Gene: CBX8

57332
PC3|RC1
chromobox 8
protein-coding
17q25.3
Ensembl:ENSG00000141570 MIM:617354 Vega:OTTHUMG00000150416 UniprotKB:Q9HC52
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.304e-1 (AD)  5.163e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CBX40.752
USP190.722
ZNF2820.721
ZNF2130.717
TAOK20.712
HYOU10.71
PTCD10.71
KAT50.709
ABCF10.708
ARMC60.705

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.423
HBD-0.402
ADH1B-0.4
MTRNR2L6-0.396
MTRNR2L9-0.383
MTRNR2L10-0.382
OR4F29-0.38
H3F3C-0.38
RSPO1-0.374
IL18RAP-0.365

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CBX8 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of CBX8 mRNA17562736
C015001arsenitearsenite results in increased methylation of CBX8 promoter23974009
C006780bisphenol Abisphenol A results in increased methylation of CBX8 promoter27312807
C006780bisphenol Abisphenol A affects the expression of CBX8 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CBX8 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CBX8 promoter22457795
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CBX8 mRNA20350560
D019327Copper SulfateCopper Sulfate results in decreased expression of CBX8 mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CBX8 mRNA28628672
C061365flusilazoleflusilazole affects the expression of CBX8 mRNA21195148
C409722hexaconazolehexaconazole affects the expression of CBX8 mRNA21195148
D017313FenretinideFenretinide results in decreased expression of CBX8 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CBX8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CBX8 mRNA28628672
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CBX8 mRNA25890327
D008694MethamphetamineMethamphetamine results in decreased expression of CBX8 mRNA19564919
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CBX8 mRNA19710929
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CBX8 mRNA28903501
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CBX8 mRNA19073995
C017947sodium arsenitesodium arsenite results in decreased expression of CBX8 mRNA16014739
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBX8 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of CBX8 mRNA25975270
C032910triadimefontriadimefon affects the expression of CBX8 mRNA21195148
D014635Valproic AcidValproic Acid results in increased methylation of CBX8 gene29154799
D014635Valproic AcidValproic Acid affects the expression of CBX8 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of CBX8 mRNA19136453

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003727single-stranded RNA binding-IEA-  
GO:0005515protein binding-IPI16169070  17332741  18927235  19636380  20543829  20601937  
21282530  22094252  23260655  25416956  26496610  27505670  
27705803  
GO:0035064methylated histone binding-IDA21029866  
GO:0097027ubiquitin-protein transferase activator activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP19636380  21282530  
GO:0006351transcription, DNA-templated-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0016574histone ubiquitination-IEA-  
GO:0032967positive regulation of collagen biosynthetic process-IEA-  
GO:0045739positive regulation of DNA repair-IEA-  
GO:0050790regulation of catalytic activity-IEA-  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA19636380  
GO:0000792heterochromatin-IEA-  
GO:0005634nucleus-IDA21282530  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0031519PcG protein complex-IDA21282530  
GO:0035102PRC1 complex-IDA12167701  19636380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4551638SUMOylation of chromatin organization proteinsTAS
R-HSA-4570464SUMOylation of RNA binding proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25839328Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. (2015 Apr 2)Zhang LAm J Hum Genet