Gene: PTPN1

5770
PTP1B
protein tyrosine phosphatase, non-receptor type 1
protein-coding
20q13.13
Ensembl:ENSG00000196396 MIM:176885 Vega:OTTHUMG00000032729 UniprotKB:P18031
NG_012119.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.485e-1 (AD)  7.803e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP980.882
TMEM430.875
TXLNA0.856
XRN20.855
SEC61A10.855
RAF10.854
WDR10.853
NUP1880.853
CDC42SE10.848
UBE2H0.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.644
OR4F29-0.632
RERGL-0.203
KLRC2-0.194
ACY3-0.19
HES5-0.181
OR6F1-0.159
CRH-0.154
REN-0.15
IAPP-0.149

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01133Tiludronic acidSmall Molecule89987-06-4Approved|InvestigationalTarget
DB017343-(Oxalyl-Amino)-Naphthalene-2-Carboxylic AcidSmall MoleculeExperimentalTarget
DB01820Compound 12, N-Acetyl-4-[(Carboxycarbonyl)(2-Carboxyphenyl)Amino]-N-Pentyl-1-NapthylalaniamideSmall MoleculeExperimentalTarget
DB02014Compound 9Small Molecule-ExperimentalTarget
DB020722-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic AcidSmall MoleculeExperimentalTarget
DB022593-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-AmideSmall MoleculeExperimentalTarget
DB02420[[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,Small MoleculeExperimentalTarget
DB024362-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic AcidSmall MoleculeExperimentalTarget
DB02615Compound 19Small MoleculeExperimentalTarget
DB02620Sp7343-Sp7964Small MoleculeExperimentalTarget
DB026222-(Oxalyl-Amino)-Benzoic AcidSmall MoleculeExperimentalTarget
DB02651{[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)Small MoleculeExperimentalTarget
DB02662Novo Nordisk a/S CompoundSmall MoleculeExperimentalTarget
DB02784N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic AcidSmall MoleculeExperimentalTarget
DB028277-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic AcidSmall MoleculeExperimentalTarget
DB02977PNU177836Small MoleculeExperimentalTarget
DB031022-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic AcidSmall MoleculeExperimentalTarget
DB03154{[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic AcidSmall MoleculeExperimentalTarget
DB033113-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-AmideSmall MoleculeExperimentalTarget
DB034834-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric AcidSmall MoleculeExperimentalTarget
DB03557N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic AcidSmall MoleculeExperimentalTarget
DB03661Cysteinesulfonic AcidSmall MoleculeExperimentalTarget
DB036702-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic AcidSmall MoleculeExperimentalTarget
DB037144-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric AcidSmall MoleculeExperimentalTarget
DB03982Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-BenzoicacidSmall MoleculeExperimentalTarget
DB040016-(Oxalyl-Amino)-1h-Indole-5-Carboxylic AcidSmall MoleculeExperimentalTarget
DB04088N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester)Small MoleculeExperimentalTarget
DB041423-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid DimethylamideSmall MoleculeExperimentalTarget
DB04204[(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic AcidSmall MoleculeExperimentalTarget
DB04285{4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic AcidSmall MoleculeExperimentalTarget
DB045252-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic AcidSmall MoleculeExperimentalTarget
DB048001-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACIDSmall MoleculeExperimentalTarget
DB05506ISIS 113715Small Molecule-InvestigationalTarget
DB06333TrodusquemineBiotechDrug186139-09-3InvestigationalTarget
DB06521ErtiprotafibSmall Molecule251303-04-5InvestigationalTarget
DB068294-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB06887[(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acidSmall MoleculeExperimentalTarget
DB071304-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB071345-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDESmall MoleculeExperimentalTarget
DB071974-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB07263[{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acidSmall MoleculeExperimentalTarget
DB072895-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB072952-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACIDSmall MoleculeExperimentalTarget
DB072983-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB074804-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZENSmall MoleculeExperimentalTarget
DB07651N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDESmall MoleculeExperimentalTarget
DB07719[(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acidSmall MoleculeExperimentalTarget
DB077305-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDESmall MoleculeExperimentalTarget
DB080015-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB08003ISOTHIAZOLIDINONE ANALOGSmall MoleculeExperimentalTarget
DB081474-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acidSmall MoleculeExperimentalTarget
DB08371PARA-(BENZOYL)-PHENYLALANINESmall MoleculeExperimentalTarget
DB083976-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB08549(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTERSmall MoleculeExperimentalTarget
DB085915-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDESmall MoleculeExperimentalTarget
DB085931,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDESmall MoleculeExperimentalTarget
DB08783(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acidSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0407561,2-naphthoquinone"1,2-naphthoquinone results in decreased activity of PTPN1 protein"24067727
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PTPN1 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPN1 protein"24978599
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPN1 protein"24978599
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPN1 protein"24978599
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PTPN1 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PTPN1 mRNA]12710931
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of PTPN1 mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PTPN1 mRNA"21346803
C4059432-(oxalylamino)benzoic acid2-(oxalylamino)benzoic acid analog binds to and results in decreased activity of PTPN1 protein10744717
C4059432-(oxalylamino)benzoic acid2-(oxalylamino)benzoic acid results in decreased activity of PTPN1 protein10744717
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PTPN1 protein26194647
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTPN1 mRNA"23196670
C4411283-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate"3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate results in decreased activity of PTPN1 protein"20075852
C4411283-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate"3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate results in decreased activity of PTPN1 protein"21341673|2428756
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of PTPN1 mRNA12419474
D000082AcetaminophenAcetaminophen affects the expression of PTPN1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]22917016
D000171AcroleinAcrolein results in decreased activity of PTPN1 protein17655273
D000171AcroleinVanadates inhibits the reaction [Acrolein results in decreased activity of PTPN1 protein]17655273
D000244Adenosine DiphosphateAdenosine Diphosphate results in increased glutathionylation of PTPN1 protein16781456
D000244Adenosine DiphosphateCAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein]16781456
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of PTPN1 protein26072098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTPN1 mRNA16483693
D000728AndrogensAndrogens affects the expression of and affects the activity of PTPN1 protein16652382
C031385anthranilic acid[oxovanadium IV binds to anthranilic acid analog] which results in decreased activity of PTPN1 protein22864521
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PTPN1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of PTPN1 mRNA22521957
D019817Benzoic AcidBenzoic Acid analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate]24287560
D019817Benzoic AcidBenzoic Acid analog results in decreased activity of PTPN1 protein24287560
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTPN1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTPN1 mRNA"19150397
D004958EstradiolEstradiol affects the expression of PTPN1 mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of PTPN1 mRNA21179406
C074212bis(maltolato)oxovanadium(IV)bis(maltolato)oxovanadium(IV) results in decreased activity of PTPN1 protein22864521
C006780bisphenol Abisphenol A affects the expression of PTPN1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PTPN1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PTPN1 mRNA12075121|2518105
C006780bisphenol Abisphenol A results in increased methylation of PTPN1 gene28505145
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased oxidation of PTPN1 protein20482862
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PTPN1 mRNA20360939
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PTPN1 mRNA26739621
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PTPN1 protein26739621
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PTPN1 mRNA24763279
C100187chloropicrinchloropicrin results in increased expression of PTPN1 mRNA26352163
D002791Cholesterol, Dietary"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of PTPN1 protein"19509184
D002857ChromiumChromium results in decreased expression of and results in decreased activity of PTPN1 protein16424121
C079689chromium tripicolinatechromium tripicolinate results in decreased expression of and results in decreased activity of PTPN1 protein16424121
C012843cinnamic aldehydecinnamic aldehyde analog results in decreased activity of PTPN1 protein12186556
C007095cobaltiprotoporphyrin[SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of PTPN1 mRNA26026874
C007095cobaltiprotoporphyrin[SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of PTPN1 protein26026874
C007095cobaltiprotoporphyrinstannous mesoporphyrin inhibits the reaction [[SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of PTPN1 protein]26026874
D003300CopperCopper results in decreased activity of PTPN1 protein20383386
D003375CoumestrolCoumestrol results in decreased expression of PTPN1 mRNA19167446
C037886cryptotanshinonecryptotanshinone results in decreased activity of PTPN1 protein29031618
D003471CuprizoneCuprizone results in decreased expression of PTPN1 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PTPN1 mRNA23640034
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of PTPN1 mRNA]26739621
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of PTPN1 protein]26739621
D003907DexamethasonePTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]26739621
D003907DexamethasonePTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]26739621
D003907DexamethasonePTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]26739621
D003907DexamethasonePTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]]26739621
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PTPN1 mRNA21266533
D004008DiclofenacDiclofenac results in increased expression of PTPN1 mRNA26934552
D004041Dietary Fats"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of PTPN1 protein"19509184
D004041Dietary FatsDietary Fats results in increased expression of PTPN1 protein22509299|2741725
D004041Dietary Fats"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in increased expression of PTPN1 protein]"27417254
D004041Dietary FatsPTPN1 gene mutant form results in increased susceptibility to Dietary Fats22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased activity of and results in increased phosphorylation of EIF2AK3 protein22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased cleavage of ATF6 protein22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased cleavage of DDIT3 protein22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of DDIT3 mRNA22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of HSPA5 mRNA22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of HSPA5 protein22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of XBP1 protein22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased phosphorylation of EIF2S1 protein22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased splicing of XBP1 mRNA22509299
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PTPN1 mRNA20360939
D002117CalcitriolCalcitriol results in increased expression of PTPN1 mRNA16002434
C472511dimethylarsinous aciddimethylarsinous acid binds to PTPN1 protein22771847
C472511dimethylarsinous aciddimethylarsinous acid results in decreased activity of PTPN1 protein22771847
D004147DioxinsDioxins affects the expression of PTPN1 mRNA20463971
D004229DithiothreitolDithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]16781456
D004791Enzyme InhibitorsEnzyme Inhibitors results in decreased activity of PTPN1 protein22366233
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTPN1 mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PTPN1 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPN1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTPN1 mRNA12075121|1265503
D005419FlavonoidsFlavonoids results in decreased expression of PTPN1 mRNA18035473
D005632Fructose"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of PTPN1 protein"19509184
C015896fucosterolfucosterol results in decreased activity of PTPN1 protein23994501
C000599091fumosorinonefumosorinone results in decreased expression of PTPN1 protein25796170
C000599091fumosorinonefumosorinone results in decreased expression of PTPN1 protein25796170
D019833GenisteinGenistein results in increased expression of PTPN1 mRNA12075121
C063349glisoflavoneglisoflavone results in decreased activity of PTPN1 protein20724155
C004312glycidolglycidol results in increased expression of PTPN1 mRNA24915197
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PTPN1 mRNA24763279
D017313FenretinideFenretinide results in increased expression of PTPN1 mRNA28973697
D006861Hydrogen PeroxideDithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]16781456
D006861Hydrogen PeroxideHydrogen Peroxide results in increased glutathionylation of PTPN1 protein16781456
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PTPN1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of PTPN1 mRNA]26739621
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of PTPN1 protein]26739621
D0150561-Methyl-3-isobutylxanthinePTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]26739621
D0150561-Methyl-3-isobutylxanthinePTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]26739621
D0150561-Methyl-3-isobutylxanthinePTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]26739621
D0150561-Methyl-3-isobutylxanthinePTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]]26739621
C040920isoliquiritigeninisoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein]27117918
C512915isothiazolidinoneisothiazolidinone analog results in decreased activity of PTPN1 protein17028182
D048628KetolidesKetolides analog results in increased expression of PTPN1 mRNA24967691
D008095Lithocholic AcidLithocholic Acid analog results in decreased activity of PTPN1 protein23067554
D008095Lithocholic AcidLithocholic Acid results in decreased activity of PTPN1 protein23067554
D008627Mercuric ChlorideMercuric Chloride affects the expression of PTPN1 mRNA20353558
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in increased expression of PTPN1 protein]"27417254
C004925methylmercuric chloridemethylmercuric chloride results in decreased activity of PTPN1 protein28958600
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PTPN1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PTPN1 mRNA]12710931
C406082monomethylarsonous acidmonomethylarsonous acid binds to PTPN1 protein22771847
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased activity of PTPN1 protein22771847
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PTPN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTPN1 mRNA"25554681|2562005
C008644nitrophenylphosphateBenzoic Acid analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate]24287560
C008644nitrophenylphosphatePTPN1 protein results in increased hydrolysis of nitrophenylphosphate24287560
C008644nitrophenylphosphateThiazolidines analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate]24287560
D009942Organometallic CompoundsOrganometallic Compounds binds to and results in decreased activity of PTPN1 protein20383386
D009942Organometallic CompoundsOrganometallic Compounds results in decreased activity of PTPN1 protein22027948
C075743oxovanadium IV[oxovanadium IV binds to anthranilic acid analog] which results in decreased activity of PTPN1 protein22864521
C075743oxovanadium IV[oxovanadium IV binds to salicylideneaniline analog] which results in decreased activity of PTPN1 protein22864521
C075743oxovanadium IV[oxovanadium IV binds to Schiff Bases] which results in decreased activity of PTPN1 protein22864521
D019308Palmitic AcidPalmitic Acid results in increased expression of PTPN1 protein22509299
C016030pantogabpantogab results in increased expression of PTPN1 mRNA17379144
C410127PCB 180"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPN1 protein"24978599
C410127PCB 180"[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPN1 protein"24978599
C076715pervanadatepervanadate results in decreased activity of PTPN1 protein22384078
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PTPN1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PTPN1 mRNA18301758
D010936Plant ExtractsPlant Extracts results in decreased activity of PTPN1 protein18534569
C008704pyrithione[Zinc co-treated with pyrithione] results in decreased activity of PTPN1 protein22374166
D011765PyruvaldehydeAcetylcysteine inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]22917016
D011765PyruvaldehydeNFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]22917016
D011765PyruvaldehydePyruvaldehyde results in increased expression of PTPN1 protein22917016
D011765Pyruvaldehyderosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]22917016
D011794QuercetinQuercetin inhibits the reaction [TNF protein results in increased expression of PTPN1 mRNA]20943792
C059514resveratrolNFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]22917016
C059514resveratrolresveratrol results in increased activity of PTPN1 protein18567737
C059514resveratrol[resveratrol results in increased activity of PTPN1 protein] which results in decreased phosphorylation of PDGFRB protein18567737
C059514resveratrol[[resveratrol results in increased activity of PTPN1 protein] which results in decreased phosphorylation of PDGFRB protein] which results in decreased phosphorylation of MAPK1 protein18567737
C059514resveratrol[[resveratrol results in increased activity of PTPN1 protein] which results in decreased phosphorylation of PDGFRB protein] which results in decreased phosphorylation of MAPK3 protein18567737
C059514resveratrolPTPN1 protein results in increased susceptibility to resveratrol20026400
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form results in increased activity of PTPN1 protein]20028942
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form results in increased expression of PTPN1 mRNA]20028942|2580821
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form results in increased expression of PTPN1 protein]25808216
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in increased expression of PTPN1 protein]25808216
C059514resveratrolresveratrol results in increased expression of PTPN1 protein25505154
C089730rosiglitazonerosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]22917016
C022850rutamarinrutamarin results in decreased activity of PTPN1 protein22384078
C510217salicylideneaniline[oxovanadium IV binds to salicylideneaniline analog] which results in decreased activity of PTPN1 protein22864521
D012545Schiff Bases[oxovanadium IV binds to Schiff Bases] which results in decreased activity of PTPN1 protein22864521
D064586Selenic AcidSelenic Acid results in decreased activity of PTPN1 protein22366233
D064586Selenic AcidSelenic Acid results in increased expression of PTPN1 mRNA16443359
D012643SeleniumSelenium results in decreased glutathionylation of PTPN1 protein19022953
D012643SeleniumSelenium results in increased expression of PTPN1 protein19022953
D012645SelenomethionineSelenomethionine results in decreased expression of PTPN1 mRNA23399444
C078903seocalcitolseocalcitol results in increased expression of PTPN1 mRNA12040012
D012822Silicon DioxideSilicon Dioxide results in increased expression of PTPN1 mRNA23221170
D018038Sodium SeleniteSodium Selenite results in decreased activity of PTPN1 protein22366233
D018038Sodium SeleniteSodium Selenite results in increased expression of PTPN1 mRNA16443359
D053260SootSoot results in increased expression of PTPN1 mRNA26551751
C518404stannous mesoporphyrinstannous mesoporphyrin inhibits the reaction [[SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of PTPN1 protein]26026874
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in increased expression of PTPN1 protein]25808216
D013311StreptozocinStreptozocin results in increased expression of PTPN1 protein25808216
D013629TamoxifenTamoxifen affects the expression of PTPN1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTPN1 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPN1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPN1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PTPN1 mRNA25613284
C020809tetrathiomolybdatetetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein]18480265
D019284ThapsigarginPTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein]22509299
D019284ThapsigarginPTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2S1 protein]22509299
D019284ThapsigarginPTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]22509299
D019284ThapsigarginPTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]22509299
D019284ThapsigarginPTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]22509299
D019284ThapsigarginPTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]22509299
D019284ThapsigarginPTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of XBP1 mRNA]22509299
D019284ThapsigarginPTPN1 gene mutant form results in increased susceptibility to Thapsigargin22509299
D053778ThiazolidinesThiazolidines analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate]24287560
D053778ThiazolidinesThiazolidines analog results in decreased activity of PTPN1 protein24287560
D014415TunicamycinPTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein]22509299
D014415TunicamycinPTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased activity of and results in increased phosphorylation of EIF2S1 protein]22509299
D014415TunicamycinPTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased expression of DDIT3 protein]22509299
D014415TunicamycinPTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased expression of HSPA5 protein]22509299
D014415TunicamycinPTPN1 gene mutant form results in increased susceptibility to Tunicamycin22509299
C514931UA 0713UA 0713 results in decreased activity of PTPN1 protein26214522
C578831umbelliferone 6-carboxylic acidumbelliferone 6-carboxylic acid results in decreased activity of PTPN1 protein27085377
C005466ursolic acidursolic acid results in decreased activity of PTPN1 protein27085377
D014635Valproic AcidValproic Acid results in increased expression of PTPN1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of PTPN1 mRNA20546886
D014638VanadatesVanadates inhibits the reaction [Acrolein results in decreased activity of PTPN1 protein]17655273
D014638VanadatesVanadates results in decreased activity of PTPN1 protein15924436
D014638VanadatesVanadates results in decreased activity of PTPN1 protein18534569|2237416
D014638VanadatesVanadates results in increased expression of PTPN1 protein17874149
C034028vanadyl sulfatevanadyl sulfate results in decreased activity of PTPN1 protein10460753
C025643vinclozolinvinclozolin results in decreased expression of PTPN1 mRNA23034163
C111237vorinostatvorinostat results in increased expression of PTPN1 mRNA26238599
D015032ZincZinc results in decreased activity of PTPN1 protein14644152
D015032Zinc[Zinc co-treated with pyrithione] results in decreased activity of PTPN1 protein22374166
D019287Zinc SulfateZinc Sulfate results in increased expression of PTPN1 mRNA27504894
D019287Zinc SulfateZinc Sulfate results in decreased activity of PTPN1 protein10460753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0004725protein tyrosine phosphatase activity-IDA18074158  21707536  22169477  
GO:0004725protein tyrosine phosphatase activity-TAS-  
GO:0005158insulin receptor binding-IEA-  
GO:0005515protein binding-IPI8702689  8940134  8999839  9050838  9355745  9407132  
9418872  9566916  9600099  10660596  10889023  11007774  
11106648  11163213  11506178  11579209  11694501  11970898  
12023880  12176037  12237455  12614164  12634852  12857726  
12907755  14527337  14722096  15588987  15821101  15866871  
15894168  15976035  16115959  16271887  16388599  16537444  
16582879  16644720  16926280  17092689  17128263  17159996  
17197020  17416557  17481567  17974954  18387954  18515860  
18579758  19029027  19167335  19712109  20627780  21806020  
21972092  22789536  24658140  24976139  25796184  
GO:0008270zinc ion binding-IDA18074158  
GO:0019899enzyme binding-IPI22169477  
GO:0019901protein kinase binding-IPI22169477  
GO:0030971receptor tyrosine kinase binding-IPI18819921  
GO:0045296cadherin binding-HDA25468996  
GO:0046875ephrin receptor binding-IPI21135139  
GO:0051721protein phosphatase 2A binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IMP22045810  
GO:0007257activation of JUN kinase activity-IEA-  
GO:0008286insulin receptor signaling pathway-IEA-  
GO:0009966regulation of signal transduction-IMP21135139  
GO:0009968negative regulation of signal transduction-TAS-  
GO:0030100regulation of endocytosis-IDA21135139  
GO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathway-ISS-  
GO:0030968endoplasmic reticulum unfolded protein response-IDA22169477  
GO:0031532actin cytoskeleton reorganization-IMP21135139  
GO:0033157regulation of intracellular protein transport-IMP22045810  
GO:0034620cellular response to unfolded protein-TAS22013210  
GO:0035335peptidyl-tyrosine dephosphorylation-IDA21135139  
GO:0035335peptidyl-tyrosine dephosphorylation-IMP14966296  
GO:0035791platelet-derived growth factor receptor-beta signaling pathway-IMP14966296  
GO:0036498IRE1-mediated unfolded protein response-IEA-  
GO:0043407negative regulation of MAP kinase activity-IMP22045810  
GO:0046627negative regulation of insulin receptor signaling pathway-NAS11742412  
GO:0060338regulation of type I interferon-mediated signaling pathway-TAS-  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TAS-  
GO:0061098positive regulation of protein tyrosine kinase activity-IDA21216966  
GO:0070373negative regulation of ERK1 and ERK2 cascade-ISS-  
GO:1902202regulation of hepatocyte growth factor receptor signaling pathway-IMP18819921  
GO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IEA-  
GO:1903896positive regulation of IRE1-mediated unfolded protein response-TAS22013210  
GO:1903898negative regulation of PERK-mediated unfolded protein response-IDA21216966  
GO:1990264peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity-ISS-  
GO:2000646positive regulation of receptor catabolic process-IMP22045810  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-IDA21135139  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membranecolocalizes_withIDA21135139  
GO:0097443sorting endosome-ISS-  
GO:0098554cytoplasmic side of endoplasmic reticulum membrane-IDA1739967  
KEGG ID KEGG Term
hsa04520Adherens junction
hsa04910Insulin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-354192Integrin alphaIIb beta3 signalingTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6807004Negative regulation of MET activityTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS
R-HSA-877300Interferon gamma signalingIEA
R-HSA-877312Regulation of IFNG signalingIEA
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849472PTK6 Down-RegulationTAS
R-HSA-9006921Integrin signalingTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-912694Regulation of IFNA signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA
R-HSA-982772Growth hormone receptor signalingIEA
R-HSA-982772Growth hormone receptor signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28287835Single Nucleotide Polymorphisms in the PTPN1 Gene Are Associated with Susceptibility to Esophageal Squamous Cell Carcinoma: A Case-Control Study in Inner Mongolia, China. (2017 May)Ji HBGenet Test Mol Biomarkers