Gene: FAM135A

57579
KIAA1411
family with sequence similarity 135 member A
protein-coding
6q13
Ensembl:ENSG00000082269 Vega:OTTHUMG00000014991 UniprotKB:Q9P2D6
NG_054903.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.025e-1 (AD)  1.248e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMARCAD10.884
SIKE10.881
CTDSPL20.881
C5orf240.881
HOOK30.878
SCYL20.877
SNX130.877
TAF20.875
EDEM30.874
TMTC30.874

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.528
OR4F29-0.484
CSAG1-0.23
S100A1-0.222
TCF15-0.219
ZCCHC13-0.215
CRNN-0.214
SPRR2A-0.208
SMCP-0.207
RHOD-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM135A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM135A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FAM135A mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FAM135A gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FAM135A mRNA19770486
D001280AtrazineAtrazine results in decreased expression of FAM135A mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of FAM135A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAM135A mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAM135A mRNA20127859
C006780bisphenol Abisphenol A results in increased expression of FAM135A mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of FAM135A mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FAM135A mRNA24982889
D019327Copper SulfateCopper Sulfate results in increased expression of FAM135A mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of FAM135A mRNA25562108
D016572CyclosporineCyclosporine results in increased methylation of FAM135A promoter27989131
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FAM135A mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FAM135A mRNA27392435
D002945CisplatinCisplatin results in increased expression of FAM135A mRNA27594783
D000431EthanolEthanol results in decreased expression of FAM135A mRNA29018328
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FAM135A mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FAM135A mRNA27392435
C544151jinfukangjinfukang results in decreased expression of FAM135A mRNA27392435
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of FAM135A mRNA26667767
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of FAM135A mRNA27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FAM135A mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of FAM135A mRNA29191790
D011192Potassium DichromatePotassium Dichromate results in decreased expression of FAM135A mRNA23608068
D011794QuercetinQuercetin results in increased expression of FAM135A mRNA21632981
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of FAM135A mRNA26667767
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAM135A mRNA24680724
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FAM135A mRNA25613284
D013849ThimerosalThimerosal affects the expression of FAM135A mRNA27188386
C012589trichostatin Atrichostatin A results in increased expression of FAM135A mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FAM135A mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM135A mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of FAM135A mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased expression of FAM135A mRNA24935251|2915479
D014638VanadatesVanadates results in decreased expression of FAM135A mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FAM135A gene25560391
C025643vinclozolinvinclozolin results in increased expression of FAM135A mRNA23034163
C111237vorinostatvorinostat affects the expression of FAM135A mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0044255cellular lipid metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25991709Identification of candidate genes that underlie the QTL on chromosome 1 that mediates genetic differences in stress-ethanol interactions. (2015 Aug)Cook MNPhysiol Genomics