Gene: NYAP2

57624
KIAA1486
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
protein-coding
2q36.3
Ensembl:ENSG00000144460 MIM:615478 Vega:OTTHUMG00000153450 UniprotKB:Q9P242
NC_000002.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.825e-1 (AD)  6.320e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7595617chr2:225650982 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1993323chr2:225591745 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH70.892
CNTNAP50.865
CDKL50.845
GRM50.818
KLHL110.812
DCC0.808
POMK0.805
SYT160.798
CCSER10.797
C4orf500.787

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.527
COPZ2-0.511
RAB13-0.501
AGTRAP-0.482
CSAG1-0.475
APOM-0.469
HEBP2-0.468
VAMP5-0.457
MEF2B-0.457
HEY2-0.45

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NYAP2 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NYAP2 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NYAP2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NYAP2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NYAP2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NYAP2 mRNA"25510870
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NYAP2 mRNA26001963
C006780bisphenol Abisphenol A results in increased expression of NYAP2 mRNA27178563
D004041Dietary FatsDietary Fats results in increased expression of NYAP2 mRNA25016146
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NYAP2 mRNA25613284
D007854LeadLead affects the expression of NYAP2 mRNA28903495
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NYAP2 mRNA"25510870
D010936Plant ExtractsPlant Extracts results in decreased expression of NYAP2 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NYAP2 mRNA23806026
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NYAP2 mRNA25613284
D014635Valproic AcidValproic Acid results in increased methylation of NYAP2 gene29154799
D019287Zinc SulfateZinc Sulfate results in decreased expression of NYAP2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0014065phosphatidylinositol 3-kinase signaling-ISS-  
GO:0048812neuron projection morphogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal