Gene info: ID 5777

Gene: PTPN6

GENE ID: 5777

Description: protein tyrosine phosphatase, non-receptor type 6

Gene type: protein-coding

Location: 12p13.31

dbXrefs: Ensembl:ENSG00000111679 MIM:176883 Vega:OTTHUMG00000168518 UniprotKB:P29350

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.774e-1 (AD) 8.131e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SPI1	0.958
SASH3	0.946
LAPTM5	0.938
LAIR1	0.937
HCK	0.937
C3AR1	0.936
CMTM7	0.936
CD68	0.933
CYTH4	0.932
ABI3	0.931

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP2C2	-0.442
SLC7A4	-0.441
MARCH4	-0.428
NEUROD6	-0.42
KCNIP3	-0.414
ZNF835	-0.413
MAGIX	-0.413
WNT7A	-0.41
TMEM179	-0.406
ZSCAN1	-0.405

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of PTPN6 mRNA"	19162173
C447621	16-(4-fluorophenoxy)lipoxin A4	16-(4-fluorophenoxy)lipoxin A4 promotes the reaction [PTPN6 protein binds to KDR protein]	18193074
C447621	16-(4-fluorophenoxy)lipoxin A4	16-(4-fluorophenoxy)lipoxin A4 promotes the reaction [VEGFA promotes the reaction [PTPN6 protein binds to KDR protein]]	18193074
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PTPN6 mRNA"	19114083
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of PTPN6 mRNA"	20713471
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PTPN6 mRNA"	21346803
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTPN6 mRNA]	27546522
C405943	2-(oxalylamino)benzoic acid	2-(oxalylamino)benzoic acid analog results in decreased activity of PTPN6 protein	10744717
C405943	2-(oxalylamino)benzoic acid	2-(oxalylamino)benzoic acid results in decreased activity of PTPN6 protein	10744717
D000082	Acetaminophen	Acetaminophen results in decreased expression of PTPN6 mRNA	29067470
C016601	afimoxifene	afimoxifene results in decreased activity of PTPN6 protein	17272397
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PTPN6 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PTPN6 mRNA	16483693
C031385	anthranilic acid	[oxovanadium IV binds to anthranilic acid analog] which results in decreased activity of PTPN6 protein	22864521
D000967	Antimony Sodium Gluconate	Antimony Sodium Gluconate results in decreased activity of PTPN6 protein	12399974
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PTPN6 mRNA	24449571
C526219	apple polyphenol extract	apple polyphenol extract results in increased expression of PTPN6 mRNA	18351577
D001151	Arsenic	Arsenic affects the methylation of PTPN6 gene	25304211
C006632	arsenic trioxide	[arsenic trioxide co-treated with decitabine] results in increased expression of PTPN6 mRNA	24762999
C006632	arsenic trioxide	arsenic trioxide results in decreased methylation of and results in increased expression of PTPN6	19619438
C006632	arsenic trioxide	arsenic trioxide results in decreased methylation of PTPN6 promoter	19950550
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PTPN6 mRNA	19950550\|2381590
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of PTPN6 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PTPN6 mRNA	21569818
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PTPN6 mRNA	22228805
D004958	Estradiol	Estradiol results in increased expression of PTPN6 mRNA	17578864
C472777	bisperoxovanadium	PTPN6 protein affects the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]	12493747
C006780	bisphenol A	bisphenol A affects the expression of PTPN6 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of PTPN6 mRNA	18180321
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased phosphorylation of PTPN6 protein	22174045
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of PTPN6 mRNA	17553608
D000069286	Bortezomib	Bortezomib results in decreased expression of PTPN6 mRNA	17659339
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of PTPN6 mRNA	18804290
D007631	Chlordecone	Chlordecone results in increased expression of PTPN6 mRNA	17578864
D002737	Chloroprene	Chloroprene results in decreased expression of PTPN6 mRNA	23125180
D002994	Clofibrate	Clofibrate results in increased expression of PTPN6 mRNA	17585979
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of PTPN6 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of PTPN6 mRNA	27523638
D003474	Curcumin	Curcumin results in increased expression of PTPN6 mRNA	17198877
D016572	Cyclosporine	Cyclosporine results in decreased expression of PTPN6 mRNA	20106945\|2522440
D016572	Cyclosporine	Cyclosporine results in decreased expression of PTPN6 mRNA	25224403
C515055	darinaparsin	darinaparsin results in decreased expression of PTPN6 protein	25316819
C014347	decitabine	[arsenic trioxide co-treated with decitabine] results in increased expression of PTPN6 mRNA	24762999
C014347	decitabine	decitabine results in decreased methylation of PTPN6 promoter	19551406
C014347	decitabine	decitabine results in increased expression of PTPN6 mRNA	17343198\|1937955
C014347	decitabine	decitabine results in increased expression of PTPN6 protein	17343198\|1937955
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of PTPN6 mRNA	27392435
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in increased expression of PTPN6 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in increased expression of PTPN6 mRNA	27392435
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in increased expression of PTPN6 mRNA]	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of PTPN6 mRNA	26924002
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of PTPN6 mRNA	26924002
D004642	Emodin	Emodin results in increased expression of PTPN6 protein	23848338
D004642	Emodin	PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]	23848338
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of PTPN6 mRNA	17347304
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of PTPN6 mRNA	17347304
D005419	Flavonoids	Flavonoids results in decreased expression of PTPN6 mRNA	18035473
D004397	Fonofos	Fonofos results in increased methylation of PTPN6 promoter	22847954
D005839	Gentamicins	Gentamicins results in increased expression of PTPN6 mRNA	22061828
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PTPN6 mRNA	20044591
D006861	Hydrogen Peroxide	PTPN6 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of CCL20 protein]	18441283
D006861	Hydrogen Peroxide	PTPN6 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of CCL5 protein]	18441283
D006861	Hydrogen Peroxide	PTPN6 protein inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of NFKBIA protein]	18441283
D006861	Hydrogen Peroxide	PTPN6 protein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of STAT6 protein]	18441283
D006861	Hydrogen Peroxide	PTPN6 protein results in decreased susceptibility to Hydrogen Peroxide	18441283
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of PTPN6 mRNA	27392435
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in increased expression of PTPN6 mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in increased expression of PTPN6 mRNA]	27392435
C544151	jinfukang	jinfukang results in increased expression of PTPN6 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PTPN6 mRNA	23086925
C008261	lead acetate	lead acetate results in decreased expression of PTPN6 mRNA	22609695
D008070	Lipopolysaccharides	PTPN6 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]	21422245
D008070	Lipopolysaccharides	PTPN6 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]	21422245
D008070	Lipopolysaccharides	[[PTPN6 protein results in increased phosphorylation of MAPK1 protein] which results in increased activity of CEBPB protein] promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]	21422245
D008070	Lipopolysaccharides	[[PTPN6 protein results in increased phosphorylation of MAPK3 protein] which results in increased activity of CEBPB protein] promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]	21422245
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of PTPN6 mRNA	20864626
D008731	Methoxychlor	Methoxychlor results in increased methylation of PTPN6 gene	23303685
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of PTPN6 mRNA	26924002
C524250	N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine	"N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine results in increased expression of PTPN6 protein"	18638462
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PTPN6 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PTPN6 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of PTPN6 mRNA	25583101
C029938	nickel sulfate	nickel sulfate results in increased expression of PTPN6 mRNA	22714537
C507134	ON 01910	ON 01910 results in decreased expression of PTPN6 mRNA	22351695
D009942	Organometallic Compounds	Organometallic Compounds results in decreased activity of PTPN6 protein	22027948
C075743	oxovanadium IV	[oxovanadium IV binds to anthranilic acid analog] which results in decreased activity of PTPN6 protein	22864521
C075743	oxovanadium IV	[oxovanadium IV binds to salicylideneaniline analog] which results in decreased activity of PTPN6 protein	22864521
C075743	oxovanadium IV	[oxovanadium IV binds to Schiff Bases] which results in decreased activity of PTPN6 protein	22864521
D010269	Paraquat	PTPN6 protein inhibits the reaction [Paraquat results in decreased expression of IL10 protein]	18441283
D010269	Paraquat	PTPN6 protein inhibits the reaction [Paraquat results in increased expression of CCL20 protein]	18441283
D010278	Parathion	Parathion results in increased methylation of PTPN6 promoter	22847954
C073402	PD 123319	PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]	17068200
C006253	pirinixic acid	pirinixic acid results in increased expression of PTPN6 mRNA	18301758\|2081375
D010936	Plant Extracts	Plant Extracts results in increased expression of PTPN6 mRNA	18351577
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of PTPN6 mRNA	21133357
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of PTPN6 mRNA	23608068
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased activity of PTPN6 protein	17272397
C510217	salicylideneaniline	[oxovanadium IV binds to salicylideneaniline analog] which results in decreased activity of PTPN6 protein	22864521
D012545	Schiff Bases	[oxovanadium IV binds to Schiff Bases] which results in decreased activity of PTPN6 protein	22864521
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of PTPN6 mRNA	19244175
D012643	Selenium	Selenium results in increased expression of PTPN6 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of PTPN6 mRNA	25895662
D012834	Silver	Silver results in increased expression of PTPN6 mRNA	27131904
C017947	sodium arsenite	sodium arsenite results in increased expression of PTPN6 protein	19072884
D012965	Sodium Chloride	Sodium Chloride results in decreased expression of PTPN6 mRNA	23634900
D012999	Soman	Soman results in increased expression of PTPN6 mRNA	19281266
C012568	terbufos	terbufos results in increased methylation of PTPN6 promoter	22847954
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTPN6 mRNA]	27546522
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTPN6 promoter]	27546522
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PTPN6 mRNA	27546522
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PTPN6 protein	27546522
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PTPN6 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTPN6 gene]	20819909
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PTPN6 mRNA	20819909
C009495	titanium dioxide	titanium dioxide results in increased expression of PTPN6 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of PTPN6 gene	26756918
C046488	trimethyltin	trimethyltin results in increased expression of PTPN6 mRNA	20833246
D014635	Valproic Acid	Valproic Acid results in decreased expression of PTPN6 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of PTPN6 mRNA	23527032
D014635	Valproic Acid	Valproic Acid results in increased methylation of PTPN6 gene	29154799
D000068756	Valsartan	Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]	17068200
C025643	vinclozolin	vinclozolin results in increased expression of PTPN6 mRNA	20566332
D014801	Vitamin A	Vitamin A affects the localization of and affects the phosphorylation of PTPN6 protein	15963505
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of PTPN6 mRNA	19244175
D014810	Vitamin E	Vitamin E results in increased expression of PTPN6 mRNA	19244175
D015032	Zinc	Zinc results in decreased activity of PTPN6 protein	14644152

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001784	phosphotyrosine residue binding	-	IMP	12051764
GO:0001784	phosphotyrosine residue binding	-	IPI	11986327 12051764
GO:0004725	protein tyrosine phosphatase activity	-	IMP	17562706
GO:0004725	protein tyrosine phosphatase activity	-	TAS	-
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	-	IDA	11266449
GO:0005515	protein binding	-	IPI	7228577 7528537 7528577 8114715 8574854 8577729 8627166 8648092 8691146 8691154 9148918 9285411 9603468 9774457 9842885 10206955 10540326 10556798 10660620 10764762 11162587 11266449 11489943 11907092 16254138 16339535 17416557 17562706 17947393 18086677 18424730 18604210 18802077 19167335 19838216 19843936 20351292 20933011 22624718 23001144 23112346 23696226 24642916 25416956 25535246 26755705
GO:0017124	SH3 domain binding	-	IEA	-
GO:0019901	protein kinase binding	-	IPI	11266449
GO:0042169	SH2 domain binding	-	IEA	-
GO:0050839	cell adhesion molecule binding	-	IEA	-
GO:0140031	phosphorylation-dependent protein binding	-	IPI	12163025

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002244	hematopoietic progenitor cell differentiation	-	IEA	-
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	-	IEA	-
GO:0006470	protein dephosphorylation	-	IDA	11266449
GO:0006915	apoptotic process	-	TAS	10506221
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	7781604
GO:0008283	cell proliferation	-	IDA	11266449
GO:0008284	positive regulation of cell proliferation	-	IMP	19749791 19838216
GO:0008285	negative regulation of cell proliferation	-	NAS	10497187
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	-	IMP	19838216
GO:0018108	peptidyl-tyrosine phosphorylation	-	IDA	9285411 18802077
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030154	cell differentiation	-	IDA	11266449
GO:0030168	platelet activation	-	TAS	-
GO:0030220	platelet formation	-	IEA	-
GO:0031295	T cell costimulation	-	TAS	-
GO:0033277	abortive mitotic cell cycle	-	IEA	-
GO:0033630	positive regulation of cell adhesion mediated by integrin	-	IEA	-
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IMP	17562706
GO:0035556	intracellular signal transduction	-	IEA	-
GO:0035855	megakaryocyte development	-	IEA	-
GO:0042130	negative regulation of T cell proliferation	-	IEA	-
GO:0042267	natural killer cell mediated cytotoxicity	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043407	negative regulation of MAP kinase activity	-	IEA	-
GO:0045577	regulation of B cell differentiation	-	IEA	-
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	-	IMP	19749791
GO:0050853	B cell receptor signaling pathway	-	IEA	-
GO:0050859	negative regulation of B cell receptor signaling pathway	-	IEA	-
GO:0050860	negative regulation of T cell receptor signaling pathway	-	IEA	-
GO:0050900	leukocyte migration	-	TAS	-
GO:0051279	regulation of release of sequestered calcium ion into cytosol	-	IEA	-
GO:0060338	regulation of type I interferon-mediated signaling pathway	-	TAS	-
GO:0070372	regulation of ERK1 and ERK2 cascade	-	IDA	11266449
GO:0070527	platelet aggregation	-	IEA	-
GO:0071345	cellular response to cytokine stimulus	-	TAS	-
GO:2000045	regulation of G1/S transition of mitotic cell cycle	-	IMP	19838216

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	IDA	19838216
GO:0005654	nucleoplasm	-	TAS	-
GO:0005730	nucleolus	-	IDA	-
GO:0005737	cytoplasm	-	IDA	10940933 19838216
GO:0005829	cytosol	-	TAS	-
GO:0005911	cell-cell junction	-	IEA	-
GO:0016020	membrane	-	TAS	10506221
GO:0032991	protein-containing complex	-	IMP	17562706
GO:0035580	specific granule lumen	-	TAS	-
GO:0042105	alpha-beta T cell receptor complex	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 20458337
GO:1904724	tertiary granule lumen	-	TAS	-

KEGG ID	KEGG Term
hsa04520	Adherens junction
hsa04630	Jak-STAT signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa05140	Leishmaniasis

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114604	GPVI-mediated activation cascade	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	IEA
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1433557	Signaling by SCF-KIT	TAS
R-HSA-1433559	Regulation of KIT signaling	TAS
R-HSA-1500931	Cell-Cell communication	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-210990	PECAM1 interactions	TAS
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-389948	PD-1 signaling	TAS
R-HSA-391160	Signal regulatory protein family interactions	IEA
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-432142	Platelet sensitization by LDL	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-451927	Interleukin-2 family signaling	TAS
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-5690714	CD22 mediated BCR regulation	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-877300	Interferon gamma signaling	TAS
R-HSA-877300	Interferon gamma signaling	IEA
R-HSA-877312	Regulation of IFNG signaling	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9008059	Interleukin-37 signaling	TAS
R-HSA-909733	Interferon alpha/beta signaling	TAS
R-HSA-912526	Interleukin receptor SHC signaling	TAS
R-HSA-912694	Regulation of IFNA signaling	TAS
R-HSA-913531	Interferon Signaling	TAS
R-HSA-913531	Interferon Signaling	IEA
R-HSA-982772	Growth hormone receptor signaling	IEA
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	IEA
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24704585	CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study. (2014 Jul)	Harlid S	Environ Health Perspect