Gene: ZNF492

57615
ZNF115
zinc finger protein 492
protein-coding
19p12
Ensembl:ENSG00000229676 Vega:OTTHUMG00000182987 UniprotKB:Q9P255
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.375e-3 (AD)  2.299e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7250285chr19:22654306 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDGFC0.552
TMEM1680.524
UEVLD0.518
SLC9B10.508
DPH60.506
ZNF354C0.505
TMEM2090.503
DCLRE1B0.502
FAM198B0.5
SSPN0.487

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HGFAC-0.262
WFIKKN1-0.246
ASGR2-0.223
PKLR-0.212
WDR64-0.211
MAGIX-0.207
POLR2J2-0.203
GRIP2-0.203
TJP3-0.202
PLCH2-0.201

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D006046GoldGold results in decreased expression of ZNF492 mRNA25523186
D008727MethotrexateMethotrexate results in increased expression of ZNF492 mRNA24449571
C568376MT19c compoundMT19c compound results in increased expression of ZNF492 mRNA21781307
D012643SeleniumSelenium results in decreased expression of ZNF492 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ZNF492 mRNA25895662
D014638VanadatesVanadates results in decreased expression of ZNF492 mRNA22714537
D014810Vitamin EVitamin E results in decreased expression of ZNF492 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal