Gene: SCAF4

57466
SFRS15|SRA4
SR-related CTD associated factor 4
protein-coding
21q22.11
Ensembl:ENSG00000156304 MIM:616023 Vega:OTTHUMG00000084903 UniprotKB:O95104
NG_047173.1
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.999e-2 (AD)  7.688e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2833487chr21:31715550 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF3840.933
SYVN10.931
ATXN2L0.917
DDX270.909
KDM2A0.906
SEC24C0.906
MARK30.898
KANSL10.897
NCOA60.897
PI4KB0.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.642
OR4F29-0.599
KLRC2-0.298
OR4F16-0.263
GSDMC-0.253
TRDN-0.225
DIAPH3-0.208
SPRR2D-0.207
KLRB1-0.207
FAM25A-0.206

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of SCAF4 mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SCAF4 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SCAF4 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCAF4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of SCAF4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCAF4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCAF4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of SCAF4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCAF4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SCAF4 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of SCAF4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SCAF4 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SCAF4 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of SCAF4 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of SCAF4 mRNA25181051
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SCAF4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SCAF4 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of SCAF4 mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SCAF4 protein23301498
D005557FormaldehydeFormaldehyde results in decreased expression of SCAF4 mRNA20655997
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of SCAF4 mRNA22467014
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SCAF4 mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of SCAF4 mRNA18927307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SCAF4 mRNA27392435
D007854LeadLead results in decreased expression of SCAF4 mRNA19921347
D008628MercuryMercury results in increased expression of SCAF4 mRNA16823088
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SCAF4 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SCAF4 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SCAF4 mRNA23649840
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of SCAF4 mRNA19074003
C025589ochratoxin Aochratoxin A results in increased expression of SCAF4 mRNA18417182
C410127PCB 180PCB 180 results in increased expression of SCAF4 mRNA23829299
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCAF4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SCAF4 mRNA26272509
D012643SeleniumSelenium results in decreased expression of SCAF4 mRNA19244175
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of SCAF4 mRNA22467014
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of SCAF4 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCAF4 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SCAF4 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SCAF4 mRNA28065790
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of SCAF4 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of SCAF4 mRNA26272509
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCAF4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SCAF4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SCAF4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SCAF4 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SCAF4 gene25560391
D014810Vitamin EVitamin E results in decreased expression of SCAF4 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal