Gene: AS3MT

57412
CYT19
arsenite methyltransferase
protein-coding
10q24.32
Ensembl:ENSG00000214435 MIM:611806 Vega:OTTHUMG00000018972 UniprotKB:Q9HBK9
NC_000010.11
PubMed
0   ANCO-SNPs
ND|AD
6   
7.459e-2 (AD)  4.263e-1 (ND)   (Frontal_Cortex)
9.698e-2 (AD)  2.493e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HADH0.757
TMCO10.737
SGCE0.729
PRDX10.728
DHRS70.721
POLR2G0.719
TMEM590.713
ETFA0.712
POP50.708
MRPS280.708

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.582
OR4F29-0.526
OR6C74-0.226
CETP-0.203
TMEM89-0.201
KRT73-0.193
OR52H1-0.193
PATE3-0.189
DSG3-0.187
KRTAP1-1-0.185

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00118AdemetionineSmall Molecule29908-03-0Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of AS3MT mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AS3MT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AS3MT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AS3MT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AS3MT mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of AS3MT mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of AS3MT mRNA17562736
D012436S-AdenosylmethionineAS3MT protein binds to S-Adenosylmethionine22955273|2534998
D012436S-AdenosylmethionineCysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]22955273
D012436S-AdenosylmethionineGlutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]22955273|2534998
D012436S-AdenosylmethionineS-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]22955273
D012436S-Adenosylmethioninetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]22955273
D012436S-AdenosylmethionineS-Adenosylmethionine affects the activity of AS3MT protein8605285
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AS3MT protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AS3MT mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of AS3MT mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of AS3MT protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AS3MT mRNA16483693
D001151ArsenicAS3MT protein results in increased methylation of Arsenic19833739
D001151ArsenicAS3MT gene polymorphism affects the abundance of Arsenic metabolite24239724
D001151ArsenicAS3MT gene polymorphism affects the metabolism of Arsenic17637926|2053238
D001151ArsenicAS3MT gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]21605854
D001151ArsenicAS3MT gene polymorphism affects the susceptibility to Arsenic24845704
D001151Arsenic[AS3MT gene polymorphism affects the susceptibility to Arsenic] which results in increased abundance of Cacodylic Acid24845704
D001151Arsenic[AS3MT gene polymorphism affects the susceptibility to Arsenic] which results in increased abundance of monomethylarsonic acid24845704
D001151ArsenicAS3MT gene polymorphism results in increased methylation of Arsenic18334919
D001151ArsenicAS3MT gene SNP affects the metabolism of Arsenic27352405
D001151ArsenicAS3MT gene SNP affects the methylation of and affects the susceptibility to Arsenic28235556
D001151ArsenicAS3MT gene SNP affects the methylation of Arsenic19371612
D001151ArsenicAS3MT gene SNP affects the susceptibility to Arsenic19538983|2054757
D001151ArsenicAS3MT gene SNP results in decreased susceptibility to Arsenic23070617
D001151ArsenicAS3MT gene SNP results in increased susceptibility to Arsenic22747749
D001151ArsenicAS3MT intron polymorphism affects the metabolism of Arsenic18976679
D001151ArsenicAS3MT polymorphism affects the metabolism of Arsenic17450230
D001151ArsenicAS3MT protein affects the metabolism of Arsenic15929903|1640728
D001151ArsenicAS3MT protein polymorphism affects the metabolism of Arsenic15929903|2763789
D001151ArsenicAS3MT protein polymorphism affects the susceptibility to Arsenic28537708
D001151ArsenicAS3MT protein results in increased abundance of Arsenic metabolite21537954
D001151ArsenicAS3MT protein results in increased metabolism of Arsenic18414634
D001151ArsenicAS3MT protein results in increased methylation of Arsenic15808521|1684195
D001151ArsenicAS3MT SNP affects the metabolism of Arsenic25156000
D001151ArsenicAS3MT SNP affects the susceptibility to Arsenic25156000
D001151ArsenicFolic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]]20049124
D001151ArsenicSelenium inhibits the reaction [AS3MT protein results in increased methylation of Arsenic]19167370
D001151ArsenicVitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]20049124
D001151ArsenicAS3MT protein affects the susceptibility to Arsenic21385732
D001151ArsenicAS3MT protein results in increased export of Arsenic20887743
D001151ArsenicAS3MT protein results in increased methylation of Arsenic15808521
D001151ArsenicAS3MT protein affects the methylation of Arsenic20949432
D001151ArsenicAS3MT protein results in increased methylation of Arsenic15025511|1580852
D001151ArsenicAurothioglucose inhibits the reaction [AS3MT protein results in increased methylation of Arsenic]15025511
D001151ArsenicDithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]15025511
D001151Arsenictris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of Arsenic]15025511
D001151ArsenicAS3MT protein results in increased metabolism of Arsenic20887743
D001151ArsenicAS3MT protein results in increased methylation of Arsenic24154821
C025657arsenic acidAS3MT protein affects the abundance of arsenic acid19691357
C025657arsenic acidAS3MT protein affects the methylation of arsenic acid19691357
C025657arsenic acidAS3MT protein affects the secretion of arsenic acid19691357
C025657arsenic acidAS3MT protein affects the metabolism of arsenic acid15606138
C025657arsenic acidGlutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]15606138
D001152ArsenicalsArsenicals affects the reaction [AS3MT gene polymorphism affects the metabolism of Arsenicals]27370415
D001152ArsenicalsAS3MT gene polymorphism affects the reaction [Arsenicals results in increased methylation of CDKN2A promoter alternative form]23073540
D001152ArsenicalsAS3MT gene polymorphism affects the susceptibility to Arsenicals23073540
D001152ArsenicalsAS3MT gene SNP affects the methylation of Arsenicals26928318
D001152ArsenicalsAS3MT protein results in increased abundance of Arsenicals metabolite21447609
D001152Arsenicals[AS3MT protein results in increased abundance of Arsenicals metabolite] which affects the susceptibility to LATS1 gene mutant form21447609
C015001arseniteAS3MT protein binds to and results in increased methylation of arsenite22955273|2534998
C015001arsenite[AS3MT protein binds to and results in increased methylation of arsenite] which results in increased chemical synthesis of dimethylarsinous acid25349987
C015001arseniteAS3MT protein polymorphism results in increased metabolism of arsenite22868225
C015001arsenite[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid22868225
C015001arsenite[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid22868225
C015001arsenite[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of monomethylarsonic acid22868225
C015001arseniteAS3MT protein results in increased chemical synthesis of arsenite analog28537708
C015001arseniteAS3MT protein results in increased metabolism of arsenite22868225
C015001arsenite[AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid22868225
C015001arsenite[AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid22868225
C015001arsenite[AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of monomethylarsonic acid22868225
C015001arseniteAS3MT protein results in increased methylation of arsenite25325836
C015001arseniteCysteine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]25349987
C015001arseniteCysteine promotes the reaction [AS3MT protein results in increased methylation of arsenite]22955273
C015001arseniteDithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]25349987
C015001arseniteGlutathione promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]25349987
C015001arseniteGlutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]22868225
C015001arseniteGlutathione promotes the reaction [AS3MT protein results in increased methylation of arsenite]22955273
C015001arseniteS-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]22955273
C015001arsenitetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]25349987
C015001arsenitetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of arsenite]22955273
C015001arseniteAS3MT protein affects the methylation of and affects the susceptibility to arsenite21934131
C015001arseniteAS3MT results in decreased susceptibility to arsenite20423714
C015001arsenitearsenite affects the activity of AS3MT protein8605285
D018053ArsenitesAS3MT protein results in increased methylation of and results in increased susceptibility to Arsenites26577531
D018053ArsenitesAS3MT protein results in increased susceptibility to Arsenites19411561
D018053Arsenites[AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of CDC45 mRNA19411561
D018053Arsenites[AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of CHAF1A mRNA19411561
D018053Arsenites[AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of MCM2 mRNA19411561
D018053Arsenites[AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of PCNA mRNA19411561
D018053Arsenites[AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of POLA2 mRNA19411561
C093363arsenotriglutathioneAS3MT protein binds to arsenotriglutathione25325836
C032793arsenous acidAS3MT protein affects the metabolism of arsenous acid15606138
C032793arsenous acidGlutathione affects the reaction [AS3MT protein affects the metabolism of arsenous acid]15606138
D006051AurothioglucoseAurothioglucose inhibits the reaction [AS3MT protein results in increased methylation of Arsenic]15025511
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AS3MT mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of AS3MT mRNA24901218
C006780bisphenol Abisphenol A results in decreased expression of AS3MT mRNA25181051
D002065BuspironeBuspirone results in increased expression of AS3MT mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AS3MT mRNA18804290
C018475butyraldehydebutyraldehyde results in decreased expression of AS3MT mRNA26079696
D002101Cacodylic Acid[AS3MT gene polymorphism affects the susceptibility to Arsenic] which results in increased abundance of Cacodylic Acid24845704
D002101Cacodylic Acid[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid22868225
D002101Cacodylic Acid[AS3MT protein polymorphism results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of Cacodylic Acid22868225
D002101Cacodylic Acid[AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid22868225
D002101Cacodylic Acid[AS3MT protein results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of Cacodylic Acid22868225
D002101Cacodylic AcidAS3MT protein affects the reaction [APOE protein affects the susceptibility to Cacodylic Acid]28728140
D019256Cadmium ChlorideCadmium Chloride affects the expression of AS3MT mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of AS3MT mRNA17484886
C018021cobaltous chloridecobaltous chloride results in decreased expression of AS3MT mRNA24386269
D003042CocaineCocaine affects the expression of AS3MT mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of AS3MT mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in increased expression of AS3MT protein19822598
D016572CyclosporineCyclosporine results in decreased expression of AS3MT mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of AS3MT mRNA19770486
D003545CysteineCysteine affects the folding of AS3MT protein22955273
D003545CysteineCysteine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]25349987
D003545CysteineCysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]22955273
D003545CysteineCysteine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]22955273
D003545CysteineCysteine promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]22955273
D003545CysteineCysteine promotes the reaction [AS3MT protein results in increased methylation of arsenite]22955273
D003545CysteineCysteine results in increased reduction of AS3MT protein25349987
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AS3MT mRNA21266533
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of AS3MT mRNA21791302
D004041Dietary Fats[AS3MT protein co-treated with APOE protein] affects the susceptibility to Dietary Fats28728140
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of AS3MT mRNA24535843
C062856dimethylarsineAS3MT protein affects the metabolism of dimethylarsine15606138
C062856dimethylarsineGlutathione affects the reaction [AS3MT protein affects the metabolism of dimethylarsine]15606138
C472511dimethylarsinous acid[AS3MT protein binds to and results in increased methylation of arsenite] which results in increased chemical synthesis of dimethylarsinous acid25349987
C472511dimethylarsinous acid[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid22868225
C472511dimethylarsinous acid[AS3MT protein polymorphism results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of dimethylarsinous acid22868225
C472511dimethylarsinous acidAS3MT protein results in increased chemical synthesis of dimethylarsinous acid22955273|2534998
C472511dimethylarsinous acid[AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid22868225
C472511dimethylarsinous acid[AS3MT protein results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of dimethylarsinous acid22868225
C472511dimethylarsinous acidCysteine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]22955273
C472511dimethylarsinous acidGlutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]22868225
C472511dimethylarsinous acidGlutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]22955273
C472511dimethylarsinous acidtris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]22955273
C472511dimethylarsinous acidAS3MT affects the susceptibility to dimethylarsinous acid23376817
D004229DithiothreitolDithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]25349987
D004229DithiothreitolDithiothreitol results in increased reduction of AS3MT protein25349987
D004229DithiothreitolDithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]15025511
D000431EthanolEthanol results in increased expression of AS3MT mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AS3MT mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AS3MT mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AS3MT mRNA17942748
D005411Flame RetardantsFlame Retardants results in decreased expression of AS3MT mRNA27219277
D005459FluoridesAS3MT protein affects the metabolism of and affects the susceptibility to Fluorides23308176
D005485FlutamideFlutamide results in decreased expression of AS3MT mRNA24793618
D005492Folic AcidFolic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]]20049124
C039281furanfuran results in decreased expression of AS3MT mRNA25539665
D005978GlutathioneGlutathione affects the folding of AS3MT protein22955273
D005978GlutathioneGlutathione promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]25349987
D005978GlutathioneGlutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]22955273|2534998
D005978GlutathioneGlutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]22868225
D005978GlutathioneGlutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]22955273
D005978GlutathioneGlutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]22955273
D005978GlutathioneGlutathione promotes the reaction [AS3MT protein results in increased methylation of arsenite]22955273
D005978GlutathioneGlutathione results in increased reduction of and affects the folding of AS3MT protein25349987
D005978GlutathioneGlutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]15606138
D005978GlutathioneGlutathione affects the reaction [AS3MT protein affects the metabolism of arsenous acid]15606138
D005978GlutathioneGlutathione affects the reaction [AS3MT protein affects the metabolism of dimethylarsine]15606138
D005978GlutathioneGlutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine]15606138
D005978GlutathioneGlutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]15606138
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in decreased expression of AS3MT mRNA27219277
D017313FenretinideFenretinide results in increased expression of AS3MT mRNA28973697
C051890irinotecanirinotecan affects the expression of AS3MT mRNA20097248
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AS3MT mRNA23430699
C410337K 7174K 7174 results in decreased expression of AS3MT mRNA24086573
C501996methylarsoniteAS3MT protein results in increased chemical synthesis of methylarsonite22955273
C501996methylarsoniteCysteine promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]22955273
C501996methylarsoniteGlutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]22955273
C501996methylarsonitetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]22955273
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of AS3MT mRNA18804290
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of AS3MT protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of AS3MT protein26558463
C020300monomethylarsonic acid[AS3MT gene polymorphism affects the susceptibility to Arsenic] which results in increased abundance of monomethylarsonic acid24845704
C020300monomethylarsonic acid[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of monomethylarsonic acid22868225
C020300monomethylarsonic acidAS3MT protein polymorphism results in increased metabolism of monomethylarsonic acid22868225
C020300monomethylarsonic acid[AS3MT protein polymorphism results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of Cacodylic Acid22868225
C020300monomethylarsonic acid[AS3MT protein polymorphism results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of dimethylarsinous acid22868225
C020300monomethylarsonic acidAS3MT protein results in increased chemical synthesis of monomethylarsonic acid22005461
C020300monomethylarsonic acid[AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of monomethylarsonic acid22868225
C020300monomethylarsonic acidAS3MT protein results in increased metabolism of monomethylarsonic acid22868225
C020300monomethylarsonic acid[AS3MT protein results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of Cacodylic Acid22868225
C020300monomethylarsonic acid[AS3MT protein results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of dimethylarsinous acid22868225
C406082monomethylarsonous acidAS3MT protein results in increased methylation of monomethylarsonous acid25997655
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of AS3MT protein24625837
C406082monomethylarsonous acidAS3MT protein affects the reaction [APOE protein affects the susceptibility to monomethylarsonous acid]28728140
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AS3MT mRNA"25554681
D009532NickelNickel results in decreased expression of AS3MT mRNA24768652|2558310
D010100OxygenOxygen deficiency results in increased expression of AS3MT mRNA20880076
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of AS3MT mRNA21791302
D010416PentachlorophenolPentachlorophenol results in increased expression of AS3MT mRNA23892564
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of AS3MT mRNA24535843
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AS3MT mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of AS3MT mRNA26272509
D010713PhosphatidylcholinesAS3MT gene mutant form affects the metabolism of Phosphatidylcholines27591999
C006253pirinixic acidpirinixic acid results in increased expression of AS3MT mRNA18301758
D011441PropylthiouracilPropylthiouracil results in decreased expression of AS3MT mRNA24780913
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of AS3MT mRNA26100227
D012643SeleniumSelenium inhibits the reaction [AS3MT protein results in increased methylation of Arsenic]19167370
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AS3MT mRNA25895662
C017947sodium arseniteAS3MT protein affects the metabolism of sodium arsenite16407288
C017947sodium arseniteAS3MT protein polymorphism results in decreased metabolism of sodium arsenite16407288
C017947sodium arseniteAS3MT protein polymorphism results in increased metabolism of sodium arsenite16407288
C017947sodium arseniteAS3MT protein results in increased methylation of sodium arsenite21447609
C017947sodium arseniteAS3MT protein results in increased susceptibility to sodium arsenite21537954
C017947sodium arseniteAS3MT protein affects the reaction [APOE protein affects the susceptibility to sodium arsenite]28728140
C017947sodium arseniteAS3MT protein affects the reaction [[APOE protein affects the susceptibility to sodium arsenite] which results in decreased expression of ACTA2 protein]28728140
C016104sodium bichromatesodium bichromate results in decreased expression of AS3MT mRNA24612858
C016104sodium bichromatesodium bichromate affects the expression of AS3MT mRNA22110744
D013629TamoxifenTamoxifen affects the expression of AS3MT mRNA17555576
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of AS3MT mRNA15885361
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AS3MT mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AS3MT mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AS3MT mRNA17942748|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AS3MT mRNA21215274|2234250
D013853ThioacetamideThioacetamide results in decreased expression of AS3MT mRNA23411599
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of AS3MT mRNA]27469509
C009572trimethylarsineGlutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine]15606138
C052920trimethylarsine oxideAS3MT protein results in increased chemical synthesis of trimethylarsine oxide15606138
C052920trimethylarsine oxideGlutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]15606138
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AS3MT mRNA"26179874
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine affects the folding of AS3MT protein22955273
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]25349987
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]22955273
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]22955273
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]22955273
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of arsenite]22955273
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine results in increased reduction of AS3MT protein25349987
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of Arsenic]15025511
D014520UrethaneUrethane results in decreased expression of AS3MT mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AS3MT mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of AS3MT mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AS3MT mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of AS3MT mRNA17292431
D014805Vitamin B 12Folic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]]20049124
D014805Vitamin B 12Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]20049124

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008168methyltransferase activity-IBA21873635  
GO:0030791arsenite methyltransferase activity-ISS-  
GO:0030791arsenite methyltransferase activity-TAS-  
GO:0030792methylarsonite methyltransferase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009404toxin metabolic process-ISS-  
GO:0018872arsonoacetate metabolic process-ISS-  
GO:0032259methylation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21715529Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. (2011 Sep)O'Shaughnessy PJJ Clin Endocrinol Metab
23322787Heritability and preliminary genome-wide linkage analysis of arsenic metabolites in urine. (2013 Mar)Tellez-Plaza MEnviron Health Perspect
22341486Low-level arsenic exposure, AS3MT gene polymorphism and cardiovascular diseases in rural Texas counties. (2012 Feb)Gong GEnviron Res
26677206Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity. (2016 Feb)Jansen RJCancer Epidemiol Biomarkers Prev
23552396Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA. (2013 Jun)Tajuddin SMEnviron Health Perspect
27327299Association between polymorphisms in arsenic metabolism genes and urinary arsenic methylation profiles in girls and boys chronically exposed to arsenic. (2016 Aug)Recio-Vega REnviron Mol Mutagen