Gene: GATAD1

57798
CMD2B|ODAG|RG083M05.2
GATA zinc finger domain containing 1
protein-coding
7q21.2
Ensembl:ENSG00000157259 MIM:614518 Vega:OTTHUMG00000131201 UniprotKB:Q8WUU5
NG_032807.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.519e-1 (AD)  9.594e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6944759chr7:92486787 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2287179chr7:92451081 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4729043chr7:92448402 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC170.89
GOLGA10.888
DDX170.887
RBM250.885
U2SURP0.884
CREBZF0.884
SF3B10.883
PPWD10.882
TIA10.881
DDX50.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.649
OR4F29-0.607
MTRNR2L6-0.181
MTRNR2L9-0.172
KLRC2-0.171
CARD17-0.164
MTRNR2L10-0.159
OR4F16-0.156
RNF223-0.146
NANOGNB-0.145

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of GATAD1 mRNA"20453058
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GATAD1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of GATAD1 mRNA"24680724
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GATAD1 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GATAD1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GATAD1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GATAD1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GATAD1 mRNA"25510870
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GATAD1 gene27153756
D001280AtrazineAtrazine results in decreased expression of GATAD1 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of GATAD1 mRNA22323515
C006780bisphenol Abisphenol A affects the methylation of GATAD1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of GATAD1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of GATAD1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GATAD1 mRNA26472689
D019327Copper SulfateCopper Sulfate results in decreased expression of GATAD1 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of GATAD1 mRNA19167446
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GATAD1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GATAD1 mRNA27392435
D004237DiuronDiuron results in increased expression of GATAD1 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GATAD1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GATAD1 mRNA23649840
D018120FinasterideFinasteride results in increased expression of GATAD1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of GATAD1 mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GATAD1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GATAD1 mRNA23086925
C410337K 7174K 7174 results in increased expression of GATAD1 mRNA24086573
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GATAD1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GATAD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GATAD1 mRNA"25554681
D009532NickelNickel results in decreased expression of GATAD1 mRNA25583101
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GATAD1 mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of GATAD1 mRNA23811191
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GATAD1 mRNA25351596
D013467SulindacSulindac results in increased expression of GATAD1 mRNA24136188
C061133tamibarotenetamibarotene results in decreased expression of GATAD1 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of GATAD1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GATAD1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GATAD1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GATAD1 mRNA24058054
D014212TretinoinTretinoin affects the expression of GATAD1 mRNA15498508
C012589trichostatin Atrichostatin A affects the expression of GATAD1 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of GATAD1 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of GATAD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GATAD1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of GATAD1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GATAD1 gene25560391
D014810Vitamin EVitamin E results in decreased expression of GATAD1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0008270zinc ion binding-IEA-  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0031497chromatin assembly-IDA20850016  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA21965549  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal