Gene info: ID 57506

Gene: MAVS

GENE ID: 57506

Synonyms: CARDIF|IPS-1|IPS1|VISA

Description: mitochondrial antiviral signaling protein

Gene type: protein-coding

Location: 20p13

dbXrefs: Ensembl:ENSG00000088888 MIM:609676 Vega:OTTHUMG00000031765 UniprotKB:Q7Z434

RefSeq: NG_030028.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.869e-2 (AD) 1.304e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6084496	chr20:3849815 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KAT6A	0.82
KMT2C	0.794
SBF2	0.788
ATF7	0.782
MACF1	0.779
DCHS1	0.776
MED12	0.776
CTDSP2	0.762
NT5C2	0.762
PHF2	0.76

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.386
OR4F29	-0.373
MYCNOS	-0.328
CRH	-0.322
MUC12	-0.304
SULT2B1	-0.287
SMIM18	-0.279
LRRC38	-0.265
LCN1	-0.254
VGF	-0.251

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAVS mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAVS mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of MAVS mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in increased expression of MAVS mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MAVS mRNA	19770486
D001151	Arsenic	Arsenic affects the methylation of MAVS gene	25304211
C004456	beauvericin	beauvericin results in increased expression of MAVS mRNA	29203277
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAVS mRNA	19770486
C006780	bisphenol A	bisphenol A affects the expression of MAVS mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of MAVS mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in decreased expression of MAVS protein	28903499
C018475	butyraldehyde	butyraldehyde results in decreased expression of MAVS mRNA	26079696
D003300	Copper	Copper results in decreased expression of MAVS mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in increased expression of MAVS mRNA	19549813
C029892	cupric chloride	cupric chloride results in decreased expression of MAVS mRNA	24650576
C014347	decitabine	decitabine results in increased expression of MAVS mRNA	27923600
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MAVS mRNA]	27941970
D002945	Cisplatin	Cisplatin results in decreased expression of MAVS mRNA	27594783
C000944	dicrotophos	dicrotophos results in increased expression of MAVS mRNA	28302478
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MAVS protein	23301498
C492448	ICG 001	ICG 001 results in decreased expression of MAVS mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAVS mRNA	25613284
D007649	Ketamine	Ketamine results in decreased expression of MAVS mRNA	20080153
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MAVS mRNA"	18930950
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MAVS mRNA"	27183587
C440499	lipopolysaccharide, Escherichia coli O111 B4	"MAVS protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL10 mRNA]"	27183587
C440499	lipopolysaccharide, Escherichia coli O111 B4	"MAVS protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL8 mRNA]"	27183587
C440499	lipopolysaccharide, Escherichia coli O111 B4	"MAVS protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]"	27183587
D008070	Lipopolysaccharides	MAVS protein affects the reaction [Lipopolysaccharides affects the localization of RELA protein]	27183587
D008070	Lipopolysaccharides	MAVS protein affects the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]	27183587
D008070	Lipopolysaccharides	MAVS protein affects the reaction [Lipopolysaccharides results in increased expression of SELE mRNA]	27183587
D008070	Lipopolysaccharides	MAVS protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]	27183587
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of MAVS mRNA	23649840
D009020	Morphine	Morphine results in increased expression of MAVS protein	23056601
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of MAVS mRNA	23892564
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of MAVS mRNA	27029645
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of MAVS mRNA	19073995
D012999	Soman	Soman results in decreased expression of MAVS mRNA	19281266
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAVS mRNA	18465118
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAVS mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MAVS mRNA	28065790
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MAVS mRNA"	18930950
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAVS mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MAVS mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of MAVS mRNA	26272509\|2800136
D014635	Valproic Acid	Valproic Acid results in increased methylation of MAVS gene	29154799
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of MAVS mRNA"	25475078

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	16127453 16177806 17460044 17600090 18636086 18818105 19153231 19164550 19193793 19416887 19419966 19881509 19893624 19914245 20007272 20019757 20127681 21068253 21102435 21813773 21903422 22000020 22301138 22328336 22623778 22908223 22911572 23015697 23399697 23460740 23542348 23582325 24478431 24643253 24706939 25416956 28414768
GO:0019901	protein kinase binding	-	IPI	16127453
GO:0035591	signaling adaptor activity	-	IMP	20451243
GO:0050700	CARD domain binding	-	IPI	16127453

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	IDA	16127453
GO:0002218	activation of innate immune response	-	IMP	18818105
GO:0002230	positive regulation of defense response to virus by host	-	IDA	16127453
GO:0002230	positive regulation of defense response to virus by host	-	IMP	19609254
GO:0007165	signal transduction	-	IMP	20451243
GO:0016032	viral process	-	IEA	-
GO:0032480	negative regulation of type I interferon production	-	TAS	-
GO:0032727	positive regulation of interferon-alpha production	-	IDA	16127453
GO:0032727	positive regulation of interferon-alpha production	-	IMP	19609254
GO:0032728	positive regulation of interferon-beta production	-	IDA	16127453
GO:0032728	positive regulation of interferon-beta production	-	IMP	19609254 19631370
GO:0032757	positive regulation of interleukin-8 production	-	IDA	16127453
GO:0032760	positive regulation of tumor necrosis factor production	-	IDA	16127453
GO:0033160	positive regulation of protein import into nucleus, translocation	-	IDA	18818105
GO:0035549	positive regulation of interferon-beta secretion	-	IMP	21957149
GO:0042742	defense response to bacterium	-	IMP	19631370
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	HMP	12761501
GO:0045071	negative regulation of viral genome replication	-	IDA	20451243
GO:0045087	innate immune response	-	IMP	19609254 19631370
GO:0045087	innate immune response	-	TAS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	16127453 18818105
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IDA	16127453 18818105
GO:0051607	defense response to virus	-	IDA	20451243
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	-	IDA	16127453 20451243
GO:0060760	positive regulation of response to cytokine stimulus	-	IMP	21957149
GO:0071360	cellular response to exogenous dsRNA	-	IMP	16127453 21957149
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	-	IDA	16127453
GO:0071660	positive regulation of IP-10 production	-	IDA	16127453
GO:1900063	regulation of peroxisome organization	-	IMP	20451243
GO:1902741	positive regulation of interferon-alpha secretion	-	IMP	21957149
GO:1904469	positive regulation of tumor necrosis factor secretion	-	IMP	21957149
GO:2000778	positive regulation of interleukin-6 secretion	-	IMP	21957149

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IDA	-
GO:0005741	mitochondrial outer membrane	-	IDA	18818105
GO:0005741	mitochondrial outer membrane	-	TAS	-
GO:0005778	peroxisomal membrane	-	IDA	20451243
GO:0016021	integral component of membrane	-	IEA	-
GO:0031966	mitochondrial membrane	-	IDA	20451243

KEGG ID	KEGG Term
hsa04622	RIG-I-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa05160	Hepatitis C

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689896	Ovarian tumor domain proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-918233	TRAF3-dependent IRF activation pathway	TAS
R-HSA-933541	TRAF6 mediated IRF7 activation	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	IEA
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	TAS
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	TAS
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28405612	MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD. (2017 Apr 6)	Hsu AC	JCI Insight