Gene: PLEKHG1

57480
ARHGEF41
pleckstrin homology and RhoGEF domain containing G1
protein-coding
6q25.1
Ensembl:ENSG00000120278 Vega:OTTHUMG00000015824 UniprotKB:Q9ULL1
NG_051299.1
SNP Mapped
1   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.677e-1 (AD)  4.852e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17427389chr6:150841979 (GRCh38.p7)G>Aalcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24863152chr6:151134876PLEKHG11.200e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AFF10.811
RREB10.797
PXN0.796
RBMS20.793
MSN0.783
CHSY10.781
FOXO10.778
STAT30.778
TEAD10.775
MAML20.773

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.434
CRH-0.4
LRRC38-0.395
MYCNOS-0.387
ADRA1D-0.386
ABCC12-0.383
KCNS3-0.383
NMU-0.381
RTP1-0.378
SLC7A4-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLEKHG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLEKHG1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PLEKHG1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PLEKHG1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PLEKHG1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PLEKHG1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of PLEKHG1 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLEKHG1 mRNA26001963
C006780bisphenol Abisphenol A results in decreased expression of PLEKHG1 mRNA28159858
C006780bisphenol Abisphenol A results in decreased expression of PLEKHG1 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of PLEKHG1 mRNA26191083
D003471CuprizoneCuprizone results in decreased expression of PLEKHG1 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of PLEKHG1 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in increased expression of PLEKHG1 mRNA24921660
D013759DronabinolDronabinol results in decreased expression of PLEKHG1 mRNA21955143
D003703DemecolcineDemecolcine results in increased expression of PLEKHG1 mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PLEKHG1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PLEKHG1 mRNA27392435
C118739entinostatentinostat results in decreased expression of PLEKHG1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHG1 mRNA"27188386
D000431EthanolEthanol results in increased expression of PLEKHG1 mRNA21955143
D005557FormaldehydeFormaldehyde results in increased expression of PLEKHG1 mRNA23649840
C546771gardiquimodgardiquimod results in increased expression of PLEKHG1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PLEKHG1 mRNA]28003376
D017313FenretinideFenretinide results in increased expression of PLEKHG1 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PLEKHG1 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PLEKHG1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PLEKHG1 mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PLEKHG1 mRNA"20188158
D009020MorphineMorphine results in decreased expression of PLEKHG1 mRNA21955143
D009538NicotinePLEKHG1 gene SNP affects the susceptibility to Nicotine18438686
D009538NicotineNicotine results in decreased expression of PLEKHG1 mRNA21955143
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLEKHG1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PLEKHG1 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PLEKHG1 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLEKHG1 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PLEKHG1 mRNA]28003376
D012969Sodium FluorideSodium Fluoride results in decreased expression of PLEKHG1 mRNA27862939
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PLEKHG1 mRNA25172293
D014212TretinoinTretinoin results in increased expression of PLEKHG1 mRNA16169686
D014635Valproic AcidValproic Acid affects the expression of PLEKHG1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PLEKHG1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of PLEKHG1 gene29154799
D014750VincristineVincristine results in increased expression of PLEKHG1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005089Rho guanyl-nucleotide exchange factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal