Gene info: ID 5742

Gene: PTGS1

GENE ID: 5742

Description: prostaglandin-endoperoxide synthase 1

Gene type: protein-coding

Location: 9q33.2

dbXrefs: Ensembl:ENSG00000095303 MIM:176805 Vega:OTTHUMG00000020605 UniprotKB:P23219

RefSeq: NG_032900.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.244e-2 (AD) 8.720e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
APBB1IP	0.842
APBB1IP	0.842
ITGAM	0.838
ITGAM	0.838
DOCK2	0.836
NCKAP1L	0.836
NCKAP1L	0.836
DOCK2	0.836
LAPTM5	0.825
LAPTM5	0.825

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HES5	-0.353
HES5	-0.353
C9orf24	-0.279
C9orf24	-0.279
GLIPR1L2	-0.276
GLIPR1L2	-0.276
ATP2C2	-0.27
ATP2C2	-0.27
HPDL	-0.266
HPDL	-0.266

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00154	Dihomo-gamma-linolenic acid	Small Molecule	1783-84-2	Approved\|Investigational\|Nutraceutical	Target
DB00159	Icosapent	Small Molecule	10417-94-4	Approved\|Nutraceutical	Target
DB00244	Mesalazine	Small Molecule	89-57-6	Approved	Target
DB00316	Acetaminophen	Small Molecule	103-90-2	Approved	Target
DB00328	Indomethacin	Small Molecule	53-86-1	Approved\|Investigational	Target
DB00350	Minoxidil	Small Molecule	38304-91-5	Approved\|Investigational	Target
DB00461	Nabumetone	Small Molecule	42924-53-8	Approved	Target
DB00465	Ketorolac	Small Molecule	74103-06-3	Approved	Target
DB00469	Tenoxicam	Small Molecule	59804-37-4	Approved	Target
DB00500	Tolmetin	Small Molecule	26171-23-3	Approved	Target
DB00554	Piroxicam	Small Molecule	36322-90-4	Approved\|Investigational	Target
DB00573	Fenoprofen	Small Molecule	29679-58-1	Approved	Target
DB00586	Diclofenac	Small Molecule	15307-86-5	Approved	Target
DB00605	Sulindac	Small Molecule	38194-50-2	Approved\|Investigational	Target
DB00711	Diethylcarbamazine	Small Molecule	90-89-1	Approved\|Investigational	Target
DB00712	Flurbiprofen	Small Molecule	5104-49-4	Approved\|Investigational	Target
DB00749	Etodolac	Small Molecule	41340-25-4	Approved\|Investigational	Target
DB00784	Mefenamic acid	Small Molecule	61-68-7	Approved	Target
DB00788	Naproxen	Small Molecule	22204-53-1	Approved	Target
DB00795	Sulfasalazine	Small Molecule	599-79-1	Approved	Target
DB00812	Phenylbutazone	Small Molecule	50-33-9	Approved	Target
DB00814	Meloxicam	Small Molecule	71125-38-7	Approved	Target
DB00821	Carprofen	Small Molecule	53716-49-7	Approved\|Withdrawn	Target
DB00861	Diflunisal	Small Molecule	22494-42-4	Approved\|Investigational	Target
DB00870	Suprofen	Small Molecule	40828-46-4	Approved\|Withdrawn	Target
DB00936	Salicylic acid	Small Molecule	69-72-7	Approved\|Investigational	Target
DB00939	Meclofenamic acid	Small Molecule	644-62-2	Approved	Target
DB00945	Acetylsalicylic acid	Small Molecule	50-78-2	Approved	Target
DB00963	Bromfenac	Small Molecule	91714-94-2	Approved	Target
DB00991	Oxaprozin	Small Molecule	21256-18-8	Approved	Target
DB01009	Ketoprofen	Small Molecule	22071-15-4	Approved	Target
DB01014	Balsalazide	Small Molecule	80573-04-2	Approved\|Investigational	Target
DB01050	Ibuprofen	Small Molecule	15687-27-1	Approved	Target
DB01283	Lumiracoxib	Small Molecule	220991-20-8	Approved\|Investigational	Target
DB01397	Magnesium salicylate	Small Molecule	18917-89-0	Approved	Target
DB01399	Salsalate	Small Molecule	552-94-3	Approved	Target
DB01401	Choline magnesium trisalicylate	Small Molecule	64425-90-7	Approved	Target
DB01419	Antrafenine	Small Molecule	55300-29-3	Approved	Target
DB01435	Antipyrine	Small Molecule	60-80-0	Approved\|Investigational	Target
DB01600	Tiaprofenic acid	Small Molecule	33005-95-7	Approved	Target
DB01837	O-acetyl-L-serine	Small Molecule	5147-00-2	Experimental	Target
DB01892	Hyperforin	Small Molecule	11079-53-1	Nutraceutical	Target
DB02047	2-(1,1'-Biphenyl-4-Yl)Propanoic Acid	Small Molecule		Experimental	Target
DB02110	Protoporphyrin Ix Containing Co	Small Molecule		Experimental	Target
DB02198	2-Bromoacetyl Group	Small Molecule	79-08-3	Experimental	Target
DB02266	Flufenamic Acid	Small Molecule	530-78-9	Experimental	Target
DB02379	Beta-D-Glucose	Small Molecule	492-61-5	Experimental	Target
DB02709	Resveratrol	Small Molecule	501-36-0	Approved\|Experimental\|Investigational	Target
DB02773	(3-Chloro-4-Propoxy-Phenyl)-Acetic Acid	Small Molecule		Experimental	Target
DB03667	Acetic Acid Salicyloyl-Amino-Ester	Small Molecule		Experimental	Target
DB03752	P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid	Small Molecule		Experimental	Target
DB03753	Flurbiprofen Methyl Ester	Small Molecule		Experimental	Target
DB03783	Phenacetin	Small Molecule	62-44-2	Withdrawn	Target
DB04552	Niflumic Acid	Small Molecule	4394-00-7	Approved	Target
DB04557	Arachidonic Acid	Small Molecule	506-32-1	Experimental	Target
DB04817	Metamizole	Small Molecule	50567-35-6	Approved\|Investigational\|Withdrawn	Target
DB06725	Lornoxicam	Small Molecule	70374-39-9	Approved\|Investigational	Target
DB06736	Aceclofenac	Small Molecule	89796-99-6	Approved\|Investigational	Target
DB06802	Nepafenac	Small Molecule	78281-72-8	Approved\|Investigational	Target
DB07981	2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide	Small Molecule		Experimental	Target
DB07983	1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID	Small Molecule		Experimental	Target
DB07984	2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide	Small Molecule		Experimental	Target
DB08814	Triflusal	Small Molecule	322-79-2	Approved\|Investigational	Target
DB09212	Loxoprofen	Small Molecule	68767-14-6	Approved\|Investigational	Target
DB09213	Dexibuprofen	Small Molecule	51146-56-6	Approved\|Investigational	Target
DB09214	Dexketoprofen	Small Molecule	22161-81-5	Approved\|Investigational	Target
DB09215	Droxicam	Small Molecule	90101-16-9	Withdrawn	Target
DB09216	Tolfenamic Acid	Small Molecule	13710-19-5	Approved\|Investigational	Target
DB09288	Propacetamol	Small Molecule	66532-85-2	Approved\|Investigational	Target
DB09295	Talniflumate	Small Molecule	66898-62-2	Approved	Target
DB11079	Trolamine salicylate	Small Molecule	2174-16-5	Approved	Target
DB12445	Nitroaspirin	Small Molecule	175033-36-0	Investigational	Target
DB13783	Acemetacin	Small Molecule	53164-05-9	Approved\|Experimental\|Investigational	Target
DB00035	Desmopressin	Small Molecule	16679-58-6	Approved	Enzyme
DB00214	Torasemide	Small Molecule	56211-40-6	Approved	Enzyme
DB00216	Eletriptan	Small Molecule	143322-58-1	Approved\|Investigational	Enzyme
DB00250	Dapsone	Small Molecule	80-08-0	Approved\|Investigational	Enzyme
DB00313	Valproic Acid	Small Molecule	99-66-1	Approved\|Investigational	Enzyme
DB00327	Hydromorphone	Small Molecule	466-99-9	Approved\|Illicit	Enzyme
DB00402	Eszopiclone	Small Molecule	138729-47-2	Approved\|Investigational	Enzyme
DB00412	Rosiglitazone	Small Molecule	122320-73-4	Approved\|Investigational	Enzyme
DB00425	Zolpidem	Small Molecule	82626-48-0	Approved	Enzyme
DB00470	Dronabinol	Small Molecule	1972-08-3	Approved\|Illicit	Enzyme
DB00471	Montelukast	Small Molecule	158966-92-8	Approved	Enzyme
DB00533	Rofecoxib	Small Molecule	162011-90-7	Approved\|Investigational\|Withdrawn	Enzyme
DB00540	Nortriptyline	Small Molecule	72-69-5	Approved	Enzyme
DB00549	Zafirlukast	Small Molecule	107753-78-6	Approved\|Investigational	Enzyme
DB00582	Voriconazole	Small Molecule	137234-62-9	Approved\|Investigational	Enzyme
DB00586	Diclofenac	Small Molecule	15307-86-5	Approved	Enzyme
DB00619	Imatinib	Small Molecule	152459-95-5	Approved	Enzyme
DB00672	Chlorpropamide	Small Molecule	94-20-2	Approved\|Investigational	Enzyme
DB00731	Nateglinide	Small Molecule	105816-04-4	Approved\|Investigational	Enzyme
DB00744	Zileuton	Small Molecule	111406-87-2	Approved\|Investigational\|Withdrawn	Enzyme
DB00773	Etoposide	Small Molecule	33419-42-0	Approved	Enzyme
DB00796	Candesartan cilexetil	Small Molecule	145040-37-5	Approved	Enzyme
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Enzyme
DB00857	Terbinafine	Small Molecule	91161-71-6	Approved\|Investigational	Enzyme
DB01015	Sulfamethoxazole	Small Molecule	723-46-6	Approved	Enzyme
DB01029	Irbesartan	Small Molecule	138402-11-6	Approved\|Investigational	Enzyme
DB01041	Thalidomide	Small Molecule	50-35-1	Approved\|Investigational\|Withdrawn	Enzyme
DB01050	Ibuprofen	Small Molecule	15687-27-1	Approved	Enzyme
DB01075	Diphenhydramine	Small Molecule	58-73-1	Approved\|Investigational	Enzyme
DB01132	Pioglitazone	Small Molecule	111025-46-8	Approved\|Investigational	Enzyme
DB01136	Carvedilol	Small Molecule	72956-09-3	Approved\|Investigational	Enzyme
DB01181	Ifosfamide	Small Molecule	3778-73-2	Approved	Enzyme
DB01198	Zopiclone	Small Molecule	43200-80-2	Approved	Enzyme
DB01221	Ketamine	Small Molecule	6740-88-1	Approved	Enzyme
DB01355	Hexobarbital	Small Molecule	56-29-1	Approved	Enzyme
DB05109	Trabectedin	Small Molecule	114899-77-3	Approved\|Investigational	Enzyme
DB06737	Zaltoprofen	Small Molecule	74711-43-6	Approved\|Investigational	Enzyme
DB06738	Ketobemidone	Small Molecule	469-79-4	Approved\|Investigational	Enzyme
DB06739	Seratrodast	Small Molecule	112665-43-7	Approved	Enzyme
DB09061	Cannabidiol	Small Molecule	13956-29-1	Approved\|Investigational	Enzyme
DB09212	Loxoprofen	Small Molecule	68767-14-6	Approved\|Investigational	Enzyme
DB09214	Dexketoprofen	Small Molecule	22161-81-5	Approved\|Investigational	Enzyme
DB09295	Talniflumate	Small Molecule	66898-62-2	Approved	Enzyme
DB13919	Candesartan	Small Molecule	139481-59-7	Experimental	Enzyme

ID	Drug Name	Action	PubMed
C527346	11,15-dioxo-9-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid	"PTGS1 protein results in increased abundance of 11,15-dioxo-9-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid"	17993463
C527346	11,15-dioxo-9-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid	"PTGS1 protein results in increased abundance of 11,15-dioxo-9-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid"	17993463
C021201	12-HPETE	12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]]	12538810
C021201	12-HPETE	12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]	12538810
C021201	12-HPETE	Manganese inhibits the reaction [12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]]	12538810
C008033	12-hydroxy-5,8,10-heptadecatrienoic acid	"arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid]"	20933508
C008033	12-hydroxy-5,8,10-heptadecatrienoic acid	"[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid"	20933508
C522246	1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid	"1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid results in decreased activity of PTGS1 protein"	17292621
C085131	1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine	"1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine results in decreased expression of PTGS1"	21414306
C090859	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole results in decreased activity of PTGS1 protein	9146894
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"PTGS1 protein promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2]"	17439952
C115293	1-(carboxymethyl)-3,5-diphenyl-2-methylbenzene	"1-(carboxymethyl)-3,5-diphenyl-2-methylbenzene results in decreased activity of PTGS1 protein"	9719496
C400184	1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine	1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS1 mRNA	16386258
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PTGS1 mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PTGS1 mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PTGS1 mRNA"	25305463
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PTGS1 mRNA"	26808241
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PTGS1 mRNA"	27291303
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]	20564508
C036837	2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]"	25432964
C036837	2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]"	25432964
C036837	2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]"	25432964
C036837	2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]"	25432964
C036837	2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]"	25432964
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"PTGS1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"	11159734
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"PTGS1 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"	11159734
C029216	2-amino-3-methylimidazo(4,5-f)quinoline	"PTGS1 protein results in increased metabolism of 2-amino-3-methylimidazo(4,5-f)quinoline"	11159734
C034047	2-cresol	2-cresol results in decreased activity of PTGS1 protein	15664436
C081914	2-methoxybenzoic acid	2-methoxybenzoic acid inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]	12538810
C081914	2-methoxybenzoic acid	2-methoxybenzoic acid results in decreased activity of PTGS1 protein	12538810
C439024	3,5-dihydroxy-4'-methoxystilbene	"3,5-dihydroxy-4'-methoxystilbene results in decreased activity of PTGS1 protein"	27159630
C475568	3-aminobenzanthrone	PTGS1 protein affects the metabolism of and results in increased activity of 3-aminobenzanthrone	15885895
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of PTGS1 mRNA	14610520
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C006757	4-biphenylamine	PTGS1 protein results in increased metabolism of 4-biphenylamine	11159734
C006757	4-biphenylamine	PTGS1 protein results in increased metabolism of 4-biphenylamine	11159734
C032538	4-cresol	4-cresol results in decreased activity of PTGS1 protein	15664436
C478738	4-(nitroxy)butanoic acid 4-acetylaminophenyl ester	4-(nitroxy)butanoic acid 4-acetylaminophenyl ester results in decreased expression of PTGS1 mRNA	16172162
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of PTGS1 mRNA	15982314
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of PTGS1 mRNA	18571826
C106876	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone	"5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone results in decreased activity of PTGS1 protein"	9146894
C559679	5-amino-2-ethoxy-N-(3-trifluoromethylphenyl)benzamide	5-amino-2-ethoxy-N-(3-trifluoromethylphenyl)benzamide results in decreased activity of PTGS1 protein	21372527
C047254	5-phenylpent-4-enyl-1-hydroperoxide	Acetaminophen inhibits the reaction [[PTGS1 protein results in increased metabolism of 5-phenylpent-4-enyl-1-hydroperoxide] which results in increased chemical synthesis of 5-phenylpent-4-enyl-1-ol]	12538810
C047254	5-phenylpent-4-enyl-1-hydroperoxide	PTGS1 protein results in increased metabolism of 5-phenylpent-4-enyl-1-hydroperoxide	12538810
C047254	5-phenylpent-4-enyl-1-hydroperoxide	[PTGS1 protein results in increased metabolism of 5-phenylpent-4-enyl-1-hydroperoxide] which results in increased chemical synthesis of 5-phenylpent-4-enyl-1-ol	12538810
C047532	5-phenylpent-4-enyl-1-ol	Acetaminophen inhibits the reaction [[PTGS1 protein results in increased metabolism of 5-phenylpent-4-enyl-1-hydroperoxide] which results in increased chemical synthesis of 5-phenylpent-4-enyl-1-ol]	12538810
C047532	5-phenylpent-4-enyl-1-ol	[PTGS1 protein results in increased metabolism of 5-phenylpent-4-enyl-1-hydroperoxide] which results in increased chemical synthesis of 5-phenylpent-4-enyl-1-ol	12538810
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C077580	7-(deoxyadenosin-N(6)-yl)aristolactam I	PTGS1 protein results in increased activity of 7-(deoxyadenosin-N(6)-yl)aristolactam I	15386410
C067134	8-oxo-7-hydrodeoxyguanosine	"[[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine"	21163909
C067134	8-oxo-7-hydrodeoxyguanosine	[[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine	21163909
C067134	8-oxo-7-hydrodeoxyguanosine	"[[PTGS1 protein results in increased activity of and results in increased oxidation of 3,4-Dihydroxyphenylacetic Acid] which results in increased chemical synthesis of Reactive Oxygen Species] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine"	19374330
C067134	8-oxo-7-hydrodeoxyguanosine	[[PTGS1 protein results in increased activity of and results in increased oxidation of Dopamine] which results in increased chemical synthesis of Reactive Oxygen Species] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine	19374330
C067134	8-oxo-7-hydrodeoxyguanosine	[[PTGS1 protein results in increased activity of and results in increased oxidation of Levodopa] which results in increased chemical synthesis of Reactive Oxygen Species] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine	19374330
D000079	Acetaldehyde	Acetaldehyde results in increased expression of PTGS1 mRNA	17050345
D000082	Acetaminophen	Acetaminophen results in decreased activity of PTGS1 protein alternative form	12242329
D000082	Acetaminophen	Acetaminophen analog results in decreased activity of PTGS1 protein	16141368
D000082	Acetaminophen	Acetaminophen results in decreased activity of PTGS1 protein	11113024\|1614136
D000082	Acetaminophen	Acetaminophen results in decreased activity of PTGS1 protein alternative form	15263079
D000082	Acetaminophen	Acetaminophen results in decreased expression of PTGS1 mRNA	17175104
D000082	Acetaminophen	Acetaminophen results in decreased expression of PTGS1 protein alternative form	16674937
D000082	Acetaminophen	Acetaminophen results in increased expression of PTGS1 protein	26522476
D000082	Acetaminophen	PTGS1 protein affects the susceptibility to Acetaminophen	16674937
D000082	Acetaminophen	PTGS1 protein alternative form affects the susceptibility to Acetaminophen	16674937
D000082	Acetaminophen	Acetaminophen affects the activity of PTGS1 protein	20024105
D000082	Acetaminophen	Acetaminophen analog affects the activity of PTGS1 protein	20024105
D000082	Acetaminophen	Acetaminophen inhibits the reaction [[PTGS1 protein results in increased metabolism of 5-phenylpent-4-enyl-1-hydroperoxide] which results in increased chemical synthesis of 5-phenylpent-4-enyl-1-ol]	12538810
D000082	Acetaminophen	Acetaminophen results in decreased expression of PTGS1 mRNA	16172162
D000082	Acetaminophen	Acetaminophen results in decreased activity of PTGS1 protein	17606472
D000082	Acetaminophen	PTGS1 protein results in increased metabolism of Acetaminophen	14758789
C056165	acetovanillone	acetovanillone inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]	21983654
C056165	acetovanillone	acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS1 protein]	18414395
D000143	Acids	[SC 560 binds to and results in decreased activity of PTGS1 protein] promotes the reaction [Histamine results in increased secretion of Acids]	16299412
D000143	Acids	[SC 560 binds to and results in decreased activity of PTGS1 protein] promotes the reaction [Pentagastrin results in increased secretion of Acids]	16299412
D020106	Acrylamide	Acrylamide results in increased expression of PTGS1 mRNA	28959563
D012436	S-Adenosylmethionine	S-Adenosylmethionine results in decreased expression of PTGS1 mRNA	18098314
C446481	aliskiren	aliskiren inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]	27645307
C103303	alitretinoin	alitretinoin results in decreased expression of PTGS1 mRNA	15982314
C523074	allylpyrocatechol	allylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]	18431645
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of PTGS1 mRNA	28522335
C011512	alpha-naphthoflavone	alpha-naphthoflavone results in increased expression of PTGS1 mRNA	19403181
C064176	alpha-viniferin	alpha-viniferin results in decreased activity of PTGS1 protein	14531020
D000632	Aminopyrine	Aminopyrine analog results in decreased activity of PTGS1 protein	16141368
D000632	Aminopyrine	Aminopyrine results in decreased activity of PTGS1 protein	16141368
D000636	Aminosalicylic Acids	Aminosalicylic Acids results in decreased activity of PTGS1 protein	20041722
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PTGS1 mRNA	16483693
D000983	Antipyrine	Antipyrine results in decreased activity of PTGS1 protein alternative form	12242329
D000983	Antipyrine	Antipyrine analog results in decreased activity of PTGS1 protein	16141368
D000983	Antipyrine	Antipyrine results in decreased activity of PTGS1 protein	16141368
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PTGS1 mRNA	24449571
D016718	Arachidonic Acid	PTGS1 protein results in increased metabolism of Arachidonic Acid	10718109
D016718	Arachidonic Acid	Arachidonic Acid results in increased activity of PTGS1 protein	19751497\|2116390
D016718	Arachidonic Acid	"[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine"	21163909
D016718	Arachidonic Acid	"[[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine"	21163909
D016718	Arachidonic Acid	[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine	21163909
D016718	Arachidonic Acid	[[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine	21163909
D016718	Arachidonic Acid	"arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid]"	20933508
D016718	Arachidonic Acid	arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2]	20933508
D016718	Arachidonic Acid	Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	21163909
D016718	Arachidonic Acid	Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine]	21163909
D016718	Arachidonic Acid	DuP 697 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	21163909
D016718	Arachidonic Acid	PTGS1 protein alternative form results in increased metabolism of Arachidonic Acid	16141368
D016718	Arachidonic Acid	PTGS1 protein results in increased metabolism of Arachidonic Acid	16141368
D016718	Arachidonic Acid	"[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid"	20933508
D016718	Arachidonic Acid	[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2	20933508
D016718	Arachidonic Acid	resveratrol inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	19751497
D016718	Arachidonic Acid	SC 560 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	19751497\|2116390
D016718	Arachidonic Acid	valerylsalicylate inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	19751497
D016718	Arachidonic Acid	PTGS1 results in increased susceptibility to Arachidonic Acid	15863457
D016718	Arachidonic Acid	[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of prostaglandin G2	7775455
D016718	Arachidonic Acid	12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]]	12538810
D016718	Arachidonic Acid	"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]]"	12538810
D016718	Arachidonic Acid	2-methoxybenzoic acid inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]	12538810
D016718	Arachidonic Acid	Arachidonic Acid affects the reaction [Aspirin results in decreased activity of PTGS1 protein]	12398900
D016718	Arachidonic Acid	Arachidonic Acid affects the reaction [Indomethacin results in decreased activity of PTGS1 protein]	12398900
D016718	Arachidonic Acid	Arachidonic Acid results in increased activity of PTGS1 protein	11755111
D016718	Arachidonic Acid	Benzoic Acid inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]	12538810
D016718	Arachidonic Acid	Ibuprofen analog inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	11755111
D016718	Arachidonic Acid	Indomethacin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	11755111
D016718	Arachidonic Acid	Naproxen inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	11755111
D016718	Arachidonic Acid	[PTGS1 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]]	12538810
D016718	Arachidonic Acid	PTGS1 protein results in increased metabolism of Arachidonic Acid	12538810
D016718	Arachidonic Acid	Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]	12538810
D016718	Arachidonic Acid	Aspirin affects the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2]	12545150
D016718	Arachidonic Acid	Aspirin inhibits the reaction [[PTGS1 protein SNP results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2]	12545150
D016718	Arachidonic Acid	PTGS1 protein affects the metabolism of Arachidonic Acid	12902868
D016718	Arachidonic Acid	PTGS1 protein results in increased metabolism of Arachidonic Acid	12545150\|9266823
D016718	Arachidonic Acid	[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2	12545150
D016718	Arachidonic Acid	PTGS1 protein results in increased oxidation of Arachidonic Acid	25920575
D016718	Arachidonic Acid	PTGS1 protein SNP results in increased metabolism of Arachidonic Acid	12545150
D016718	Arachidonic Acid	[PTGS1 protein SNP results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2	12545150
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [Tretinoin results in increased expression of PTGS1 protein]	18354491
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PTGS1 mRNA	26705709
C517830	arzanol	"arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid]"	20933508
C517830	arzanol	arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2]	20933508
C517830	arzanol	arzanol results in decreased activity of PTGS1 protein	20933508
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of PTGS1 protein"	20855422
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]	27020608
D001241	Aspirin	Aspirin results in decreased activity of PTGS1 protein alternative form	12242329
D001241	Aspirin	Aspirin analog results in decreased activity of PTGS1 protein	16141368
D001241	Aspirin	Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	21163909
D001241	Aspirin	Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine]	21163909
D001241	Aspirin	Aspirin inhibits the reaction [PTGS1 protein results in increased susceptibility to Methamphetamine]	21163909
D001241	Aspirin	Aspirin results in decreased activity of PTGS1 protein	15843042\|1614136
D001241	Aspirin	Aspirin results in decreased expression of PTGS1 mRNA	19493461
D001241	Aspirin	Aspirin results in increased acetylation of PTGS1 protein	16484611
D001241	Aspirin	[Aspirin results in increased acetylation of PTGS1 protein] which results in decreased chemical synthesis of Thromboxane A2	16484611
D001241	Aspirin	PTGS1 gene polymorphism results in decreased susceptibility to Aspirin	16493486
D001241	Aspirin	PTGS1 gene SNP results in decreased susceptibility to Aspirin	16150050
D001241	Aspirin	PTGS1 mutant form inhibits the reaction [Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]]	20404564
D001241	Aspirin	PTGS1 polymorphism affects the susceptibility to Aspirin	19390185
D001241	Aspirin	"Aspirin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein]"	21513785
D001241	Aspirin	Aspirin results in decreased activity of PTGS1 protein	12242329
D001241	Aspirin	PTGS1 results in decreased susceptibility to [Hydrochloric Acid co-treated with Aspirin]	15236176
D001241	Aspirin	Arachidonic Acid affects the reaction [Aspirin results in decreased activity of PTGS1 protein]	12398900
D001241	Aspirin	"Aspirin promotes the reaction [fructose-1,6-diphosphate results in decreased activity of PTGS1 protein]"	27083140
D001241	Aspirin	Aspirin promotes the reaction [Pyruvaldehyde results in decreased activity of PTGS1 protein]	27083140
D001241	Aspirin	Aspirin results in decreased activity of PTGS1	12398900
D001241	Aspirin	Aspirin results in decreased activity of PTGS1 protein	16190777\|1884857
D001241	Aspirin	[Diclofenac co-treated with Aspirin] binds to PTGS1 protein	20669977
D001241	Aspirin	DuP 697 inhibits the reaction [Aspirin results in decreased activity of PTGS1]	12398900
D001241	Aspirin	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Aspirin results in decreased activity of PTGS1]	12398900
D001241	Aspirin	nimesulide inhibits the reaction [Aspirin results in decreased activity of PTGS1]	12398900
D001241	Aspirin	Aspirin affects the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2]	12545150
D001241	Aspirin	Aspirin inhibits the reaction [[PTGS1 protein SNP results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2]	12545150
D001241	Aspirin	Aspirin results in decreased activity of PTGS1	20608787
D001241	Aspirin	Aspirin results in decreased activity of PTGS1 protein	11376495\|1157746
D001241	Aspirin	Aspirin results in increased acetylation of and results in decreased activity of PTGS1 protein	16936242
D016589	Astemizole	Astemizole results in decreased expression of PTGS1 mRNA	20221588
D001280	Atrazine	Atrazine results in increased expression of PTGS1 mRNA	22378314
D001397	Azoxymethane	Azoxymethane results in decreased expression of PTGS1 mRNA	17190766
C029876	benzidine	PTGS1 protein results in increased metabolism of benzidine	11159734
C029876	benzidine	PTGS1 protein results in increased metabolism of benzidine	11159734
C017228	benzo(a)pyrene 7,8-dihydrodiol	"PTGS1 protein results in increased metabolism of benzo(a)pyrene 7,8-dihydrodiol"	11159734
C017228	benzo(a)pyrene 7,8-dihydrodiol	"PTGS1 protein results in increased metabolism of benzo(a)pyrene 7,8-dihydrodiol"	11159734
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of PTGS1 mRNA	26377693
D019817	Benzoic Acid	Benzoic Acid inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]	12538810
D019817	Benzoic Acid	Benzoic Acid results in decreased activity of PTGS1 protein	12538810
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PTGS1 mRNA	19403181
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PTGS1 mRNA	20713471
D004958	Estradiol	Estradiol affects the expression of PTGS1 mRNA	24349563
D004958	Estradiol	Estradiol affects the expression of PTGS1 mRNA	22574217
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of PTGS1 mRNA	20660070
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of PTGS1 mRNA	17404688
D001622	Betaine	Betaine results in decreased expression of PTGS1 mRNA	26391144
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in decreased expression of PTGS1 mRNA	15912405
C006780	bisphenol A	bisphenol A affects the expression of PTGS1 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of PTGS1 mRNA	20170705
C006780	bisphenol A	bisphenol A results in decreased expression of PTGS1 mRNA	27685785
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTGS1 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of PTGS1 mRNA	22718145
C006780	bisphenol A	bisphenol A results in decreased expression of PTGS1 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PTGS1 mRNA	22079614
D019819	Budesonide	"Budesonide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS1 mRNA]"	15734790
D002034	Bumetanide	Bumetanide results in increased expression of PTGS1 mRNA	14504926
D002045	Bupivacaine	Bupivacaine results in increased expression of PTGS1 mRNA	18165598
D002064	Buserelin	Buserelin results in increased activity of PTGS1 protein	22592497
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased expression of PTGS1 protein	11696405
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene analog results in decreased activity of PTGS1 protein	16690318
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased activity of PTGS1 protein	15604817
D020148	Butyric Acid	Butyric Acid results in increased expression of PTGS1 mRNA	17928716
D002104	Cadmium	Cadmium affects the expression of PTGS1 mRNA	11351503
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PTGS1 protein	25645360
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PTGS1 mRNA	25645360
D019256	Cadmium Chloride	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Cadmium Chloride results in increased expression of PTGS1 mRNA]	25645360
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PTGS1 mRNA	25993096
C034939	cadmium sulfide	cadmium sulfide results in decreased expression of PTGS1 mRNA	27866839
D002118	Calcium	Calcium affects the expression of PTGS1 mRNA	15913539
C459604	candoxin	candoxin results in decreased expression of PTGS1 mRNA	16309724
D002251	Carbon Tetrachloride	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]"	25432964
D002251	Carbon Tetrachloride	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]"	25432964
D002251	Carbon Tetrachloride	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]"	25432964
D002251	Carbon Tetrachloride	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]"	25432964
D002251	Carbon Tetrachloride	"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]"	25432964
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of PTGS1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PTGS1 mRNA	27339419
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased degradation of and results in decreased expression of NFKBIA protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]]	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSM mRNA]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene C4]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene D4]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene E4]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased degradation of and results in decreased expression of NFKBIA protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LTC4S mRNA]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form results in increased susceptibility to Carbon Tetrachloride	25432964
C043211	carvedilol	carvedilol results in decreased expression of PTGS1 mRNA	16741616
D002392	Catechin	Catechin results in decreased activity of PTGS1 protein	11962253
D000068579	Celecoxib	Celecoxib analog results in decreased activity of PTGS1 protein	16141368
D000068579	Celecoxib	Celecoxib results in decreased activity of PTGS1 protein	16141368
D000068579	Celecoxib	Celecoxib binds to PTGS1 protein	20669977
D000068579	Celecoxib	Celecoxib results in decreased expression of PTGS1 mRNA alternative form	11375891
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of PTGS1 mRNA	26272509
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin results in increased expression of PTGS1 mRNA	24255720
C007095	cobaltiprotoporphyrin	FOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of PTGS1 mRNA]	24255720
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PTGS1 mRNA	19320972
D003345	Corticosterone	Corticosterone results in increased expression of PTGS1 mRNA	15755911
D003345	Corticosterone	Corticosterone results in increased expression of PTGS1 protein	15755911
C423222	cotylenin A	cotylenin A promotes the reaction [lithocholic acid acetate results in increased expression of PTGS1 mRNA]	18242698
C423222	cotylenin A	cotylenin A results in increased expression of PTGS1 mRNA	16129123
D003404	Creatinine	[SC 560 results in decreased activity of PTGS1 protein] which results in increased abundance of Creatinine	19629487
D003474	Curcumin	Curcumin results in decreased expression of PTGS1 mRNA	20816778
C017154	cyanidin	cyanidin results in decreased activity of PTGS1 protein	10075763
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of PTGS1 mRNA	21041162
D003634	DDT	DDT results in decreased expression of PTGS1 mRNA	25014179
C014347	decitabine	decitabine affects the expression of PTGS1 mRNA	23300844
D003671	DEET	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PTGS1 mRNA	28659758
C477734	delta-viniferin	PTGS1 protein affects the chemical synthesis of delta-viniferin	15688382
D003907	Dexamethasone	Dexamethasone inhibits the reaction [IL1A protein results in increased expression of PTGS1 mRNA]	15167967
D003907	Dexamethasone	Dexamethasone inhibits the reaction [IL1A protein results in increased expression of PTGS1 protein]	15167967
D003907	Dexamethasone	Dexamethasone results in increased expression of PTGS1 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTGS1 mRNA	28628672
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 protein]	16880258
D003907	Dexamethasone	Dexamethasone results in increased expression of PTGS1 mRNA	21041162
D003907	Dexamethasone	DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 protein]]	16880258
D003907	Dexamethasone	Dexamethasone results in increased expression of PTGS1 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of PTGS1 mRNA]	20032058
D002945	Cisplatin	Cisplatin affects the expression of PTGS1 mRNA	23300844
D002945	Cisplatin	Cisplatin results in increased expression of PTGS1 mRNA	27594783
D002945	Cisplatin	PTGS1 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	[Cisplatin co-treated with Lutein] results in decreased expression of PTGS1 mRNA	24865317
D002945	Cisplatin	Cisplatin results in decreased expression of PTGS1 mRNA	24865317
D004008	Diclofenac	Diclofenac results in decreased activity of PTGS1 protein alternative form	12242329
D004008	Diclofenac	Diclofenac analog results in decreased activity of PTGS1 protein	16141368
D004008	Diclofenac	Diclofenac results in decreased activity of PTGS1 protein	16141368
D004008	Diclofenac	Diclofenac results in decreased activity of PTGS1 protein	12242329
D004008	Diclofenac	Diclofenac results in increased expression of PTGS1 mRNA	26934552
D004008	Diclofenac	Diclofenac binds to PTGS1 protein	20669977
D004008	Diclofenac	[Diclofenac co-treated with Aspirin] binds to PTGS1 protein	20669977
D004008	Diclofenac	Diclofenac results in decreased activity of PTGS1 protein	24412305
D004008	Diclofenac	Diclofenac results in decreased activity of PTGS1 protein	9258749
D004008	Diclofenac	Diclofenac results in decreased expression of PTGS1 protein	19031110
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of PTGS1 mRNA	18253720
D000875	Anthralin	Anthralin results in decreased activity of PTGS1 protein	23611293
D002117	Calcitriol	Calcitriol results in increased expression of PTGS1 mRNA	16129123\|1824269
D002117	Calcitriol	PTGS1 protein results in increased susceptibility to Calcitriol	11455568
D002117	Calcitriol	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased susceptibility to Calcitriol	11455568
D015650	24,25-Dihydroxyvitamin D 3	"PTGS1 protein results in increased susceptibility to 24,25-Dihydroxyvitamin D 3"	10653606
D015650	24,25-Dihydroxyvitamin D 3	"[resveratrol results in decreased activity of PTGS1 protein] which results in decreased susceptibility to 24,25-Dihydroxyvitamin D 3"	10653606
D015102	3,4-Dihydroxyphenylacetic Acid	"PTGS1 protein results in increased activity of and results in increased oxidation of 3,4-Dihydroxyphenylacetic Acid"	19374330
D015102	3,4-Dihydroxyphenylacetic Acid	"[PTGS1 protein results in increased activity of and results in increased oxidation of 3,4-Dihydroxyphenylacetic Acid] which results in increased chemical synthesis of Reactive Oxygen Species"	19374330
D015102	3,4-Dihydroxyphenylacetic Acid	"[[PTGS1 protein results in increased activity of and results in increased oxidation of 3,4-Dihydroxyphenylacetic Acid] which results in increased chemical synthesis of Reactive Oxygen Species] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine"	19374330
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of PTGS1 mRNA"	27840820
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of PTGS1 mRNA	25380136
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in decreased expression of PTGS1 mRNA	21878375
D004177	Dipyrone	Dipyrone results in decreased activity of PTGS1 protein alternative form	12242329
D004177	Dipyrone	Dipyrone results in decreased activity of PTGS1 protein	11852909
D004177	Dipyrone	Dipyrone analog results in decreased activity of PTGS1 protein	16141368
D004177	Dipyrone	Dipyrone results in decreased activity of PTGS1 protein	16141368
D004177	Dipyrone	Dipyrone results in decreased activity of PTGS1 protein	12242329
D007980	Levodopa	[PTGS1 protein results in increased activity of and results in increased oxidation of Levodopa] which results in increased chemical synthesis of Reactive Oxygen Species	19374330
D007980	Levodopa	[[PTGS1 protein results in increased activity of and results in increased oxidation of Levodopa] which results in increased chemical synthesis of Reactive Oxygen Species] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine	19374330
D007980	Levodopa	PTGS1 protein results in increased oxidation of and results in increased activity of Levodopa	19374330
D004298	Dopamine	PTGS1 protein results in increased activity of and results in increased oxidation of Dopamine	19374330
D004298	Dopamine	[PTGS1 protein results in increased activity of and results in increased oxidation of Dopamine] which results in increased chemical synthesis of Reactive Oxygen Species	19374330
D004298	Dopamine	[[PTGS1 protein results in increased activity of and results in increased oxidation of Dopamine] which results in increased chemical synthesis of Reactive Oxygen Species] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine	19374330
D004317	Doxorubicin	PPARA protein affects the reaction [PTGS1 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]	17671096
D004317	Doxorubicin	PTGS1 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]	17671096
C064874	DuP 697	DuP 697 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	21163909
C064874	DuP 697	DuP 697 inhibits the reaction [Aspirin results in decreased activity of PTGS1]	12398900
C064874	DuP 697	DuP 697 inhibits the reaction [Indomethacin results in decreased activity of PTGS1]	12398900
C042986	ebselen	ebselen results in decreased activity of PTGS1 protein	7590103
D004656	Enalapril	Enalapril results in decreased expression of PTGS1 mRNA	25037058
C118739	entinostat	entinostat results in increased expression of PTGS1 mRNA	27188386
C062669	epicatechin gallate	epicatechin gallate results in decreased activity of PTGS1 protein	11962253
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of PTGS1 mRNA	20816778
D004837	Epinephrine	PTGS1 protein results in increased oxidation of and results in increased activity of Epinephrine	19374330
C091891	epsilon-viniferin	PTGS1 protein affects the chemical synthesis of epsilon-viniferin	15688382
C017296	estrone sulfate	PTGS1 protein promotes the reaction [EGF protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]	15238352
C017296	estrone sulfate	PTGS1 protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]	15238352
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PTGS1 mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PTGS1 mRNA	18936297
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PTGS1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGS1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PTGS1 mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PTGS1 mRNA	17557909
D017308	Etodolac	Etodolac results in decreased activity of PTGS1 protein	9146894
D015738	Famotidine	Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]	27645307
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of PTGS1 mRNA	18253720
C004999	ferulic acid	ferulic acid results in decreased expression of PTGS1 mRNA	20816778
D005419	Flavonoids	Flavonoids results in increased expression of PTGS1 mRNA	18035473
C059178	flosulide	flosulide results in decreased activity of PTGS1 protein	9146894
C014557	flunixin	flunixin results in decreased activity of PTGS1 protein	12967936
D005475	Flupenthixol	Flupenthixol results in decreased expression of PTGS1 protein	8897462
D005480	Flurbiprofen	Flurbiprofen results in decreased activity of PTGS1 protein	18848576
D005480	Flurbiprofen	Flurbiprofen binds to and results in decreased activity of PTGS1 protein	20669977
D005480	Flurbiprofen	Flurbiprofen results in decreased activity of PTGS1 protein	9233713\|9258749
D005485	Flutamide	Flutamide results in decreased expression of PTGS1 mRNA	24136188
D005557	Formaldehyde	acetovanillone inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]	21983654
D005557	Formaldehyde	Ascorbic Acid inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]	27020608
D005557	Formaldehyde	Formaldehyde inhibits the reaction [Ovalbumin results in increased expression of PTGS1 mRNA]	23871789
D005557	Formaldehyde	Formaldehyde results in decreased expression of PTGS1 mRNA	23871789
D005557	Formaldehyde	Formaldehyde results in increased expression of PTGS1 mRNA	21983654\|2484412
D005557	Formaldehyde	Indomethacin inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]	21983654
D005557	Formaldehyde	Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]	21983654
D005620	Freund's Adjuvant	Freund's Adjuvant results in decreased expression of PTGS1 mRNA	20846436
C029063	fructose-1,6-diphosphate	"Aspirin promotes the reaction [fructose-1,6-diphosphate results in decreased activity of PTGS1 protein]"	27083140
C029063	fructose-1,6-diphosphate	"fructose-1,6-diphosphate results in decreased activity of PTGS1 protein"	27083140
C039281	furan	furan results in decreased expression of PTGS1 mRNA	25539665
D005665	Furosemide	Furosemide affects the expression of PTGS1 mRNA	11961000
D005665	Furosemide	Furosemide affects the expression of PTGS1 protein	11961000
D005688	Galactosamine	[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA	22107987
D005688	Galactosamine	Indomethacin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA]	22107987
D005688	Galactosamine	nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA]	22107987
C001277	geldanamycin	geldanamycin results in decreased expression of PTGS1 mRNA	26705709
C056507	gemcitabine	gemcitabine results in decreased expression of PTGS1 mRNA	17039268
D019833	Genistein	Genistein affects the expression of PTGS1 mRNA	26865667
D019833	Genistein	Genistein results in decreased expression of PTGS1 mRNA	20816778
D005839	Gentamicins	Gentamicins results in increased expression of PTGS1 mRNA	22061828
D005947	Glucose	Glucose results in decreased activity of PTGS1 protein	27083140
D005947	Glucose	Glucose results in increased expression of PTGS1 protein	12888618
C094503	glyceryl 2-arachidonate	[Indomethacin results in decreased expression of PTGS1] which results in increased activity of glyceryl 2-arachidonate	17245358
D006427	Hemin	Hemin affects the folding of PTGS1 protein	8648609
D006427	Hemin	Hemin inhibits the reaction [N-(carboxyheptyl)maleimide affects the folding of PTGS1 protein]	8648609
D019377	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]]"	12538810
D019377	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]"	12538810
D006632	Histamine	[SC 560 binds to and results in decreased activity of PTGS1 protein] promotes the reaction [Histamine results in increased secretion of Acids]	16299412
D017313	Fenretinide	Fenretinide results in increased expression of PTGS1 mRNA	28973697
D017313	Fenretinide	Fenretinide results in decreased expression of PTGS1 mRNA	10697514
D006851	Hydrochloric Acid	PTGS1 results in decreased susceptibility to Hydrochloric Acid	15236176
D006851	Hydrochloric Acid	PTGS1 results in decreased susceptibility to [Hydrochloric Acid co-treated with Aspirin]	15236176
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]	12538810
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [resveratrol results in decreased activity of PTGS1 protein]	15020596
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased activity of PTGS1 protein	15604817
D007052	Ibuprofen	Ibuprofen results in decreased activity of PTGS1 protein alternative form	12242329
D007052	Ibuprofen	Ibuprofen analog results in decreased activity of PTGS1 protein	16141368
D007052	Ibuprofen	Ibuprofen results in decreased activity of PTGS1 protein	16141368\|1716413
D007052	Ibuprofen	Ibuprofen results in decreased activity of PTGS1 protein	12242329
D007052	Ibuprofen	Ibuprofen analog inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	11755111
D007052	Ibuprofen	Ibuprofen binds to PTGS1 protein	22091869
D007052	Ibuprofen	Ibuprofen inhibits the reaction [Indomethacin results in decreased activity of PTGS1 protein]	12398900
D007052	Ibuprofen	Ibuprofen results in decreased expression of PTGS1 mRNA	10697514
D007093	Imidazoles	Imidazoles analog results in decreased activity of PTGS1 protein	16190777
D007213	Indomethacin	Indomethacin results in decreased activity of PTGS1 protein alternative form	12242329
D007213	Indomethacin	Indomethacin results in decreased activity of PTGS1 protein	11852909
D007213	Indomethacin	Indomethacin analog results in decreased activity of PTGS1 protein	16141368
D007213	Indomethacin	Indomethacin binds to and results in decreased activity of PTGS1 protein	9146894
D007213	Indomethacin	Indomethacin inhibits the reaction [PTGS1 protein results in increased chemical synthesis of Dinoprostone]	16354411
D007213	Indomethacin	Indomethacin results in decreased activity of PTGS1 protein	14726416\|1614136
D007213	Indomethacin	Indomethacin results in decreased expression of PTGS1 protein	14736730
D007213	Indomethacin	Indomethacin results in increased expression of PTGS1 protein	15482327
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTGS1 mRNA	28628672
D007213	Indomethacin	allylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]	18431645
D007213	Indomethacin	Indomethacin binds to PTGS1 protein	17243824
D007213	Indomethacin	Indomethacin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA]	22107987
D007213	Indomethacin	"Indomethacin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein]"	21513785
D007213	Indomethacin	Indomethacin results in decreased activity of PTGS1 protein	11239499\|1224232
D007213	Indomethacin	Indomethacin results in decreased expression of PTGS1 protein	17977527\|1823739
D007213	Indomethacin	malabaricone B inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]	17977527
D007213	Indomethacin	malabaricone C inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]	17977527
D007213	Indomethacin	Plant Extracts inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]	18237397
D007213	Indomethacin	Arachidonic Acid affects the reaction [Indomethacin results in decreased activity of PTGS1 protein]	12398900
D007213	Indomethacin	DuP 697 inhibits the reaction [Indomethacin results in decreased activity of PTGS1]	12398900
D007213	Indomethacin	Ibuprofen inhibits the reaction [Indomethacin results in decreased activity of PTGS1 protein]	12398900
D007213	Indomethacin	Indomethacin analog results in decreased activity of PTGS1 protein	16690318
D007213	Indomethacin	Indomethacin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	11755111
D007213	Indomethacin	Indomethacin inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Indomethacin results in decreased activity of PTGS1]]	12398900
D007213	Indomethacin	Indomethacin results in decreased activity of PTGS1 protein	12398900\|1619077
D007213	Indomethacin	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Indomethacin results in decreased activity of PTGS1 protein]	12398900
D007213	Indomethacin	nimesulide inhibits the reaction [Indomethacin results in decreased activity of PTGS1]	12398900
D007213	Indomethacin	aliskiren inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]	27645307
D007213	Indomethacin	Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]	27645307
D007213	Indomethacin	Indomethacin inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]	21983654
D007213	Indomethacin	Indomethacin results in decreased activity of PTGS1 protein	9258749
D007213	Indomethacin	Indomethacin results in decreased expression of PTGS1	17245358
D007213	Indomethacin	Indomethacin results in decreased expression of PTGS1 mRNA	25168850
D007213	Indomethacin	[Indomethacin results in decreased expression of PTGS1] which results in increased activity of glyceryl 2-arachidonate	17245358
D007213	Indomethacin	Indomethacin results in increased activity of PTGS1 protein	20361948
D007213	Indomethacin	Indomethacin results in increased expression of PTGS1 mRNA	18299717\|2764530
D007213	Indomethacin	patchouli alcohol inhibits the reaction [Indomethacin results in decreased expression of PTGS1 mRNA]	25168850
D007213	Indomethacin	rebamipide inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]	18299717
D007213	Indomethacin	Indomethacin results in decreased activity of PTGS1 protein	11376495\|1260662
C448299	iron protoporphyrin IX	iron protoporphyrin IX results in increased activity of PTGS1 protein	12538810
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTGS1 mRNA	28628672
C040920	isoliquiritigenin	isoliquiritigenin results in decreased expression of PTGS1 mRNA	25094029
D007545	Isoproterenol	Isoproterenol results in increased expression of PTGS1 mRNA	20003209
D020910	Ketorolac	Ketorolac results in decreased activity of PTGS1 protein	17175104
D020910	Ketorolac	Ketorolac results in decreased expression of PTGS1 mRNA	17175104
D017999	Leukotriene E4	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene E4]	25432964
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Aspirin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein]"	21513785
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Indomethacin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein]"	21513785
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 mRNA"	21513785
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein"	21513785
C440499	lipopolysaccharide, Escherichia coli O111 B4	"mitragynine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein]"	21513785
C440499	lipopolysaccharide, Escherichia coli O111 B4	"PTGS1 protein promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2]"	17439952
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Budesonide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS1 mRNA]"	15734790
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of PTGS1 mRNA	24211328
D008070	Lipopolysaccharides	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA	22777745
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 protein]	16880258
D008070	Lipopolysaccharides	DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 protein]]	16880258
D008070	Lipopolysaccharides	[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA	22107987
D008070	Lipopolysaccharides	Indomethacin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA]	22107987
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PTGS1 protein	16880258
D008070	Lipopolysaccharides	nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA]	22107987
D008070	Lipopolysaccharides	PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins]	16787386
D008070	Lipopolysaccharides	PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins analog]	16787386
D008070	Lipopolysaccharides	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased susceptibility to Lipopolysaccharides	11321505
C502354	lithocholic acid acetate	cotylenin A promotes the reaction [lithocholic acid acetate results in increased expression of PTGS1 mRNA]	18242698
C502354	lithocholic acid acetate	lithocholic acid acetate results in increased expression of PTGS1 mRNA	18242698
C059451	lornoxicam	lornoxicam results in decreased activity of PTGS1 protein	10450786
C040656	loxoprofen	loxoprofen results in decreased activity of PTGS1 protein	16473424
D017997	Leukotriene C4	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene C4]	25432964
D017998	Leukotriene D4	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene D4]	25432964
D014975	Lutein	[Cisplatin co-treated with Lutein] results in decreased expression of PTGS1 mRNA	24865317
D008244	Lysophosphatidylcholines	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]	20564508
D008244	Lysophosphatidylcholines	Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA	20564508
D008244	Lysophosphatidylcholines	resveratrol inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]	20564508
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PTGS1 mRNA	26378955
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PTGS1 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] affects the expression of PTGS1 mRNA	26378955
C071788	malabaricone B	malabaricone B inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]	17977527
C071787	malabaricone C	malabaricone C inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]	17977527
D008301	Maleimides	Maleimides analog results in decreased activity of PTGS1 protein	8648609
D008345	Manganese	Manganese inhibits the reaction [12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]]	12538810
C038654	manganese protoporphyrin	manganese protoporphyrin results in decreased activity of PTGS1 protein	12538810
C042720	mercuric bromide	mercuric bromide results in decreased expression of PTGS1 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
D008694	Methamphetamine	[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine	21163909
D008694	Methamphetamine	[[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine	21163909
D008694	Methamphetamine	Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine]	21163909
D008694	Methamphetamine	Aspirin inhibits the reaction [PTGS1 protein results in increased susceptibility to Methamphetamine]	21163909
D008694	Methamphetamine	PTGS1 protein results in increased susceptibility to Methamphetamine	21163909
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of PTGS1 mRNA	20713471
D008753	Methylenebis(chloroaniline)	PTGS1 protein results in increased metabolism of Methylenebis(chloroaniline)	11159734
D015104	3,4-Methylenedioxyamphetamine	"[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine"	21163909
D015104	3,4-Methylenedioxyamphetamine	"[[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine"	21163909
D015104	3,4-Methylenedioxyamphetamine	"PTGS1 protein results in increased susceptibility to 3,4-Methylenedioxyamphetamine"	21163909
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PTGS1 mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PTGS1 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PTGS1 mRNA	26011545
D008825	Miconazole	Miconazole results in decreased expression of PTGS1 mRNA	22262564
D015735	Mifepristone	Mifepristone results in decreased expression of PTGS1 mRNA	17584828
D015735	Mifepristone	Mifepristone results in increased expression of PTGS1 mRNA	19439560
D015735	Mifepristone	Mifepristone results in decreased expression of PTGS1 mRNA	25972201
D008911	Minocycline	Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA]	18706994
C001801	mitragynine	"mitragynine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein]"	21513785
C060893	MK-886	MK-886 results in decreased activity of PTGS1 protein	23305233
C054999	mofezolac	mofezolac results in decreased activity of PTGS1 protein	27050768
C054999	mofezolac	[mofezolac results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone	27050768
C054999	mofezolac	[mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 mRNA	27050768
C054999	mofezolac	[mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 protein	27050768
C054999	mofezolac	[mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 mRNA	27050768
C054999	mofezolac	[mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 protein	27050768
C054999	mofezolac	[mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 mRNA	27050768
C054999	mofezolac	[mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 protein	27050768
C054999	mofezolac	mofezolac results in decreased activity of PTGS1 protein	9777656
C054999	mofezolac	mofezolac results in decreased activity of PTGS1 protein	21510291
C054999	mofezolac	mofezolac results in decreased expression of PTGS1	21510291
C054999	mofezolac	mofezolac results in decreased activity of PTGS1 protein	15167967\|1647342
C406082	monomethylarsonous acid	monomethylarsonous acid affects the expression of PTGS1 mRNA	25177542
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of PTGS1 mRNA	22108045
D009020	Morphine	Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA]	18706994
D009020	Morphine	Morphine results in decreased expression of PTGS1 mRNA	15183518
D009020	Morphine	Morphine results in increased expression of PTGS1 mRNA	18706994
D009151	Mustard Gas	PTGS1 protein results in decreased susceptibility to Mustard Gas	15451306
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Cadmium Chloride results in increased expression of PTGS1 mRNA]	25645360
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS1 protein	15155531\|1584304
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	Indomethacin inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Indomethacin results in decreased activity of PTGS1]]	12398900
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Aspirin results in decreased activity of PTGS1]	12398900
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Indomethacin results in decreased activity of PTGS1 protein]	12398900
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS1 protein	9258749
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	[SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]	21873648
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS1 protein	11321505
C468797	N-(3-phenoxy-4-pyridinyl)trifluoromethanesulfonamide	N-(3-phenoxy-4-pyridinyl)trifluoromethanesulfonamide results in decreased activity of PTGS1 protein	12408728
C550711	N-(5-amino-2-pyridinyl)-4-trifluoromethylbenzamide	N-(5-amino-2-pyridinyl)-4-trifluoromethylbenzamide results in decreased activity of PTGS1 protein	18363350
C550711	N-(5-amino-2-pyridinyl)-4-trifluoromethylbenzamide	N-(5-amino-2-pyridinyl)-4-trifluoromethylbenzamide results in decreased activity of PTGS1 protein	20185310\|2137252
C035605	nabumetone	nabumetone metabolite results in decreased activity of PTGS1 protein	9258749
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of PTGS1 mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PTGS1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PTGS1 mRNA"	25554681
D037742	Nanotubes, Carbon	"[OVAL protein co-treated with Nanotubes, Carbon] results in decreased expression of PTGS1 mRNA"	23642096
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of PTGS1 mRNA	25380136
D009288	Naproxen	Naproxen results in decreased activity of PTGS1 protein	17164136
D009288	Naproxen	Naproxen inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	11755111
D009288	Naproxen	Naproxen results in decreased activity of PTGS1 protein	9258749
D009288	Naproxen	Naproxen results in decreased activity of PTGS1 protein	15198071
C005273	naringenin	naringenin results in increased expression of PTGS1 mRNA	24561720
C109338	N-(carboxyheptyl)maleimide	Hemin inhibits the reaction [N-(carboxyheptyl)maleimide affects the folding of PTGS1 protein]	8648609
C109338	N-(carboxyheptyl)maleimide	N-(carboxyheptyl)maleimide analog affects the folding of PTGS1 protein	8648609
C109338	N-(carboxyheptyl)maleimide	N-(carboxyheptyl)maleimide binds to and affects the folding of and results in decreased activity of PTGS1 protein	8648609
D009525	Niacin	PTGS1 protein promotes the reaction [Niacin results in increased activity of PPARG protein]	16386710
D009525	Niacin	PTGS1 protein results in increased susceptibility to Niacin	16322797
D009525	Niacin	Niacin results in decreased expression of PTGS1 protein	19420110
C022838	nickel chloride	nickel chloride results in decreased expression of PTGS1 mRNA	14645679
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of PTGS1 mRNA	24952340
C012655	nimesulide	nimesulide results in increased expression of PTGS1 protein	15482327
C012655	nimesulide	nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA]	22107987
C012655	nimesulide	nimesulide results in decreased expression of PTGS1 protein	19782545
C012655	nimesulide	nimesulide binds to PTGS1 protein	20669977
C012655	nimesulide	nimesulide inhibits the reaction [Aspirin results in decreased activity of PTGS1]	12398900
C012655	nimesulide	nimesulide inhibits the reaction [Indomethacin results in decreased activity of PTGS1]	12398900
D009569	Nitric Oxide	Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]	21983654
C007350	nitrofen	nitrofen results in increased expression of PTGS1 mRNA	12612200
C007350	nitrofen	nitrofen results in increased expression of PTGS1 protein	12612200
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of PTGS1 mRNA	12189197\|1761671
C014707	nitrosobenzylmethylamine	resveratrol inhibits the reaction [nitrosobenzylmethylamine results in increased expression of PTGS1 mRNA]	12189197
D009647	Normetanephrine	PTGS1 protein results in increased oxidation of and results in increased activity of Normetanephrine	19374330
D010047	Ovalbumin	Formaldehyde inhibits the reaction [Ovalbumin results in increased expression of PTGS1 mRNA]	23871789
D010047	Ovalbumin	Ovalbumin results in increased expression of PTGS1 mRNA	23871789
D010069	Oxadiazoles	[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of PTGS1 mRNA	23212921
D010126	Ozone	Ozone results in increased expression of PTGS1 mRNA	19555225
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of PTGS1 mRNA	26272509
D010269	Paraquat	Paraquat results in increased expression of PTGS1 mRNA	22996356
D010269	Paraquat	[Quercetin co-treated with Paraquat] results in increased expression of PTGS1 mRNA	22996356
D010269	Paraquat	APOD protein affects the reaction [Paraquat results in decreased expression of PTGS1 mRNA]	21688324
D010269	Paraquat	Paraquat results in decreased expression of PTGS1 mRNA	21688324
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in increased expression of PTGS1 mRNA	17715259
C052983	patchouli alcohol	patchouli alcohol inhibits the reaction [Indomethacin results in decreased expression of PTGS1 mRNA]	25168850
D010396	Penicillamine	Penicillamine results in increased expression of PTGS1 mRNA	22843330
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of PTGS1 mRNA	26705709
D010418	Pentagastrin	[SC 560 binds to and results in decreased activity of PTGS1 protein] promotes the reaction [Pentagastrin results in increased secretion of Acids]	16299412
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of PTGS1 mRNA	19162173
D026023	Permethrin	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PTGS1 mRNA	28659758
D015232	Dinoprostone	PTGS1 protein results in increased chemical synthesis of Dinoprostone	14508638
D015232	Dinoprostone	PTGS1 protein results in increased chemical synthesis of Dinoprostone	10718109
D015232	Dinoprostone	Indomethacin inhibits the reaction [PTGS1 protein results in increased chemical synthesis of Dinoprostone]	16354411
D015232	Dinoprostone	PTGS1 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]	19751497
D015232	Dinoprostone	PTGS1 protein results in increased chemical synthesis of Dinoprostone	16894348
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased degradation of and results in decreased expression of NFKBIA protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]]	25432964
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]	25432964
D015232	Dinoprostone	[mofezolac results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone	27050768
D015232	Dinoprostone	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone	19066340
D015232	Dinoprostone	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone	27050768
D015232	Dinoprostone	[SC 58560 results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone	10484518
D015232	Dinoprostone	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone	15866108
D015232	Dinoprostone	Dinoprostone results in decreased susceptibility to [resveratrol results in decreased activity of PTGS1 protein]	10594344
D015232	Dinoprostone	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone	10594344
D015232	Dinoprostone	[SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]	21873648
D015232	Dinoprostone	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone	21873648
D015232	Dinoprostone	PTGS1 protein affects the chemical synthesis of Dinoprostone	12902868
D015232	Dinoprostone	PTGS1 protein results in increased abundance of Dinoprostone	20041722
D015232	Dinoprostone	PTGS1 protein results in increased chemical synthesis of Dinoprostone	10231640\|1708448
D044262	Prostaglandin H2	[PTGS1 protein results in increased metabolism of prostaglandin G2] which results in increased chemical synthesis of Prostaglandin H2	7775455
D044262	Prostaglandin H2	Aspirin affects the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2]	12545150
D044262	Prostaglandin H2	Aspirin inhibits the reaction [[PTGS1 protein SNP results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2]	12545150
D044262	Prostaglandin H2	[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2	12545150
D044262	Prostaglandin H2	[PTGS1 protein SNP results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Prostaglandin H2	12545150
D010615	Phenacetin	Phenacetin results in decreased activity of PTGS1 protein alternative form	12242329
D010615	Phenacetin	Phenacetin analog results in decreased activity of PTGS1 protein	16141368
D010615	Phenacetin	Phenacetin results in decreased activity of PTGS1 protein	16141368
D010615	Phenacetin	Phenacetin results in decreased activity of PTGS1 protein	17606472
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PTGS1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of PTGS1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of PTGS1 mRNA	19482888
D010656	Phenylephrine	FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine]	17641673
D010656	Phenylephrine	PTGS1 protein affects the susceptibility to Phenylephrine	17641673
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of PTGS1 mRNA	26272509
C016658	phorbolol myristate acetate	phorbolol myristate acetate results in decreased expression of PTGS1 mRNA	14508638
D010705	Phosgene	Phosgene affects the expression of PTGS1 mRNA	16300373
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in increased expression of PTGS1 mRNA	17715259
C006253	pirinixic acid	pirinixic acid results in decreased expression of PTGS1 mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in decreased expression of PTGS1 mRNA	19162173
D010894	Piroxicam	Piroxicam results in decreased activity of PTGS1 protein	9258749
D010894	Piroxicam	Piroxicam results in decreased activity of PTGS1 protein	17606472\|1962948
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]	18237397
D010936	Plant Extracts	Plant Extracts results in decreased activity of PTGS1 protein	22674731
D028321	Plant Preparations	Plant Preparations results in decreased activity of PTGS1 protein	24675710
D010972	Platelet Activating Factor	Platelet Activating Factor results in increased expression of PTGS1 mRNA	16386258
C058229	polydatin	polydatin results in decreased activity of PTGS1 protein	11962253
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of PTGS1 mRNA	18332044
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of PTGS1 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of PTGS1 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of PTGS1 mRNA	17404688\|2179573
D011374	Progesterone	Progesterone results in decreased expression of PTGS1 mRNA	22238285
D011374	Progesterone	Progesterone results in increased expression of PTGS1 mRNA	20726854
C038291	prostaglandin G2	[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of prostaglandin G2	7775455
C038291	prostaglandin G2	[PTGS1 protein results in increased metabolism of prostaglandin G2] which results in increased chemical synthesis of Prostaglandin H2	7775455
C038291	prostaglandin G2	PTGS1 protein results in increased abundance of prostaglandin G2	12538810
C038291	prostaglandin G2	[PTGS1 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]]	12538810
C038291	prostaglandin G2	[PTGS1 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]	12538810
D011453	Prostaglandins	PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins]	16787386
D011453	Prostaglandins	PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins analog]	16787386
D011719	Pyrazines	Pyrazines results in decreased activity of PTGS1 protein	22342441
D011720	Pyrazoles	Pyrazoles results in decreased activity of PTGS1 protein	22019186
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PTGS1 mRNA	28659758
D011733	Pyridoxamine	Pyridoxamine results in decreased activity of PTGS1 protein	20041722
C010423	pyrithione zinc	pyrithione zinc results in decreased expression of PTGS1 mRNA	21424779
D011758	Pyrroles	Pyrroles analog affects the folding of PTGS1 protein	8648609
D011765	Pyruvaldehyde	Aspirin promotes the reaction [Pyruvaldehyde results in decreased activity of PTGS1 protein]	27083140
D011765	Pyruvaldehyde	Pyruvaldehyde results in decreased activity of PTGS1 protein	27083140
D011791	Quartz	Quartz results in decreased expression of PTGS1 mRNA	27917503
D011794	Quercetin	[Quercetin co-treated with Paraquat] results in increased expression of PTGS1 mRNA	22996356
D011794	Quercetin	Quercetin results in decreased activity of PTGS1 protein	15155531
D011794	Quercetin	Quercetin results in increased expression of PTGS1 mRNA	22996356
D011794	Quercetin	Quercetin results in decreased activity of PTGS1 protein	16552572
D011794	Quercetin	Quercetin results in decreased expression of PTGS1 mRNA	19056647
C502851	quinocetone	quinocetone results in increased expression of PTGS1 mRNA	27046791
C406527	R 115866	R 115866 results in decreased expression of PTGS1 mRNA	20580668
D017382	Reactive Oxygen Species	"[PTGS1 protein results in increased activity of and results in increased oxidation of 3,4-Dihydroxyphenylacetic Acid] which results in increased chemical synthesis of Reactive Oxygen Species"	19374330
D017382	Reactive Oxygen Species	"[[PTGS1 protein results in increased activity of and results in increased oxidation of 3,4-Dihydroxyphenylacetic Acid] which results in increased chemical synthesis of Reactive Oxygen Species] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine"	19374330
D017382	Reactive Oxygen Species	[PTGS1 protein results in increased activity of and results in increased oxidation of Dopamine] which results in increased chemical synthesis of Reactive Oxygen Species	19374330
D017382	Reactive Oxygen Species	[[PTGS1 protein results in increased activity of and results in increased oxidation of Dopamine] which results in increased chemical synthesis of Reactive Oxygen Species] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine	19374330
D017382	Reactive Oxygen Species	[PTGS1 protein results in increased activity of and results in increased oxidation of Levodopa] which results in increased chemical synthesis of Reactive Oxygen Species	19374330
D017382	Reactive Oxygen Species	[[PTGS1 protein results in increased activity of and results in increased oxidation of Levodopa] which results in increased chemical synthesis of Reactive Oxygen Species] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine	19374330
C052785	rebamipide	rebamipide inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]	18299717
C052785	rebamipide	rebamipide results in increased expression of PTGS1 mRNA	18299717
C059514	resveratrol	resveratrol inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	19751497
C059514	resveratrol	resveratrol metabolite results in decreased activity of PTGS1 protein	20527891
C059514	resveratrol	resveratrol results in decreased activity of PTGS1 protein	15155531\|2052789
C059514	resveratrol	resveratrol results in decreased expression of PTGS1 mRNA	20816778
C059514	resveratrol	resveratrol analog results in increased expression of PTGS1 mRNA	19066340
C059514	resveratrol	resveratrol analog results in increased expression of PTGS1 protein	19066340
C059514	resveratrol	resveratrol results in decreased activity of PTGS1 protein	11962253\|1906634
C059514	resveratrol	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone	19066340
C059514	resveratrol	resveratrol results in decreased expression of PTGS1 mRNA	19066340\|1994010
C059514	resveratrol	resveratrol results in decreased expression of PTGS1 protein	19066340
C059514	resveratrol	Hydrogen Peroxide promotes the reaction [resveratrol results in decreased activity of PTGS1 protein]	15020596
C059514	resveratrol	resveratrol analog results in decreased activity of PTGS1 protein	27159630
C059514	resveratrol	resveratrol binds to and affects the folding of and results in decreased activity of PTGS1 protein	15020596
C059514	resveratrol	resveratrol results in decreased activity of PTGS1 protein	15866108\|2715963
C059514	resveratrol	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone	15866108
C059514	resveratrol	Dinoprostone results in decreased susceptibility to [resveratrol results in decreased activity of PTGS1 protein]	10594344
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of PTGS1 mRNA	25905778
C059514	resveratrol	resveratrol inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]	20564508
C059514	resveratrol	resveratrol inhibits the reaction [nitrosobenzylmethylamine results in increased expression of PTGS1 mRNA]	12189197
C059514	resveratrol	resveratrol results in decreased activity of PTGS1 protein	10791687
C059514	resveratrol	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone	10594344
C059514	resveratrol	"[resveratrol results in decreased activity of PTGS1 protein] which results in decreased susceptibility to 24,25-Dihydroxyvitamin D 3"	10653606
C059514	resveratrol	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased susceptibility to Lipopolysaccharides	11321505
C059514	resveratrol	resveratrol results in decreased expression of PTGS1 protein	19693696
C059514	resveratrol	resveratrol results in decreased activity of PTGS1 protein	10594344\|1065360
C059514	resveratrol	[resveratrol results in decreased activity of PTGS1 protein] which results in decreased susceptibility to Calcitriol	11455568
D015474	Isotretinoin	Isotretinoin results in decreased expression of PTGS1 mRNA	15982314
C488333	Ro 65-7199	Ro 65-7199 affects the expression of PTGS1 mRNA	14610520
C116926	rofecoxib	rofecoxib analog results in decreased activity of PTGS1 protein	16141368
C116926	rofecoxib	rofecoxib results in decreased activity of PTGS1 protein	16141368
C116926	rofecoxib	rofecoxib results in decreased expression of PTGS1 mRNA	17175104
C116926	rofecoxib	rofecoxib results in decreased activity of PTGS1 protein	11321505
C087123	romidepsin	PTGS1 mutant form inhibits the reaction [Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]]	20404564
C409370	SC 299	SC 299 binds to PTGS1 protein	12398900
C115461	SC 560	SC 560 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	19751497\|2116390
C115461	SC 560	SC 560 results in decreased activity of PTGS1 protein	14633654\|1689434
