Gene: MIB1

57534
DIP-1|DIP1|LVNC7|MIB|ZZANK2|ZZZ6
mindbomb E3 ubiquitin protein ligase 1
protein-coding
18q11.2
Ensembl:ENSG00000101752 MIM:608677 Vega:OTTHUMG00000131753 UniprotKB:Q86YT6
NG_033272.2
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.751e-1 (AD)  4.870e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOC50.919
EEA10.87
TAOK10.869
RSF10.869
UBL30.861
USP80.859
SNX130.856
TM9SF30.856
TMEM167A0.853
IPO70.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.647
OR4F29-0.633
AZU1-0.226
MUC6-0.216
NPIPA2-0.208
CSAG1-0.207
PPIAL4G-0.201
RSPO1-0.198
DAZ1-0.194
SPRR2F-0.188

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MIB1 mRNA"28903501
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MIB1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of MIB1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MIB1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MIB1 mRNA19770486
D047310ApigeninApigenin results in increased expression of MIB1 mRNA22359648
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MIB1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MIB1 mRNA"20018196
C006780bisphenol Abisphenol A results in decreased expression of MIB1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of MIB1 mRNA29097150
C018475butyraldehydebutyraldehyde results in decreased expression of MIB1 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MIB1 gene20938992
D002994ClofibrateClofibrate results in decreased expression of MIB1 mRNA23811191
D019327Copper SulfateCopper Sulfate results in increased expression of MIB1 mRNA19549813
D013759DronabinolDronabinol results in increased expression of MIB1 mRNA16597638
D004041Dietary FatsDietary Fats results in increased expression of MIB1 mRNA18042831|1903023
D002117CalcitriolCalcitriol results in increased expression of MIB1 mRNA16002434
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MIB1 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MIB1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of MIB1 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of MIB1 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MIB1 mRNA20044591
D007545IsoproterenolIsoproterenol results in increased expression of MIB1 mRNA20003209
C544151jinfukangjinfukang results in decreased expression of MIB1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MIB1 mRNA24796395
D007649KetamineKetamine results in increased expression of MIB1 mRNA20080153
D018021Lithium ChlorideLithium Chloride results in decreased expression of MIB1 mRNA23527032
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MIB1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MIB1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MIB1 mRNA"26251327
D000073878Palm OilPalm Oil results in increased expression of MIB1 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MIB1 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MIB1 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of MIB1 mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of MIB1 mRNA23557933
C009277sodium arsenatesodium arsenate results in increased expression of MIB1 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MIB1 mRNA21570461
D014415TunicamycinTunicamycin results in decreased expression of MIB1 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of MIB1 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MIB1 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MIB1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-IBA21873635  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI21903422  28712572  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001568blood vessel development-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0001756somitogenesis-IEA-  
GO:0001841neural tube formation-IEA-  
GO:0001947heart looping-IEA-  
GO:0006897endocytosis-IBA21873635  
GO:0007219Notch signaling pathway-IBA21873635  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045807positive regulation of endocytosis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005813centrosome-IDA21399614  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0031410cytoplasmic vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in CancerTAS
R-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24099733Prognostic factors in a multicentre study of 247 atypical pulmonary carcinoids. (2014 Apr)Daddi NEur J Cardiothorac Surg
15705190Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema. (2005 Feb 10)Calabrese FRespir Res
25210770Evaluation of HPV infection and smoking status impacts on cell proliferation in epithelial layers of cervical neoplasia. (2014)Guillaud MPLoS One