Gene: CNOT6

57472
CCR4|Ccr4a
CCR4-NOT transcription complex subunit 6
protein-coding
5q35.3
Ensembl:ENSG00000113300 MIM:608951 Vega:OTTHUMG00000130935 UniprotKB:Q9ULM6
NC_000005.10
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.818e-1 (AD)  8.808e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMAD40.893
MED130.882
NIPBL0.876
PKN20.869
PCF110.868
LATS10.861
SLAIN20.859
SETX0.857
MED13L0.856
UBR50.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.632
OR4F29-0.609
CRH-0.256
NANOGNB-0.238
TMEM114-0.214
LRRC26-0.193
HCRT-0.184
PRSS56-0.183
C22orf42-0.181
SOX14-0.18

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CNOT6 mRNA19770486
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CNOT6 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of CNOT6 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CNOT6 mRNA25270620
C006780bisphenol Abisphenol A affects the expression of CNOT6 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CNOT6 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CNOT6 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CNOT6 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of CNOT6 mRNA26079696
D019327Copper SulfateCopper Sulfate results in increased expression of CNOT6 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CNOT6 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CNOT6 mRNA21266533
D018120FinasterideFinasteride results in increased expression of CNOT6 mRNA24136188
D017313FenretinideFenretinide results in increased expression of CNOT6 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of CNOT6 mRNA27392435
C005219methyl cellosolvemethyl cellosolve results in increased expression of CNOT6 mRNA21061450
C028007nickel monoxidenickel monoxide results in decreased expression of CNOT6 mRNA19167457
D010795Phthalic AcidsPhthalic Acids results in increased expression of CNOT6 mRNA21061450
D010936Plant ExtractsPlant Extracts results in increased expression of CNOT6 mRNA23557933
D013467SulindacSulindac results in decreased expression of CNOT6 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CNOT6 mRNA21215274
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CNOT6 gene27618143
D014635Valproic AcidValproic Acid results in decreased expression of CNOT6 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of CNOT6 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CNOT6 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IEA-  
GO:0004532exoribonuclease activity-IDA11889047  
GO:0004535poly(A)-specific ribonuclease activity-IDA11889047  18377426  
GO:0004535poly(A)-specific ribonuclease activity-TAS-  
GO:0005515protein binding-IPI11747467  15687258  17452450  18180299  18326031  21981923  
22977175  26496610  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening-IMP20595389  
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening-TAS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006417regulation of translation-IEA-  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0008284positive regulation of cell proliferation-IMP21233283  
GO:0010606positive regulation of cytoplasmic mRNA processing body assembly-IMP21233283  
GO:0035195gene silencing by miRNA-TAS20065043  
GO:0043928exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay-IDA20065043  
GO:0070966nuclear-transcribed mRNA catabolic process, no-go decay-IMP15314026  
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic-IEA-  
GO:2000327positive regulation of ligand-dependent nuclear receptor transcription coactivator activity-IDA18180299  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030014CCR4-NOT complex-IDA19558367  
KEGG ID KEGG Term
hsa03018RNA degradation
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-429914Deadenylation-dependent mRNA decayTAS
R-HSA-429947Deadenylation of mRNATAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804115TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal