Gene info: ID 578

Gene: BAK1

GENE ID: 578

Synonyms: BAK|BAK-LIKE|BCL2L7|CDN1

Description: BCL2 antagonist/killer 1

Gene type: protein-coding

Location: 6p21.31

dbXrefs: Ensembl:ENSG00000030110 MIM:600516 Vega:OTTHUMG00000014530 UniprotKB:Q16611

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : 3.295e-2 (AD) 3.843e-1 (ND) (Frontal_Cortex)

Pascal p-value : 4.615e-3 (AD) 8.652e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MPV17L2	0.835
SLC35A4	0.823
P4HB	0.815
AAR2	0.812
SLC35F6	0.811
EMD	0.808
HM13	0.807
NKIRAS2	0.806
SURF4	0.804
EIF4A1	0.803

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.585
OR4F29	-0.537
MTRNR2L6	-0.227
OR6C74	-0.222
MTRNR2L9	-0.22
HMHB1	-0.216
KLRC2	-0.209
C17orf112	-0.192
CTNNA3	-0.19
MTRNR2L10	-0.174

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in decreased expression of BAK1 protein"	19433268
C105351	1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene	"BAK1 protein affects the susceptibility to 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"	19768117
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAK1 mRNA"	27589474
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of BAK1 protein"	20638727
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in decreased expression of BAK1 mRNA	12208782
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of BAK1 mRNA	24140754
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of BAK1 mRNA"	18648102
C078956	4-methylthioamphetamine	4-methylthioamphetamine results in increased expression of BAK1 protein	23820845
C078956	4-methylthioamphetamine	"[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BAK1 protein"	23820845
C580598	5-OH-BDE-47	5-OH-BDE-47 results in decreased expression of BAK1 mRNA	27589474
C580599	6-OH-BDE-47	6-OH-BDE-47 results in decreased expression of BAK1 mRNA	27589474
D000082	Acetaminophen	Acetaminophen results in increased expression of BAK1 mRNA	27761495
D000082	Acetaminophen	Acetaminophen affects the expression of BAK1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of BAK1 protein	22939915
D000082	Acetaminophen	dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein]	22939915
C043377	acetochlor	acetochlor results in increased expression of BAK1 protein	25291404
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAK1]	23339468
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of BAK1 mRNA]	21533816
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of BAK1 mRNA]	21549813
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 mRNA]	22085843
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 protein]	22085843
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]	28296042
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]	28296042
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of BAK1 mRNA	22100608
C004363	alantolactone	alantolactone results in increased expression of BAK1 protein	22721982
C010845	aluminum chloride	BAK1 protein affects the susceptibility to aluminum chloride	19740541
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BAK1 mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of BAK1 protein	23820845
D003913	Dextroamphetamine	"[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BAK1 protein"	23820845
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of BAK1 mRNA	24449571
C006632	arsenic trioxide	[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BAK1 protein	24126434
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of BAK1 mRNA	11940349\|1753043
C006632	arsenic trioxide	arsenic trioxide results in increased expression of BAK1 protein	19695276\|2517435
C006632	arsenic trioxide	Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of BAK1 mRNA]	21533816
C006632	arsenic trioxide	"arsenic trioxide promotes the reaction [Drugs, Chinese Herbal results in increased expression of BAK1 protein]"	28587418
C006632	arsenic trioxide	arsenic trioxide results in increased expression of BAK1 mRNA	21533816
C006632	arsenic trioxide	BAK1 protein affects the susceptibility to arsenic trioxide	15979664
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of BAK1 mRNA	19730151
C015001	arsenite	arsenite results in increased activity of BAK1 protein	17553788
D001205	Ascorbic Acid	[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BAK1 protein	24126434
D001241	Aspirin	Aspirin results in increased expression of BAK1 protein	11532860
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of BAK1 protein	19935899
D001310	Auranofin	BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]	18789312
D001310	Auranofin	BAK1 results in increased susceptibility to Auranofin	18789312
D001310	Auranofin	[BAX co-treated with BAK1] results in increased susceptibility to Auranofin	21172426
D001374	Azacitidine	Azacitidine results in increased expression of BAK1 mRNA	15547111
D001374	Azacitidine	[Azacitidine co-treated with entinostat] results in increased expression of BAK1 mRNA	21224363
D001374	Azacitidine	Azacitidine results in increased expression of BAK1 mRNA	21224363
C547126	AZM551248	AZM551248 results in increased expression of BAK1 mRNA	22323515
C427308	benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone	benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [docetaxel affects the folding of and results in increased activity of BAK1 protein]	17308071
C427308	benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone	benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein]	15917298
C403753	benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone	[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [resveratrol results in increased localization of BAK1 protein]	12902349
D004958	Estradiol	Estradiol results in decreased expression of BAK1 mRNA	23373633
C006780	bisphenol A	bisphenol A results in decreased expression of BAK1 protein	21277958
C006780	bisphenol A	bisphenol A results in increased expression of BAK1 mRNA	25181051\|2729622
D000069286	Bortezomib	BAK1 affects the reaction [Bortezomib results in increased susceptibility to and results in increased activity of TNFSF10 protein]	17326159
D000069286	Bortezomib	Bortezomib results in increased expression of BAK1 protein	17326159
D000069286	Bortezomib	[nutlin 3 co-treated with Bortezomib] results in increased activity of BAK1 protein	20850924
D000069286	Bortezomib	BAK1 protein results in increased susceptibility to [Bortezomib co-treated with TNFSF10 protein]	12902978
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of BAK1 mRNA	12419474
C018475	butyraldehyde	butyraldehyde results in increased expression of BAK1 mRNA	26079696
D002087	Butyrates	Butyrates results in increased expression of BAK1 mRNA	16042588
D002087	Butyrates	[perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein	15781658
D002104	Cadmium	Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAK1]	23339468
D002104	Cadmium	Cadmium results in increased expression of BAK1	23339468
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of BAK1 mRNA	25035189
D019256	Cadmium Chloride	Selenium inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 mRNA]	25035189
D019256	Cadmium Chloride	[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein	26607349
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of BAK1 protein	26607349
D019256	Cadmium Chloride	MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]	26607349
D019256	Cadmium Chloride	Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]	26607349
D019256	Cadmium Chloride	Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]	26607349
C034939	cadmium sulfide	cadmium sulfide results in decreased expression of BAK1 mRNA	27866839
D002211	Capsaicin	Capsaicin results in increased expression of BAK1 mRNA	19502594
D002211	Capsaicin	Capsaicin results in increased activity of BAK1 protein	17295509
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of BAK1 protein	23279844\|2543296
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]]	25432964
D002251	Carbon Tetrachloride	Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]	23279844
D002251	Carbon Tetrachloride	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]	23279844
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]	25432964
D002251	Carbon Tetrachloride	SC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]	25432964
D002251	Carbon Tetrachloride	[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BAK1 mRNA	16610055
C054133	casticin	casticin results in increased expression of BAK1 protein	27862857
D000068579	Celecoxib	Celecoxib analog results in increased expression of BAK1 protein	19682443
D000068579	Celecoxib	Celecoxib results in increased expression of BAK1 mRNA	19428934
D000068579	Celecoxib	Celecoxib results in increased expression of BAK1 protein	19428934\|1968244
D000068579	Celecoxib	BAK1 results in decreased susceptibility to Celecoxib	18349538
D002509	Cephaloridine	Cephaloridine results in increased expression of BAK1 mRNA	18500788
C024989	coenzyme Q10	coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein]	27087047
D003300	Copper	Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 mRNA]	22085843
D003300	Copper	Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 protein]	22085843
D003300	Copper	[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 mRNA	22085843
D003300	Copper	[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 protein	22085843
D003474	Curcumin	Curcumin results in increased expression of BAK1 mRNA	17332930
D003474	Curcumin	Curcumin results in increased expression of BAK1 protein	17332930\|1822626
D003474	Curcumin	TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]	18226269
D003474	Curcumin	BAK1 protein results in increased susceptibility to Curcumin	17277231
D003474	Curcumin	Curcumin results in increased expression of BAK1 protein	17277231
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of BAK1 mRNA	23726867
D003609	Dactinomycin	Dactinomycin promotes the reaction [BAK1 protein binds to BAK1 protein]	26670606
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAK1 mRNA]	21281706
C014347	decitabine	decitabine results in increased expression of BAK1 mRNA	17908484
C107676	deguelin	deguelin results in increased expression of BAK1 protein	26592500
C007262	deoxynivalenol	deoxynivalenol results in increased expression of BAK1 mRNA	20702593
C040424	destruxin B	destruxin B results in increased expression of BAK1 protein	24434019
C040424	destruxin B	sorafenib promotes the reaction [destruxin B results in increased expression of BAK1 protein]	24434019
D003907	Dexamethasone	Dexamethasone results in increased expression of BAK1 mRNA	19428934
D003907	Dexamethasone	Dexamethasone results in increased expression of BAK1 protein	19428934
D064730	Dexrazoxane	[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAK1 mRNA	26873546
C042577	diallyl trisulfide	diallyl trisulfide results in increased activity of BAK1 protein	23412769
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of BAK1 protein	17513609
C042577	diallyl trisulfide	SOD2 protein inhibits the reaction [diallyl trisulfide results in increased activity of BAK1 protein]	23412769
D003976	Diazinon	Diazinon affects the expression of BAK1 mRNA	22546817
D002945	Cisplatin	BAK1 protein results in increased susceptibility to Cisplatin	17688235
D002945	Cisplatin	[Cisplatin co-treated with fisetin] results in increased expression of BAK1 protein	21216935
D002945	Cisplatin	Cisplatin results in increased expression of BAK1 mRNA	11099651\|2739243
D002945	Cisplatin	Cisplatin results in increased expression of BAK1 protein	21052098\|2228522
D002945	Cisplatin	ING4 protein promotes the reaction [Cisplatin results in increased expression of BAK1 protein]	21052098
D002945	Cisplatin	[BAX co-treated with BAK1] results in increased susceptibility to Cisplatin	21172426
D003633	Dichlorodiphenyl Dichloroethylene	Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAK1 mRNA]	21281706
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of BAK1 mRNA	21281706\|2138449
D004008	Diclofenac	Diclofenac results in increased activity of BAK1 protein	18191430
D004026	Dieldrin	Dieldrin affects the expression of BAK1 mRNA	22546817
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BAK1 mRNA	27048571
D004052	Diethylnitrosamine	DMU-212 inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BAK1 mRNA]	27048571
C019357	dioscin	dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein]	22939915
D004221	Disulfiram	[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BAK1 protein	24126434
C521792	DMU-212	DMU-212 results in increased expression of BAK1 mRNA	24055891
C521792	DMU-212	DMU-212 inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BAK1 mRNA]	27048571
C067311	docetaxel	BCL2 inhibits the reaction [docetaxel affects the folding of and results in increased activity of BAK1 protein]	17308071
C067311	docetaxel	benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [docetaxel affects the folding of and results in increased activity of BAK1 protein]	17308071
C067311	docetaxel	docetaxel affects the folding of and results in increased activity of BAK1 protein	17308071
C067311	docetaxel	docetaxel results in increased activity of BAK1 protein	17317842
C067311	docetaxel	pyrazolanthrone inhibits the reaction [docetaxel results in increased activity of BAK1 protein]	17317842
C067311	docetaxel	U 0126 promotes the reaction [docetaxel results in increased activity of BAK1 protein]	17317842
D004317	Doxorubicin	BAK1 protein results in decreased susceptibility to Doxorubicin	11313874
D004317	Doxorubicin	BAK1 protein results in increased susceptibility to Doxorubicin	17688235
D004317	Doxorubicin	BAK1 protein results in increased susceptibility to [Doxorubicin co-treated with PI103]	20856197
D004317	Doxorubicin	benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein]	15917298
D004317	Doxorubicin	Doxorubicin results in increased activity of BAK1 protein	15917298
D004317	Doxorubicin	Doxorubicin results in increased expression of and results in increased activity of BAK1 protein	20856197
D004317	Doxorubicin	Doxorubicin results in increased expression of BAK1 protein	20856197
D004317	Doxorubicin	rottlerin inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein]	15917298
D004317	Doxorubicin	[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAK1 mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in increased expression of BAK1 mRNA	26873546
D004317	Doxorubicin	coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein]	27087047
D004317	Doxorubicin	Doxorubicin results in increased expression of BAK1 protein	27087047
D004365	Drugs, Chinese Herbal	"arsenic trioxide promotes the reaction [Drugs, Chinese Herbal results in increased expression of BAK1 protein]"	28587418
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of BAK1 protein"	28587418
C118739	entinostat	entinostat results in increased expression of BAK1 protein	21041383
C118739	entinostat	[Azacitidine co-treated with entinostat] results in increased expression of BAK1 mRNA	21224363
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of BAK1 mRNA	18851785
C007366	erythritol anhydride	erythritol anhydride results in increased expression of BAK1	17693053
C007628	esculetin	esculetin results in increased expression of BAK1 protein	26388407
D000431	Ethanol	Ethanol results in increased expression of BAK1 protein	27270636
D000431	Ethanol	SIAH1 protein promotes the reaction [Ethanol results in increased expression of BAK1 protein]	27270636
D000431	Ethanol	[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BAK1 mRNA	16610055
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of BAK1 mRNA	17557909
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of BAK1 mRNA	23649840
D005047	Etoposide	BAK1 protein results in increased susceptibility to Etoposide	17688235
D005047	Etoposide	Etoposide affects the expression of BAK1 protein	15215046
D005047	Etoposide	Etoposide results in increased activity of BAK1 protein	21745461
D005047	Etoposide	nimesulide inhibits the reaction [Etoposide results in increased activity of BAK1 protein]	21745461
D005047	Etoposide	BAK1 protein affects the susceptibility to Etoposide	16077961
C017875	fisetin	[Cisplatin co-treated with fisetin] results in increased expression of BAK1 protein	21216935
D005419	Flavonoids	Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]	23279844
C024352	fludarabine	BAK1 protein affects the susceptibility to [LAQ824 co-treated with fludarabine]	18852132
C024352	fludarabine	[LAQ824 co-treated with fludarabine] results in increased activity of BAK1 protein	18852132
D005472	Fluorouracil	BAK1 mRNA results in increased susceptibility to Fluorouracil	18593893
D005472	Fluorouracil	Fluorouracil results in increased expression of BAK1	9792140
D005472	Fluorouracil	Fluorouracil results in increased expression of BAK1 mRNA	16557594
D005472	Fluorouracil	Fluorouracil results in increased expression of BAK1 protein	15489892
D005472	Fluorouracil	mithramycin A inhibits the reaction [Fluorouracil results in increased expression of BAK1 protein]	15489892
D004397	Fonofos	Fonofos results in increased methylation of BAK1 promoter	22847954
D005557	Formaldehyde	Formaldehyde results in decreased expression of BAK1 mRNA	23322811
D005620	Freund's Adjuvant	[Urethane co-treated with Freund's Adjuvant] results in increased expression of BAK1 mRNA	12400877
C039281	furan	furan results in increased expression of BAK1 mRNA	22079235\|2619464
D005665	Furosemide	Furosemide affects the expression of BAK1 mRNA	17497460
D006046	Gold	Gold results in increased expression of BAK1 mRNA	22178767
D017313	Fenretinide	Fenretinide results in increased expression of BAK1 protein	17273769
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of BAK1 mRNA	12419474
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of BAK1 protein	14505808
D006861	Hydrogen Peroxide	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAK1 protein]	14505808
C051414	hydroxygenkwanin	hydroxygenkwanin results in increased expression of BAK1 protein	24144774
D007213	Indomethacin	Indomethacin results in increased expression of BAK1 protein	11532860
D007213	Indomethacin	Indomethacin results in increased expression of BAK1 mRNA	19220725
D007213	Indomethacin	Indomethacin results in increased expression of BAK1 protein	18375387
D007213	Indomethacin	Melatonin inhibits the reaction [Indomethacin results in increased expression of BAK1 mRNA]	19220725
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BAK1 mRNA	25613284
D007530	Isoflurane	Isoflurane results in decreased expression of BAK1 mRNA	16978161
D007545	Isoproterenol	Isoproterenol results in decreased expression of BAK1 mRNA	24286936
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of BAK1 protein	11222086
D048628	Ketolides	Ketolides analog results in decreased expression of BAK1 mRNA	24967691
D064747	Lansoprazole	Lansoprazole results in increased expression of BAK1 protein	18375387
C477361	LAQ824	BAK1 protein affects the susceptibility to [LAQ824 co-treated with fludarabine]	18852132
C477361	LAQ824	[LAQ824 co-treated with fludarabine] results in increased activity of BAK1 protein	18852132
D008095	Lithocholic Acid	"[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in decreased expression of BAK1 protein"	19433268
D008095	Lithocholic Acid	[Lithocholic Acid co-treated with Phenobarbital] results in decreased expression of BAK1 protein	19433268
D008095	Lithocholic Acid	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAK1 protein	19433268
D019808	Losartan	Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA]	15502641
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BAK1 mRNA	26378955
D008344	Maneb	BAK1 protein affects the susceptibility to Maneb	18266926
D008344	Maneb	Maneb inhibits the reaction [BAK1 protein affects the susceptibility to Paraquat]	18266926
D008344	Maneb	Maneb results in increased expression of BAK1 mRNA	18266926
D008344	Maneb	Maneb results in increased expression of BAK1 protein	18266926
D008344	Maneb	[Paraquat co-treated with Maneb] results in increased expression of BAK1 protein	18266926
D008344	Maneb	Paraquat inhibits the reaction [BAK1 protein affects the susceptibility to Maneb]	18266926
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA	23963992
D008344	Maneb	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]	23963992
D008344	Maneb	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]	23963992
D008466	Mechlorethamine	Mechlorethamine results in increased expression of BAK1 protein	22285227
D008550	Melatonin	[Melatonin co-treated with Tretinoin] results in increased expression of BAK1 protein	10965999
D008550	Melatonin	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]	23963992
D008550	Melatonin	Melatonin inhibits the reaction [Indomethacin results in increased expression of BAK1 mRNA]	19220725
D008558	Melphalan	Melphalan results in increased expression of BAK1 protein	22285227
D008694	Methamphetamine	Methamphetamine results in increased expression of BAK1 protein	23820845
D008694	Methamphetamine	"[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BAK1 protein"	23820845
D008727	Methotrexate	Methotrexate results in increased expression of BAK1 mRNA	21678067
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of BAK1 protein	10809232
C553655	methyl antcinate A	methyl antcinate A results in increased expression of BAK1 protein	20557081
D008767	Methylmercury Compounds	Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of BAK1 mRNA]	21549813
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of BAK1 mRNA	21549813
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of BAK1 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BAK1 protein"	23820845
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BAK1 protein"	23820845
D008769	Methylnitronitrosoguanidine	BAK1 protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]	18376143
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of BAK1 mRNA	18266926
D008911	Minocycline	[Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein	15004018
C066851	mithramycin A	mithramycin A inhibits the reaction [Fluorouracil results in increased expression of BAK1 protein]	15489892
D009020	Morphine	Morphine results in increased expression of BAK1 protein	19070643
C568376	MT19c compound	MT19c compound results in decreased expression of BAK1 mRNA	21781307
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of BAK1 protein	16505121
C455139	myrtucommulone A	myrtucommulone A results in decreased expression of BAK1 mRNA	26032814
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of BAK1 mRNA"	15585362
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of BAK1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of BAK1 mRNA"	25554681
C005273	naringenin	naringenin results in increased expression of BAK1 protein	27838343
C528561	navitoclax	[navitoclax co-treated with vorinostat] affects the activity of BAK1 protein	21652541
D009532	Nickel	Nickel results in increased expression of BAK1 mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride results in increased expression of BAK1 mRNA	26585591
C022838	nickel chloride	nickel chloride affects the expression of BAK1 mRNA	22546817
C022838	nickel chloride	nickel chloride results in increased expression of BAK1 mRNA	21843586
C029938	nickel sulfate	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]	28296042
C029938	nickel sulfate	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]	28296042
C029938	nickel sulfate	nickel sulfate results in increased expression of BAK1 mRNA	28296042
C029938	nickel sulfate	nickel sulfate results in increased expression of BAK1 protein	28296042
C029938	nickel sulfate	TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]	28296042
C029938	nickel sulfate	TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]	28296042
D009534	Niclosamide	[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA	25988281
C012655	nimesulide	nimesulide inhibits the reaction [Etoposide results in increased activity of BAK1 protein]	21745461
C012655	nimesulide	BAK1 results in decreased susceptibility to nimesulide	18349538
C482205	nutlin 3	[nutlin 3 co-treated with Bortezomib] results in increased activity of BAK1 protein	20850924
C520962	obatoclax	obatoclax inhibits the reaction [MCL1 protein binds to BAK1 protein]	21750559
C025589	ochratoxin A	ochratoxin A results in decreased expression of BAK1 protein	19367635
C025589	ochratoxin A	ochratoxin A results in increased expression of BAK1 mRNA	23358140
C507134	ON 01910	ON 01910 inhibits the reaction [BAX protein binds to BAK1 protein]	22351695
D050607	Organogold Compounds	[BAX co-treated with BAK1] results in increased susceptibility to Organogold Compounds	21172426
D008939	Mitotane	Mitotane results in increased expression of BAK1 mRNA	23485034
D017239	Paclitaxel	BAK1 protein results in increased susceptibility to Paclitaxel	17688235
D017239	Paclitaxel	Paclitaxel affects the expression of BAK1 mRNA	10822281
D017239	Paclitaxel	Paclitaxel affects the expression of BAK1 protein	10822281
D017239	Paclitaxel	Paclitaxel results in increased expression of BAK1 mRNA	10822281
D017239	Paclitaxel	Paclitaxel results in increased expression of BAK1 protein	10822281\|2412643
D017239	Paclitaxel	[BAK1 protein mutant form co-treated with BAX protein mutant form] inhibits the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]	17652622
D010269	Paraquat	BAK1 protein affects the susceptibility to Paraquat	18056701\|1826692
D010269	Paraquat	Maneb inhibits the reaction [BAK1 protein affects the susceptibility to Paraquat]	18266926
D010269	Paraquat	[Paraquat co-treated with Maneb] results in increased expression of BAK1 protein	18266926
D010269	Paraquat	Paraquat inhibits the reaction [BAK1 protein affects the susceptibility to Maneb]	18266926
D010269	Paraquat	Paraquat results in decreased expression of BAK1 mRNA	18836921
D010269	Paraquat	Paraquat results in increased expression of BAK1 mRNA	18056701\|1826692
D010269	Paraquat	Paraquat results in increased expression of BAK1 protein	18056701\|1826692
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA	23963992
D010269	Paraquat	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]	23963992
D010269	Paraquat	Paraquat results in increased expression of BAK1 protein	18056701
D010269	Paraquat	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]	23963992
D010269	Paraquat	NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of BAK1 mRNA]	22678742
D010269	Paraquat	Paraquat promotes the reaction [BAX protein binds to BAK1 protein]	25947082
D010269	Paraquat	Paraquat results in increased expression of BAK1 mRNA	22678742
D010269	Paraquat	Paraquat results in increased expression of BAK1 protein	22678742
D010278	Parathion	Parathion results in increased methylation of BAK1 promoter	22847954
C002669	parthenolide	parthenolide results in increased expression of BAK1 protein	16024633
D052638	Particulate Matter	Particulate Matter promotes the reaction [BAK1 protein binds to BCL2L1 protein]	28189646
C105905	perifosine	[perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein	15781658
C105905	perifosine	[perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein	15781658
C105905	perifosine	[perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein	15781658
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]]	25432964
D010634	Phenobarbital	[Lithocholic Acid co-treated with Phenobarbital] results in decreased expression of BAK1 protein	19433268
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BAK1 mRNA	27048571
D010634	Phenobarbital	DMU-212 inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BAK1 mRNA]	27048571
C522973	PI103	BAK1 protein results in increased susceptibility to [Doxorubicin co-treated with PI103]	20856197
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]	23279844
C013649	plastochromanol 8	plastochromanol 8 results in decreased expression of BAK1 protein	23941772
D011094	Polyethyleneimine	[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA	25988281
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of BAK1 mRNA	24583197
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of BAK1 protein	24583197
D011285	Pregnenolone Carbonitrile	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAK1 protein	19433268
C107773	pterostilbene	pterostilbene results in increased expression of BAK1 protein	23313376
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [docetaxel results in increased activity of BAK1 protein]	17317842
C031280	pyrazole	[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BAK1 mRNA	16610055
C020972	pyrrolidine dithiocarbamic acid	Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 mRNA]	22085843
C020972	pyrrolidine dithiocarbamic acid	Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 protein]	22085843
C020972	pyrrolidine dithiocarbamic acid	[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 mRNA	22085843
C020972	pyrrolidine dithiocarbamic acid	[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 protein	22085843
D011794	Quercetin	Quercetin metabolite results in increased expression of BAK1 protein	16280456
D011794	Quercetin	Quercetin results in increased expression of BAK1 protein	24368982
D011794	Quercetin	Quercetin results in increased expression of BAK1 protein	17039455
D011794	Quercetin	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAK1 protein]	14505808
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of BAK1 mRNA	16202921
C059514	resveratrol	BAK1 protein promotes the reaction [resveratrol results in increased secretion of AIFM1 protein]	22245142
C059514	resveratrol	BAK1 protein results in increased susceptibility to resveratrol	16550006\|2224514
C059514	resveratrol	BCL2L11 protein promotes the reaction [resveratrol results in increased activity of BAK1 protein]	22245142
C059514	resveratrol	[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [resveratrol results in increased localization of BAK1 protein]	12902349
C059514	resveratrol	CASP2 protein affects the reaction [resveratrol affects the folding of BAK1 protein]	16617056
C059514	resveratrol	resveratrol affects the folding of BAK1 protein	16617056
C059514	resveratrol	resveratrol results in increased activity of BAK1 protein	22245142\|2264496
C059514	resveratrol	resveratrol results in increased expression of and results in increased localization of BAK1 protein	12902349
C059514	resveratrol	resveratrol results in increased expression of BAK1 mRNA	12002526\|1256957
C059514	resveratrol	resveratrol results in increased expression of BAK1 protein	16731767\|1763646
D019438	Ritonavir	Ritonavir results in increased expression of BAK1 protein	19386116
C089730	rosiglitazone	rosiglitazone results in increased expression of BAK1 mRNA	17639046
C085746	rottlerin	rottlerin inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein]	15917298
C093642	SB 203580	SB 203580 inhibits the reaction [Sulindac affects the localization of BAK1 protein]	17136320
C115461	SC 560	SC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]	25432964
D012643	Selenium	Selenium inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 mRNA]	25035189
C002979	selenomethylselenocysteine	selenomethylselenocysteine metabolite results in increased expression of BAK1 mRNA	25321483
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of BAK1 mRNA"	25530474
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of BAK1 protein"	25530474
D012838	Silymarin	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]	23963992
C017947	sodium arsenite	sodium arsenite results in decreased expression of BAK1 mRNA	16014739
D018038	Sodium Selenite	Sodium Selenite results in increased expression of BAK1 mRNA	16705456
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]	26607349
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]	26607349
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAK1 protein]	26607349
C471405	sorafenib	MCL1 protein inhibits the reaction [[sorafenib co-treated with TNFSF10 protein] affects the folding of and results in increased activity of BAK1 protein]	17909059
C471405	sorafenib	[sorafenib co-treated with TNFSF10 protein] affects the folding of and results in increased activity of BAK1 protein	17909059
C471405	sorafenib	sorafenib promotes the reaction [destruxin B results in increased expression of BAK1 protein]	24434019
C471405	sorafenib	sorafenib results in decreased expression of BAK1 protein	16109713
C471405	sorafenib	sorafenib results in increased activity of BAK1 protein	16452220
C471405	sorafenib	sorafenib results in increased expression of BAK1 protein	18200035
D013141	Spiro Compounds	Spiro Compounds analog results in decreased expression of BAK1 protein	25320076
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BAK1 mRNA	26378955
D013467	Sulindac	SB 203580 inhibits the reaction [Sulindac affects the localization of BAK1 protein]	17136320
D013467	Sulindac	Sulindac affects the localization of BAK1 protein	17136320
C025462	sulindac sulfide	BAK1 results in increased susceptibility to sulindac sulfide	18349538
C025463	sulindac sulfone	BAK1 results in increased susceptibility to sulindac sulfone	18349538
C061133	tamibarotene	tamibarotene results in increased expression of BAK1 mRNA	15498508
C003959	TEMPO	TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]	28296042
C003959	TEMPO	TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]	28296042
C012568	terbufos	terbufos results in increased methylation of BAK1 promoter	22847954
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of BAK1 protein	27592553
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of BAK1 protein	26901245
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BAK1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BAK1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BAK1 mRNA	19520675
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of BAK1 protein	11139146
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BAK1 mRNA	25613284
D007978	Levamisole	Levamisole results in increased expression of BAK1 protein	11139434
C009438	tetrandrine	tetrandrine results in increased expression of BAK1 protein	26822499
D013853	Thioacetamide	Thioacetamide results in increased expression of BAK1 mRNA	23411599
D013852	Thiotepa	Thiotepa affects the expression of BAK1 protein	10822281
D013852	Thiotepa	Thiotepa results in increased expression of BAK1 protein	10822281
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of BAK1 mRNA	16137721
D014212	Tretinoin	[Melatonin co-treated with Tretinoin] results in increased expression of BAK1 protein	10965999
