Gene: DHX37

57647
DDX37|Dhr1
DEAH-box helicase 37
protein-coding
12q24.31
Ensembl:ENSG00000150990 MIM:617362 Vega:OTTHUMG00000168547 UniprotKB:Q8IY37
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.587e-1 (AD)  3.713e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4580006chr12:124976121 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDCD110.869
HMGXB30.858
ABCF10.855
PPAN0.854
DDX540.844
RAB350.844
CSNK1D0.843
GTPBP20.843
DHX160.842
ZZEF10.842

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.505
OR4F29-0.466
MTRNR2L6-0.416
MTRNR2L9-0.401
MTRNR2L10-0.369
OR4F16-0.33
LRRIQ1-0.31
P2RY14-0.305
RSPO1-0.304
KLRC2-0.296

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of DHX37 mRNA25596134
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of DHX37 mRNA"20406850
D000393Air PollutantsAir Pollutants analog results in increased expression of DHX37 mRNA21757418
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of DHX37 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DHX37 mRNA24449571
D001280AtrazineAtrazine results in increased expression of DHX37 mRNA25929836
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DHX37 mRNA28628672
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DHX37 mRNA28628672
D002330CarmustineDHX37 mRNA affects the susceptibility to Carmustine16365179
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of DHX37 mRNA25596134
C059262cidofovircidofovir results in decreased expression of DHX37 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of DHX37 mRNA25596134
D016572CyclosporineCyclosporine results in increased expression of DHX37 mRNA25596134
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DHX37 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DHX37 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of DHX37 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of DHX37 mRNA28302478
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DHX37 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of DHX37 mRNA27776689
D011345FenofibrateFenofibrate results in increased expression of DHX37 mRNA25596134
D007052IbuprofenIbuprofen results in increased expression of DHX37 mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DHX37 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DHX37 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DHX37 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DHX37 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DHX37 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DHX37 mRNA23086925
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of DHX37 mRNA"24972896
D008687MetforminMetformin results in increased expression of DHX37 mRNA25596134
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DHX37 mRNA26011545
D010100OxygenOxygen deficiency affects the expression of DHX37 mRNA25596134
D010795Phthalic AcidsPhthalic Acids results in increased expression of DHX37 mRNA21061450
D011192Potassium DichromatePotassium Dichromate results in decreased expression of DHX37 protein23718831
C047246temozolomideDHX37 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DHX37 mRNA22903824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DHX37 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DHX37 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of DHX37 mRNA23411599
D014520UrethaneUrethane results in decreased expression of DHX37 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DHX37 mRNA25979313

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0034459ATP-dependent 3'-5' RNA helicase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)-IBA21873635  
GO:0006364rRNA processing-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6790901rRNA modification in the nucleus and cytosolIEA
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72312rRNA processingIEA
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolIEA
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNAIEA
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal