Gene: MKL2

57496
MRTF-B|MRTFB|NPD001
MKL1/myocardin like 2
protein-coding
16p13.12
Ensembl:ENSG00000186260 MIM:609463 Vega:OTTHUMG00000177379 UniprotKB:Q9ULH7
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.242e-2 (AD)  2.293e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MEF2A0.939
FBXO110.926
RASAL20.919
MYO9A0.919
TUBGCP40.917
SCN8A0.914
RNF1110.912
STXBP50.91
UBE4A0.91
MTPN0.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.528
BCL7C-0.515
RARRES2-0.5
HEY2-0.479
COPZ2-0.478
RBP1-0.459
ROM1-0.458
HMX1-0.438
PPP1R14B-0.436
MPST-0.43

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0127962-butenal2-butenal results in decreased expression of MKL2 mRNA20471460
C0541213-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanoneMKL2 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone25622337
D000082AcetaminophenAcetaminophen results in decreased expression of MKL2 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of MKL2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of MKL2 mRNA17562736
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MKL2 mRNA"17331233
C547126AZM551248AZM551248 results in decreased expression of MKL2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MKL2 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of MKL2 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MKL2 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of MKL2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MKL2 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of MKL2 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of MKL2 mRNA19549813
C000944dicrotophosdicrotophos results in increased expression of MKL2 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of MKL2 mRNA25016146
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MKL2 mRNA22079256
D017313FenretinideFenretinide results in increased expression of MKL2 mRNA28973697
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MKL2 mRNA"24972896
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of MKL2 mRNA22563483
D008558MelphalanMelphalan results in decreased expression of MKL2 mRNA22363485
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to MKL2 promoter]20348232
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MKL2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MKL2 mRNA"26251327
D009532NickelNickel results in decreased expression of MKL2 mRNA25583101
C464660obeticholic acidobeticholic acid results in decreased expression of MKL2 mRNA27939613
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of MKL2 mRNA22563483
D010269ParaquatParaquat results in increased expression of MKL2 mRNA22563483
D010634PhenobarbitalPhenobarbital affects the expression of MKL2 mRNA19136022
C006253pirinixic acidpirinixic acid affects the expression of MKL2 mRNA19136022
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MKL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MKL2 mRNA22079256
C428725pyridabenpyridaben results in increased expression of MKL2 mRNA22563483
C059514resveratrolresveratrol results in decreased expression of MKL2 mRNA23750556
D015474IsotretinoinIsotretinoin results in increased expression of MKL2 mRNA20436886
D012834SilverSilver results in decreased expression of MKL2 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MKL2 mRNA25975270
D013792ThalidomideThalidomide results in increased expression of MKL2 mRNA28892372
D014520UrethaneUrethane results in decreased expression of MKL2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of MKL2 mRNA24383497|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of MKL2 gene29154799
D014640VancomycinVancomycin results in decreased expression of MKL2 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in increased expression of MKL2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IDA14565952  
GO:0005515protein binding-IPI12397177  14565952  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0007517muscle organ development-IEA-  
GO:0045844positive regulation of striated muscle tissue development-IDA14565952  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA14565952  
GO:0051145smooth muscle cell differentiation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC14565952  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29452776Women-specific risk factors for heart failure: A genetic approach. (2018 Mar)van der Kemp JMaturitas