Gene: SH3RF1

57630
POSH|RNF142|SH3MD2
SH3 domain containing ring finger 1
protein-coding
4q32.3-q33
Ensembl:ENSG00000154447 Vega:OTTHUMG00000161010 UniprotKB:Q7Z6J0
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.885e-2 (AD)  8.402e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11552640chr4:170080712SH3RF1Gene body1.446e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF1B0.802
HDHD20.789
ZNF6290.789
TOP2B0.789
ACTR20.787
PPP2R5C0.785
ABI20.784
SEC630.78
RALB0.779
TAF5L0.778

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.634
OR4F29-0.616
S100A7-0.29
C7orf61-0.252
GAGE10-0.243
NPIPB6-0.243
MIA-0.242
SLC7A9-0.238
FXYD3-0.237
RAX2-0.229

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of SH3RF1 mRNA19041380
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SH3RF1 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SH3RF1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of SH3RF1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SH3RF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SH3RF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SH3RF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SH3RF1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SH3RF1 mRNA29067470
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of SH3RF1 mRNA]21233418
D001151ArsenicArsenic affects the methylation of SH3RF1 gene25304211
D001280AtrazineAtrazine results in increased expression of SH3RF1 mRNA25929836
D001379AzathioprineAzathioprine results in increased expression of SH3RF1 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of SH3RF1 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SH3RF1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SH3RF1 mRNA21871943|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SH3RF1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SH3RF1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SH3RF1 mRNA"19150397
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SH3RF1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SH3RF1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SH3RF1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SH3RF1 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of SH3RF1 mRNA25979313
C018021cobaltous chloridecobaltous chloride results in decreased expression of SH3RF1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of SH3RF1 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of SH3RF1 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of SH3RF1 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SH3RF1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SH3RF1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SH3RF1 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SH3RF1 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of SH3RF1 mRNA25016146
C118739entinostatentinostat results in decreased expression of SH3RF1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SH3RF1 mRNA"27188386
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of SH3RF1 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of SH3RF1 mRNA21233418
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SH3RF1 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of SH3RF1 mRNA20655997
D017313FenretinideFenretinide results in increased expression of SH3RF1 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SH3RF1 protein18951874
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SH3RF1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SH3RF1 mRNA24796395
C045463leflunomideleflunomide results in increased expression of SH3RF1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SH3RF1 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SH3RF1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SH3RF1 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of SH3RF1 mRNA16809437
C025589ochratoxin Aochratoxin A results in decreased expression of SH3RF1 mRNA18417182
D011794QuercetinQuercetin results in increased expression of SH3RF1 mRNA21632981
C009277sodium arsenatesodium arsenate results in increased expression of SH3RF1 mRNA21795629
D012999SomanSoman results in increased expression of SH3RF1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SH3RF1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SH3RF1 mRNA21570461
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SH3RF1 protein18951874
D013853ThioacetamideThioacetamide results in increased expression of SH3RF1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SH3RF1 mRNA20133372
C024746tobacco tartobacco tar results in decreased expression of SH3RF1 mRNA19559774
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SH3RF1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SH3RF1 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SH3RF1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SH3RF1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of SH3RF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SH3RF1 mRNA23527032|2915479
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SH3RF1 gene25560391
D024483Vitamin K 3Vitamin K 3 results in increased expression of SH3RF1 mRNA25270620

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20696164  20936779  21586138  25438054  
GO:0016740transferase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0007257activation of JUN kinase activity-ISS-  
GO:0043066negative regulation of apoptotic process-IMP21586138  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IMP21586138  
GO:0043370regulation of CD4-positive, alpha-beta T cell differentiation-ISS-  
GO:0051865protein autoubiquitination-IMP20696164  
GO:2000564regulation of CD8-positive, alpha-beta T cell proliferation-ISS-  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IMP21586138  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-IDA21586138  
GO:0030027lamellipodium-ISS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23644744Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations. (2013 Sep)Deng QCarcinogenesis