Gene: PTPN2

5771
PTN2|PTPT|TC-PTP|TCELLPTP|TCPTP
protein tyrosine phosphatase, non-receptor type 2
protein-coding
18p11.21
Ensembl:ENSG00000175354 MIM:176887 Vega:OTTHUMG00000131702 UniprotKB:P17706
NG_029116.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.710e-2 (AD)  5.735e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF1490.866
ERP440.855
CREG10.852
USP150.851
ADPGK0.848
HEXB0.832
IFNGR20.83
PTBP30.828
NSMAF0.826
FKBP150.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.487
OR4F29-0.455
HES5-0.349
HPSE2-0.312
PYGM-0.287
ARSF-0.274
NXNL1-0.274
DIAPH3-0.271
KCNJ16-0.267
NWD1-0.258

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PTPN2 mRNA"19162173
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PTPN2 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PTPN2 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PTPN2 mRNA"19114083
D000082AcetaminophenAcetaminophen affects the expression of PTPN2 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTPN2 mRNA16483693
C031385anthranilic acid[oxovanadium IV binds to anthranilic acid analog] which results in decreased activity of PTPN2 protein22864521
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PTPN2 mRNA24449571
D001280AtrazineAtrazine results in increased expression of PTPN2 mRNA18585445
D019817Benzoic AcidBenzoic Acid analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]24287560
D019817Benzoic AcidBenzoic Acid analog results in decreased activity of PTPN2 protein24287560
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPN2 mRNA20064835
C074212bis(maltolato)oxovanadium(IV)bis(maltolato)oxovanadium(IV) results in decreased activity of PTPN2 protein11936837
C472777bisperoxovanadiumPTPN2 protein affects the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]12493747
C006780bisphenol Abisphenol A results in decreased expression of PTPN2 mRNA20678512|2927551
C006780bisphenol Abisphenol A results in increased expression of PTPN2 mRNA25181051
D002087ButyratesButyrates results in decreased expression of PTPN2 mRNA14674679
D016572CyclosporineCyclosporine results in increased expression of PTPN2 mRNA25562108
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PTPN2 mRNA16556975
D003907DexamethasoneDexamethasone results in decreased expression of PTPN2 mRNA21356098
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PTPN2 mRNA21266533
D004008DiclofenacDiclofenac results in increased expression of PTPN2 mRNA26934552
C000944dicrotophosdicrotophos results in decreased expression of PTPN2 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of PTPN2 mRNA25016146
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of PTPN2 mRNA20064776
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTPN2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPN2 mRNA17942748
D005419FlavonoidsFlavonoids results in decreased expression of PTPN2 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PTPN2 mRNA28329830
D005839GentamicinsGentamicins results in increased expression of PTPN2 mRNA22061828
D005897GlafenineGlafenine results in increased expression of PTPN2 mRNA24136188
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PTPN2 mRNA16556975
D017313FenretinideFenretinide results in increased expression of PTPN2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PTPN2 mRNA18951874
C492448ICG 001ICG 001 results in decreased expression of PTPN2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PTPN2 mRNA25613284
C410337K 7174K 7174 results in increased expression of PTPN2 mRNA24086573
C008261lead acetatelead acetate results in decreased expression of PTPN2 mRNA21829687
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTPN2 mRNA"18930950
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PTPN2 mRNA21641980
C013598methoxyacetic acidmethoxyacetic acid affects the expression of PTPN2 mRNA20864626
D008731MethoxychlorMethoxychlor results in decreased expression of PTPN2 mRNA21782745
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PTPN2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTPN2 mRNA"25554681
D009532NickelNickel results in increased expression of PTPN2 mRNA24768652|2558310
C008644nitrophenylphosphateBenzoic Acid analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]24287560
C008644nitrophenylphosphatePTPN2 protein results in increased hydrolysis of nitrophenylphosphate24287560
C008644nitrophenylphosphateThiazolidines analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]24287560
D009942Organometallic CompoundsOrganometallic Compounds results in decreased activity of PTPN2 protein22027948
C075743oxovanadium IV[oxovanadium IV binds to anthranilic acid analog] which results in decreased activity of PTPN2 protein22864521
C075743oxovanadium IV[oxovanadium IV binds to salicylideneaniline analog] which results in decreased activity of PTPN2 protein22864521
C075743oxovanadium IV[oxovanadium IV binds to Schiff Bases] which results in decreased activity of PTPN2 protein22864521
C016030pantogabpantogab results in increased expression of PTPN2 mRNA17379144
C006253pirinixic acidpirinixic acid results in increased expression of PTPN2 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PTPN2 mRNA28903501
D011794QuercetinQuercetin results in decreased expression of PTPN2 mRNA21356098
C510217salicylideneaniline[oxovanadium IV binds to salicylideneaniline analog] which results in decreased activity of PTPN2 protein22864521
D012545Schiff Bases[oxovanadium IV binds to Schiff Bases] which results in decreased activity of PTPN2 protein22864521
D012822Silicon DioxideSilicon Dioxide results in increased expression of PTPN2 mRNA23221170
D053260SootSoot results in increased expression of PTPN2 mRNA26551751
D010042OuabainOuabain results in decreased expression of PTPN2 mRNA16412265
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PTPN2 mRNA21641980
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPN2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PTPN2 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PTPN2 mRNA25613284
D013806TheophyllineTheophylline results in increased expression of PTPN2 mRNA18951874
D053778ThiazolidinesThiazolidines analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]24287560
D053778ThiazolidinesThiazolidines analog results in decreased activity of PTPN2 protein24287560
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PTPN2 mRNA28111298
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of PTPN2 mRNA"21356098
C483909torcetrapibtorcetrapib results in increased expression of PTPN2 mRNA23228038
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of PTPN2 gene27618143
C012589trichostatin Atrichostatin A affects the expression of PTPN2 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of PTPN2 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PTPN2 mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTPN2 mRNA"18930950
D014635Valproic AcidValproic Acid results in decreased expression of PTPN2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of PTPN2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PTPN2 mRNA15901671
D014638VanadatesVanadates results in decreased expression of PTPN2 mRNA22714537
D012256RiboflavinRiboflavin results in decreased expression of PTPN2 mRNA21356098

