Gene: PPM1H

57460
ARHCL1|NERPP-2C|URCC2
protein phosphatase, Mg2+/Mn2+ dependent 1H
protein-coding
12q14.1-q14.2
Ensembl:ENSG00000111110 MIM:616016 Vega:OTTHUMG00000169990 UniprotKB:Q9ULR3
NC_000012.12
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.524e-1 (AD)  7.532e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7967481chr12:62911903 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12303266chr12:62774165 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs342171chr12:62720730 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NLK0.972
REPS20.971
CLCN40.966
DNAJC60.966
MAPK90.962
AK50.961
EPB41L30.961
PPP3CB0.961
HSPA12A0.96
DYNC1I10.958

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.538
RAB13-0.504
CSAG1-0.503
CHST14-0.494
MYL3-0.492
WWTR1-0.489
TGIF1-0.486
LRAT-0.48
INHBB-0.479
CMTM3-0.476

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of PPM1H mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PPM1H protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PPM1H mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PPM1H mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PPM1H mRNA24449571
D001379AzathioprineAzathioprine results in decreased expression of PPM1H mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPM1H mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPM1H mRNA21715664
D004958EstradiolEstradiol results in decreased expression of PPM1H mRNA19484750
C006780bisphenol Abisphenol A results in decreased methylation of PPM1H promoter27312807
C006780bisphenol Abisphenol A affects the expression of PPM1H mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PPM1H mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PPM1H mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of PPM1H gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of PPM1H protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PPM1H mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of PPM1H mRNA26079696
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PPM1H mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of PPM1H mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PPM1H mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of PPM1H mRNA19770486
C014347decitabinedecitabine affects the expression of PPM1H mRNA17145863
C000944dicrotophosdicrotophos results in increased expression of PPM1H mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of PPM1H mRNA26485663
C118739entinostatentinostat results in increased expression of PPM1H mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PPM1H protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PPM1H mRNA29097150
C061365flusilazoleflusilazole results in increased expression of PPM1H mRNA28263823
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of PPM1H mRNA24680724
D017313FenretinideFenretinide results in increased expression of PPM1H mRNA28973697
D007854LeadLead affects the expression of PPM1H mRNA28903495
D007854LeadLead results in increased expression of PPM1H mRNA19921347
D018021Lithium ChlorideLithium Chloride results in increased expression of PPM1H mRNA23527032
D008558MelphalanMelphalan results in decreased expression of PPM1H mRNA22363485
C042720mercuric bromidemercuric bromide results in increased expression of PPM1H mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PPM1H mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PPM1H mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PPM1H mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PPM1H mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PPM1H mRNA"25554681
D009532NickelNickel results in decreased expression of PPM1H mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of PPM1H mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PPM1H mRNA20971185
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PPM1H mRNA26272509
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of PPM1H mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of PPM1H mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PPM1H mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of PPM1H mRNA22238285
D011794QuercetinQuercetin results in decreased expression of PPM1H mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in increased expression of PPM1H mRNA25351596
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of PPM1H mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPM1H mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPM1H mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPM1H mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPM1H mRNA21215274
D013853ThioacetamideThioacetamide results in increased expression of PPM1H mRNA23411599
D014212TretinoinTretinoin results in increased expression of PPM1H mRNA21934132
D014212TretinoinTretinoin results in increased expression of PPM1H mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PPM1H mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PPM1H mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1H mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PPM1H mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PPM1H mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PPM1H gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of PPM1H mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004721phosphoprotein phosphatase activity-IMP22586611  
GO:0004722protein serine/threonine phosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA22586611  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA22586611  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal