Gene: PTMS

5763
ParaT
parathymosin
protein-coding
12p13.31
Ensembl:ENSG00000159335 MIM:168440 Vega:OTTHUMG00000169196 UniprotKB:P20962
NC_000012.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.759e-1 (AD)  3.766e-3 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20006825chr12:6874964PTMS3.900e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V1F0.92
MLF20.918
CLTB0.915
MEA10.915
PPP1CA0.913
ATP6V0C0.908
EPN10.906
NEDD80.905
TPI10.904
STK250.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.794
OR4F29-0.765
CTNNA3-0.278
HBD-0.274
ADH1B-0.261
FCGR3B-0.259
VNN2-0.257
TRPV5-0.252
CXCR2-0.252
REST-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of PTMS mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PTMS mRNA"21354444
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PTMS mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTMS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTMS mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PTMS protein20106945
D000638AmiodaroneAmiodarone affects the expression of PTMS mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTMS mRNA16483693
D000667AmpicillinAmpicillin results in increased expression of PTMS mRNA21632981
D001280AtrazineAtrazine results in increased expression of PTMS mRNA22378314
D001553BenzbromaroneBenzbromarone affects the expression of PTMS mRNA19483382
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTMS mRNA17905399
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTMS mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTMS mRNA22610609
C095105bexarotenebexarotene results in increased expression of PTMS mRNA16648578
C006780bisphenol Abisphenol A results in decreased methylation of PTMS promoter27312807
C006780bisphenol Abisphenol A affects the expression of PTMS mRNA25181051
D001761BleomycinBleomycin results in increased expression of PTMS protein25933445
C018475butyraldehydebutyraldehyde results in decreased expression of PTMS mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of PTMS mRNA26191083
D002104CadmiumCadmium results in decreased expression of PTMS mRNA23369406
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PTMS mRNA12760830
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of PTMS mRNA19395590
D002994ClofibrateClofibrate affects the expression of PTMS mRNA19483382
D002995Clofibric AcidClofibric Acid affects the expression of PTMS mRNA17602206
D003024ClozapineClozapine results in increased expression of PTMS mRNA14647396
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTMS mRNA19320972
D016572CyclosporineCyclosporine results in decreased expression of PTMS mRNA20106945|2798913
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of PTMS mRNA21658437
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of PTMS mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of PTMS mRNA"21785161
D004391DustDust results in decreased expression of PTMS mRNA17805423
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PTMS mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PTMS mRNA29097150
D005001EthionineEthionine affects the expression of PTMS mRNA19483382
D005419FlavonoidsFlavonoids results in decreased expression of PTMS mRNA18035473
C069837fullerene C60fullerene C60 affects the expression of PTMS mRNA19167457
C039281furanfuran results in increased methylation of PTMS gene22079235
D019833GenisteinGenistein results in decreased expression of PTMS mRNA16705744
D006220HaloperidolHaloperidol results in increased expression of PTMS mRNA14647396
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PTMS mRNA12419474
C492448ICG 001ICG 001 results in decreased expression of PTMS mRNA26191083
C544151jinfukangjinfukang results in increased expression of PTMS mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of PTMS mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PTMS mRNA23430699
D007657Ketone BodiesKetone Bodies results in increased expression of PTMS mRNA16807920
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PTMS mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTMS mRNA"27188386
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTMS mRNA17905399
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PTMS mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PTMS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTMS mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of PTMS mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of PTMS mRNA19167457
C012655nimesulidenimesulide results in decreased expression of PTMS mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of PTMS mRNA19483382
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PTMS mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PTMS mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of PTMS mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PTMS mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of PTMS mRNA23811191
C006253pirinixic acidpirinixic acid affects the expression of PTMS mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of PTMS mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of PTMS mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of PTMS mRNA11678601
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PTMS mRNA28903501
D011441PropylthiouracilPropylthiouracil affects the expression of PTMS mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of PTMS mRNA24780913
D015125OxyquinolineOxyquinoline results in increased expression of PTMS mRNA21632981
D012643SeleniumSelenium results in increased expression of PTMS mRNA19244175
C080703SK&F 83959SK&F 83959 results in increased expression of PTMS protein25852303
C017947sodium arsenitesodium arsenite affects the methylation of PTMS gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of PTMS mRNA22561333
D012969Sodium FluorideSodium Fluoride results in decreased expression of PTMS mRNA27862939
D013629TamoxifenTamoxifen affects the expression of PTMS mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTMS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTMS mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTMS mRNA16054898|2121527
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of PTMS mRNA28973375
D013849ThimerosalThimerosal results in decreased expression of PTMS mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of PTMS mRNA19483382
C009495titanium dioxidetitanium dioxide affects the expression of PTMS mRNA23557971
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTMS mRNA17905399
D014415TunicamycinTunicamycin results in decreased expression of PTMS mRNA22378314
C000602704UF010 compoundUF010 compound results in increased acetylation of PTMS protein25699604
D014635Valproic AcidValproic Acid affects the expression of PTMS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PTMS mRNA29154799
C025643vinclozolinvinclozolin results in decreased expression of PTMS mRNA23034163
D014810Vitamin EVitamin E results in increased expression of PTMS mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0002376immune system process-IEA-  
GO:0006260DNA replication-TAS10854063  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS10854063  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27541571Analysis of Chlorination, Nitration, and Nitrosylation of Tyrosine and Oxidation of Methionine and Cysteine in Hemoglobin from Type 2 Diabetes Mellitus Patients by Nanoflow Liquid Chromatography Tandem Mass Spectrometry. (2016 Sep 20)Chen HJAnal Chem
25465468Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications. (2014)Song BJRedox Biol
28558143Parsing disease-relevant protein modifications from epiphenomena: perspective on the structural basis of SOD1-mediated ALS. (2017 Jul)Schmitt NDJ Mass Spectrom