C115461	SC 560	SC 560 results in decreased activity of PTGS1 protein	15718289\|2543296
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone	27050768
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 mRNA	27050768
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 protein	27050768
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 mRNA	27050768
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 protein	27050768
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 mRNA	27050768
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 protein	27050768
C115461	SC 560	SC 560 results in decreased activity of PTGS1 protein	12163478\|2545157
C115461	SC 560	[SC 560 binds to and results in decreased activity of PTGS1 protein] promotes the reaction [Histamine results in increased secretion of Acids]	16299412
C115461	SC 560	[SC 560 binds to and results in decreased activity of PTGS1 protein] promotes the reaction [Pentagastrin results in increased secretion of Acids]	16299412
C115461	SC 560	SC 560 results in decreased activity of PTGS1 protein	16944022
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]	21873648
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone	21873648
C115461	SC 560	[SC 560 results in decreased activity of PTGS1 protein] which results in increased abundance of Creatinine	19629487
C115461	SC 560	SC 560 results in decreased expression of PTGS1 protein	20668099
C115461	SC 560	SC 560 results in decreased activity of PTGS1 protein	11250881\|1537986
C404729	SC 58560	SC 58560 results in decreased activity of PTGS1 protein	10484518
C404729	SC 58560	[SC 58560 results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone	10484518
C404729	SC 58560	SC 58560 results in decreased activity of PTGS1 protein	10484518
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of PTGS1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of PTGS1 mRNA	19073995\|2322117
D012906	Smoke	Smoke results in decreased expression of PTGS1 mRNA	17255567
C009277	sodium arsenate	sodium arsenate results in increased expression of PTGS1 mRNA	24349563
C017947	sodium arsenite	sodium arsenite results in increased activity of PTGS1 protein	22236721
C016104	sodium bichromate	sodium bichromate results in decreased expression of PTGS1 mRNA	17685462
C016104	sodium bichromate	sodium bichromate results in increased expression of PTGS1 mRNA	12325037
C009279	sodium bisulfite	[SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]	21873648
D012965	Sodium Chloride	[AGT protein co-treated with Sodium Chloride] affects the expression of PTGS1 mRNA	27225954
D012980	Sodium Salicylate	12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]]	12538810
D012980	Sodium Salicylate	12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]	12538810
D012980	Sodium Salicylate	"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]]"	12538810
D012980	Sodium Salicylate	"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]"	12538810
D012980	Sodium Salicylate	Hydrogen Peroxide affects the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]	12538810
D012980	Sodium Salicylate	Manganese inhibits the reaction [12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]]	12538810
D012980	Sodium Salicylate	[PTGS1 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]]	12538810
D012980	Sodium Salicylate	[PTGS1 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]	12538810
D012980	Sodium Salicylate	Sodium Salicylate inhibits the reaction [PTGS1 protein results in increased metabolism of Arachidonic Acid]	12538810
D012980	Sodium Salicylate	Sodium Salicylate results in decreased activity of PTGS1 protein	12538810
C025026	sodium sulfite	[SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]	21873648
D053260	Soot	Soot results in increased expression of PTGS1 mRNA	22461453\|2655175
D053260	Soot	Soot results in increased expression of PTGS1 mRNA	21914721
D013311	Streptozocin	acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS1 protein]	18414395
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of PTGS1 mRNA	25905778
D013311	Streptozocin	Streptozocin results in increased expression of PTGS1 protein	12888618\|1841439
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PTGS1 mRNA	26378955
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PTGS1 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] affects the expression of PTGS1 mRNA	26378955
D013388	Succinimides	Succinimides analog affects the folding of PTGS1 protein	8648609
D013467	Sulindac	Sulindac analog binds to and results in decreased activity of PTGS1 protein	11844707
D013467	Sulindac	Sulindac binds to and results in decreased activity of PTGS1 protein	11844707
D013467	Sulindac	Sulindac results in decreased expression of PTGS1 mRNA alternative form	11375891
D013467	Sulindac	Sulindac results in increased expression of PTGS1 mRNA	12586211
C025462	sulindac sulfide	sulindac sulfide results in decreased activity of PTGS1 protein	11245490
C025462	sulindac sulfide	sulindac sulfide binds to and results in decreased activity of PTGS1 protein	11844707
C025463	sulindac sulfone	sulindac sulfone results in decreased expression of PTGS1 mRNA alternative form	11375891
C073135	tepoxalin	tepoxalin results in decreased activity of PTGS1 protein	7775455
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of PTGS1 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PTGS1 mRNA	19403181
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PTGS1 mRNA	21570461\|2821309
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGS1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS1 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PTGS1 mRNA	10607728\|1661135
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of PTGS1	10381133
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of PTGS1 mRNA	10370867
D013853	Thioacetamide	Thioacetamide results in decreased expression of PTGS1 mRNA	23411599
D013883	Thiostrepton	Thiostrepton results in increased expression of PTGS1 mRNA	22321511
D013928	Thromboxane A2	[Aspirin results in increased acetylation of PTGS1 protein] which results in decreased chemical synthesis of Thromboxane A2	16484611
D013928	Thromboxane A2	PTGS1 gene SNP affects the chemical synthesis of Thromboxane A2	16150050
D013928	Thromboxane A2	PTGS1 results in increased chemical synthesis of Thromboxane A2	15863457
D013929	Thromboxane B2	arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2]	20933508
D013929	Thromboxane B2	[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2	20933508
C009495	titanium dioxide	titanium dioxide results in increased expression of PTGS1 mRNA	23557971\|2776080
D014212	Tretinoin	arsenic trioxide inhibits the reaction [Tretinoin results in increased expression of PTGS1 protein]	18354491
D014212	Tretinoin	Tretinoin metabolite results in decreased expression of PTGS1 mRNA	15982314
D014212	Tretinoin	Tretinoin results in increased expression of PTGS1 mRNA	16129123\|1835449
D014212	Tretinoin	Tretinoin results in increased expression of PTGS1 protein	16894348\|1835449
C012589	trichostatin A	trichostatin A results in decreased expression of PTGS1 mRNA	24935251
C012589	trichostatin A	trichostatin A results in increased expression of PTGS1 mRNA	24935251
C012589	trichostatin A	trichostatin A results in decreased expression of PTGS1 mRNA	15901671
C017769	tricin	tricin results in decreased activity of PTGS1 protein	16552572
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of PTGS1 mRNA	25526689
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of PTGS1 mRNA	25526689
C050414	tripterine	tripterine results in increased expression of PTGS1 mRNA	25477506
C057693	troglitazone	troglitazone results in decreased expression of PTGS1 mRNA	19631733
D014520	Urethane	Urethane results in increased expression of PTGS1 mRNA	11497255
D014520	Urethane	Urethane results in increased expression of PTGS1 protein	11497255
D014520	Urethane	Urethane results in decreased expression of PTGS1 mRNA	11211925
C073339	usnic acid	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA	22777745
C401835	valerylsalicylate	valerylsalicylate inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]	19751497
C401835	valerylsalicylate	valerylsalicylate results in decreased activity of PTGS1 protein	15700047\|2030481
D014635	Valproic Acid	Valproic Acid affects the expression of PTGS1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of PTGS1 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in decreased expression of PTGS1 mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of PTGS1 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of PTGS1 mRNA	23034163
D002762	Cholecalciferol	Cholecalciferol results in increased expression of PTGS1 mRNA	17170073
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTGS1 mRNA"	27188386
C104536	xanthohumol	xanthohumol results in decreased activity of PTGS1 protein	17590382
D015032	Zinc	Zinc deficiency results in increased expression of PTGS1 mRNA	18356318
D015054	Zymosan	PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins]	16787386
D015054	Zymosan	PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins analog]	16787386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004601	peroxidase activity	-	TAS	-
GO:0004666	prostaglandin-endoperoxide synthase activity	-	IDA	1380156
GO:0004666	prostaglandin-endoperoxide synthase activity	-	TAS	-
GO:0020037	heme binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-
GO:0051213	dioxygenase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001516	prostaglandin biosynthetic process	-	ISS	-
GO:0006805	xenobiotic metabolic process	-	TAS	-
GO:0006954	inflammatory response	-	IEA	-
GO:0006979	response to oxidative stress	-	IEA	-
GO:0008217	regulation of blood pressure	-	ISS	-
GO:0019371	cyclooxygenase pathway	-	IDA	1380156
GO:0019371	cyclooxygenase pathway	-	TAS	-
GO:0055114	oxidation-reduction process	-	IEA	-
GO:0098869	cellular oxidant detoxification	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	12355421
GO:0005737	cytoplasm	-	ISS	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005794	Golgi apparatus	-	IDA	-
GO:0031090	organelle membrane	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0043231	intracellular membrane-bounded organelle	-	ISS	-
GO:0070062	extracellular exosome	-	HDA	18570454

KEGG ID	KEGG Term
hsa00590	Arachidonic acid metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-140180	COX reactions	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-2142753	Arachidonic acid metabolism	TAS
R-HSA-2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-8978868	Fatty acid metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28431615	Association between PTGS1 polymorphisms and functional outcomes in Chinese patients with stroke during aspirin therapy: Interaction with smoking. (2017 May 15)	Cai H	J Neurol Sci
27548026	Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. (2016 Oct)	Sidahmed E	Nutr Cancer
22678777	PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. (2013 Jan)	Habermann N	Genes Nutr
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