Gene: IGDCC4

57722
DDM36|NOPE
immunoglobulin superfamily DCC subclass member 4
protein-coding
15q22.31
Ensembl:ENSG00000103742 MIM:616810 Vega:OTTHUMG00000133136 UniprotKB:Q8TDY8
NC_000015.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.482e-1 (AD)  7.335e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM189A20.807
ASAP30.797
ERBB20.795
ARHGEF60.793
ITGB40.79
MTM10.786
DOCK70.784
AQP40.781
PLCD10.78
LIMK20.778

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VIT-0.376
ADRA1D-0.374
ABCC12-0.37
CRH-0.36
DUSP27-0.359
KRT5-0.356
KCNS3-0.353
HCRTR1-0.347
VGF-0.343
KRT83-0.34

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of IGDCC4 mRNA16788091
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of IGDCC4 mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGDCC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGDCC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGDCC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGDCC4 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of IGDCC4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IGDCC4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IGDCC4 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IGDCC4 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of IGDCC4 mRNA24449571
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of IGDCC4 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IGDCC4 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IGDCC4 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IGDCC4 mRNA"20382639
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of IGDCC4 mRNA25912373
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGDCC4 mRNA20938992
D003471CuprizoneCuprizone results in decreased expression of IGDCC4 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of IGDCC4 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of IGDCC4 mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of IGDCC4 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of IGDCC4 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of IGDCC4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of IGDCC4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of IGDCC4 mRNA25270620
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IGDCC4 mRNA24535843
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of IGDCC4 mRNA23649840
D005047EtoposideEtoposide results in increased expression of IGDCC4 mRNA25270620
C540355fenamidonefenamidone results in increased expression of IGDCC4 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGDCC4 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of IGDCC4 mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of IGDCC4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IGDCC4 mRNA26752646
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGDCC4 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of IGDCC4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IGDCC4 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IGDCC4 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IGDCC4 mRNA"26251327
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of IGDCC4 mRNA25270620
D016685MitomycinMitomycin results in increased expression of IGDCC4 mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of IGDCC4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IGDCC4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IGDCC4 mRNA"25620056
D009532NickelNickel results in decreased expression of IGDCC4 mRNA24768652
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of IGDCC4 mRNA25729387
C046012pentanalpentanal results in increased expression of IGDCC4 mRNA26079696
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of IGDCC4 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of IGDCC4 mRNA17426115|2081375
C005556propionaldehydepropionaldehyde results in increased expression of IGDCC4 mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of IGDCC4 mRNA27029645
D011794QuercetinQuercetin results in increased expression of IGDCC4 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IGDCC4 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGDCC4 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IGDCC4 mRNA18691609
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IGDCC4 mRNA19770486
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of IGDCC4 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of IGDCC4 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGDCC4 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of IGDCC4 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IGDCC4 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGDCC4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of IGDCC4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of IGDCC4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of IGDCC4 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IGDCC4 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of IGDCC4 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of IGDCC4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28264723Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. (2017 Mar 7)Lin XBMC Med
24398667Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers. (2014 Jun)Tessema MCarcinogenesis