Gene: PTGER2

5732
EP2
prostaglandin E receptor 2
protein-coding
14q22.1
Ensembl:ENSG00000125384 MIM:176804 Vega:OTTHUMG00000140300 UniprotKB:P43116
NG_013082.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.154e-2 (AD)  4.275e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09208942chr14:52794647PTGER27.000e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARP150.716
CD960.711
PTGER40.706
PTGDR0.697
BMP50.692
GIPC20.686
BMX0.684
UBL4B0.677
CLEC12A0.673
LY750.672

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.429
FEZF2-0.402
HHATL-0.398
DBP-0.378
MAGIX-0.371
FUT9-0.361
RHCG-0.36
GRM3-0.355
C15orf59-0.352
EPHB1-0.351

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00770AlprostadilSmall Molecule745-65-3Approved|InvestigationalTarget
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTarget
DB00929MisoprostolSmall Molecule59122-46-2ApprovedTarget
DB08964GemeprostSmall Molecule64318-79-2Approved|WithdrawnTarget
DB09211LimaprostSmall Molecule74397-12-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PTGER2 mRNA19933214
C4861822,3-bis(4-hydroxyphenyl)-propionitrile"2,3-bis(4-hydroxyphenyl)-propionitrile results in decreased expression of PTGER2 mRNA"22257560
C0261142-xylene2-xylene results in increased expression of PTGER2 mRNA20359517
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of PTGER2 mRNA"22257560
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER2 protein binds to SRC protein]19407222
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid[6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde]16360148
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid[6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein] which results in decreased susceptibility to Formaldehyde16360148
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein11882577|1636014
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid6-isopropoxy-9-oxoxanthene-2-carboxylic acid results in decreased activity of PTGER2 protein20678559
D000242Cyclic AMP[Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP23526216
D000242Cyclic AMPnickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP]23526216
C046926AH 23848[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER2 protein binds to SRC protein]19407222
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTGER2 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of PTGER2 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PTGER2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of PTGER2 mRNA20458559
D001194AsbestosAsbestos results in decreased expression of PTGER2 mRNA22398240
D001241AspirinPTGER2 SNP affects the susceptibility to Aspirin15496426
D001554BenzeneBenzene results in increased expression of PTGER2 mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTGER2 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTGER2 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of PTGER2 mRNA22257560
D004958EstradiolEstradiol results in increased expression of PTGER2 protein22257560
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PTGER2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PTGER2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PTGER2 mRNA20096755
C048491butaprostbutaprost results in increased activity of PTGER2 protein25715797
C048491butaprostLipopolysaccharides promotes the reaction [butaprost results in increased activity of PTGER2 protein]25715797
C048491butaprostbutaprost binds to and results in increased activity of PTGER2 protein11595431|1462268
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PTGER2 mRNA16644059
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PTGER2 mRNA20971185
D015230Prostaglandin D2Prostaglandin D2 binds to and results in increased activity of PTGER2 protein27636113
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PTGER2 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of PTGER220578217
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTGER2 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTGER2 mRNA15620428
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PTGER2 mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PTGER2 mRNA15620428
D002117CalcitriolCalcitriol results in decreased expression of PTGER2 mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PTGER2 mRNA25380136
C024629dimethyl phthalatedimethyl phthalate results in increased expression of PTGER2 mRNA26924002
D01506416,16-Dimethylprostaglandin E2"16,16-Dimethylprostaglandin E2 binds to and results in increased activity of PTGER2 protein"11595431
D004237DiuronDiuron results in increased expression of PTGER2 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTGER2 mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGER2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PTGER2 mRNA17351261
C004912ethylbenzeneethylbenzene results in increased expression of PTGER2 mRNA20359517
D018683Excitatory Amino Acid AgentsDinoprostone inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]]15131310
D018683Excitatory Amino Acid AgentsExcitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]15131310
D004397FonofosFonofos results in increased methylation of PTGER2 promoter22847954
D005557Formaldehyde[6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde]16360148
D005557Formaldehyde[6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein] which results in decreased susceptibility to Formaldehyde16360148
D006427HeminPTGER2 gene mutant form results in increased susceptibility to Hemin25451967
D017313FenretinideFenretinide results in increased expression of PTGER2 mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of PTGER2 mRNA17555711
D007213IndomethacinIndomethacin results in decreased expression of PTGER2 protein17555711
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PTGER2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PTGER2 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PTGER2 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PTGER2 mRNA24796395
D007654KetoconazolePTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]16784723
D007654KetoconazolePTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]16784723
D007654KetoconazolePTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]16784723
D007654KetoconazolePTGER2 protein results in increased susceptibility to Ketoconazole16784723
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [butaprost results in increased activity of PTGER2 protein]25715797
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTGER2 mRNA25715797
D008628MercuryMercury results in increased expression of PTGER2 mRNA12730625
D008752Methylene ChlorideMethylene Chloride results in increased expression of PTGER2 mRNA20359517
D015735MifepristoneMifepristone results in increased expression of PTGER2 mRNA19801535
D015735MifepristoneMifepristone results in increased expression of PTGER2 protein19801535
D016595Misoprostol[6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde]16360148
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PTGER2 mRNA26924002
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGER2 protein17709599
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Sulfur Dioxide results in increased expression of PTGER2 protein]21873648
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PTGER2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTGER2 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PTGER2 mRNA25380136
D009532NickelNickel results in increased expression of PTGER2 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of PTGER2 mRNA19167457
C029938nickel sulfate[Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate23526216
C029938nickel sulfate[[Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein23526216
C029938nickel sulfatenickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP]23526216
C029938nickel sulfatenickel sulfate results in increased expression of PTGER2 mRNA16100012
C025256nonylphenolnonylphenol results in decreased expression of PTGER2 mRNA15620428
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PTGER2 mRNA19074003
C570897NSC668394NSC668394 results in decreased expression of PTGER2 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PTGER2 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PTGER2 mRNA25729387
D010269ParaquatParaquat affects the expression of PTGER2 mRNA18198484
D010278ParathionParathion results in increased methylation of PTGER2 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of PTGER2 mRNA22178795
D010396PenicillaminePenicillamine results in increased expression of PTGER2 mRNA19575532
D015232DinoprostoneDinoprostone results in decreased expression of PTGER2 mRNA22120546
D015232DinoprostoneDinoprostone binds to and results in increased activity of PTGER2 protein27636113
D015232DinoprostoneDinoprostone inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]]15131310
D015232DinoprostoneDinoprostone results in increased activity of PTGER2 protein23526216
D015232Dinoprostone[Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP23526216
D015232Dinoprostone[Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate23526216
D015232Dinoprostone[[Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein23526216
D015232DinoprostoneDinoprostone results in increased expression of PTGER2 protein17709599
D015232Dinoprostonenickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP]23526216
D015232DinoprostonePTGER2 protein promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein]17761898
D015232DinoprostoneDinoprostone results in increased activity of PTGER2 protein15930264
D015232DinoprostonePTGER2 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]17408863
D010936Plant ExtractsPlant Extracts results in decreased expression of PTGER2 mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of PTGER2 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of PTGER2 protein21558462
D011374ProgesteroneProgesterone results in increased expression of PTGER2 mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of PTGER2 protein19801535
D011374ProgesteroneProgesterone results in decreased expression of PTGER217510236
C005556propionaldehydepropionaldehyde results in increased expression of PTGER2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PTGER2 mRNA24780913
D000527AlprostadilAlprostadil results in decreased expression of PTGER2 mRNA22120546
D015237DinoprostDinoprost binds to and results in increased activity of PTGER2 protein27636113
C502851quinocetonequinocetone results in increased expression of PTGER2 mRNA27046791
D064586Selenic AcidSelenic Acid results in increased expression of PTGER2 mRNA16444006
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PTGER2 mRNA25895662
C009279sodium bisulfite[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER2 protein21873648
D018038Sodium SeleniteSodium Selenite results in increased expression of PTGER2 mRNA18175754
C025026sodium sulfite[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER2 protein21873648
D013458Sulfur DioxideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Sulfur Dioxide results in increased expression of PTGER2 protein]21873648
D013458Sulfur DioxideSulfur Dioxide results in increased expression of PTGER2 protein21873648
D013629TamoxifenTamoxifen affects the expression of PTGER2 mRNA17555576
C041359terbinafinePTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]16784723
C041359terbinafinePTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]16784723
C041359terbinafinePTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]16784723
C041359terbinafinePTGER2 protein results in increased susceptibility to terbinafine16784723
C012568terbufosterbufos results in increased methylation of PTGER2 promoter22847954
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PTGER2 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTGER2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGER2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTGER2 mRNA19933214
D014050TolueneToluene results in increased expression of PTGER2 mRNA20359517
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PTGER2 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of PTGER2 mRNA20359517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PTGER2 mRNA25526689
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PTGER2 mRNA23537331|2552668
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PTGER2 mRNA"26179874
D014520Urethane[Urethane co-treated with IFNG protein] results in increased expression of PTGER2 mRNA12810352
D014635Valproic AcidValproic Acid results in decreased methylation of PTGER2 gene29154799
D014638VanadatesVanadates results in increased expression of PTGER2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PTGER2 gene25560391
C017963vinyl carbamatevinyl carbamate results in decreased expression of PTGER2 mRNA17849452
D015032ZincZinc deficiency results in decreased expression of PTGER2 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004957prostaglandin E receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-ISS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0032570response to progesterone-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0071380cellular response to prostaglandin E stimulus-IBA21873635  
GO:0071380cellular response to prostaglandin E stimulus-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS10462542  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-391903Eicosanoid ligand-binding receptorsTAS
R-HSA-391908Prostanoid ligand receptorsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18666211Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer: association with prognosis, PTGER2 expression, and epidermal growth factor receptor mutation. (2008 Sep 15)Tian LCancer
27548026Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. (2016 Oct)Sidahmed ENutr Cancer
16879213Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach. (2006 Aug)Hegener HHJ Thromb Haemost