Gene: PTK7

5754
CCK-4|CCK4
protein tyrosine kinase 7 (inactive)
protein-coding
6p21.1
Ensembl:ENSG00000112655 MIM:601890 Vega:OTTHUMG00000014721 UniprotKB:Q13308
NC_000006.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.114e-1 (AD)  1.320e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3805944chr6:43077724 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18336453chr6:43082296PTK7Gene body4.357e-4Alcohol use disorders26763658
cg20819617chr6:43045052PTK75.500e-9Smoking27651444
cg18336453chr6:43082296PTK76.580e-9Alcohol consumption per day27843151
cg18336453chr6:43082296PTK74.840e-10Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZYX0.707
ZNF1330.705
HCN30.698
GMPPA0.696
STK360.689
PTPRU0.689
NARF0.686
TSHZ20.685
DVL20.684
SLC35F10.681

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.372
OR4F29-0.33
NDNF-0.242
LHFPL1-0.242
ASB4-0.235
RERGL-0.226
MYOM1-0.218
FGFBP2-0.21
MTRNR2L2-0.205
KCNJ13-0.204

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of PTK7 mRNA"23829299
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of PTK7 mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PTK7 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of PTK7 protein"25670856
D000082AcetaminophenAcetaminophen results in decreased expression of PTK7 mRNA26690555
D001280AtrazineAtrazine results in increased expression of PTK7 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of PTK7 mRNA22323515
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PTK7 mRNA20823114
C006780bisphenol Abisphenol A results in increased expression of PTK7 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PTK7 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PTK7 gene28505145
C584509C646 compoundC646 compound results in increased expression of PTK7 mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of PTK7 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of PTK7 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of PTK7 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTK7 mRNA21266533
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PTK7 mRNA20823114
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PTK7 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PTK7 mRNA27392435
C039281furanfuran results in increased expression of PTK7 mRNA27387713
D017313FenretinideFenretinide results in increased expression of PTK7 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PTK7 mRNA27392435
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PTK7 mRNA20823114
D008727MethotrexateMethotrexate affects the expression of PTK7 mRNA18502557
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PTK7 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PTK7 mRNA25729387
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PTK7 protein26178269
D010936Plant ExtractsPlant Extracts results in decreased expression of PTK7 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of PTK7 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PTK7 mRNA21427059
C078903seocalcitolseocalcitol results in increased expression of PTK7 mRNA12040012
C017947sodium arsenitesodium arsenite affects the methylation of PTK7 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of PTK7 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTK7 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTK7 mRNA22298810
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PTK7 mRNA25729387
D014212TretinoinTretinoin results in increased expression of PTK7 mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PTK7 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of PTK7 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of PTK7 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PTK7 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IEA-  
GO:0005515protein binding-IPI21132015  
GO:0005524ATP binding-IEA-  
GO:1904929coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway-NAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0001736establishment of planar polarity-IBA21873635  
GO:0001736establishment of planar polarity-IEA-  
GO:0003281ventricular septum development-IEA-  
GO:0003401axis elongation-IBA21873635  
GO:0003401axis elongation-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-TAS7478540  
GO:0010976positive regulation of neuron projection development-IMP17910947  
GO:0016477cell migration-IMP20837484  
GO:0031532actin cytoskeleton reorganization-IMP20837484  
GO:0042060wound healing-IEA-  
GO:0045198establishment of epithelial cell apical/basal polarity-IEA-  
GO:0060026convergent extension-IEA-  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-IMP21132015  
GO:0060484lung-associated mesenchyme development-IEA-  
GO:0060976coronary vasculature development-IEA-  
GO:0071300cellular response to retinoic acid-IMP17910947  
GO:0090103cochlea morphogenesis-IEA-  
GO:0090179planar cell polarity pathway involved in neural tube closure-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IEA-  
GO:0005911cell-cell junction-IBA21873635  
GO:0005911cell-cell junction-IDA20837484  
GO:0005925focal adhesion-HDA21423176  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26642056In Utero Cigarette Smoke Affects Allergic Airway Disease But Does Not Alter the Lung Methylome. (2015)Eyring KRPLoS One