Gene: MKL1

57591
BSAC|MAL|MKL|MRTF-A
megakaryoblastic leukemia (translocation) 1
protein-coding
22q13.1-q13.2
Ensembl:ENSG00000196588 MIM:606078 Vega:OTTHUMG00000151146 UniprotKB:Q969V6
NC_000022.11
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.542e-1 (AD)  6.915e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP2A20.944
NMT10.941
FBXO310.941
IP6K10.938
CABIN10.935
BAIAP20.933
URGCP0.932
MBOAT70.932
SIN3B0.931
CARM10.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.604
OR4F29-0.56
MBNL3-0.391
SH2D1A-0.388
ASB4-0.383
RAI14-0.378
HEY2-0.36
CTNNA3-0.356
LRRCC1-0.356
KLRB1-0.354

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08080LATRUNCULIN BSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Oxygen affects the localization of MKL1 protein]"23517783
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MKL1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MKL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MKL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MKL1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of MKL1 mRNA17562736
C006780bisphenol Abisphenol A results in increased expression of MKL1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MKL1 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of MKL1 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MKL1 mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MKL1 mRNA24763279
C523455CCG 1423CCG 1423 affects the localization of MKL1 protein21393865
C523455CCG 1423CCG 1423 inhibits the reaction [Palmitic Acid affects the localization of MKL1 protein]21393865
D019327Copper SulfateCopper Sulfate results in increased expression of MKL1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MKL1 mRNA25562108
D015638Cytochalasin DCytochalasin D inhibits the reaction [Oxygen affects the localization of MKL1 protein]23517783
D003907DexamethasoneDexamethasone results in decreased expression of MKL1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of MKL1 mRNA]20032058
D003976DiazinonDiazinon affects the expression of MKL1 mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MKL1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MKL1 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of MKL1 mRNA28302478
D004026DieldrinDieldrin affects the expression of MKL1 mRNA22546817
C118739entinostatentinostat results in decreased expression of MKL1 mRNA27188386
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum inhibits the reaction [Oxygen affects the localization of MKL1 protein]"23517783
D005557FormaldehydeFormaldehyde results in decreased expression of MKL1 mRNA20655997
D005839GentamicinsGentamicins results in increased expression of MKL1 mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MKL1 mRNA24763279
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MKL1 mRNA20044591
C057531jasplakinolidejasplakinolide affects the localization of MKL1 protein23517783
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MKL1 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MKL1 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MKL1 mRNA23649840
C025589ochratoxin Aochratoxin A results in increased expression of MKL1 mRNA23358140
D010100Oxygen"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Oxygen affects the localization of MKL1 protein]"23517783
D010100OxygenCytochalasin D inhibits the reaction [Oxygen affects the localization of MKL1 protein]23517783
D010100Oxygen"exoenzyme C3, Clostridium botulinum inhibits the reaction [Oxygen affects the localization of MKL1 protein]"23517783
D010100OxygenMKL1 protein affects the reaction [Oxygen results in increased expression of ACTA2 mRNA]23517783
D010100OxygenMKL1 protein affects the reaction [Oxygen results in increased expression of ACTA2 protein]23517783
D010100OxygenOxygen promotes the reaction [MKL1 protein binds to ACTA2 promoter]23517783
D010100OxygenOxygen results in increased expression of and affects the localization of MKL1 protein23517783
D010100OxygenOxygen results in increased expression of MKL1 mRNA23517783
D019308Palmitic AcidCCG 1423 inhibits the reaction [Palmitic Acid affects the localization of MKL1 protein]21393865
D019308Palmitic AcidPalmitic Acid affects the localization of MKL1 protein21393865
C016030pantogabpantogab results in increased expression of MKL1 mRNA17379144
D010936Plant ExtractsPlant Extracts results in decreased expression of MKL1 mRNA23557933
D018038Sodium SeleniteSodium Selenite results in increased expression of MKL1 mRNA18175754
D012999SomanSoman results in decreased expression of MKL1 mRNA19281266
D010042OuabainOuabain results in decreased expression of MKL1 mRNA28795476
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of MKL1 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the localization of MKL1 protein27697457
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MKL1 mRNA21570461
D014212TretinoinTretinoin results in increased expression of MKL1 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MKL1 mRNA"26179874
D014520UrethaneUrethane results in increased expression of MKL1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MKL1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of MKL1 mRNA26272509
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MKL1 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of MKL1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-ISS-  
GO:0003779actin binding-IDA24440334  
GO:0003785actin monomer binding-ISS-  
GO:0005515protein binding-IPI12397177  14565952  19350017  
GO:0043522leucine zipper domain binding-IPI14970199  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0010735positive regulation of transcription via serum response element binding-IDA24440334  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA14970199  
GO:0051145smooth muscle cell differentiation-IBA21873635  
GO:0051145smooth muscle cell differentiation-IMP14970199  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA14970199  24440334  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA14970199  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal