Gene: DSCAML1

57453
DSCAM2
DS cell adhesion molecule like 1
protein-coding
11q23.3
Ensembl:ENSG00000177103 MIM:611782 Vega:OTTHUMG00000167071 UniprotKB:Q8TD84
NG_051656.1
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.363e-1 (AD)  8.796e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs553637chr11:117590887 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGPAT40.887
NACAD0.883
NFASC0.88
HID10.865
AATK0.862
SEC14L50.859
DPYSL50.848
ABCA20.847
SRCIN10.846
ARHGEF20.83

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.439
PDZK1IP1-0.407
EGFLAM-0.403
OR4F29-0.4
GJB2-0.396
TNFRSF11B-0.381
NMI-0.379
LYN-0.378
FAM89A-0.375
RGS22-0.371

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate results in increased methylation of DSCAML1 gene"25445006
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DSCAML1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DSCAML1 mRNA"21394737
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DSCAML1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DSCAML1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DSCAML1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DSCAML1 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DSCAML1 mRNA"28973690
D000082AcetaminophenAcetaminophen affects the expression of DSCAML1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DSCAML1 gene28458013
D000447AldehydesAldehydes results in decreased expression of DSCAML1 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of DSCAML1 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DSCAML1 mRNA21871943
C006780bisphenol Abisphenol A results in increased methylation of DSCAML1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of DSCAML1 mRNA26079696
D002104CadmiumCadmium results in decreased expression of DSCAML1 mRNA24376830
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DSCAML1 mRNA]27941970
D004317DoxorubicinDoxorubicin affects the methylation of DSCAML1 gene28962528
D008345ManganeseManganese results in increased expression of DSCAML1 mRNA26745496
C025340manganese chloridemanganese chloride results in increased expression of DSCAML1 mRNA26745496
D009020MorphineMorphine results in increased expression of DSCAML1 mRNA20144693
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DSCAML1 mRNA"25510870
C046012pentanalpentanal results in decreased expression of DSCAML1 mRNA26079696
D011192Potassium DichromatePotassium Dichromate affects the expression of DSCAML1 mRNA23608068
C005556propionaldehydepropionaldehyde results in decreased expression of DSCAML1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of DSCAML1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DSCAML1 mRNA25895662
D012834SilverSilver results in increased expression of DSCAML1 mRNA26551752
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of DSCAML1 gene26431795
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of DSCAML1 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of DSCAML1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of DSCAML1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042803protein homodimerization activity-IDA11453658  
GO ID GO Term Qualifier Evidence PubMed
GO:0001709cell fate determination-NAS12051741  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IDA11453658  
GO:0007409axonogenesis-NAS11453658  
GO:0007417central nervous system development-NAS12051741  
GO:0007420brain development-IDA12051741  
GO:0009953dorsal/ventral pattern formation-NAS12051741  
GO:0048704embryonic skeletal system morphogenesis-IDA12051741  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA11453658  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-373752Netrin-1 signalingTAS
R-HSA-376172DSCAM interactionsTAS
R-HSA-422475Axon guidanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21445666Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. (2011 Sep)Wang KSJ Neural Transm (Vienna)