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-EXP12138178  
GO:0004725protein tyrosine phosphatase activity-IDA12612081  
GO:0004725protein tyrosine phosphatase activity-IMP11909529  14966296  
GO:0004725protein tyrosine phosphatase activity-TAS-  
GO:0004726non-membrane spanning protein tyrosine phosphatase activity-IEA-  
GO:0005178integrin binding-IPI15592458  
GO:0005515protein binding-IPI12907755  15696169  16595549  22080863  
GO:0019901protein kinase binding-IPI11909529  
GO:0019905syntaxin binding-IPI23006999  
GO:0030971receptor tyrosine kinase binding-IPI18819921  
GO:0097677STAT family protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0008285negative regulation of cell proliferation-IMP15592458  
GO:0008286insulin receptor signaling pathway-ISS-  
GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway-ISS-  
GO:0010888negative regulation of lipid storage-ISS-  
GO:0030183B cell differentiation-ISS-  
GO:0030217T cell differentiation-ISS-  
GO:0030218erythrocyte differentiation-ISS-  
GO:0035335peptidyl-tyrosine dephosphorylation-IMP11909529  14966296  
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway-IMP15592458  
GO:0042532negative regulation of tyrosine phosphorylation of STAT protein-IMP12138178  
GO:0042593glucose homeostasis-ISS-  
GO:0045650negative regulation of macrophage differentiation-ISS-  
GO:0045722positive regulation of gluconeogenesis-ISS-  
GO:0046627negative regulation of insulin receptor signaling pathway-ISS-  
GO:0050728negative regulation of inflammatory response-ISS-  
GO:0050860negative regulation of T cell receptor signaling pathway-ISS-  
GO:0050922negative regulation of chemotaxis-ISS-  
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TAS-  
GO:0060336negative regulation of interferon-gamma-mediated signaling pathway-ISS-  
GO:0060339negative regulation of type I interferon-mediated signaling pathway-IMP11909529  
GO:0061099negative regulation of protein tyrosine kinase activity-IEA-  
GO:0070104negative regulation of interleukin-6-mediated signaling pathway-IEA-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-ISS-  
GO:0071345cellular response to cytokine stimulus-TAS-  
GO:1902202regulation of hepatocyte growth factor receptor signaling pathway-IMP18819921  
GO:1902206negative regulation of interleukin-2-mediated signaling pathway-IMP11909529  
GO:1902215negative regulation of interleukin-4-mediated signaling pathway-IEA-  
GO:1902227negative regulation of macrophage colony-stimulating factor signaling pathway-ISS-  
GO:1902233negative regulation of positive thymic T cell selection-ISS-  
GO:1902237positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IEA-  
GO:1903899positive regulation of PERK-mediated unfolded protein response-IEA-  
GO:2000587negative regulation of platelet-derived growth factor receptor-beta signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005783endoplasmic reticulum-IDA10940933  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IDA23006999  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membranecolocalizes_withIDA15592458  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6807004Negative regulation of MET activityTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-877312Regulation of IFNG signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9008059Interleukin-37 signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19953089Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease. (2010 May)van der Heide FAm J Gastroenterol
23577190PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)Suzuki TPLoS One