Gene: PTGIS

5740
CYP8|CYP8A1|PGIS|PTGI
prostaglandin I2 synthase
protein-coding
20q13.13
Ensembl:ENSG00000124212 MIM:601699 Vega:OTTHUMG00000033077 UniprotKB:Q16647
NG_007940.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.354e-1 (AD)  6.721e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1QTNF20.71
NPNT0.673
SAMD50.669
ACE0.665
KLF80.653
SCARA50.647
ACTA2-AS10.635
NTN40.63
SYNPO20.627
SLC6A200.623

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STON2-0.479
RFX4-0.478
OTOS-0.439
BMPR1B-0.438
PLIN5-0.434
SLC14A1-0.426
KLF15-0.425
CYP2J2-0.424
ROM1-0.423
RHOBTB3-0.422

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00812PhenylbutazoneSmall Molecule50-33-9ApprovedTarget
DB01240EpoprostenolSmall Molecule35121-78-9ApprovedTarget
DB08675(5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acidSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PTGIS mRNA"26377693
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of PTGIS mRNA]"19414516
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of PTGIS mRNA"21724226
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PTGIS mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGIS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGIS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGIS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGIS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGIS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGIS mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PTGIS mRNA17562736
D000171AcroleinAcrolein results in decreased expression of PTGIS mRNA17255567
D000171AcroleinAcrolein results in decreased expression of PTGIS protein17255567
D020106AcrylamideAcrylamide results in decreased expression of PTGIS mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PTGIS mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PTGIS mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTGIS mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PTGIS mRNA24449571
D001194AsbestosAsbestos results in decreased expression of PTGIS mRNA22398240
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of PTGIS mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTGIS mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PTGIS mRNA"20382639
D004958EstradiolEstradiol results in increased expression of PTGIS mRNA19484750
C006780bisphenol Abisphenol A affects the expression of PTGIS mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PTGIS mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PTGIS mRNA12075121
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PTGIS mRNA24982889
C081643candesartancandesartan results in decreased expression of PTGIS mRNA14871019
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PTGIS mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PTGIS mRNA16644059
D002331CarnitineCarnitine results in increased expression of PTGIS mRNA19491382
D002331Carnitine[Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha19491382
D002331CarnitinePTGIS protein results in increased susceptibility to Carnitine19491382
C418118CI 1044CI 1044 results in increased expression of PTGIS mRNA17569694
D002994ClofibrateClofibrate results in decreased expression of PTGIS mRNA17585979
D000069439DasatinibDasatinib results in increased expression of PTGIS mRNA20579391
D013759DronabinolDronabinol results in decreased expression of PTGIS mRNA16616335
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PTGIS mRNA]27941970
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PTGIS mRNA16054899
D004041Dietary FatsDietary Fats results in increased expression of PTGIS mRNA18042831
C058705diethyl malatediethyl malate affects the expression of PTGIS mRNA24814887
D002117CalcitriolCalcitriol results in decreased expression of PTGIS mRNA26485663
D004237DiuronDiuron results in decreased expression of PTGIS mRNA25152437
D004317DoxorubicinDoxorubicin results in increased oxidation of PTGIS protein28818578
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of PTGIS mRNA25198161
C118739entinostatentinostat results in decreased expression of PTGIS mRNA26272509
C118739entinostatentinostat results in increased expression of PTGIS mRNA27188386
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGIS mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTGIS mRNA12075121
C039281furanfuran results in increased expression of PTGIS mRNA27387713
D019833GenisteinGenistein results in increased expression of PTGIS mRNA12075121
D005839GentamicinsGentamicins results in decreased expression of PTGIS mRNA19491382
D005897GlafenineGlafenine results in decreased expression of PTGIS mRNA24136188
D007213IndomethacinIndomethacin inhibits the reaction [TNF protein results in increased activity of PTGIS protein]11165876
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PTGIS mRNA16054899
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PTGIS mRNA26752646
D0151216-Ketoprostaglandin F1 alpha[Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha19491382
D0151216-Ketoprostaglandin F1 alphaPTGIS protein results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha19491382
D008727MethotrexateMethotrexate results in decreased expression of PTGIS mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PTGIS mRNA23458150
D009151Mustard GasMustard Gas results in increased expression of PTGIS mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTGIS mRNA"25554681|2562005
D010100OxygenOxygen deficiency results in increased expression of PTGIS mRNA26516004
D000073878Palm OilPalm Oil results in increased expression of PTGIS mRNA18042831
D052638Particulate Matter[APOE gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of PTGIS mRNA22746401
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PTGIS mRNA18692542
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PTGIS mRNA22237054
D010634PhenobarbitalPhenobarbital results in decreased expression of PTGIS mRNA19162173
D010656PhenylephrinePhenylephrine results in increased expression of PTGIS mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGIS mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PTGIS mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of PTGIS mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PTGIS mRNA19162173
C005556propionaldehydepropionaldehyde results in increased expression of PTGIS mRNA17255567
D011441PropylthiouracilPropylthiouracil results in decreased expression of PTGIS mRNA24780913
D015237DinoprostDinoprost results in decreased expression of PTGIS mRNA20484870
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PTGIS mRNA16079270
C116926rofecoxibrofecoxib results in decreased expression of PTGIS mRNA17175104
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PTGIS mRNA16054899
C089730rosiglitazonerosiglitazone affects the expression of PTGIS mRNA17245590
D012906SmokeSmoke results in decreased expression of PTGIS mRNA17255567
C017947sodium arsenitesodium arsenite results in decreased expression of PTGIS mRNA20965206
D012965Sodium Chloride[AGT protein co-treated with Sodium Chloride] affects the expression of PTGIS mRNA27225954
D012969Sodium FluorideSodium Fluoride results in increased expression of PTGIS protein28918527
D018038Sodium SeleniteSodium Selenite affects the expression of PTGIS mRNA21669866
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTGIS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTGIS mRNA15591033
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTGIS mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTGIS mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTGIS mRNA11752688|2121527
C009495titanium dioxidetitanium dioxide results in decreased expression of PTGIS mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of PTGIS mRNA27760801
D014212TretinoinTretinoin results in decreased expression of PTGIS mRNA21934132
D014212TretinoinTretinoin results in increased expression of PTGIS mRNA20488242
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PTGIS mRNA25526689
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PTGIS mRNA25526689
C406224valdecoxibvaldecoxib results in decreased expression of PTGIS mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGIS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PTGIS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PTGIS mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of PTGIS gene29154799
D014635Valproic AcidValproic Acid affects the expression of PTGIS mRNA17292431
D001335Vehicle Emissions[APOE gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of PTGIS mRNA22746401
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of PTGIS mRNA19165385
C025643vinclozolinvinclozolin results in decreased expression of PTGIS mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of PTGIS mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-IEA-  
GO:0005506iron ion binding-IEA-  
GO:0005515protein binding-IPI20122998  
GO:0008116prostaglandin-I synthase activity-IBA21873635  
GO:0008116prostaglandin-I synthase activity-IDA20122998  21296955  
GO:0008116prostaglandin-I synthase activity-TAS-  
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen-IEA-  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IDA17020766  
GO ID GO Term Qualifier Evidence PubMed
GO:0001516prostaglandin biosynthetic process-IBA21873635  
GO:0001516prostaglandin biosynthetic process-IDA20122998  21296955  
GO:0006690icosanoid metabolic process-TAS-  
GO:0007566embryo implantation-IEA-  
GO:0019371cyclooxygenase pathway-TAS-  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA20159982  
GO:0034356NAD biosynthesis via nicotinamide riboside salvage pathway-TAS-  
GO:0035360positive regulation of peroxisome proliferator activated receptor signaling pathway-IDA11551955  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0045019negative regulation of nitric oxide biosynthetic process-IDA20159982  
GO:0045766positive regulation of angiogenesis-IMP20122998  
GO:0046697decidualization-IEA-  
GO:0050728negative regulation of inflammatory response-IDA20159982  
GO:0055114oxidation-reduction process-IEA-  
GO:0071347cellular response to interleukin-1-IEP8185632  
GO:0071354cellular response to interleukin-6-IEP8185632  
GO:0071456cellular response to hypoxia-IDA21296955  
GO:0097190apoptotic signaling pathway-IDA11551955  
GO:1900119positive regulation of execution phase of apoptosis-IDA11551955  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-ISS-  
GO:0005634nucleus-IDA21035466  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA21035466  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005901caveola-IDA20122998  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-192105Synthesis of bile acids and bile saltsTAS
R-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolTAS
R-HSA-193775Synthesis of bile acids and bile salts via 24-hydroxycholesterolTAS
R-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterolTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-196807Nicotinate metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-197264Nicotinamide salvagingTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-211979EicosanoidsTAS
R-HSA-211994Sterols are 12-hydroxylated by CYP8B1TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2162123Synthesis of Prostaglandins (PG) and Thromboxanes (TX)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17070428Assessment of the genetic component of hypertension. (2006 Nov)Yamada YAm J Hypertens