Gene: PTGER3

5733
EP3|EP3-I|EP3-II|EP3-III|EP3-IV|EP3-VI|EP3e|PGE2-R
prostaglandin E receptor 3
protein-coding
1p31.1
Ensembl:ENSG00000050628 MIM:176806 Vega:OTTHUMG00000009399 UniprotKB:P43115
NG_029509.1
PubMed
0   ANCO-SNPs
ND
1   
4.312e-1 (AD)  7.324e-1 (ND)   (Frontal_Cortex)
3.988e-1 (AD)  7.223e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDH200.584
ANKRD500.574
TOM1L10.569
SSTR10.565
ANKRD60.565
RPS6KA60.564
GLRA30.562
RAB27B0.556
GNG20.547
RGS170.546

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHST14-0.343
TMEM88-0.332
SIPA1-0.332
ANPEP-0.331
FBLN1-0.329
FCGRT-0.329
SOD3-0.324
SOX18-0.32
SYDE1-0.316
ALDH3B1-0.312

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00905BimatoprostSmall Molecule155206-00-1Approved|InvestigationalTarget
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTarget
DB00929MisoprostolSmall Molecule59122-46-2ApprovedTarget
DB08964GemeprostSmall Molecule64318-79-2Approved|WithdrawnTarget
DB09211LimaprostSmall Molecule74397-12-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C03240511-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1"11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 results in increased phosphorylation of PTGER3 protein alternative form"15937517
C03240511-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1"11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 binds to and results in increased activity of PTGER3 protein"10525081
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTGER3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTGER3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTGER3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTGER3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTGER3 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of PTGER3 mRNA25088246
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of PTGER3 mRNA28522335
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of PTGER3 mRNA"22257560
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER3 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PTGER3 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER3 mRNA"27188386
D020106AcrylamideAcrylamide analog binds to and results in decreased activity of PTGER3 protein18287210
D000242Cyclic AMP[Dinoprostone results in increased activity of PTGER3 protein] which results in decreased abundance of Cyclic AMP10357836
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PTGER3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTGER3 mRNA16483693
C015001arsenitearsenite results in decreased expression of PTGER3 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of PTGER3 mRNA]18929588
D001241AspirinPTGER3 polymorphism affects the susceptibility to Aspirin20587336
D001280AtrazineAtrazine results in decreased expression of PTGER3 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of PTGER3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PTGER3 gene25435355
D004958EstradiolEstradiol affects the expression of PTGER3 mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of PTGER3 mRNA20404318
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of PTGER3 mRNA]20404318
D004958EstradiolEstradiol results in increased expression of PTGER3 mRNA16474171
D004958EstradiolEstradiol results in decreased expression of PTGER3 mRNA19484750
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PTGER3 protein22257560
D004958EstradiolEstradiol results in decreased expression of PTGER3 mRNA22257560
D004958EstradiolEstradiol results in increased expression of PTGER3 protein22257560
C095105bexarotenebexarotene results in decreased expression of PTGER3 mRNA17849452
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of PTGER3 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of PTGER3 mRNA16474171|2768578
C006780bisphenol Abisphenol A results in decreased expression of PTGER3 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of PTGER3 mRNA18958704
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PTGER3 mRNA25993096
D002118CalciumPTGER3 protein affects the reaction [Dinoprostone results in decreased transport of Calcium]12535167
D002118CalciumPTGER3 protein affects the reaction [ONO AE 248 results in decreased transport of Calcium]12535167
D000068579CelecoxibCelecoxib inhibits the reaction [Heymann Nephritis Antigenic Complex results in increased expression of PTGER3 mRNA]14636300
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PTGER3 gene20938992
C039671ciglitazone[Cisplatin co-treated with ciglitazone] results in decreased expression of PTGER321681689
D0150842,4-Dichlorophenoxyacetic Acid"2,4-Dichlorophenoxyacetic Acid results in decreased expression of PTGER3 mRNA"15878651
D003907DexamethasoneDexamethasone results in increased expression of PTGER3 mRNA25047013
D002945Cisplatin[Cisplatin co-treated with ciglitazone] results in decreased expression of PTGER321681689
D004041Dietary FatsDietary Fats results in decreased expression of PTGER3 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PTGER3 mRNA19638242
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of PTGER3 mRNA"27840820
D01506416,16-Dimethylprostaglandin E2"16,16-Dimethylprostaglandin E2 binds to and results in increased activity of PTGER3 protein"11595431
D01506416,16-Dimethylprostaglandin E2"PTGER3 gene mutant form affects the susceptibility to 16,16-Dimethylprostaglandin E2"11595431
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of PTGER3 mRNA17374397
D004237DiuronDiuron results in decreased expression of PTGER3 mRNA25152437
D005054EugenolEugenol results in decreased expression of PTGER3 mRNA17374397
D018690Excitatory Amino Acid AgonistsPTGER3 results in increased susceptibility to Excitatory Amino Acid Agonists17275922
D005485FlutamideFlutamide results in decreased expression of PTGER3 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PTGER3 gene20938992
D005557Formaldehyde[L-826266 binds to and results in decreased activity of PTGER3 protein] inhibits the reaction [Misoprostol results in decreased susceptibility to Formaldehyde]16360148
D005557Formaldehyde[L-826266 binds to and results in decreased activity of PTGER3 protein] which results in decreased susceptibility to Formaldehyde16360148
D019833GenisteinGenistein results in increased expression of PTGER3 mRNA16474171
D005897GlafenineGlafenine results in decreased expression of PTGER3 mRNA24136188
C412815GW 4064GW 4064 results in decreased expression of PTGER3 mRNA26655953
D006533HeptachlorHeptachlor results in decreased expression of PTGER3 mRNA23153324
D026541Heymann Nephritis Antigenic ComplexCelecoxib inhibits the reaction [Heymann Nephritis Antigenic Complex results in increased expression of PTGER3 mRNA]14636300
D026541Heymann Nephritis Antigenic ComplexHeymann Nephritis Antigenic Complex results in increased expression of PTGER3 mRNA14636300
D007052IbuprofenIbuprofen affects the expression of PTGER3 mRNA17070997
D007654KetoconazolePTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]16784723
D007654KetoconazolePTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]16784723
D007654KetoconazolePTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]16784723
D007654KetoconazolePTGER3 protein results in increased susceptibility to Ketoconazole16784723
C508710L-826266[L-826266 binds to and results in decreased activity of PTGER3 protein] inhibits the reaction [Misoprostol results in decreased susceptibility to Formaldehyde]16360148
C508710L-826266[L-826266 binds to and results in decreased activity of PTGER3 protein] which results in decreased susceptibility to Formaldehyde16360148
C508710L-826266L-826266 binds to and results in decreased activity of PTGER3 protein16360148|1829710
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PTGER3 gene20938992
D015735MifepristoneMifepristone results in increased expression of and affects the localization of PTGER3 protein19801535
D016595Misoprostol[L-826266 binds to and results in decreased activity of PTGER3 protein] inhibits the reaction [Misoprostol results in decreased susceptibility to Formaldehyde]16360148
C528911N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide"N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide results in decreased expression of PTGER3 mRNA"18287210
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PTGER3 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTGER3 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PTGER3 mRNA19812364
C029938nickel sulfatenickel sulfate results in decreased expression of PTGER3 mRNA16780908|1737439
C121546ONO AE 248PTGER3 results in increased susceptibility to ONO AE 24811375261
C121546ONO AE 248PTGER3 protein affects the reaction [ONO AE 248 results in decreased transport of Calcium]12535167
C121546ONO AE 248ONO AE 248 binds to and results in increased activity of PTGER3 protein11375261|1727592
C095324ONO-NT 012ONO-NT 012 binds to and results in increased activity of PTGER3 protein11595431
D010081OxazoloneOxazolone results in decreased expression of PTGER3 mRNA17374397
D000073878Palm OilPalm Oil results in decreased expression of PTGER3 mRNA18042831
D010269ParaquatParaquat results in decreased expression of PTGER3 mRNA17077588
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTGER3 mRNA"25510870
D015232DinoprostoneDinoprostone results in increased expression of PTGER3 mRNA22120546
D015232DinoprostoneDinoprostone binds to and results in increased activity of PTGER3 protein17242161
D015232DinoprostoneDinoprostone results in increased activity of PTGER3 protein10357836
D015232Dinoprostone[Dinoprostone results in increased activity of PTGER3 protein] which results in decreased abundance of Cyclic AMP10357836
D015232DinoprostonePTGER3 affects the susceptibility to Dinoprostone11375261
D015232DinoprostoneDinoprostone binds to PTGER3 protein15937517
D015232DinoprostoneDinoprostone binds to PTGER3 protein alternative form15937517
D015232DinoprostoneDinoprostone results in increased expression of PTGER3 mRNA14636300
D015232DinoprostonePTGER3 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]17408863
D015232DinoprostonePTGER3 protein affects the reaction [Dinoprostone results in decreased transport of Calcium]12535167
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of PTGER3 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of PTGER3 mRNA20813756
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of PTGER3 mRNA16474171
C009042pristanepristane results in increased expression of PTGER3 mRNA15075356
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PTGER3 protein22257560
D011441PropylthiouracilPropylthiouracil results in increased expression of PTGER3 mRNA24780913
D000527AlprostadilAlprostadil results in increased expression of PTGER3 mRNA22120546
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNA19059307
C116926rofecoxibrofecoxib results in decreased expression of PTGER3 mRNA17070997
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased expression of PTGER3 mRNA"10432392
D012999SomanSoman results in increased expression of PTGER3 mRNA19281266
D019311StaurosporineStaurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PTGER3 protein alternative form]15937517
D019311StaurosporineStaurosporine results in decreased phosphorylation of PTGER3 protein alternative form15937517
C016767sulprostonesulprostone binds to and results in increased activity of PTGER3 protein10357836
C016767sulprostonesulprostone binds to and results in increased activity of PTGER3 protein10525081|1188257
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNA19059307
C041359terbinafinePTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]16784723
C041359terbinafinePTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]16784723
C041359terbinafinePTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]16784723
C041359terbinafinePTGER3 protein results in increased susceptibility to terbinafine16784723
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTGER3 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTGER3 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTGER3 mRNA26232522
D013755Tetradecanoylphorbol AcetateStaurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PTGER3 protein alternative form]15937517
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of PTGER3 protein alternative form15937517
D013853ThioacetamideThioacetamide results in increased expression of PTGER3 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of PTGER3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PTGER3 mRNA19969065
D014212TretinoinTretinoin results in decreased expression of PTGER3 mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of PTGER3 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PTGER3 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PTGER3 gene25560391
C017963vinyl carbamatevinyl carbamate results in increased expression of PTGER3 mRNA17849452
D002762CholecalciferolCholecalciferol results in increased expression of PTGER3 mRNA17170073

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004957prostaglandin E receptor activity-IBA21873635  
GO:0004957prostaglandin E receptor activity-NAS9073510  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0008219cell death-TAS10947062  
GO:0014827intestine smooth muscle contraction-IBA21873635  
GO:0031622positive regulation of fever generation-ISS-  
GO:0060455negative regulation of gastric acid secretion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-TAS10336471  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8307176  
GO:0016021integral component of membrane-NAS9073510  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-391903Eicosanoid ligand-binding receptorsTAS
R-HSA-391908Prostanoid ligand receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19562039Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. (2009 Jun 29)Sober SPLoS One