Gene: STIM2

57620
-
stromal interaction molecule 2
protein-coding
4p15.2
Ensembl:ENSG00000109689 MIM:610841 Vega:OTTHUMG00000097805 UniprotKB:Q9P246
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.439e-1 (AD)  3.966e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18777299chr4:26994740STIM23.000e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RALGAPB0.923
TMEM1310.911
UBE3C0.91
SUDS30.906
AP1G10.903
XPO70.902
CCPG10.901
HECTD10.9
TRAPPC110.9
PIAS20.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.608
OR4F29-0.57
MYL3-0.336
MTRNR2L10-0.307
ANXA13-0.305
MTRNR2L9-0.294
CSAG1-0.292
MTRNR2L6-0.287
ZNF114-0.283
FAM89A-0.282

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of STIM2 protein26194647
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of STIM2 mRNA]"19467301
D000082AcetaminophenAcetaminophen results in increased expression of STIM2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of STIM2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of STIM2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of STIM2 mRNA24449571
D001151ArsenicArsenic affects the methylation of STIM2 gene25304211
D001280AtrazineAtrazine results in decreased expression of STIM2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STIM2 mRNA21632981
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STIM2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of STIM2 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of STIM2 mRNA20977926
D002994ClofibrateClofibrate results in decreased expression of STIM2 mRNA23811191
D003471CuprizoneCuprizone results in decreased expression of STIM2 mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STIM2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of STIM2 mRNA21266533
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of STIM2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of STIM2 mRNA19030233|1946730
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of STIM2 mRNA]19030233
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of STIM2 mRNA18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STIM2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STIM2 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of STIM2 mRNA24796395
D007854LeadLead affects the expression of STIM2 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of STIM2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of STIM2 mRNA"20188158
C046012pentanalpentanal results in decreased expression of STIM2 mRNA26079696
D010634PhenobarbitalPhenobarbital results in increased expression of STIM2 mRNA19270015
C006253pirinixic acidpirinixic acid results in decreased expression of STIM2 mRNA23811191
C045950propiconazolepropiconazole results in increased expression of STIM2 mRNA21278054
D011794QuercetinQuercetin affects the expression of STIM2 mRNA21632981
C089032rimonabantrimonabant affects the expression of STIM2 mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of STIM2 mRNA]19030233
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STIM2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STIM2 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STIM2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STIM2 mRNA21215274
D019284ThapsigarginThapsigargin results in decreased expression of STIM2 protein24648495
D013849ThimerosalThimerosal results in increased expression of STIM2 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of STIM2 mRNA28065790
D014520UrethaneUrethane results in increased expression of STIM2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of STIM2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of STIM2 mRNA23179753|2800136
C025643vinclozolinvinclozolin results in decreased expression of STIM2 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005246calcium channel regulator activity-IBA21873635  
GO:0005246calcium channel regulator activity-IMP18160041  
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IDA18166150  
GO:0005515protein binding-IPI11463338  17905723  
GO:0015279store-operated calcium channel activity-IDA16860747  
GO ID GO Term Qualifier Evidence PubMed
GO:0002115store-operated calcium entry-IBA21873635  
GO:0006874cellular calcium ion homeostasis-IBA21873635  
GO:0006874cellular calcium ion homeostasis-IMP18160041  
GO:0032237activation of store-operated calcium channel activity-IBA21873635  
GO:0032237activation of store-operated calcium channel activity-IDA17905723  
GO:0032237activation of store-operated calcium channel activity-IMP18160041  
GO:0051928positive regulation of calcium ion transport-IDA17905723  
GO:0051928positive regulation of calcium ion transport-IMP18160041  
GO:0070588calcium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA18160041  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA18160041  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25623308[Polarization of neutrophils from patients with asthma, chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease overlap syndrome]. (2014 Dec 30)Deng FZhonghua Yi Xue Za Zhi