Gene info: ID 5741

Gene: PTH

GENE ID: 5741

Synonyms: PTH1

Description: parathyroid hormone

Gene type: protein-coding

Location: 11p15.3

dbXrefs: Ensembl:ENSG00000152266 MIM:168450 Vega:OTTHUMG00000165785 UniprotKB:P01270

RefSeq: NG_008962.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 166

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.805e-1 (AD) 1.247e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PRAMEF8	0.8
DIO1	0.559
TRIM43	0.525
TFF3	0.457
CYP39A1	0.436
LDLRAD1	0.434
SERPINC1	0.43
RASSF6	0.425
TG	0.414
DDI1	0.413

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FOXP3	-0.253
KBTBD12	-0.235
ADAMTS17	-0.235
IDUA	-0.234
DDTL	-0.233
UBAP2	-0.232
D2HGDH	-0.23
GON4L	-0.226
CNPY4	-0.226
MTHFSD	-0.225

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04419	D-norleucine	Small Molecule	327-56-0	Experimental	Target
DB05883	ABX-PTH	BiotechDrug	-	Investigational	Target

ID	Drug Name	Action	PubMed
C087630	1,25-dihydroxy-16-ene-vitamin D3	"1,25-dihydroxy-16-ene-vitamin D3 results in decreased expression of PTH"	14646396
C097949	1,25-dihydroxyvitamin D	"1,25-dihydroxyvitamin D results in decreased expression of PTH protein"	10638776
C097949	1,25-dihydroxyvitamin D	"1,25-dihydroxyvitamin D results in decreased expression of PTH mRNA"	18304585
C408047	1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3	"1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3 results in decreased expression of PTH protein"	14646396
C042533	1 alpha-hydroxyergocalciferol	1 alpha-hydroxyergocalciferol results in decreased secretion of PTH protein	16221703
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PTH protein results in decreased uptake of Phosphates]	27432882
C046728	2,2'-azobis(2-amidinopropane)	"2,2'-azobis(2-amidinopropane) results in increased oxidation of PTH protein"	19455640
C046728	2,2'-azobis(2-amidinopropane)	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of PTH protein]"	19455640
C046728	2,2'-azobis(2-amidinopropane)	"Pyridoxine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of PTH protein]"	19455640
C104450	25-hydroxyvitamin D	25-hydroxyvitamin D results in decreased expression of PTH mRNA	18304585
C104450	25-hydroxyvitamin D	Ketoconazole inhibits the reaction [25-hydroxyvitamin D results in decreased expression of PTH mRNA]	18304585
C521167	2-methylene-19-nor-(20S)-1 alpha-hydroxy-bishomopregnacalciferol	2-methylene-19-nor-(20S)-1 alpha-hydroxy-bishomopregnacalciferol results in decreased expression of PTH protein	17444814
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of PTH protein]"	19455640
D000242	Cyclic AMP	aluminum chloride inhibits the reaction [PTH protein affects the abundance of Cyclic AMP]	2153849
D000242	Cyclic AMP	PTH protein affects the abundance of Cyclic AMP	2153849
D000242	Cyclic AMP	PTH protein results in increased abundance of Cyclic AMP	26851681
D000242	Cyclic AMP	Aluminum inhibits the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]	9626627
D000242	Cyclic AMP	Aluminum promotes the reaction [Cholera Toxin promotes the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]]	9626627
D000242	Cyclic AMP	Cholera Toxin promotes the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]	9626627
D000242	Cyclic AMP	Pertussis Toxin inhibits the reaction [Aluminum inhibits the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]]	9626627
D000242	Cyclic AMP	PTH protein results in increased chemical synthesis of Cyclic AMP	9626627
C008088	alfacalcidol	alfacalcidol results in decreased secretion of PTH protein	16221703
C008088	alfacalcidol	alfacalcidol results in decreased expression of PTH protein	11675047
D000535	Aluminum	[TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein	10978387
D000535	Aluminum	Aluminum inhibits the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]	9626627
D000535	Aluminum	Aluminum promotes the reaction [Cholera Toxin promotes the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]]	9626627
D000535	Aluminum	Aluminum results in decreased susceptibility to PTH protein	9626627
D000535	Aluminum	Pertussis Toxin inhibits the reaction [Aluminum inhibits the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]]	9626627
C010845	aluminum chloride	aluminum chloride inhibits the reaction [PTH protein affects the abundance of Cyclic AMP]	2153849
C010845	aluminum chloride	aluminum chloride results in decreased susceptibility to PTH protein	2153849
C010845	aluminum chloride	aluminum chloride results in decreased expression of PTH mRNA	11274267
C010845	aluminum chloride	aluminum chloride results in decreased expression of PTH protein	11274267\|1275326
D017607	Aluminum Compounds	Aluminum Compounds results in decreased expression of PTH mRNA	16316325
D017607	Aluminum Compounds	Aluminum Compounds results in decreased secretion of PTH protein	16316325
D017607	Aluminum Compounds	Calcium affects the reaction [Aluminum Compounds results in decreased expression of PTH mRNA]	16316325
D017607	Aluminum Compounds	Calcium affects the reaction [Aluminum Compounds results in decreased secretion of PTH protein]	16316325
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PTH mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of PTH gene	25304211
C506649	BCI-210	BCI-210 results in decreased secretion of PTH protein	16221703
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PTH mRNA	15034205
D004958	Estradiol	Estradiol results in increased expression of PTH mRNA	23373633
D004958	Estradiol	Estradiol results in increased expression of PTH mRNA	17998272
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [PTH protein results in decreased uptake of Phosphates]	27432882
C006780	bisphenol A	bisphenol A results in decreased expression of PTH mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PTH mRNA	22079614
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased oxidation of PTH protein	19455640
D002104	Cadmium	"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased uptake of Cadmium]"	7524195
D002104	Cadmium	"Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased uptake of Cadmium]]"	7524195
D002104	Cadmium	Nifedipine inhibits the reaction [PTH protein results in increased uptake of Cadmium]	7524195
D002104	Cadmium	PTH protein results in increased uptake of Cadmium	7524195
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PTH protein	22708652
D019256	Cadmium Chloride	"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased import of Cadmium Chloride]"	1648802
D019256	Cadmium Chloride	"Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased import of Cadmium Chloride]]"	1648802
D019256	Cadmium Chloride	PTH protein results in increased import of Cadmium Chloride	1648802
D000001	Calcimycin	Calcimycin results in decreased expression of PTH mRNA	18096993
D002118	Calcium	Calcium results in decreased expression of PTH mRNA	18096993
D002118	Calcium	[Calcitriol co-treated with Calcium] results in decreased expression of PTH protein	80633
D002118	Calcium	Calcium results in decreased expression of PTH protein	6330156
D002118	Calcium	[Cholecalciferol co-treated with Calcium] results in decreased expression of PTH protein	80633
D002118	Calcium	PTH protein affects the metabolism of Calcium	15891005
D002118	Calcium	PTH protein modified form results in increased abundance of Calcium	16094769
D002118	Calcium	Calcium affects the reaction [Aluminum Compounds results in decreased expression of PTH mRNA]	16316325
D002118	Calcium	Calcium affects the reaction [Aluminum Compounds results in decreased secretion of PTH protein]	16316325
D002118	Calcium	Calcium affects the reaction [Calcitriol results in decreased expression of PTH mRNA]	16316325
D002118	Calcium	Calcium affects the reaction [Calcitriol results in decreased secretion of PTH protein]	16316325
D002118	Calcium	Calcium deficiency inhibits the reaction [KHSRP protein binds to PTH 3' UTR]	18583400
D002118	Calcium	Calcium deficiency promotes the reaction [HNRNPD protein binds to PTH 3' UTR]	18583400
D002118	Calcium	Calcium deficiency results in increased stability of PTH mRNA	18583400
D002118	Calcium	PTH protein results in decreased abundance of Calcium	17476578
D002118	Calcium	Calcium results in decreased secretion of PTH protein	21306167
D002119	Calcium Carbonate	Calcium Carbonate affects the expression of PTH protein	8481062
D002119	Calcium Carbonate	Calcium Carbonate results in decreased expression of PTH protein	16006300\|1752077
D000068896	Canagliflozin	Canagliflozin results in decreased expression of PTH protein	25289773
D002772	Cholera Toxin	Aluminum promotes the reaction [Cholera Toxin promotes the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]]	9626627
D002772	Cholera Toxin	Cholera Toxin promotes the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]	9626627
D000069449	Cinacalcet Hydrochloride	[Cinacalcet Hydrochloride co-treated with Vitamin D] results in decreased expression of PTH protein	22118402
D000069449	Cinacalcet Hydrochloride	Cinacalcet Hydrochloride results in decreased expression of PTH protein	17060004\|1825637
D000069449	Cinacalcet Hydrochloride	Cinacalcet Hydrochloride results in decreased secretion of PTH protein	21541686
D000069449	Cinacalcet Hydrochloride	Cinacalcet Hydrochloride results in decreased expression of PTH	19560849
D003300	Copper	Copper deficiency results in increased expression of PTH mRNA	26033743
D003300	Copper	Copper results in decreased susceptibility to PTH protein	16327168
D003300	Copper	Copper results in increased oxidation of PTH protein	19455640
D003345	Corticosterone	[Corticosterone co-treated with PTH protein] results in decreased expression of TNFRSF11B mRNA	17476578
D003345	Corticosterone	[Corticosterone co-treated with PTH protein] results in decreased expression of TNFSF11 mRNA	17476578
D003907	Dexamethasone	PTH protein modified form inhibits the reaction [Dexamethasone results in decreased expression of COL2A1 protein]	27608943
D003907	Dexamethasone	PTH protein modified form inhibits the reaction [Dexamethasone results in increased expression of COL10A1 protein]	27608943
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of PTH mRNA	26033743
D002117	Calcitriol	Calcitriol promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
D002117	Calcitriol	Calcitriol promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
D002117	Calcitriol	Calcitriol results in decreased expression of PTH mRNA	17302875
D002117	Calcitriol	Calcitriol results in decreased expression of PTH protein	17302875
D002117	Calcitriol	Calcitriol results in decreased secretion of PTH protein	16221703
D002117	Calcitriol	Ketoconazole promotes the reaction [Calcitriol results in decreased expression of PTH mRNA]	17302875
D002117	Calcitriol	Ketoconazole promotes the reaction [Calcitriol results in decreased expression of PTH protein]	17302875
D002117	Calcitriol	Calcitriol affects the expression of PTH protein	8711172
D002117	Calcitriol	[Calcitriol co-treated with Calcium] results in decreased expression of PTH protein	80633
D002117	Calcitriol	Calcitriol results in decreased expression of PTH mRNA	8052367
D002117	Calcitriol	Calcitriol results in decreased expression of PTH protein	10027919\|1236912
D002117	Calcitriol	Calcitriol results in decreased secretion of PTH protein	21350317
D002117	Calcitriol	PTH protein affects the chemical synthesis of Calcitriol	15891005
D002117	Calcitriol	Calcitriol results in decreased expression of PTH mRNA	16316325
D002117	Calcitriol	Calcitriol results in decreased expression of PTH protein	11305809\|1239963
D002117	Calcitriol	Calcitriol results in decreased secretion of PTH protein	16316325
D002117	Calcitriol	Calcium affects the reaction [Calcitriol results in decreased expression of PTH mRNA]	16316325
D002117	Calcitriol	Calcium affects the reaction [Calcitriol results in decreased secretion of PTH protein]	16316325
D015650	24,25-Dihydroxyvitamin D 3	"24,25-Dihydroxyvitamin D 3 results in increased expression of PTH protein"	6760236
D015650	24,25-Dihydroxyvitamin D 3	"24,25-Dihydroxyvitamin D 3 results in decreased expression of PTH protein"	11305809
D004492	Edetic Acid	Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein]	19455640
D000431	Ethanol	[Ethanol co-treated with lead acetate] results in increased expression of PTH protein	23376407
D005290	Ferric Compounds	[Hydrogen Peroxide co-treated with Ferric Compounds] results in increased oxidation of PTH protein	19455640
D005296	Ferrous Compounds	Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein]	19455640
D005296	Ferrous Compounds	[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein	19455640
D005296	Ferrous Compounds	Mannitol inhibits the reaction [[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein]	19455640
D005296	Ferrous Compounds	Methionine inhibits the reaction [[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein]	19455640
D005419	Flavonoids	Flavonoids results in increased expression of PTH mRNA	18035473
D005665	Furosemide	Furosemide results in increased expression of PTH protein	15086907
D005665	Furosemide	NPS R-467 inhibits the reaction [Furosemide results in increased expression of PTH protein]	15086907
C027235	gallium nitrate	gallium nitrate inhibits the reaction [Tamoxifen results in decreased expression of PTH protein]	16837906
D005839	Gentamicins	Gentamicins inhibits the reaction [PTH protein results in increased activity of CKB protein]	2822142
D006851	Hydrochloric Acid	PTH protein results in decreased secretion of Hydrochloric Acid	20380354
D006861	Hydrogen Peroxide	Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein]	19455640
D006861	Hydrogen Peroxide	[Hydrogen Peroxide co-treated with Ferric Compounds] results in increased oxidation of PTH protein	19455640
D006861	Hydrogen Peroxide	[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein	19455640
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased oxidation of PTH protein	19455640
D006861	Hydrogen Peroxide	Mannitol inhibits the reaction [[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein]	19455640
D006861	Hydrogen Peroxide	Methionine inhibits the reaction [[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein]	19455640
D006861	Hydrogen Peroxide	Methionine inhibits the reaction [Hydrogen Peroxide results in increased oxidation of PTH protein]	19455640
D002112	Calcifediol	Calcifediol promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
D002112	Calcifediol	Calcifediol promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
D002112	Calcifediol	Calcifediol inhibits the reaction [Theophylline results in increased expression of PTH protein]	26851681
D007654	Ketoconazole	Calcifediol promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
D007654	Ketoconazole	Calcifediol promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
D007654	Ketoconazole	Calcitriol promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
D007654	Ketoconazole	Calcitriol promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [Calcitriol results in decreased expression of PTH mRNA]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [Calcitriol results in decreased expression of PTH protein]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [seocalcitol analog results in decreased expression of PTH mRNA]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [seocalcitol analog results in decreased expression of PTH protein]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [seocalcitol results in decreased expression of PTH mRNA]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [seocalcitol results in decreased expression of PTH protein]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [Vitamin D analog results in decreased expression of PTH mRNA]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [Vitamin D analog results in decreased expression of PTH protein]	17302875
D007654	Ketoconazole	Ketoconazole results in decreased expression of PTH mRNA	17302875
D007654	Ketoconazole	Ketoconazole results in decreased expression of PTH protein	17302875
D007654	Ketoconazole	seocalcitol analog promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
D007654	Ketoconazole	seocalcitol analog promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
D007654	Ketoconazole	seocalcitol promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
D007654	Ketoconazole	seocalcitol promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
D007654	Ketoconazole	Vitamin D analog promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
D007654	Ketoconazole	Vitamin D analog promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
D007654	Ketoconazole	Ketoconazole inhibits the reaction [25-hydroxyvitamin D results in decreased expression of PTH mRNA]	18304585
C008261	lead acetate	[Ethanol co-treated with lead acetate] results in increased expression of PTH protein	23376407
D008094	Lithium	Lithium results in increased expression of PTH protein	10423626\|581022\|
D008094	Lithium	Lithium results in increased expression of PTH protein	8840263
D016651	Lithium Carbonate	Lithium Carbonate results in increased expression of PTH protein	18234408\|3083797
D008353	Mannitol	Mannitol inhibits the reaction [[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein]	19455640
C051883	maxacalcitol	maxacalcitol results in decreased expression of PTH mRNA	8455354
C051883	maxacalcitol	maxacalcitol results in decreased expression of PTH protein	10027919
C051883	maxacalcitol	maxacalcitol results in decreased expression of PTH protein	16189633\|8840326
C051883	maxacalcitol	maxacalcitol results in decreased secretion of PTH protein	11576942
C051883	maxacalcitol	maxacalcitol results in decreased expression of PTH mRNA	8455354
D008715	Methionine	Methionine inhibits the reaction [[Hydrogen Peroxide co-treated with Ferrous Compounds] results in increased oxidation of PTH protein]	19455640
D008715	Methionine	Methionine inhibits the reaction [Hydrogen Peroxide results in increased oxidation of PTH protein]	19455640
C558527	N-(1-ethyl-1-(4-methylphenyl)propyl)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxamide	"N-(1-ethyl-1-(4-methylphenyl)propyl)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxamide results in increased secretion of PTH protein"	21306167
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PTH protein results in decreased uptake of Phosphates]	27432882
C107873	N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine	N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine results in decreased expression of PTH mRNA	18096993
C107873	N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine	N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine inhibits the reaction [[Adenine co-treated with Phosphorus] results in increased expression of PTH protein]	16291838
D009532	Nickel	Nickel affects the expression of PTH mRNA	14575637
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of PTH mRNA]	14575637
D009543	Nifedipine	"Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased uptake of Cadmium]]"	7524195
D009543	Nifedipine	Nifedipine inhibits the reaction [PTH protein results in increased uptake of Cadmium]	7524195
D009543	Nifedipine	"Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased import of Cadmium Chloride]]"	1648802
C111654	NPS R-467	NPS R-467 inhibits the reaction [Furosemide results in increased expression of PTH protein]	15086907
C084656	paricalcitol	paricalcitol results in decreased expression of PTH protein	12631365
C084656	paricalcitol	paricalcitol results in decreased secretion of PTH protein	15898824
D037342	Pertussis Toxin	Pertussis Toxin inhibits the reaction [Aluminum inhibits the reaction [PTH protein results in increased chemical synthesis of Cyclic AMP]]	9626627
D010672	Phenytoin	Phenytoin results in increased expression of PTH protein	20683115
D010710	Phosphates	Phosphates results in increased secretion of PTH protein	10027919
D010710	Phosphates	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PTH protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	bisindolylmaleimide I inhibits the reaction [PTH protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PTH protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	Phosphates results in increased expression of PTH protein	18256372
D010710	Phosphates	PTH protein results in decreased uptake of Phosphates	27432882
D010710	Phosphates	SLC9A3R1 protein promotes the reaction [PTH protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	Phosphates results in increased expression of PTH protein	12399635
D010758	Phosphorus	[Adenine co-treated with Phosphorus] results in increased expression of PTH mRNA	16291838
D010758	Phosphorus	[Adenine co-treated with Phosphorus] results in increased expression of PTH protein	16291838
D010758	Phosphorus	N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine inhibits the reaction [[Adenine co-treated with Phosphorus] results in increased expression of PTH protein]	16291838
D010758	Phosphorus	Phosphorus deficiency inhibits the reaction [HNRNPD protein binds to PTH 3' UTR]	18583400
D010758	Phosphorus	Phosphorus deficiency promotes the reaction [KHSRP protein binds to PTH 3' UTR]	18583400
D010758	Phosphorus	Phosphorus deficiency results in decreased stability of PTH mRNA	18583400
D010758	Phosphorus	PTH protein results in decreased abundance of Phosphorus	17476578
D010758	Phosphorus	Phosphorus affects the expression of and affects the secretion of PTH protein	16272627
D016226	Phosphorus, Dietary	"Phosphorus, Dietary results in increased expression of PTH protein"	15618618\|1563024
D011374	Progesterone	Progesterone affects the expression of PTH mRNA	19690047
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors results in decreased expression of PTH protein	21976371
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of PTH protein	1328752
D001498	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased uptake of Cadmium]"	7524195
D001498	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	"Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased uptake of Cadmium]]"	7524195
D001498	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased import of Cadmium Chloride]"	1648802
D001498	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	"Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [PTH protein results in increased import of Cadmium Chloride]]"	1648802
D011736	Pyridoxine	"Pyridoxine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of PTH protein]"	19455640
D011794	Quercetin	Quercetin inhibits the reaction [PTH protein results in increased activity of CKB protein]	2822142
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of PTH protein	17823083
C064183	Ro 23-7553	Ro 23-7553 results in decreased expression of PTH	14646396
C078903	seocalcitol	Ketoconazole promotes the reaction [seocalcitol analog results in decreased expression of PTH mRNA]	17302875
C078903	seocalcitol	Ketoconazole promotes the reaction [seocalcitol analog results in decreased expression of PTH protein]	17302875
C078903	seocalcitol	Ketoconazole promotes the reaction [seocalcitol results in decreased expression of PTH mRNA]	17302875
C078903	seocalcitol	Ketoconazole promotes the reaction [seocalcitol results in decreased expression of PTH protein]	17302875
C078903	seocalcitol	seocalcitol analog promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
C078903	seocalcitol	seocalcitol analog promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
C078903	seocalcitol	seocalcitol analog results in decreased expression of PTH mRNA	17302875
C078903	seocalcitol	seocalcitol analog results in decreased expression of PTH protein	17302875
C078903	seocalcitol	seocalcitol promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
C078903	seocalcitol	seocalcitol promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
C078903	seocalcitol	seocalcitol results in decreased expression of PTH mRNA	17302875
C078903	seocalcitol	seocalcitol results in decreased expression of PTH protein	17302875
C078903	seocalcitol	seocalcitol results in decreased expression of PTH	9662243
D000069603	Sevelamer	Sevelamer results in decreased expression of PTH protein	16272627
D012906	Smoke	Smoke results in decreased expression of PTH protein	18035141
C017947	sodium arsenite	sodium arsenite results in increased expression of PTH mRNA	17998272
D053260	Soot	Soot results in increased expression of PTH mRNA	26551751
D013629	Tamoxifen	gallium nitrate inhibits the reaction [Tamoxifen results in decreased expression of PTH protein]	16837906
D013629	Tamoxifen	Tamoxifen results in decreased expression of PTH protein	16837906
D016593	Terfenadine	Terfenadine results in decreased expression of PTH protein	15872215
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PTH mRNA	15034205
D019284	Thapsigargin	Thapsigargin results in decreased expression of PTH mRNA	18096993
D013806	Theophylline	Calcifediol inhibits the reaction [Theophylline results in increased expression of PTH protein]	26851681
D013806	Theophylline	Theophylline results in increased expression of PTH protein	26851681
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of ACSL3 mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of CD24 mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of COL11A1 mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of DBP mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of ELN mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of IGHG mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of LOXL1 mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of LOX mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of MAF mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of MEGF6 mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of MMP14 mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of NSG1 mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of OMD mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of PLAGL1 mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of PLAT mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of SPARC mRNA]	18635661
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of TESK1 mRNA]	18635661
D014212	Tretinoin	Tretinoin inhibits the reaction [PTH protein results in increased activity of CKB protein]	2822142
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of PTH mRNA]	14575637
D014501	Uranium	Uranium results in decreased expression of PTH protein	16502312
D014501	Uranium	Uranium results in increased expression of PTH protein	16436523
C034028	vanadyl sulfate	vanadyl sulfate results in decreased expression of PTH mRNA	16330358
C025643	vinclozolin	vinclozolin results in increased expression of PTH mRNA	22615374
D000225	Adenine	[Adenine co-treated with Phosphorus] results in increased expression of PTH mRNA	16291838
D000225	Adenine	[Adenine co-treated with Phosphorus] results in increased expression of PTH protein	16291838
D000225	Adenine	Adenine inhibits the reaction [KHSRP protein binds to PTH 3' UTR]	18583400
D000225	Adenine	Adenine promotes the reaction [HNRNPD protein binds to PTH 3' UTR]	18583400
D000225	Adenine	Adenine results in increased expression of PTH protein	16272627
D000225	Adenine	Adenine results in increased stability of PTH mRNA	18583400
D000225	Adenine	N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine inhibits the reaction [[Adenine co-treated with Phosphorus] results in increased expression of PTH protein]	16291838
D014807	Vitamin D	Ketoconazole promotes the reaction [Vitamin D analog results in decreased expression of PTH mRNA]	17302875
D014807	Vitamin D	Ketoconazole promotes the reaction [Vitamin D analog results in decreased expression of PTH protein]	17302875
D014807	Vitamin D	Vitamin D analog promotes the reaction [Ketoconazole results in decreased expression of PTH mRNA]	17302875
D014807	Vitamin D	Vitamin D analog promotes the reaction [Ketoconazole results in decreased expression of PTH protein]	17302875
D014807	Vitamin D	Vitamin D analog results in decreased expression of PTH mRNA	17302875
D014807	Vitamin D	Vitamin D analog results in decreased expression of PTH protein	17302875
D014807	Vitamin D	[Cinacalcet Hydrochloride co-treated with Vitamin D] results in decreased expression of PTH protein	22118402
D014807	Vitamin D	Vitamin D results in decreased expression of PTH protein	16608887\|2155674
D002762	Cholecalciferol	[Cholecalciferol co-treated with Calcium] results in decreased expression of PTH protein	80633
D002762	Cholecalciferol	Cholecalciferol results in decreased expression of PTH protein	21179201\|8711172
D002762	Cholecalciferol	Cholecalciferol results in decreased expression of PTH mRNA	11332696
D002762	Cholecalciferol	Cholecalciferol results in decreased secretion of PTH protein	11332696
D014812	Vitamin K	Vitamin K results in increased activity of PTH protein	11564701
D014859	Warfarin	Warfarin results in decreased activity of PTH protein	11564701

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	-	IMP	17696759
GO:0005179	hormone activity	-	IBA	21873635
GO:0005179	hormone activity	-	IMP	11604398
GO:0031856	parathyroid hormone receptor binding	-	IBA	21873635
GO:0031857	type 1 parathyroid hormone receptor binding	-	IMP	11604398
GO:0047485	protein N-terminus binding	-	IMP	11604398
GO:0048018	receptor ligand activity	-	IMP	11604398
GO:0051428	peptide hormone receptor binding	-	IDA	19674967
GO:0051428	peptide hormone receptor binding	-	IMP	11604398

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	17696759
GO:0001501	skeletal system development	-	TAS	10913913
GO:0006874	cellular calcium ion homeostasis	-	IEA	-
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	IDA	90087
GO:0007202	activation of phospholipase C activity	-	IMP	11604398
GO:0007266	Rho protein signal transduction	-	IEA	-
GO:0007267	cell-cell signaling	-	IBA	21873635
GO:0008628	hormone-mediated apoptotic signaling pathway	-	TAS	10913913
GO:0009967	positive regulation of signal transduction	-	IEA	-
GO:0010288	response to lead ion	-	IEA	-
GO:0010468	regulation of gene expression	-	IDA	90087
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0030501	positive regulation of bone mineralization	-	IDA	17696759
GO:0032331	negative regulation of chondrocyte differentiation	-	IEA	-
GO:0033280	response to vitamin D	-	IEA	-
GO:0034645	cellular macromolecule biosynthetic process	-	IDA	19723499
GO:0045453	bone resorption	-	NAS	15080150
GO:0045471	response to ethanol	-	IEA	-
GO:0045725	positive regulation of glycogen biosynthetic process	-	IDA	21076856
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	19723499
GO:0046058	cAMP metabolic process	-	TAS	9927325
GO:0046326	positive regulation of glucose import	-	IDA	21076856
GO:0046686	response to cadmium ion	-	IEA	-
GO:0048873	homeostasis of number of cells within a tissue	-	IEA	-
GO:0060732	positive regulation of inositol phosphate biosynthetic process	-	IMP	11604398
GO:0071107	response to parathyroid hormone	-	IEA	-
GO:0071774	response to fibroblast growth factor	-	IEA	-
GO:0071864	positive regulation of cell proliferation in bone marrow	-	IEA	-
GO:0071866	negative regulation of apoptotic process in bone marrow	-	IEA	-
GO:0090290	positive regulation of osteoclast proliferation	-	IEA	-
GO:1900158	negative regulation of bone mineralization involved in bone maturation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005622	intracellular	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373080	Class B/2 (Secretin family receptors)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
14686748	Different risk factors for the maximum and the mean carotid intima-media thickness in hemodialysis patients. (2003 Nov)	Nakashima A	Intern Med
8989268	Olfactory dysfunction in type I pseudohypoparathyroidism: dissociation from Gs alpha protein deficiency. (1997 Jan)	Doty RL	J Clin Endocrinol Metab
23954837	Association of alkaline phosphatase with acute myocardial infarction in a population with high prevalence of hypovitaminosis D. (2013 Oct 21)	Iqbal MP	Clin Chim Acta
23945218	Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH. (2013 Aug 15)	Shirazi L	BMC Womens Health
21403888	Improvement of hypertension after parathyroidectomy of patients suffering from primary hyperparathyroidism. (2011)	Broulik PD	Int J Endocrinol
10583303	Postmenopausal osteoporosis is more related to hormonal aberrations than to lifestyle factors. (1999 Oct)	Landin-Wilhelmsen K	Clin Endocrinol (Oxf)
25198368	Relationship between vitamin D deficiency and chronic low back pain in postmenopausal women. (2013)	Rkain H	Curr Rheumatol Rev
28107028	Interrelationship of clinical, radiographic and haematological features in patients under bisphosphonate therapy. (2017 Apr)	Koth VS	Dentomaxillofac Radiol
22007967	Renal resistive index and parathyroid hormone relationship with renal function in nondiabetic patients. (2012)	Trovato GM	Endocr Res
22333003	Clinical profiles and risk factors for outcomes in older patients with cervical and trochanteric hip fracture: similarities and differences. (2012 Feb 15)	Fisher AA	J Trauma Manag Outcomes
16155312	[Prevalence of secondary hyperparathyroidism (SHPT) and causal factors in adult population in Reykjavik area]. (2005 Feb)	Karlsson SL	Laeknabladid
7715435	[Alcoholic osteopathy]. (1994)	Sarli M	Medicina (B Aires)
26188533	Prevalence and correlates of mitral annular calcification in adults with chronic kidney disease: Results from CRIC study. (2015 Sep)	Abd Alamir M	Atherosclerosis
23818972	Bone mineral density, bone turnover markers and fractures in patients with systemic sclerosis: a case control study. (2013)	Atteritano M	PLoS One
18035141	Maternal smoking and the vitamin D-parathyroid hormone system during the perinatal period. (2007 Dec)	Diaz-Gomez NM	J Pediatr
12480799	To drink or not to drink: how are alcohol, caffeine and past smoking related to bone mineral density in elderly women? (2002 Dec)	Ilich JZ	J Am Coll Nutr
23928672	PTH: a new target in arteriosclerosis? (2013 Oct)	Buizert PJ	J Clin Endocrinol Metab
7847587	Magnesium deficiency in alcoholism: possible contribution to osteoporosis and cardiovascular disease in alcoholics. (1994 Oct)	Abbott L	Alcohol Clin Exp Res
7474670	High-resolution B-mode ultrasonography in evaluation of atherosclerosis in uremia. (1995 Sep)	Kawagishi T	Kidney Int
12846770	The role of hyperparathyroidism, erythropoietin therapy, and CMV infection in the failure of arteriovenous fistula in hemodialysis. (2003 Aug)	Grandaliano G	Kidney Int
28491855	Nephrolithiasis in elderly population; effect of demographic characteristics. (2017 Mar)	Moudi E	J Nephropathol
21993566	Depression is associated with low levels of 25-hydroxyvitamin D among Jordanian adults: results from a national population survey. (2012 Jun)	Jaddou HY	Eur Arch Psychiatry Clin Neurosci
21534240	Smoking and hyperparathyroidism in patients with end-stage renal disease (ESRD). (2012 Jan-Feb)	Tripepi G	J Nephrol
20549487	The effects of low dose parathyroid hormone on lumbar vertebrae in a rat model for chronic alcohol abuse. (2011 Apr)	Howe KS	Osteoporos Int
9808330	Lithium carbonate therapy is not a risk factor for osteoporosis. (1998 Sep)	Cohen O	Horm Metab Res
10602348	The influence of smoking on vitamin D status and calcium metabolism. (1999 Dec)	Brot C	Eur J Clin Nutr
8293349	Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy. (1993 Dec)	Mellstrom D	Calcif Tissue Int
27666692	[Smoking & Bone.] (2016)	Watanabe R	Clin Calcium
29498343	Serum 25-hydroxyvitamin D, calcium and parathyroid hormone levels in Native and European populations in Greenland. (2018 Feb)	Andersen S	Br J Nutr
25623657	An association between abnormal bone turnover, systemic inflammation, and osteoporosis in patients with chronic pancreatitis: a case-matched study. (2015 Feb)	Duggan SN	Am J Gastroenterol
17845893	Osteoporosis risk factors and association with somatotypes in males. (2007 Oct)	Saitoglu M	Arch Med Res
24672596	Phenytoin toxicity from cocaine adulteration. (2014 Mar)	Roldan CJ	West J Emerg Med
20184562	Effect of a comprehensive lifestyle modification program on the bone density of male heavy drinkers. (2010 May)	Matsui T	Alcohol Clin Exp Res
10962356	Smoking and bone metabolism in elderly women. (2000 Sep)	Rapuri PB	Bone
17142943	Effect of smoking and smoking cessation on bone mass, bone remodeling, vitamin D, PTH and sex hormones. (2006 Jul-Sep)	Supervia A	J Musculoskelet Neuronal Interact
11981073	Insomnia in maintenance haemodialysis patients. (2002 May)	Sabbatini M	Nephrol Dial Transplant
19019181	Factors associated with elevated or blunted PTH response in vitamin D insufficient adults. (2009 Apr)	Gunnarsson O	J Intern Med
20973965	Association between vitamin D insufficiency and tuberculosis in a Vietnamese population. (2010 Oct 25)	Ho-Pham LT	BMC Infect Dis
27795978	Smoking habits and parathyroid hormone concentrations in young adults: The CARDIA study. (2016 Dec)	Fujiyoshi A	Bone Rep
26134682	Serum 25-hydroxyvitamin D, parathyroid hormone, calcium intake, and bone mineral density in Spanish adults. (2016 Jan)	Olmos JM	Osteoporos Int
16231506	[Incidence and risk factors for non-traumatic lower extremity amputation in hemodialysis patients]. (2005)	Sanchez Perales MC	Nefrologia
25124570	Parathyroid hormone gene rs6256 and calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer in Iran. (2014)	Mahmoudi T	Asian Pac J Cancer Prev
18167138	Primary hyperparathyroidism and the skeleton. (2008 Jul)	Mosekilde L	Clin Endocrinol (Oxf)
14671166	Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. (2003 Dec)	Visser M	J Clin Endocrinol Metab
15479594	Calcium metabolism in pre- and postmenopausal morbidly obese women at baseline and after laparoscopic Roux-en-Y gastric bypass. (2004 Sep)	El-Kadre LJ	Obes Surg
11687921	Determinants of mean arterial pressure and pulse pressure in chronic haemodialysis patients. (2001 Nov)	Abdelfatah AB	J Hum Hypertens
16386530	Cytomegalovirus replication and "herpesvirus burden" as risk factor of cardiovascular events in the first year after renal transplantation. (2005 Nov)	Gomez E	Transplant Proc
23987237	Adiposity and the relationship between vitamin D and blood pressure. (2013 Dec)	Sulistyoningrum DC	Metabolism
24505486	Bone mineral metabolism parameters and urinary albumin excretion in a representative US population sample. (2014)	Ellam T	PLoS One
24375224	Association of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone with mortality among middle-aged and older European men. (2014 Jul)	Lee DM	Age Ageing
7736316	Serum intact parathyroid hormone in a random population sample of men and women: relationship to anthropometry, life-style factors, blood pressure, and vitamin D. (1995 Feb)	Landin-Wilhelmsen K	Calcif Tissue Int
26462160	FGF-23/Vitamin D Axis in Type 1 Diabetes: The Potential Role of Mineral Metabolism in Arterial Stiffness. (2015)	Llaurado G	PLoS One
27630919	Osseous Consolidation of an Aseptic Delayed Union of a Lower Leg Fracture after Parathyroid Hormone Therapy - A Case Report. (2016 Jul)	Kastirr I	J Clin Diagn Res
18799088	Aetiology and clinical characteristics of male osteoporosis. Have they changed in the last few years? (2008 Jul-Aug)	Peris P	Clin Exp Rheumatol
1392187	Hypomagnesemia with increased metabolism of parathyroid hormone and reduced responsiveness to calcitropic hormones. (1992 Jun)	Mori S	Intern Med
18219161	Parathyroid hormone and vitamin D levels are independently associated with calcific aortic stenosis. (2008 Feb)	Linhartova K	Circ J
11701680	High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. (2001 Nov)	Mei J	J Clin Endocrinol Metab
26910625	Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly. (2016 Feb 23)	Shinkov A	Arch Endocrinol Metab
21085485	Associations of serum 25-hydroxyvitamin D, parathyroid hormone and calcium with cardiovascular risk factors: analysis of 3 NHANES cycles (2001-2006). (2010 Nov 9)	Fraser A	PLoS One
11000682	[Preoperative markers for risk of post-tonsillectomy bleeding in adults]. (2000 Jun-Jul)	Gamiz MJ	Acta Otorrinolaringol Esp
19451355	Plasma parathyroid hormone and the risk of cardiovascular mortality in the community. (2009 Jun 2)	Hagstrom E	Circulation
16093907	Serum parathyroid hormone as a predictor of increase in systolic blood pressure in men. (2005 Sep)	Jorde R	J Hypertens
15167209	Serum parathyroid hormone levels predict coronary heart disease: the Tromso Study. (2004 Feb)	Kamycheva E	Eur J Cardiovasc Prev Rehabil
20631996	Determinants of plasma parathyroid hormone levels in young women. (2010 Sep)	Paik JM	Calcif Tissue Int
28883932	Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial. (2017)	Vargas Buonfiglio LG	BMJ Open Respir Res
22802085	Endocrine and clinical correlates of myostatin serum concentration in men--the STRAMBO study. (2012 Oct)	Szulc P	J Clin Endocrinol Metab
25248355	Association between serum vitamin D, parathyroid hormone and metabolic syndrome in middle-aged and older Korean adults. (2015 Apr)	Kim J	Eur J Clin Nutr
24312334	Bone mineral density measurements, bone markers and serum vitamin D concentrations in men with chronic non-cirrhotic untreated hepatitis C. (2013)	Orsini LG	PLoS One
21521334	The relationship between PTH and 25-hydroxy vitamin D early in pregnancy. (2011 Sep)	Haddow JE	Clin Endocrinol (Oxf)
19280273	Determinants of 25-hydroxyvitamin D levels in African-American and Caucasian male veterans. (2009 Oct)	Benjamin A	Osteoporos Int
18091361	Parathyroid hormone status does not influence blood and bone lead levels in dialysis patients. (2007 Dec)	Ghosh-Narang J	Am J Med Sci
15769995	Arterial stiffness in mild primary hyperparathyroidism. (2005 Jun)	Rubin MR	J Clin Endocrinol Metab
26762886	Epidemiology and determinants of pruritus in pre-dialysis chronic kidney disease patients. (2016 Apr)	Solak B	Int Urol Nephrol
16523414	Biochemical markers of endothelial activation in primary hyperparathyroidism. (2006 Feb)	Fallo F	Horm Metab Res
26270762	Successful Bone Healing of Nonunion After Ulnar Shortening Osteotomy for Smokers Treated With Teriparatide. (2015 Aug)	Uemura T	Orthopedics
20501463	Factors associated with aortic stiffness and its change over time in peritoneal dialysis patients. (2010 Dec)	Jung JY	Nephrol Dial Transplant
19539290	Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis. (2009 Dec)	Reis JP	Atherosclerosis
22211795	Not all elderly people benefit from vitamin D supplementation with respect to physical function: results from the Osteoporotic Fractures in Men Study, Hong Kong. (2012 Feb)	Chan R	J Am Geriatr Soc
26461969	The effect of opioid dependence on conventional and novel biochemical parameters of bone metabolism. (2015)	Balodimos S	Am J Drug Alcohol Abuse
17964181	Does a high UV environment ensure adequate vitamin D status? (2007 Dec 14)	Kimlin M	J Photochem Photobiol B
12072039	Prospective 10-year study of the determinants of bone density and bone loss in normal postmenopausal women, including the effect of hormone replacement therapy. (2002 Jun)	Wu F	Clin Endocrinol (Oxf)
16571177	Vitamin D status of 51-75-year-old Irish women: its determinants and impact on biochemical indices of bone turnover. (2006 Apr)	Hill TR	Public Health Nutr
18299475	The association between serum parathyroid hormone and bone mineral density, and the impact of smoking: the Tromso Study. (2008 Mar)	Sneve M	Eur J Endocrinol
21595731	Serum 25-hydroxyvitamin D levels and the metabolic syndrome in older persons: a population-based study. (2011 Nov)	Oosterwerff MM	Clin Endocrinol (Oxf)
17547711	Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in older men and women. (2007 Jun)	Snijder MB	J Intern Med
2045462	Bone disorder in men with chronic alcoholism: a reversible disease? (1991 Jul)	Lindholm J	J Clin Endocrinol Metab
11095443	Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population. (2000 Nov)	Harris SS	J Clin Endocrinol Metab
22031523	Aortic valve calcification in mild primary hyperparathyroidism. (2012 Jan)	Iwata S	J Clin Endocrinol Metab
15868280	Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women. (2005 Jul)	Lauridsen AL	Calcif Tissue Int
25780608	Assessment of potential biomarkers of subclinical vitamin K deficiency in patients with end-stage kidney disease. (2014)	Elliott MJ	Can J Kidney Health Dis
24449665	Vitamin D, parathyroid hormone, and serum lipid profiles in a middle-aged and elderly Chinese population. (2014 Jun)	Chen WR	Endocr Pract
22074799	Urbanization of black South African women may increase risk of low bone mass due to low vitamin D status, low calcium intake, and high bone turnover. (2011 Oct)	Kruger MC	Nutr Res
20797986	Plasma parathyroid hormone and risk of congestive heart failure in the community. (2010 Nov)	Hagstrom E	Eur J Heart Fail
9435418	Seasonal variation of biochemical indexes of bone turnover: results of a population-based study. (1998 Jan)	Woitge HW	J Clin Endocrinol Metab
11883410	Relationships between intestinal calcium absorption, serum vitamin D metabolites and smoking in postmenopausal women. (2002 Jan)	Need AG	Osteoporos Int
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