Gene: HECW2

57520
NDHSAL|NEDL2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
protein-coding
2q32.3
Ensembl:ENSG00000138411 MIM:617245 Vega:OTTHUMG00000154435 UniprotKB:Q9P2P5
NG_053156.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.753e-1 (AD)  3.400e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPRD0.945
SLITRK10.934
PEX5L0.932
ADAM220.931
SAMD120.931
STOX20.929
PPFIA20.928
DGKI0.928
NALCN0.927
CLCN40.926

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.562
EMP3-0.544
RNF135-0.533
CSAG1-0.526
RHOD-0.525
PDZK1IP1-0.501
MDFI-0.5
TEAD3-0.496
PGF-0.493
HEBP2-0.491

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HECW2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HECW2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of HECW2 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HECW2 mRNA24449571
D001151ArsenicArsenic results in decreased expression of HECW2 mRNA19654921
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HECW2 mRNA21569818|2196490
D004958EstradiolEstradiol results in increased expression of HECW2 mRNA25210133
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of HECW2 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of HECW2 mRNA25594700
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of HECW2 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of HECW2 mRNA29097150
C018475butyraldehydebutyraldehyde results in decreased expression of HECW2 mRNA26079696
D003042CocaineCocaine results in decreased expression of HECW2 mRNA17898221
D016572CyclosporineCyclosporine results in decreased expression of HECW2 mRNA27989131
D013759DronabinolDronabinol results in decreased expression of HECW2 mRNA16616335
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HECW2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HECW2 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of HECW2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of HECW2 mRNA21592394
D004317DoxorubicinDoxorubicin results in increased expression of HECW2 mRNA25896364
D000431EthanolEthanol results in decreased expression of HECW2 mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HECW2 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HECW2 mRNA23649840
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of HECW2 mRNA20846436
C069837fullerene C60fullerene C60 results in decreased expression of HECW2 mRNA19167457
C039281furanfuran results in increased methylation of HECW2 gene22079235
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HECW2 mRNA27392435
D008558MelphalanMelphalan results in decreased expression of HECW2 mRNA22363485
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HECW2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HECW2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HECW2 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of HECW2 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of HECW2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HECW2 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of HECW2 mRNA19167457
C016030pantogabpantogab results in increased expression of HECW2 mRNA17379144
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HECW2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of HECW2 mRNA26272509
C017947sodium arsenitesodium arsenite results in increased expression of HECW2 mRNA22714537
D053260SootSoot affects the expression of HECW2 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of HECW2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of HECW2 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of HECW2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HECW2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of HECW2 mRNA25975270
C009495titanium dioxidetitanium dioxide results in decreased expression of HECW2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HECW2 mRNA20133372
D014241TrichloroethyleneTrichloroethylene results in increased methylation of HECW2 gene27618143
D014635Valproic AcidValproic Acid affects the expression of HECW2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HECW2 mRNA23179753|2800136
C029297vinylidene chloridevinylidene chloride results in decreased expression of HECW2 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of HECW2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI24163370  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IEA-  
GO:0030071regulation of mitotic metaphase/anaphase transition-IMP24163370  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0045732positive regulation of protein catabolic process-IBA21873635  
GO:0048814regulation of dendrite morphogenesis-IBA21873635  
GO:2000650negative regulation of sodium ion transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0072686mitotic spindle-IDA24163370  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28747766DNA methylation signatures of chronic alcohol dependence in purified CD3(+) T-cells of patients undergoing alcohol treatment. (2017 Jul 26)Bruckmann CSci Rep