Gene: LRRC4C

57689
NGL-1|NGL1
leucine rich repeat containing 4C
protein-coding
11p12
Ensembl:ENSG00000148948 MIM:608817 Vega:OTTHUMG00000166383 UniprotKB:Q9HCJ2
NC_000011.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.821e-1 (AD)  4.295e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10501226chr11:40280456 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4369393chr11:40204831 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26553513chr11:40310738LRRC4C4.430e-8Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLITRK30.945
LRRTM30.942
ATL10.94
GABRA30.934
NMNAT20.931
MYCBP20.93
ADAM220.93
PIK3CB0.929
SYNJ10.929
G3BP20.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.516
COPZ2-0.488
EVC2-0.486
CHST14-0.475
RAB13-0.475
SYDE1-0.473
CSAG1-0.472
RNF135-0.47
TGIF1-0.466
RHOD-0.463

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC4C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC4C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC4C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC4C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC4C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC4C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC4C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC4C mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRRC4C mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of LRRC4C mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LRRC4C gene28505145
D002220CarbamazepineCarbamazepine affects the expression of LRRC4C mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LRRC4C mRNA17484886
D003471CuprizoneCuprizone results in decreased expression of LRRC4C mRNA26577399
C014347decitabinedecitabine results in decreased methylation of LRRC4C gene27923600
D017313FenretinideFenretinide results in decreased expression of LRRC4C mRNA28973697
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LRRC4C mRNA"24972896
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC4C mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of LRRC4C mRNA26272509
D011374ProgesteroneProgesterone results in increased expression of LRRC4C mRNA19690047
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LRRC4C mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LRRC4C mRNA23806026
D012999SomanSoman results in decreased expression of LRRC4C mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRRC4C mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRRC4C mRNA22808131
C011559tributyltintributyltin results in decreased expression of LRRC4C mRNA27614199
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC4C mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of LRRC4C mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of LRRC4C mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC4C mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of LRRC4C mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of LRRC4C mRNA24383497|2627250
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LRRC4C gene25560391
C025643vinclozolinvinclozolin affects the expression of LRRC4C mRNA19015723
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC4C mRNA"27188386
C111237vorinostatvorinostat results in increased expression of LRRC4C mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14595443  21946559  
GO:0050839cell adhesion molecule binding-IPI23986473  
GO:0098632cell-cell adhesion mediator activity-IGI23986473  
GO ID GO Term Qualifier Evidence PubMed
GO:0050770regulation of axonogenesis-IDA14595443  
GO:0099560synaptic membrane adhesion-IGI23986473  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0016020membrane-IDA14595443  
GO:0016021integral component of membrane-NAS14595443  
GO:0030054cell junction-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal