3	0.973
CREG2	0.973
FAXC	0.971
ADAM22	0.97
ATRNL1	0.97
SYNJ1	0.97

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSAG1	-0.587
HEY2	-0.562
RAB13	-0.554
RNF135	-0.548
MYL3	-0.547
COPZ2	-0.531
CHST14	-0.526
ROM1	-0.517
CMTM3	-0.516
FLT3LG	-0.516

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01390	Sodium bicarbonate	Small Molecule	144-55-8	Approved	Transporter

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A10 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A10 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A10 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A10 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A10 mRNA"	25510870
D000082	Acetaminophen	Acetaminophen results in increased expression of SLC4A10 mRNA	22230336
D020106	Acrylamide	Acrylamide results in decreased expression of SLC4A10 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SLC4A10 gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of SLC4A10 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SLC4A10 mRNA	16483693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SLC4A10 mRNA	26001963
C006780	bisphenol A	bisphenol A affects the expression of SLC4A10 mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in increased expression of SLC4A10 protein	28903499
D003042	Cocaine	Cocaine results in increased expression of SLC4A10 protein	25100957
C546771	gardiquimod	gardiquimod results in increased expression of SLC4A10 mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SLC4A10 mRNA]	28003376
C018091	maduramicin	maduramicin results in increased expression of SLC4A10 mRNA	29128925
D008345	Manganese	Manganese results in decreased expression of SLC4A10 mRNA	17175027
C025340	manganese chloride	manganese chloride results in decreased expression of SLC4A10 mRNA	17175027
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of SLC4A10 mRNA	22401849
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A10 mRNA"	25510870
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of SLC4A10 mRNA	23608068
D011374	Progesterone	Progesterone results in increased expression of SLC4A10 mRNA	19690047
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SLC4A10 mRNA]	28003376
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SLC4A10 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of SLC4A10 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005452	inorganic anion exchanger activity	-	TAS	-
GO:0008509	anion transmembrane transporter activity	-	IBA	21873635
GO:0008510	sodium:bicarbonate symporter activity	-	IBA	21873635
GO:0015301	anion:anion antiporter activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006814	sodium ion transport	-	IEA	-
GO:0006821	chloride transport	-	NAS	10993873
GO:0009416	response to light stimulus	-	IEA	-
GO:0009791	post-embryonic development	-	IEA	-
GO:0015701	bicarbonate transport	-	IBA	21873635
GO:0015701	bicarbonate transport	-	NAS	10993873
GO:0015701	bicarbonate transport	-	TAS	-
GO:0021860	pyramidal neuron development	-	IEA	-
GO:0035264	multicellular organism growth	-	IEA	-
GO:0035641	locomotory exploration behavior	-	IEA	-
GO:0048854	brain morphogenesis	-	IEA	-
GO:0051453	regulation of intracellular pH	-	IBA	21873635
GO:0098656	anion transmembrane transport	-	IEA	-
GO:1902600	proton transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0016021	integral component of membrane	-	NAS	10993873
GO:0016323	basolateral plasma membrane	-	IEA	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0097440	apical dendrite	-	IEA	-
GO:0097441	basal dendrite	-	IEA	-
GO:0097442	CA3 pyramidal cell dendrite	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425381	Bicarbonate transporters	TAS
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal