Gene: CPNE5

57699
COPN5|CPN5
copine 5
protein-coding
6p21.2
Ensembl:ENSG00000124772 MIM:604209 Vega:OTTHUMG00000014602 UniprotKB:Q9HCH3
NC_000006.12
PubMed|SNP Mapped
2   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.035e-2 (AD)  6.825e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs75913810chr6:36800584 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7769970chr6:36767703 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23309670chr6:36756830CPNE56.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAP1GAP0.956
PHYHIP0.941
PTPN50.939
EPHB60.938
MAST30.934
CAMKV0.934
SYT70.933
PRKCG0.928
VIPR10.928
PDE1B0.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.522
RAI14-0.484
YES1-0.479
OR4F29-0.478
REST-0.463
WWTR1-0.461
TFPI2-0.46
MBNL3-0.453
CNN2-0.452
COPZ2-0.451

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of CPNE5 mRNA"26377693
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CPNE5 mRNA25088246
C0238294-nitroso-N-phenylanilineCPNE5 gene SNP affects the susceptibility to 4-nitroso-N-phenylaniline25622337
D000082AcetaminophenAcetaminophen results in increased expression of CPNE5 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of CPNE5 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CPNE5 mRNA21298039
D001104ArbutinArbutin results in increased expression of CPNE5 mRNA17103032
D001280AtrazineAtrazine results in decreased expression of CPNE5 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of CPNE5 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPNE5 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPNE5 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPNE5 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPNE5 mRNA22610609
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPNE5 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of CPNE5 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CPNE5 promoter22457795
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPNE5 mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of CPNE5 mRNA27858113
D004041Dietary FatsDietary Fats results in increased expression of CPNE5 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of CPNE5 mRNA26033743
C479799(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in increased expression of CPNE5 mRNA15528975
C024565ethylene dichlorideethylene dichloride results in decreased expression of CPNE5 mRNA28189721
D005839GentamicinsGentamicins results in decreased expression of CPNE5 mRNA22061828
C011890kojic acidkojic acid results in increased expression of CPNE5 mRNA16595896
D007854LeadLead affects the expression of CPNE5 mRNA28903495
C523799MRK 003MRK 003 results in decreased expression of CPNE5 mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CPNE5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CPNE5 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of CPNE5 mRNA19167457
D052638Particulate Matter[CPNE5 gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of CPNE5 mRNA21222557|2122255
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CPNE5 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CPNE5 mRNA18301758
D010936Plant ExtractsPlant Extracts results in decreased expression of CPNE5 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CPNE5 mRNA25895662
D053260SootSoot results in decreased expression of CPNE5 mRNA22461453|2655175
C009495titanium dioxidetitanium dioxide results in decreased expression of CPNE5 mRNA21259345|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CPNE5 mRNA28065790
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CPNE5 mRNA19042947
D014635Valproic AcidValproic Acid results in increased methylation of CPNE5 gene29154799
D001335Vehicle Emissions[CPNE5 gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of CPNE5 mRNA21222557|2122255
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of CPNE5 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005544calcium-dependent phospholipid binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0071277cellular response to calcium ion-IBA21873635  
GO:1903861positive regulation of dendrite extension-IDA23999003  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0043005neuron projection-IEA-  
GO:0043204perikaryon-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26522866Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations. (2015 Dec)Wang KSJ Psychiatr Res