Gene: CIP2A

57650
KIAA1524|p90
cell proliferation regulating inhibitor of protein phosphatase 2A
protein-coding
3q13.13
Ensembl:ENSG00000163507 MIM:610643 Vega:OTTHUMG00000159233 UniprotKB:Q8TCG1
NC_000003.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.680e-1 (AD)  8.797e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of CIP2A mRNA22230336
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CIP2A mRNA"20382639
D004958EstradiolEstradiol results in increased expression of CIP2A mRNA19167446
C006780bisphenol Abisphenol A results in decreased expression of CIP2A mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CIP2A mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CIP2A protein24527689
D019327Copper SulfateCopper Sulfate results in decreased expression of CIP2A mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CIP2A mRNA19167446
D000069439DasatinibDasatinib results in decreased expression of CIP2A mRNA20579391
D002945CisplatinCisplatin results in decreased expression of CIP2A mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of CIP2A mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of CIP2A mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CIP2A mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CIP2A protein23301498
D008154LucanthoneLucanthone results in decreased expression of CIP2A mRNA21148553
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CIP2A mRNA26011545
D010126OzoneOzone results in decreased expression of CIP2A mRNA24336422
D010936Plant ExtractsPlant Extracts results in increased expression of CIP2A mRNA23557933
D017035PravastatinPravastatin results in decreased expression of CIP2A mRNA27225895
C005556propionaldehydepropionaldehyde results in decreased expression of CIP2A mRNA26079696
D011794QuercetinQuercetin results in increased expression of CIP2A mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CIP2A mRNA19167446
C017947sodium arsenitesodium arsenite results in decreased expression of CIP2A mRNA17998272
C075117squalestatin 1squalestatin 1 results in decreased expression of CIP2A mRNA27225895
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CIP2A mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CIP2A mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CIP2A mRNA20106945
D014635Valproic AcidValproic Acid affects the expression of CIP2A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CIP2A mRNA23179753|2718838
C029297vinylidene chloridevinylidene chloride results in increased expression of CIP2A mRNA26682919
C111237vorinostatvorinostat results in increased expression of CIP2A mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17632056  28174209  
GO:0042803protein homodimerization activity-IDA28174209  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0007283spermatogenesis-IEA-  
GO:2000179positive regulation of neural precursor cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21655278Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer. (2011)Ma LPLoS One
24046827Increased expression of CIP2A in cholangiocarcinoma and correlation with poor prognosis. (2013 Jun)Xu PHepatogastroenterology
26894380CIP2A down regulation enhances the sensitivity of pancreatic cancer cells to gemcitabine. (2016 Mar 22)Xu POncotarget