Gene: LRFN2

57497
FIGLER2|KIAA1246|SALM1
leucine rich repeat and fibronectin type III domain containing 2
protein-coding
6p21.2-p21.1
Ensembl:ENSG00000156564 MIM:612808 Vega:OTTHUMG00000014662 UniprotKB:Q9ULH4
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.922e-1 (AD)  6.185e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2436728chr6:40397862 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RTN4RL10.948
GFRA20.939
SLC8A20.936
AACS0.93
LINGO10.926
SLC30A30.926
SLC6A70.926
ADAM110.924
DOC2A0.922
ABCG40.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.667
WWTR1-0.638
YES1-0.637
RBPMS-0.618
CNN2-0.617
HEY2-0.604
RAI14-0.601
RNF135-0.593
NEDD4-0.584
GNG11-0.583

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C547126AZM551248AZM551248 results in increased expression of LRFN2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to LRFN2 promoter]19654925
C006780bisphenol Abisphenol A affects the expression of LRFN2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of LRFN2 promoter22457795
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of LRFN2 mRNA26033743
D003300CopperCopper deficiency results in increased expression of LRFN2 mRNA26033743
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of LRFN2 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of LRFN2 mRNA26033743
D002117CalcitriolCalcitriol results in decreased expression of LRFN2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of LRFN2 mRNA21592394
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of LRFN2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of LRFN2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LRFN2 promoter]19654925
D014212TretinoinTretinoin results in decreased expression of LRFN2 mRNA23724009
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LRFN2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-8849932Synaptic adhesion-like moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal