Gene: DOCK6

57572
AOS2|ZIR1
dedicator of cytokinesis 6
protein-coding
19p13.2
Ensembl:ENSG00000130158 MIM:614194 Vega:OTTHUMG00000180826 UniprotKB:Q96HP0
NG_031953.1
SNP Mapped
5   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.936e-1 (AD)  9.747e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17699089chr19:11233119 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12463177chr19:11231004 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4804154chr19:11223503 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3810308chr19:11222920 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3826815chr19:11221829 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PXN0.884
CDH50.875
RBMS20.865
LAMB20.863
PEAR10.861
MYO1C0.847
HLA-E0.846
STARD80.845
EPHB40.844
TINAGL10.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.56
CRH-0.508
PPEF1-0.485
PTPRR-0.475
MARCH4-0.47
SLC7A4-0.466
KCNB2-0.463
ATOH7-0.453
ABCC12-0.451
NEUROD6-0.446

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK6 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of DOCK6 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DOCK6 mRNA24449571
D034341Aristolochic AcidsAristolochic Acids results in increased expression of DOCK6 mRNA19717638
C015001arsenitearsenite results in decreased methylation of DOCK6 promoter23974009
D001280AtrazineAtrazine results in increased expression of DOCK6 mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of DOCK6 mRNA26377693
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DOCK6 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of DOCK6 mRNA25181051
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK6 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of DOCK6 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DOCK6 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of DOCK6 mRNA19320972
D003471CuprizoneCuprizone results in increased expression of DOCK6 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of DOCK6 mRNA25562108
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DOCK6 promoter23359474
C000944dicrotophosdicrotophos results in increased expression of DOCK6 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of DOCK6 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of DOCK6 mRNA]19850644
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DOCK6 promoter23359474
C118739entinostatentinostat results in increased expression of DOCK6 mRNA27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DOCK6 mRNA20938992
D007854LeadLead results in increased expression of DOCK6 mRNA19921347
C042720mercuric bromidemercuric bromide results in decreased expression of DOCK6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK6 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of DOCK6 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DOCK6 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of DOCK6 mRNA24449571
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of DOCK6 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DOCK6 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DOCK6 mRNA"25554681|2562005
C025589ochratoxin Aochratoxin A results in increased expression of DOCK6 mRNA19717638
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DOCK6 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of DOCK6 mRNA23811191
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of DOCK6 mRNA28973375
D013849ThimerosalThimerosal results in decreased expression of DOCK6 mRNA27188386
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DOCK6 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of DOCK6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DOCK6 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DOCK6 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0007596blood coagulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal