Gene info: ID 57761

Gene: TRIB3

GENE ID: 57761

Synonyms: C20orf97|NIPK|SINK|SKIP3|TRB3

Description: tribbles pseudokinase 3

Gene type: protein-coding

Location: 20p13

dbXrefs: Ensembl:ENSG00000101255 MIM:607898 Vega:OTTHUMG00000031627 UniprotKB:Q96RU7

RefSeq: NC_000020.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.745e-1 (AD) 7.045e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SESN2	0.774
KLHL25	0.758
STK40	0.706
ZFAND2A	0.701
TMIE	0.692
SHMT2	0.666
NFKBIE	0.663
MED26	0.663
MRPL18	0.662
NKIRAS2	0.66

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SNX22	-0.297
OR4F5	-0.282
OMD	-0.273
SLCO1A2	-0.269
PDE11A	-0.268
CTNNA3	-0.262
PAIP2B	-0.26
C5orf64	-0.257
OR4F29	-0.255
MYOM1	-0.249

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TRIB3 mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TRIB3 mRNA]"	27071940
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of TRIB3 mRNA"	19162173
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TRIB3 mRNA"	22698814\|2890350
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of TRIB3 mRNA	28329830
C032668	1-nitropyrene	1-nitropyrene results in increased expression of TRIB3 mRNA	19041380
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TRIB3 mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TRIB3 mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of TRIB3 mRNA"	19095052
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [TRIB3 protein affects the expression of ACOX1 protein]"	21190014
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [TRIB3 protein affects the expression of CD36 protein]"	21190014
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [TRIB3 protein affects the expression of CEBPA protein]"	21190014
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [TRIB3 protein affects the expression of PPARG protein]"	21190014
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in increased expression of TRIB3 mRNA	22193206
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TRIB3 mRNA"	21346803
C012796	2-butenal	2-butenal results in increased expression of TRIB3 mRNA	20471460
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TRIB3 mRNA"	22262711
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TRIB3 mRNA"	20959002
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in decreased expression of TRIB3 mRNA"	24172598
C549543	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of TRIB3 mRNA	25716159
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of TRIB3 mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of TRIB3 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of TRIB3 mRNA"	19561079
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA	24291486
C027576	4-hydroxy-2-nonenal	4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]	24291486
C027576	4-hydroxy-2-nonenal	Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]	24291486
C121358	4-phenylbutylamine	4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]	24291486
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of TRIB3 mRNA"	19936915
D000082	Acetaminophen	Acetaminophen affects the expression of TRIB3 mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in increased expression of TRIB3 mRNA	21420995\|2673962
D000082	Acetaminophen	Acetaminophen affects the expression of TRIB3 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of TRIB3 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TRIB3 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in increased expression of TRIB3 mRNA	17202762
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [elesclomol results in increased expression of TRIB3 mRNA]	18723479
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]	24291486
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TRIB3 mRNA	21632981\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TRIB3 mRNA	19770486
C038491	allyl sulfide	allyl sulfide promotes the reaction [Ethanol results in increased expression of TRIB3 mRNA]	20116195
C103505	AM 251	AM 251 results in increased expression of TRIB3 mRNA	16500647
D000638	Amiodarone	Amiodarone affects the expression of TRIB3 mRNA	25064622
D000638	Amiodarone	Amiodarone results in increased expression of TRIB3 mRNA	19774075
D000638	Amiodarone	Amiodarone results in increased expression of TRIB3 mRNA	24535564
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TRIB3 mRNA	16483693
D000968	Antimycin A	Antimycin A results in increased expression of TRIB3 mRNA	19304788
C519728	archazolid B	archazolid B results in increased expression of TRIB3 mRNA	25218289
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TRIB3 mRNA	24356939\|2670570
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TRIB3 mRNA	23892647
C006632	arsenic trioxide	salubrinal promotes the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]	23892647
C006632	arsenic trioxide	Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]	23892647
C015001	arsenite	arsenite affects the expression of TRIB3 mRNA	22959463
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of TRIB3 mRNA"	17331233\|2575705
D001205	Ascorbic Acid	Ascorbic Acid results in decreased expression of TRIB3 mRNA	19197388
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in increased expression of TRIB3 mRNA	17639512
D001280	Atrazine	Atrazine results in decreased expression of TRIB3 mRNA	22378314
D001280	Atrazine	Atrazine results in increased expression of TRIB3 mRNA	27614199
C406592	azaspiracid	azaspiracid results in increased expression of TRIB3 mRNA	21853993\|2893901
D001379	Azathioprine	Azathioprine results in increased expression of TRIB3 mRNA	22623647
C547126	AZM551248	AZM551248 results in decreased expression of TRIB3 mRNA	22323515
C487081	belinostat	belinostat results in decreased expression of TRIB3 mRNA	27188386
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of TRIB3 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in decreased expression of TRIB3 mRNA	24356939
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TRIB3 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to TRIB3 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TRIB3 mRNA	19770486\|2171566
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TRIB3 mRNA	21569818\|2222880
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRIB3 mRNA"	20382639
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of TRIB3 mRNA	20876846
D004958	Estradiol	Estradiol results in increased expression of TRIB3 mRNA	20876846
D004958	Estradiol	Estradiol results in increased expression of TRIB3 mRNA	20106945
D004958	Estradiol	Estradiol results in increased expression of TRIB3 mRNA	19484750
C044887	beta-methylcholine	beta-methylcholine affects the expression of TRIB3 mRNA	21179406
D001629	Bezafibrate	[Bezafibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA	19593819
C053541	bicalutamide	bicalutamide results in increased expression of TRIB3 mRNA	15638997
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of TRIB3 mRNA	15912405
C006780	bisphenol A	bisphenol A affects the expression of TRIB3 mRNA	21786754\|2355768
C006780	bisphenol A	bisphenol A affects the expression of TRIB3 mRNA	20170705
C006780	bisphenol A	bisphenol A results in increased expression of TRIB3 mRNA	25912373\|2797991
C006780	bisphenol A	bisphenol A results in increased expression of TRIB3 mRNA	25270620
C006780	bisphenol A	bisphenol A results in increased expression of TRIB3 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of TRIB3 mRNA	23253260
D000069286	Bortezomib	[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of TRIB3 mRNA	25522274
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TRIB3 mRNA	22079614
D001973	Bromodeoxyuridine	Bromodeoxyuridine results in decreased expression of TRIB3 mRNA	24910943
C584509	C646 compound	C646 compound results in increased expression of TRIB3 mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of TRIB3 mRNA	24284285
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of TRIB3 mRNA	22110744
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TRIB3 mRNA	19010381
D002185	Cannabidiol	Cannabidiol results in increased expression of TRIB3 mRNA	21542829
D002220	Carbamazepine	Carbamazepine affects the expression of TRIB3 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TRIB3 mRNA	27339419
D002509	Cephaloridine	Cephaloridine results in increased expression of TRIB3 mRNA	18500788
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of TRIB3 mRNA	18178546
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of TRIB3 mRNA	26272509
C100187	chloropicrin	chloropicrin affects the expression of TRIB3 mRNA	26352163
D002746	Chlorpromazine	Chlorpromazine affects the expression of TRIB3 mRNA	25064622
D008076	Cholesterol, HDL	"TRIB3 protein affects the abundance of Cholesterol, HDL"	21190014
C039671	ciglitazone	ciglitazone results in increased expression of TRIB3 mRNA	22193206
D002922	Ciguatoxins	Ciguatoxins affects the expression of TRIB3 mRNA	18353800
D002994	Clofibrate	Clofibrate affects the expression of TRIB3 mRNA	23811191
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of TRIB3 mRNA	17585979
D002994	Clofibrate	[Clofibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA	19593819
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TRIB3 mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TRIB3 mRNA	24612858
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TRIB3 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TRIB3 mRNA	24386269
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of TRIB3 mRNA	20971185
D003300	Copper	[Organoselenium Compounds binds to Copper] which results in increased expression of TRIB3 mRNA	25167922
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TRIB3 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TRIB3 mRNA	18579281
C029892	cupric chloride	cupric chloride results in increased expression of TRIB3 mRNA	17211630
C030973	cupric oxide	cupric oxide results in increased expression of TRIB3 mRNA	22077320
D003471	Cuprizone	Cuprizone results in increased expression of TRIB3 mRNA	26057786\|2657739
D003474	Curcumin	Curcumin results in increased expression of TRIB3 mRNA	18719366
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of TRIB3 mRNA	17383702
D003520	Cyclophosphamide	Cyclophosphamide metabolite results in decreased expression of TRIB3 mRNA	24356939
D016572	Cyclosporine	Cyclosporine affects the expression of TRIB3 mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in increased expression of TRIB3 mRNA	19159671\|2010694
D016572	Cyclosporine	Cyclosporine results in increased expression of TRIB3 mRNA	19770486\|2395849
C014347	decitabine	decitabine affects the expression of TRIB3 mRNA	23300844
D013759	Dronabinol	ALK mutant form promotes the reaction [Dronabinol results in increased expression of TRIB3 mRNA]	21233844
D013759	Dronabinol	Dronabinol results in decreased phosphorylation of TRIB3 protein	21233844
D013759	Dronabinol	Dronabinol results in increased expression of TRIB3 mRNA	16616335\|1681865
D013759	Dronabinol	MDK inhibits the reaction [Dronabinol results in increased expression of TRIB3 mRNA]	21233844
D013759	Dronabinol	NUPR1 affects the reaction [Dronabinol results in increased expression of TRIB3 mRNA]	16616335
D013759	Dronabinol	TRIB3 results in increased susceptibility to Dronabinol	16818650
D013759	Dronabinol	Dronabinol results in increased expression of TRIB3 mRNA	16616335\|2154282
D013759	Dronabinol	NUPR1 affects the reaction [Dronabinol results in increased expression of TRIB3 mRNA]	16616335
D013759	Dronabinol	AREG inhibits the reaction [Dronabinol results in increased expression of TRIB3 mRNA]	19229996
D013759	Dronabinol	Dronabinol results in increased expression of TRIB3 mRNA	16616335\|1922999
D013759	Dronabinol	TRIB3 results in increased susceptibility to Dronabinol	16616335
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of TRIB3 mRNA	23253260
D003907	Dexamethasone	Dexamethasone results in decreased expression of TRIB3 mRNA	25047013
D003907	Dexamethasone	Dexamethasone results in increased expression of TRIB3 mRNA	19853017
D003907	Dexamethasone	Dexamethasone results in decreased expression of TRIB3 mRNA	22733784
D003976	Diazinon	Diazinon affects the expression of TRIB3 mRNA	22546817
C016366	dibenzothiophene	dibenzothiophene results in increased expression of TRIB3 mRNA	23656968
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TRIB3 mRNA	28973377
D002945	Cisplatin	Cisplatin affects the expression of TRIB3 mRNA	23300844
D002945	Cisplatin	Cisplatin results in increased expression of TRIB3 mRNA	19561079\|2759478
D002945	Cisplatin	TRIB3 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	Cisplatin results in decreased expression of TRIB3 mRNA	21151649\|2527062
D002945	Cisplatin	Cisplatin results in decreased expression of TRIB3 mRNA	22023808
D004008	Diclofenac	Diclofenac results in decreased expression of TRIB3 mRNA	26934552
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in increased expression of TRIB3 mRNA	15784690
D004026	Dieldrin	Dieldrin affects the expression of TRIB3 mRNA	22546817
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of TRIB3 mRNA	28433925
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of TRIB3 mRNA	28433925
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TRIB3 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TRIB3 mRNA	19638242
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TRIB3 mRNA	22129741
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of TRIB3 mRNA	22467019
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TRIB3 mRNA	25380136
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of TRIB3 mRNA	22193206
D004237	Diuron	Diuron metabolite results in decreased expression of TRIB3 mRNA	24172598
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of TRIB3 mRNA"	23811387
C512195	elesclomol	Acetylcysteine inhibits the reaction [elesclomol results in increased expression of TRIB3 mRNA]	18723479
C512195	elesclomol	elesclomol results in increased expression of TRIB3 mRNA	18723479
C118739	entinostat	entinostat results in increased expression of TRIB3 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
D000431	Ethanol	allyl sulfide promotes the reaction [Ethanol results in increased expression of TRIB3 mRNA]	20116195
D000431	Ethanol	Ethanol results in increased expression of TRIB3 mRNA	20116195
D000431	Ethanol	fomepizole inhibits the reaction [Ethanol results in increased expression of TRIB3 mRNA]	20116195
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of TRIB3 mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of TRIB3 mRNA	20170705
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TRIB3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRIB3 mRNA	17942748
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of TRIB3 mRNA	23649840
D005047	Etoposide	Etoposide results in decreased expression of TRIB3 mRNA	25270620
D005230	Fatty Acids, Nonesterified	"TRIB3 protein affects the abundance of Fatty Acids, Nonesterified"	21190014
D011345	Fenofibrate	Fenofibrate inhibits the reaction [TGFB1 protein results in decreased expression of TRIB3 mRNA]	19593819
D011345	Fenofibrate	[Fenofibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA	19593819
C000499	ferric oxide	ferric oxide analog results in decreased expression of TRIB3 mRNA	24525745
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of TRIB3 mRNA	28329830
D005472	Fluorouracil	Fluorouracil affects the expression of TRIB3 mRNA	16584549
D005485	Flutamide	Flutamide results in increased expression of TRIB3 mRNA	24136188
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of TRIB3 mRNA	24657277
C010238	fomepizole	fomepizole inhibits the reaction [Ethanol results in increased expression of TRIB3 mRNA]	20116195
D004397	Fonofos	Fonofos results in decreased methylation of TRIB3 promoter	22847954
D005557	Formaldehyde	Formaldehyde results in increased expression of TRIB3 mRNA	17938736\|2766457
D005632	Fructose	Fructose results in increased expression of TRIB3 mRNA	22698815
D005632	Fructose	Phenylbutyrates inhibits the reaction [Fructose results in increased expression of TRIB3 mRNA]	22698815
D005632	Fructose	Fructose results in increased expression of TRIB3 mRNA	18497449
C039281	furan	furan results in decreased expression of TRIB3 mRNA	24183702
D019833	Genistein	Genistein results in increased expression of TRIB3 mRNA	26865667
D005947	Glucose	TRIB3 protein affects the reaction [INS1 protein results in increased uptake of Glucose]	21190014
D005978	Glutathione	Glutathione deficiency results in increased expression of TRIB3 mRNA	20621112
C004312	glycidol	glycidol results in increased expression of TRIB3 mRNA	24915197
D006834	Hydrazines	Hydrazines results in increased expression of TRIB3 mRNA	21647536
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of TRIB3 mRNA	26846883
C492448	ICG 001	ICG 001 results in increased expression of TRIB3 mRNA	26191083
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of TRIB3 mRNA	21396975
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TRIB3 mRNA	22129741
D007213	Indomethacin	Indomethacin results in increased expression of TRIB3 mRNA	17401462
D007213	Indomethacin	Indomethacin results in increased expression of TRIB3 mRNA	16184411
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRIB3 mRNA	25613284
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of TRIB3 mRNA	25307878
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TRIB3 mRNA	25307878\|2675264
C410337	K 7174	K 7174 results in increased expression of TRIB3 mRNA	24086573
D007854	Lead	Lead results in decreased expression of TRIB3 mRNA	19921347
C008261	lead acetate	lead acetate results in increased expression of TRIB3 mRNA	25270620
C045463	leflunomide	leflunomide results in increased expression of TRIB3 mRNA	28988120
C045463	leflunomide	leflunomide results in increased expression of TRIB3 mRNA	24136188
D001556	Lindane	Lindane results in increased expression of TRIB3 mRNA	24356939
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of TRIB3 mRNA"	24972896
C442865	lipopolysaccharide, Helicobacter pylori	"lipopolysaccharide, Helicobacter pylori results in decreased expression of TRIB3 mRNA"	21220698
C442865	lipopolysaccharide, Helicobacter pylori	"[lipopolysaccharide, Helicobacter pylori results in decreased expression of TRIB3 mRNA] promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CCL20 mRNA]"	21220698
C442865	lipopolysaccharide, Helicobacter pylori	"[lipopolysaccharide, Helicobacter pylori results in decreased expression of TRIB3 mRNA] promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CXCL8 mRNA]"	21220698
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of TRIB3 mRNA	22235868
D018021	Lithium Chloride	Lithium Chloride results in increased expression of TRIB3 mRNA	23527032
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in decreased expression of TRIB3 mRNA	24525745
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
D008628	Mercury	Mercury results in decreased expression of TRIB3 mRNA	19937285
D008701	Methapyrilene	Methapyrilene results in increased expression of TRIB3 mRNA	22484513
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of TRIB3 mRNA	24657277
C002950	methylformamide	methylformamide affects the expression of TRIB3 mRNA	17040096
C002950	methylformamide	methylformamide analog affects the expression of TRIB3 mRNA	17040096
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TRIB3 mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TRIB3 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TRIB3 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of TRIB3 mRNA	24810058
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of TRIB3 mRNA	22776087
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of TRIB3 mRNA	16026605
D016685	Mitomycin	Mitomycin results in decreased expression of TRIB3 mRNA	25270620
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of TRIB3 mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA	16357179
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of TRIB3 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of TRIB3 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TRIB3 mRNA"	25620056
D009285	Naphthoquinones	Naphthoquinones results in increased expression of TRIB3 mRNA	23811387
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of TRIB3 mRNA	25380136
C051752	nefazodone	nefazodone results in increased expression of TRIB3 mRNA	24136188
C022838	nickel chloride	nickel chloride affects the expression of TRIB3 mRNA	22546817
C028007	nickel monoxide	nickel monoxide results in increased expression of TRIB3 mRNA	19167457
C012655	nimesulide	nimesulide results in increased expression of TRIB3 mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of TRIB3 mRNA	17616710
C008661	nobiletin	nobiletin results in increased expression of TRIB3 mRNA	23321314
C008661	nobiletin	nobiletin results in increased expression of TRIB3 mRNA	23321314
C570896	NSC305787	NSC305787 results in increased expression of TRIB3 mRNA	27137931
C570897	NSC668394	EZR protein affects the reaction [NSC668394 results in increased expression of TRIB3 mRNA]	27137931
C570897	NSC668394	NSC668394 results in increased expression of TRIB3 mRNA	27137931
C570897	NSC668394	NSC668394 results in increased expression of TRIB3 mRNA	27137931
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of TRIB3 mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in decreased acetylation of TRIB3 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in decreased acetylation of TRIB3 promoter] which results in decreased expression of TRIB3 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in decreased expression of TRIB3 mRNA	29098329
C025589	ochratoxin A	ochratoxin A results in increased expression of TRIB3 mRNA	23358140
D016566	Organoselenium Compounds	[Organoselenium Compounds binds to Copper] which results in increased expression of TRIB3 mRNA	25167922
D008939	Mitotane	Mitotane results in increased expression of TRIB3 mRNA	22966885
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of TRIB3 mRNA	25729387
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TRIB3 mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of TRIB3 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of TRIB3 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TRIB3 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TRIB3 mRNA]	17655762
D010269	Paraquat	Paraquat affects the expression of TRIB3 mRNA	25064622
D010278	Parathion	Parathion results in decreased methylation of TRIB3 promoter	22847954
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of TRIB3 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of TRIB3 mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TRIB3 mRNA]	17655762
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of TRIB3 mRNA	18593933
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of TRIB3 mRNA	19095052
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of TRIB3 mRNA	26705709
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TRIB3 mRNA	27614199
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TRIB3 mRNA	19162173
D010615	Phenacetin	Phenacetin results in increased expression of TRIB3 mRNA	17082564
D010634	Phenobarbital	Phenobarbital affects the expression of TRIB3 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in increased expression of TRIB3 mRNA	19270015\|2309116
D010634	Phenobarbital	Phenobarbital results in increased expression of TRIB3 mRNA	19162173
D010654	Phenylbutyrates	Phenylbutyrates inhibits the reaction [Fructose results in increased expression of TRIB3 mRNA]	22698815
D010656	Phenylephrine	Phenylephrine results in increased expression of TRIB3 mRNA	18158353
C030299	phenylhydrazine	phenylhydrazine results in increased expression of TRIB3 mRNA	17082564
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TRIB3 mRNA	26272509
C018637	phorone	phorone affects the expression of TRIB3 mRNA	18198479
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA	19710929
C006253	pirinixic acid	[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA	19593819
C006253	pirinixic acid	pirinixic acid results in increased expression of TRIB3 mRNA	20813756\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of TRIB3 protein	19748123
C006253	pirinixic acid	pirinixic acid results in increased expression of TRIB3 mRNA	19162173
D010894	Piroxicam	Piroxicam results in decreased expression of TRIB3 mRNA	21858171
D011137	Polystyrenes	Polystyrenes results in increased expression of TRIB3 mRNA	25102311
C019536	potassium bromate	potassium bromate results in increased expression of TRIB3 mRNA	23588252
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of TRIB3 mRNA	23608068
D011192	Potassium Dichromate	Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA]	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of TRIB3 mRNA	19162173
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of TRIB3 mRNA	20876846
D011374	Progesterone	Progesterone results in decreased expression of TRIB3 mRNA	20631399
D011374	Progesterone	Progesterone results in increased expression of TRIB3 mRNA	18037150\|2179573
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in increased expression of TRIB3 mRNA	17639512
C089730	rosiglitazone	rosiglitazone results in decreased expression of TRIB3 mRNA	25572481
D012402	Rotenone	CEBPB protein affects the reaction [Rotenone results in increased expression of TRIB3 mRNA]	19304788
D012402	Rotenone	DDIT3 protein affects the reaction [Rotenone results in increased expression of TRIB3 mRNA]	19304788
D012402	Rotenone	Rotenone results in increased expression of TRIB3 mRNA	19304788
C496827	salubrinal	salubrinal promotes the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]	23892647
D012643	Selenium	Selenium results in decreased expression of TRIB3 mRNA	28810182
C009250	sevoflurane	sevoflurane affects the expression of TRIB3 mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of TRIB3 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TRIB3 mRNA	19073995
D012834	Silver	Silver analog results in increased expression of TRIB3 mRNA	24974767
D012834	Silver	Silver results in increased expression of TRIB3 mRNA	26014281\|2895954
D020123	Sirolimus	[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of TRIB3 mRNA	25307878
C017947	sodium arsenite	sodium arsenite results in decreased expression of TRIB3 mRNA	20371982\|2859598
C017947	sodium arsenite	sodium arsenite results in increased expression of TRIB3 mRNA	19505541
C017947	sodium arsenite	sodium arsenite results in increased expression of TRIB3 mRNA alternative form	19505541
C017947	sodium arsenite	sodium arsenite results in increased expression of TRIB3 protein	19505541
C017947	sodium arsenite	sodium arsenite results in increased expression of TRIB3 mRNA	16014739
C016104	sodium bichromate	sodium bichromate results in increased expression of TRIB3 mRNA	24612858
C016104	sodium bichromate	sodium bichromate results in increased expression of TRIB3 mRNA	25993096
D018038	Sodium Selenite	Sodium Selenite results in increased expression of TRIB3 mRNA	18175754\|2438354
C031183	stearic acid	stearic acid results in increased expression of TRIB3 mRNA	26739624
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TRIB3 mRNA"	18579281
D016559	Tacrolimus	Tacrolimus results in increased expression of TRIB3 mRNA	23958496
C012568	terbufos	terbufos results in decreased methylation of TRIB3 promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TRIB3 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TRIB3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRIB3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TRIB3 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TRIB3 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TRIB3 mRNA	18178546\|2095900
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of TRIB3 mRNA	28973375
D013752	Tetracycline	Tetracycline affects the expression of TRIB3 mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRIB3 mRNA	25613284
D013792	Thalidomide	Thalidomide analog results in increased expression of TRIB3 mRNA	20525221
D019284	Thapsigargin	Thapsigargin results in increased expression of TRIB3 mRNA	22378314
D013849	Thimerosal	Thimerosal results in decreased expression of TRIB3 mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of TRIB3 mRNA	25064622
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]	23892647
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA]	23608068
C009495	titanium dioxide	titanium dioxide results in decreased expression of TRIB3 mRNA	29128614
C009495	titanium dioxide	titanium dioxide results in increased expression of TRIB3 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of TRIB3 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of TRIB3 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of TRIB3 mRNA	23830798
C011559	tributyltin	tributyltin results in increased expression of TRIB3 mRNA	21683754
C012589	trichostatin A	trichostatin A results in decreased expression of TRIB3 mRNA	28542535
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TRIB3 mRNA"	26743178
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TRIB3 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of TRIB3 mRNA	29024780
C057693	troglitazone	troglitazone results in decreased expression of TRIB3 mRNA	25572481
C057693	troglitazone	troglitazone results in increased expression of TRIB3 mRNA	19140230
C057693	troglitazone	troglitazone results in decreased expression of TRIB3 mRNA	28973697
D017973	Tungsten Compounds	Tungsten Compounds results in increased expression of TRIB3 mRNA	28666766
D014415	Tunicamycin	Tunicamycin results in increased expression of TRIB3 mRNA	22378314
D014415	Tunicamycin	Tunicamycin results in increased expression of TRIB3 mRNA	24291486
D014520	Urethane	Urethane results in decreased expression of TRIB3 mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of TRIB3 mRNA	15885361
C406224	valdecoxib	valdecoxib results in increased expression of TRIB3 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of TRIB3 mRNA	25064622
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIB3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of TRIB3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of TRIB3 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of TRIB3 mRNA	24535564
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of TRIB3 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of TRIB3 mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TRIB3 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of TRIB3 mRNA	19465080
C029297	vinylidene chloride	vinylidene chloride results in increased expression of TRIB3 mRNA	26682919
D014810	Vitamin E	Vitamin E results in decreased expression of TRIB3 mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of TRIB3 mRNA	25270620
C070417	Win 55212-2	Win 55212-2 results in increased expression of TRIB3 protein	16818650
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in increased expression of TRIB3 mRNA	15784690
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of TRIB3 mRNA	18593933
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of TRIB3 mRNA	16357179
D015034	Zinc Oxide	Zinc Oxide affects the expression of TRIB3 mRNA	28648595
D015034	Zinc Oxide	Zinc Oxide affects the expression of TRIB3 protein	28648595
C088658	zoledronic acid	zoledronic acid results in increased expression of TRIB3 mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003714	transcription corepressor activity	-	ISS	-
GO:0004860	protein kinase inhibitor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	12743605 15775988 16147992 17872950 23455924 25416956 25910212
GO:0005524	ATP binding	-	IEA	-
GO:0016301	kinase activity	NOT	IDA	12743605
GO:0019901	protein kinase binding	-	IPI	12791994 15299019
GO:0019901	protein kinase binding	-	ISS	-
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0031625	ubiquitin protein ligase binding	-	ISS	16794074
GO:0055106	ubiquitin-protein transferase regulator activity	-	ISS	20410507

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	15775988
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006468	protein phosphorylation	-	IEA	-
GO:0006469	negative regulation of protein kinase activity	-	IDA	12791994
GO:0010827	regulation of glucose transmembrane transport	-	ISS	12791994
GO:0019216	regulation of lipid metabolic process	-	TAS	-
GO:0032092	positive regulation of protein binding	-	ISS	16794074
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	-	IBA	21873635
GO:0032869	cellular response to insulin stimulus	-	ISS	12791994
GO:0034976	response to endoplasmic reticulum stress	-	IDA	15775988
GO:0043405	regulation of MAP kinase activity	-	IBA	21873635
GO:0043405	regulation of MAP kinase activity	-	IDA	15299019
GO:0045599	negative regulation of fat cell differentiation	-	ISS	17576771
GO:0045717	negative regulation of fatty acid biosynthetic process	-	ISS	16794074
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	15775988
GO:0051443	positive regulation of ubiquitin-protein transferase activity	-	ISS	16794074
GO:0051898	negative regulation of protein kinase B signaling	-	TAS	-
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	-	IDA	15775988
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	-	TAS	22934019

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-165158	Activation of AKT2	TAS
R-HSA-168256	Immune System	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-389356	CD28 co-stimulation	TAS
R-HSA-389357	CD28 dependent PI3K/Akt signaling	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-5218920	VEGFR2 mediated vascular permeability	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25447894	The functional Q84R polymorphism of TRIB3 gene is associated with diabetic nephropathy in Chinese type 2 diabetic patients. (2015 Jan 25)	Zhang W	Gene
26868433	Is common genetic variation at IRS1, ENPP1 and TRIB3 loci associated with cardiometabolic phenotypes in type 2 diabetes? An exploratory analysis of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 5. (2016 Mar)	Trombetta M	Nutr Metab Cardiovasc Dis