Gene: PRX

57716
CMT4F
periaxin
protein-coding
19q13.2
Ensembl:ENSG00000105227 MIM:605725 Vega:OTTHUMG00000182597 UniprotKB:Q9BXM0
NG_007979.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.008e-1 (AD)  1.914e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01447828chr19:40919465PRX7.100e-12Smoking27651444
cg15393221chr19:40919485PRX5.300e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STARD80.763
FGR0.755
TIE10.749
PKN30.748
TGM20.746
PODXL0.739
FLT10.736
ACSL50.731
DOCK60.729
SLC52A30.724

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.383
SMIM18-0.35
VWC2-0.332
PPEF1-0.322
ST8SIA2-0.321
ABCC12-0.321
AARD-0.312
ADRA1D-0.309
HCRTR2-0.305
CRHBP-0.305

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PRX mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRX mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PRX mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRX mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRX mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRX mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRX mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of PRX mRNA29067470
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRX mRNA16483693
D001280AtrazineAtrazine results in decreased expression of PRX mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRX mRNA21569818|2261060
D004958EstradiolEstradiol affects the expression of PRX mRNA23557687
C006780bisphenol Abisphenol A affects the expression of PRX mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of PRX mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of PRX mRNA19549813
D004041Dietary FatsDietary Fats results in increased expression of PRX mRNA18042831
C069837fullerene C60fullerene C60 results in increased expression of PRX mRNA19167457
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PRX mRNA20044591
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRX mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of PRX mRNA19167457
D000073878Palm OilPalm Oil results in increased expression of PRX mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRX mRNA"25510870
D010705PhosgenePhosgene affects the expression of PRX mRNA16300373
D012643SeleniumSelenium results in increased expression of PRX mRNA19244175
D012999SomanSoman results in increased expression of PRX mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRX mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRX mRNA19933214
C009495titanium dioxidetitanium dioxide results in decreased expression of PRX mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of PRX gene26756918
D014520UrethaneUrethane results in increased expression of PRX mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of PRX gene29154799
D014635Valproic AcidValproic Acid affects the expression of PRX mRNA17292431
C025643vinclozolinvinclozolin affects the expression of PRX mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI17474147  21044950  
GO ID GO Term Qualifier Evidence PubMed
GO:0008366axon ensheathment-NAS11133365  
GO:0043484regulation of RNA splicing-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA24633211  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA24633211  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030315T-tubule-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18179358Does the oxidative stress in chronic obstructive pulmonary disease cause thioredoxin/peroxiredoxin oxidation? (2008 Apr)Lehtonen STAntioxid Redox Signal
24296751Autoantibodies as potential biomarkers for the early detection of esophageal squamous cell carcinoma. (2014 Jan)Xu YWAm J Gastroenterol