Gene: XPO5

57510
exp5
exportin 5
protein-coding
6p21.1
Ensembl:ENSG00000124571 MIM:607845 Vega:OTTHUMG00000014742 UniprotKB:Q9HAV4
NG_051658.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.261e-1 (AD)  6.975e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QRICH10.913
GTF3C20.913
AP1G10.911
NAT100.911
TMEM1310.909
ACAD80.908
HMGXB30.904
CELF10.904
CDK130.904
TRIM90.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.604
OR4F29-0.548
KLRC2-0.335
SH2D1A-0.323
ANXA13-0.308
CTNNA3-0.306
PDE11A-0.264
C5orf64-0.257
KLRC3-0.256
TNFRSF13B-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of XPO5 mRNA14583596
D020106AcrylamideAcrylamide results in increased expression of XPO5 mRNA28959563
D000393Air PollutantsXPO5 gene SNP affects the susceptibility to Air Pollutants26724585
D000393Air Pollutants[XPO5 gene SNP affects the susceptibility to Air Pollutants] which affects the expression of MIR96 mRNA26724585
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of XPO5 mRNA"19446018
D001280AtrazineAtrazine results in decreased expression of XPO5 mRNA22378314
D001554BenzeneBenzene results in increased expression of XPO5 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of XPO5 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of XPO5 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of XPO5 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of XPO5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of XPO5 gene28505145
D000069286BortezomibBortezomib results in decreased expression of XPO5 mRNA20977926
C018475butyraldehydebutyraldehyde results in decreased expression of XPO5 mRNA26079696
D002104CadmiumCadmium results in decreased expression of XPO5 mRNA23369406
D019256Cadmium ChlorideCadmium Chloride results in increased expression of XPO5 mRNA23741332
C018021cobaltous chloridecobaltous chloride results in decreased expression of XPO5 mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of XPO5 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of XPO5 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of XPO5 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of XPO5 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of XPO5 mRNA16847355|1861484
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of XPO5 protein23301498
D004967EstrogensEstrogens results in increased expression of XPO5 mRNA20852728
D007213IndomethacinIndomethacin results in increased expression of XPO5 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of XPO5 mRNA25613284
D007854LeadLead results in decreased expression of XPO5 mRNA19921347
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of XPO5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of XPO5 mRNA"25554681
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of XPO5 protein26879310
D011192Potassium DichromatePotassium Dichromate results in increased expression of XPO5 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of XPO5 mRNA20852728
C059514resveratrolresveratrol results in increased expression of XPO5 protein25505154
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of XPO5 mRNA21427059
D012969Sodium FluorideSodium Fluoride results in increased expression of XPO5 protein28918527
D053260SootXPO5 gene SNP affects the susceptibility to Soot26724585
D053260Soot[XPO5 gene SNP affects the susceptibility to Soot] which affects the expression of MIR96 mRNA26724585
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XPO5 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of XPO5 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of XPO5 protein24648495
D014212TretinoinTretinoin results in decreased expression of XPO5 mRNA18614847
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of XPO5 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of XPO5 mRNA28973697
D014520UrethaneUrethane results in decreased expression of XPO5 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of XPO5 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of XPO5 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of XPO5 mRNA21427059
D001335Vehicle EmissionsXPO5 gene SNP affects the susceptibility to Vehicle Emissions26724585
D001335Vehicle Emissions[XPO5 gene SNP affects the susceptibility to Vehicle Emissions] which affects the expression of MIR96 mRNA26724585
D024483Vitamin K 3Vitamin K 3 affects the expression of XPO5 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0003723RNA binding-TAS-  
GO:0003729mRNA binding-IDA21297638  
GO:0005049nuclear export signal receptor activity-IBA21873635  
GO:0005049nuclear export signal receptor activity-IMP14681208  
GO:0005515protein binding-IPI11777942  17314511  17353931  19124606  26878725  
GO:0008536Ran GTPase binding-IDA11777942  
GO:0008536Ran GTPase binding-IPI14681208  20951941  
GO:0008565protein transporter activity-IEA-  
GO:0070883pre-miRNA binding-IDA21297638  
GO:0070883pre-miRNA bindingcontributes_toIDA14681208  
GO:0070883pre-miRNA binding-NAS19965479  
GO ID GO Term Qualifier Evidence PubMed
GO:0006405RNA export from nucleus-IBA21873635  
GO:0006611protein export from nucleus-IDA11777942  24209753  
GO:0010586miRNA metabolic process-TAS-  
GO:0035281pre-miRNA export from nucleus-IDA15613540  
GO:0035281pre-miRNA export from nucleus-IMP14681208  
GO:0035281pre-miRNA export from nucleus-NAS19965479  
GO:0046825regulation of protein export from nucleus-IBA21873635  
GO:1900370positive regulation of RNA interference-IDA15613540  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11777942  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA11777942  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0035068micro-ribonucleoprotein complex-IDA19965479  
GO:0042272nuclear RNA export factor complex-IDA19965479  
GO:0042565RNA nuclear export complex-IBA21873635  
GO:0042565RNA nuclear export complex-IDA14681208  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-203927MicroRNA (miRNA) biogenesisTAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25127693A let-7 microRNA polymorphism in the KRAS 3'-UTR is prognostic in oropharyngeal cancer. (2014 Oct)De Ruyck KCancer Epidemiol