Gene: MYH7B

57644
MHC14|MYH14
myosin heavy chain 7B
protein-coding
20q11.22
Ensembl:ENSG00000078814 MIM:609928 Vega:OTTHUMG00000032320 UniprotKB:A7E2Y1
NG_016984.2
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.562e-1 (AD)  9.653e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6579204chr20:34965874 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6088664chr20:34963297 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12390057chr20:33585849MYH7BGene body2.781e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCHO10.861
PLA2G60.846
NACAD0.837
AATK0.837
INF20.827
KLC40.827
ADCK10.825
SEC14L50.825
EML20.804
HID10.803

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EGFLAM-0.478
GJB2-0.457
ARHGEF35-0.457
MTRNR2L8-0.456
MTRNR2L9-0.445
MTRNR2L6-0.444
MTRNR2L2-0.44
MTRNR2L10-0.434
TGFBI-0.428
SDR42E1-0.428

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MYH7B mRNA"28903501
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of MYH7B mRNA"21346803
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of MYH7B mRNA21298039
D001151ArsenicArsenic affects the methylation of MYH7B gene25304211
C006780bisphenol Abisphenol A results in increased methylation of MYH7B promoter24433282
C006780bisphenol Abisphenol A results in decreased expression of MYH7B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MYH7B gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of MYH7B mRNA22079614
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of MYH7B protein"23026733
D002994ClofibrateClofibrate results in decreased expression of MYH7B mRNA22300585
C039281furanfuran results in increased expression of MYH7B mRNA25539665
D007545IsoproterenolIsoproterenol results in decreased expression of MYH7B mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MYH7B mRNA26752646
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of MYH7B protein"23026733
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MYH7B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MYH7B mRNA"25554681
D011441PropylthiouracilPropylthiouracil results in decreased expression of MYH7B mRNA24780913
D013739TestosteroneTestosterone affects the reaction [Testosterone deficiency affects the expression of MYH7B mRNA]21045173
D013739TestosteroneTestosterone deficiency affects the expression of MYH7B mRNA21045173
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of MYH7B mRNA28973375
D013853ThioacetamideThioacetamide results in increased expression of MYH7B mRNA23411599
D014635Valproic AcidValproic Acid results in increased methylation of MYH7B gene29154799
C025643vinclozolinvinclozolin results in increased expression of MYH7B mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IEA-  
GO:0005515protein binding-IPI23455924  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IEA-  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007018microtubule-based movement-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-IEA-  
GO:0032982myosin filament-IEA-  
GO:0097512cardiac myofibril-IEA-  
KEGG ID KEGG Term
hsa04530Tight junction
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal