Gene: NLGN4X

57502
ASPGX2|AUTSX2|HLNX|HNL4X|NLGN4
neuroligin 4 X-linked
protein-coding
Xp22.32-p22.31
Ensembl:ENSG00000146938 MIM:300427 Vega:OTTHUMG00000021093 UniprotKB:Q8N0W4
NG_008881.2
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHL10.948
GRIA20.933
PCDH70.926
NRXN10.924
DENND5B0.924
BTRC0.922
ANK20.921
PPM1L0.921
CAND10.918
SFXN10.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.525
TFPI2-0.493
OR4F5-0.491
RAI14-0.463
FZD10-0.46
CNN2-0.459
HEY2-0.448
CDC42EP5-0.446
RUNX3-0.432
CMTM3-0.432

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NLGN4X gene27153756
D002104CadmiumCadmium results in decreased expression of NLGN4X mRNA24376830
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NLGN4X mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of NLGN4X mRNA23649840
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NLGN4X mRNA"24972896
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of NLGN4X mRNA20843944
D011374ProgesteroneProgesterone results in increased expression of NLGN4X mRNA17404688|2086464
D012834SilverSilver results in decreased expression of NLGN4X mRNA26551752
D014635Valproic AcidValproic Acid results in decreased expression of NLGN4X mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of NLGN4X gene29154799
C088658zoledronic acidzoledronic acid results in increased expression of NLGN4X mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11368788  17292328  20543817  
GO:0031404chloride ion binding-IDA18093521  
GO:0042043neurexin family protein binding-IBA21873635  
GO:0042043neurexin family protein binding-IDA19726642  
GO:0042043neurexin family protein binding-IPI18093521  
GO:0042803protein homodimerization activity-IDA18093521  
GO:0050839cell adhesion molecule binding-TAS18923512  
GO:0097110scaffold protein binding-IPI11368788  17292328  
GO ID GO Term Qualifier Evidence PubMed
GO:0003360brainstem development-ISS18227507  
GO:0007158neuron cell-cell adhesion-IBA21873635  
GO:0007158neuron cell-cell adhesion-TAS18923512  
GO:0007612learning-IMP12669065  
GO:0021549cerebellum development-ISS18227507  
GO:0030182neuron differentiation-NAS21278334  
GO:0030534adult behavior-IMP12669065  
GO:0035176social behavior-IMP12669065  19726642  
GO:0035265organ growth-ISS18227507  
GO:0045216cell-cell junction organization-NAS11368788  
GO:0050804modulation of chemical synaptic transmission-IBA21873635  
GO:0050808synapse organization-IMP15150161  
GO:0050808synapse organization-NAS11368788  
GO:0071625vocalization behavior-IMP12669065  19726642  
GO:0071625vocalization behavior-ISS18227507  
GO:0090394negative regulation of excitatory postsynaptic potential-IDA19726642  
GO:0097104postsynaptic membrane assembly-IBA21873635  
GO:0097105presynaptic membrane assembly-IBA21873635  
GO:0097105presynaptic membrane assembly-IDA19726642  
GO:0099054presynapse assembly-TAS21838267  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA19726642  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA11368788  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA15150161  17292328  19726642  
GO:0014069postsynaptic density-IEA-  
GO:0016021integral component of membrane-NAS16377159  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IDA19726642  
GO:0045202synapse-IBA21873635  
GO:0045202synapse-ISS18227507  
GO:0045211postsynaptic membrane-IEA-  
GO:0060076excitatory synapse-IDA15620359  
GO:0089717spanning component of membrane-TAS21838267  
GO:0098983symmetric, GABA-ergic, inhibitory synapse-TAS21838267  
GO:0098985asymmetric, glutamatergic, excitatory synapse-TAS21838267  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23907288Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence. (2013 Dec)Zuo LPsychiatr Genet