Gene info: ID 5734

Gene: PTGER4

GENE ID: 5734

Synonyms: EP4|EP4R

Description: prostaglandin E receptor 4

Gene type: protein-coding

Location: 5p13.1

dbXrefs: Ensembl:ENSG00000171522 MIM:601586 Vega:OTTHUMG00000094769 UniprotKB:P35408

RefSeq: NG_047000.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.091e-1 (AD) 8.096e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FAM129A	0.798
TNFAIP8	0.788
VEGFC	0.786
CYTIP	0.786
EDNRA	0.781
BNC2	0.779
FAM20A	0.77
FBLIM1	0.767
GPX8	0.766
SPTLC3	0.758

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
BDH1	-0.442
FEZF2	-0.441
RNFT2	-0.436
ASPDH	-0.436
RS1	-0.427
FUT9	-0.419
ANKRD24	-0.414
CCDC24	-0.413
TEX29	-0.412
SLC25A10	-0.408

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00917	Dinoprostone	Small Molecule	363-24-6	Approved	Target
DB00929	Misoprostol	Small Molecule	59122-46-2	Approved	Target
DB09211	Limaprost	Small Molecule	74397-12-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C034008	11-deoxyprostaglandin E1	11-deoxyprostaglandin E1 binds to and results in increased activity of PTGER4 protein	11595431
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of PTGER4 mRNA"	20453058
C486182	2,3-bis(4-hydroxyphenyl)-propionitrile	"2,3-bis(4-hydroxyphenyl)-propionitrile results in decreased expression of PTGER4 mRNA"	22257560
C012796	2-butenal	2-butenal results in decreased expression of PTGER4 mRNA	20471460
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in decreased expression of PTGER4 mRNA"	24172598
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of PTGER4 mRNA"	22257560
C487890	4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid	4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid binds to and results in decreased activity of PTGER4 protein	18030065
C487890	4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid	4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid results in decreased activity of PTGER4 protein	15976003
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER4 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of PTGER4 mRNA	19191707
C545122	5-(3-(2-(3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylate	5-(3-(2-(3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylate binds to and results in increased activity of PTGER4 protein	20008547
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER4 mRNA"	27188386
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER4 protein binds to SRC protein]	19407222
C011987	8-isoprostaglandin E2	PTGER4 protein affects the susceptibility to 8-isoprostaglandin E2	22565502
D000082	Acetaminophen	Acetaminophen results in increased expression of PTGER4 mRNA	26690555
D000242	Cyclic AMP	[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP	23526216
D000242	Cyclic AMP	nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP]	23526216
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PTGER4 gene	27153756
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER4 protein binds to SRC protein]	19407222
C046926	AH 23848	AH 23848 binds to and results in decreased activity of PTGER4 protein	19407222
C046926	AH 23848	AH 23848 results in decreased activity of PTGER4 protein	20678559
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PTGER4 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of PTGER4 mRNA"	22863853
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PTGER4 mRNA	24449571
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of PTGER4 mRNA"	25351596
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PTGER4 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PTGER4 mRNA	21714911
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PTGER4 mRNA"	20382639
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PTGER4 mRNA	19619570
D004958	Estradiol	Estradiol inhibits the reaction [TNF protein results in increased expression of PTGER4 mRNA]	24771768
D004958	Estradiol	Estradiol results in decreased expression of PTGER4 mRNA	21185374
D004958	Estradiol	Estradiol results in increased expression of PTGER4 mRNA	19153601\|1961957
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of PTGER4 mRNA	15829624
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of PTGER4 protein	15829624
D004958	Estradiol	Estradiol results in decreased expression of PTGER4 mRNA	22257560
D004958	Estradiol	Estradiol results in increased expression of PTGER4 protein	22257560
D004958	Estradiol	PTGER4 mutant form inhibits the reaction [Estradiol results in increased expression of PPP1R9B protein]	17408863
C095105	bexarotene	bexarotene results in decreased expression of PTGER4 mRNA	17849452
C006780	bisphenol A	bisphenol A results in decreased expression of PTGER4 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of PTGER4 mRNA	28079927
C006780	bisphenol A	bisphenol A results in decreased expression of PTGER4 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of PTGER4 mRNA	20096755
D019274	Botulinum Toxins, Type A	"Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased expression of PTGER4 protein]"	18514386
C018475	butyraldehyde	butyraldehyde results in increased expression of PTGER4 mRNA	26079696
D002104	Cadmium	Cadmium affects the expression of PTGER4 mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PTGER4 mRNA	23741332
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of PTGER4 mRNA	17484886
D000068579	Celecoxib	[Celecoxib co-treated with Heymann Nephritis Antigenic Complex] affects the expression of PTGER4 mRNA	14636300
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTGER4 mRNA	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PTGER4 mRNA	19320972
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of PTGER4 mRNA	20971185
D003520	Cyclophosphamide	"Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased expression of PTGER4 protein]"	18514386
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of PTGER4 protein	18514386\|2034604
D003703	Demecolcine	Demecolcine results in increased expression of PTGER4 mRNA	23649840
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PTGER4 mRNA	15620428
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PTGER4 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of PTGER4 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of PTGER4 mRNA	27594783
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of PTGER4 mRNA	15620428
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of PTGER4 mRNA	15620428
D002117	Calcitriol	Calcitriol results in decreased expression of PTGER4 mRNA	16002434
D015064	16,16-Dimethylprostaglandin E2	"16,16-Dimethylprostaglandin E2 binds to and results in increased activity of PTGER4 protein"	11595431
D004237	Diuron	Diuron metabolite results in decreased expression of PTGER4 mRNA	24172598
D004237	Diuron	Diuron results in increased expression of PTGER4 mRNA	21551480
D004317	Doxorubicin	[Doxorubicin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA	19643929
D004317	Doxorubicin	[Doxorubicin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein	19643929
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PTGER4 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PTGER4 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGER4 mRNA	17942748
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTGER4 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of PTGER4 mRNA	20655997
D005557	Formaldehyde	[L-161982 binds to and results in decreased activity of PTGER4 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde]	16360148
D005557	Formaldehyde	[L-161982 binds to and results in decreased activity of PTGER4 protein] which results in decreased susceptibility to Formaldehyde	16360148
C070081	fulvestrant	fulvestrant inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGER4 mRNA]]	24771768
D005665	Furosemide	PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]	15976003
D005665	Furosemide	PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein]	15976003
D005947	Glucose	Glucose results in increased expression of PTGER4 mRNA	12888618
D005947	Glucose	Glucose results in increased expression of PTGER4 protein	12888618
D026541	Heymann Nephritis Antigenic Complex	[Celecoxib co-treated with Heymann Nephritis Antigenic Complex] affects the expression of PTGER4 mRNA	14636300
D017313	Fenretinide	Fenretinide results in increased expression of PTGER4 mRNA	28973697
C029424	hydrazine	hydrazine results in decreased expression of PTGER4 mRNA	15282401
C475919	hydroxytamoxifen	GPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of PTGER4 mRNA]	19153601
C475919	hydroxytamoxifen	hydroxytamoxifen results in increased expression of PTGER4 mRNA	19153601
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTGER4 mRNA	25613284
C040920	isoliquiritigenin	isoliquiritigenin results in decreased expression of PTGER4 mRNA	25094029
C040920	isoliquiritigenin	isoliquiritigenin results in decreased expression of PTGER4 protein	25094029
C119620	kenpaullone	kenpaullone results in decreased expression of PTGER4 mRNA	17993264
D020910	Ketorolac	Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA]	10800959
C508711	L-161982	L-161982 binds to and results in decreased activity of PTGER4 protein	16360148\|1639694
C508711	L-161982	[L-161982 binds to and results in decreased activity of PTGER4 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde]	16360148
C508711	L-161982	[L-161982 binds to and results in decreased activity of PTGER4 protein] which results in decreased susceptibility to Formaldehyde	16360148
D008353	Mannitol	Mannitol results in decreased expression of PTGER4 mRNA	12888618
C065757	meloxicam	meloxicam inhibits the reaction [IFNE protein results in decreased expression of PTGER4 mRNA]	21270428
C065757	meloxicam	meloxicam results in decreased expression of PTGER4 mRNA	21270428
C042720	mercuric bromide	mercuric bromide results in increased expression of PTGER4 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER4 mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTGER4 mRNA	20938992
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of PTGER4 mRNA	25926378
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PTGER4 mRNA	23649840
D015741	Metribolone	Metribolone results in increased expression of PTGER4 mRNA	17010675
C545573	MF-310	MF-310 binds to and results in decreased activity of PTGER4 protein	21215624
C557885	MF 592	MF 592 binds to and results in decreased activity of PTGER4 protein	21215624
D015735	Mifepristone	Mifepristone results in increased expression of PTGER4 mRNA	19801535
D015735	Mifepristone	Mifepristone results in increased expression of PTGER4 protein	19801535
D016595	Misoprostol	[L-161982 binds to and results in decreased activity of PTGER4 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde]	16360148
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Sulfur Dioxide results in increased expression of PTGER4 protein]	21873648
C528911	N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide	"N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide binds to and results in decreased activity of PTGER4 protein"	18287210
C528911	N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide	"N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide results in decreased expression of PTGER4 mRNA"	18287210
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PTGER4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PTGER4 mRNA"	25554681
D009281	Naphthalenes	Naphthalenes analog binds to and results in decreased activity of PTGER4 protein	21215624
D009532	Nickel	Nickel results in increased expression of PTGER4 mRNA	25583101
C029938	nickel sulfate	[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate	23526216
C029938	nickel sulfate	[[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein	23526216
C029938	nickel sulfate	nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP]	23526216
C029938	nickel sulfate	nickel sulfate results in increased expression of PTGER4 mRNA	22714537
C025256	nonylphenol	nonylphenol results in decreased expression of PTGER4 mRNA	15620428
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of PTGER4 mRNA	20971185
C018620	oleoresins	oleoresins results in decreased expression of PTGER4 mRNA	20008804
C461399	ONO-AE1-329	PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF mRNA]]	11301049
C461399	ONO-AE1-329	PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF protein]]	11301049
C461399	ONO-AE1-329	PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 mRNA]]	11301049
C461399	ONO-AE1-329	PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 protein]]	11301049
C461399	ONO-AE1-329	ONO-AE1-329 binds to and results in increased activity of PTGER4 protein	11595431\|1972983
D010100	Oxygen	Oxygen deficiency results in decreased expression of PTGER4 mRNA	26516004
D017239	Paclitaxel	Paclitaxel results in decreased expression of PTGER4 mRNA	15585946
C496932	panobinostat	panobinostat results in increased expression of PTGER4 mRNA	26272509
D052638	Particulate Matter	Particulate Matter results in decreased expression of PTGER4 mRNA	22178795
D015232	Dinoprostone	Dinoprostone results in decreased expression of PTGER4 mRNA	22120546
D015232	Dinoprostone	Dinoprostone results in increased activity of PTGER4 protein	23526216
D015232	Dinoprostone	[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP	23526216
D015232	Dinoprostone	[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate	23526216
D015232	Dinoprostone	[[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein	23526216
D015232	Dinoprostone	nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP]	23526216
D015232	Dinoprostone	Dinoprostone binds to and results in decreased activity of PTGER4 protein	12009843
D015232	Dinoprostone	Dinoprostone results in increased expression of PTGER4 mRNA	10800959
D015232	Dinoprostone	PTGER4 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]	17408863
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER4 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PTGER4 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of PTGER4 mRNA	17426115\|2081375
D010894	Piroxicam	Piroxicam results in decreased expression of PTGER4 mRNA	21858171
D010938	Plant Oils	Plant Oils results in increased expression of PTGER4 mRNA	23370395
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of PTGER4 mRNA	21334430
C009042	pristane	pristane results in increased expression of PTGER4 mRNA	15075356
D011374	Progesterone	Progesterone results in increased expression of PTGER4 mRNA	23018184
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of PTGER4 mRNA	15829624
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of PTGER4 protein	15829624
D011374	Progesterone	Progesterone results in decreased expression of PTGER4 protein	19801535
D000527	Alprostadil	Alprostadil results in decreased expression of PTGER4 mRNA	22120546
D011691	Puromycin	[Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA	19643929
D011691	Puromycin	[Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein	19643929
D011804	Quinolines	Quinolines analog binds to and results in decreased activity of PTGER4 protein	21215624
C052785	rebamipide	rebamipide results in increased expression of PTGER4 mRNA	10882227
C059514	resveratrol	fulvestrant inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGER4 mRNA]]	24771768
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of PTGER4 mRNA]	24771768
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of PTGER4 mRNA	25351596
C017947	sodium arsenite	sodium arsenite results in increased stability of PTGER4 mRNA	25493608
C017947	sodium arsenite	sodium arsenite results in decreased expression of PTGER4 mRNA	16014739
C009279	sodium bisulfite	[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER4 protein	21873648
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary deficiency results in increased expression of PTGER4 mRNA"	10432392
D018038	Sodium Selenite	Sodium Selenite results in increased expression of PTGER4 mRNA	18175754
C025026	sodium sulfite	[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER4 protein	21873648
D053260	Soot	Soot results in increased expression of PTGER4 mRNA	26551751
D013453	Sulfonylurea Compounds	Sulfonylurea Compounds analog binds to and results in decreased activity of PTGER4 protein	21215624
D013458	Sulfur Dioxide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Sulfur Dioxide results in increased expression of PTGER4 protein]	21873648
D013458	Sulfur Dioxide	Sulfur Dioxide results in increased expression of PTGER4 protein	21873648
D013629	Tamoxifen	Tamoxifen affects the expression of PTGER4 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PTGER4 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PTGER4 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGER4 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PTGER4 mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTGER4 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of PTGER4 mRNA	28065790
C012589	trichostatin A	trichostatin A results in increased expression of PTGER4 mRNA	24935251
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of PTGER4 mRNA	25526689
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of PTGER4 mRNA	25526689
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PTGER4 mRNA"	26179874
D014520	Urethane	Urethane results in decreased expression of PTGER4 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTGER4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of PTGER4 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of PTGER4 mRNA	23179753\|2438349
D014640	Vancomycin	Vancomycin results in decreased expression of PTGER4 mRNA	18930951
D014750	Vincristine	Vincristine results in increased expression of PTGER4 mRNA	23649840
C017963	vinyl carbamate	vinyl carbamate results in decreased expression of PTGER4 mRNA	17849452
C088658	zoledronic acid	zoledronic acid results in increased expression of PTGER4 mRNA	24714768
D015054	Zymosan	PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF mRNA]]	11301049
D015054	Zymosan	PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF protein]]	11301049
D015054	Zymosan	PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 mRNA]]	11301049
D015054	Zymosan	PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 protein]]	11301049

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004957	prostaglandin E receptor activity	-	IBA	21873635
GO:0004957	prostaglandin E receptor activity	-	IDA	8163486
GO:0005515	protein binding	-	IPI	16424369

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006954	inflammatory response	-	IBA	21873635
GO:0006955	immune response	-	IEP	8862514
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	IDA	8163486
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IBA	21873635
GO:0007254	JNK cascade	-	ISS	-
GO:0009612	response to mechanical stimulus	-	IEP	21723865
GO:0030278	regulation of ossification	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0033624	negative regulation of integrin activation	-	IDA	21681739
GO:0042093	T-helper cell differentiation	-	ISS	-
GO:0050710	negative regulation of cytokine secretion	-	ISS	-
GO:0050715	positive regulation of cytokine secretion	-	ISS	-
GO:0050728	negative regulation of inflammatory response	-	IDA	16424369
GO:0050729	positive regulation of inflammatory response	-	ISS	-
GO:0051492	regulation of stress fiber assembly	-	ISS	-
GO:0060348	bone development	-	ISS	-
GO:0070371	ERK1 and ERK2 cascade	-	ISS	-
GO:0071260	cellular response to mechanical stimulus	-	ISS	-
GO:0071380	cellular response to prostaglandin E stimulus	-	IBA	21873635
GO:2000420	negative regulation of eosinophil extravasation	-	IDA	21681739

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005622	intracellular	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	NAS	8163486

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-391903	Eicosanoid ligand-binding receptors	TAS
R-HSA-391908	Prostanoid ligand receptors	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28631723	Pharmacogenetic biomarkers of response in Crohn's disease. (2018 Jan)	Linares-Pineda TM	Pharmacogenomics J
27548026	Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. (2016 Oct)	Sidahmed E	Nutr Cancer
28400866	Association of ERAP1, IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis. (2017)	Ozen G	Open Rheumatol J
23861218	Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population. (2013 Nov)	Song HR	Mol Carcinog