D014212	Tretinoin	Tretinoin results in decreased expression of BAK1 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of BAK1 mRNA	15498508\|1589460
D014212	Tretinoin	Tretinoin results in increased expression of BAK1 protein	16778211
C012589	trichostatin A	[perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein	15781658
C012589	trichostatin A	trichostatin A results in decreased expression of BAK1 mRNA	23558232
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of BAK1 mRNA	19042947
D014302	Trinitrobenzenesulfonic Acid	Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA]	15502641
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA	15502641
D014361	Trypsin Inhibitors	Trypsin Inhibitors results in increased expression of BAK1 mRNA	19481592
D014361	Trypsin Inhibitors	Trypsin Inhibitors results in increased expression of BAK1 protein	19481592
D014415	Tunicamycin	Tunicamycin results in increased activity of BAK1 protein	17553788
C113580	U 0126	U 0126 promotes the reaction [docetaxel results in increased activity of BAK1 protein]	17317842
C000592878	UMI-77	UMI-77 inhibits the reaction [MCL1 protein binds to BAK1 protein]	24019208
C000592878	UMI-77	UMI-77 results in increased expression of BAK1 protein	24019208
D017974	Uranium Compounds	Uranium Compounds results in increased expression of BAK1 mRNA	19654044
D014520	Urethane	Urethane results in increased expression of BAK1 mRNA	28818685
D014520	Urethane	[Urethane co-treated with Freund's Adjuvant] results in increased expression of BAK1 mRNA	12400877
C005466	ursolic acid	ursolic acid results in increased activity of BAK1 protein	20630652
D014635	Valproic Acid	Valproic Acid results in decreased expression of BAK1 mRNA	21427059
D014635	Valproic Acid	Valproic Acid results in increased expression of BAK1 mRNA	21427059
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [BAK1 protein binds to BCL2L1 protein]	28189646
C521013	veliparib	BAK1 protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]	18376143
D014750	Vincristine	BAK1 protein affects the susceptibility to Vincristine	22178383
C029297	vinylidene chloride	vinylidene chloride results in increased expression of BAK1 mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of BAK1 mRNA	20044591
C111237	vorinostat	[navitoclax co-treated with vorinostat] affects the activity of BAK1 protein	21652541
C111237	vorinostat	[perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein	15781658
C111237	vorinostat	TNFSF10 protein promotes the reaction [vorinostat results in increased expression of BAK1 mRNA]	19509267
C111237	vorinostat	TNFSF10 protein promotes the reaction [vorinostat results in increased expression of BAK1 protein]	19509267
C111237	vorinostat	vorinostat affects the activity of BAK1 protein	21652541
C111237	vorinostat	vorinostat results in increased expression of BAK1 mRNA	19509267
C111237	vorinostat	vorinostat results in increased expression of BAK1 protein	16144943\|1950926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003674	molecular_function	-	ND	-
GO:0005515	protein binding	-	IPI	9027312 9111042 9463381 9843949 9881696 10374970 10381623 10950869 11571294 12624108 14596824 15901672 16189514 16439990 17097560 17289999 17446862 17606912 18040043 19060904 19968986 20023629 21036904 21132008 22516262 23055042 23604079 23680104 23782464 25416956 26004684 26344567
GO:0031072	heat shock protein binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	15901672 16439990 17446862 21041309 23782464
GO:0042803	protein homodimerization activity	-	IBA	21873635
GO:0042803	protein homodimerization activity	-	IDA	23028632
GO:0044325	ion channel binding	-	IPI	25296756
GO:0046872	metal ion binding	-	IEA	-
GO:0046982	protein heterodimerization activity	-	IBA	21873635
GO:0046982	protein heterodimerization activity	-	IPI	10837489
GO:0051087	chaperone binding	-	IEA	-
GO:0051400	BH domain binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001782	B cell homeostasis	-	IEA	-
GO:0001783	B cell apoptotic process	-	IEA	-
GO:0001836	release of cytochrome c from mitochondria	-	IDA	9843949 16199525
GO:0001836	release of cytochrome c from mitochondria	-	IGI	21041309
GO:0001974	blood vessel remodeling	-	IEA	-
GO:0002262	myeloid cell homeostasis	-	IEA	-
GO:0002352	B cell negative selection	-	IEA	-
GO:0006915	apoptotic process	-	IDA	23028632
GO:0006915	apoptotic process	-	NAS	7715731
GO:0007420	brain development	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0008053	mitochondrial fusion	-	IEA	-
GO:0008283	cell proliferation	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	-	IBA	21873635
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	-	IEA	-
GO:0009620	response to fungus	-	IEA	-
GO:0010046	response to mycotoxin	-	IEA	-
GO:0010225	response to UV-C	-	IEA	-
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	-	IDA	9843949
GO:0010332	response to gamma radiation	-	IEA	-
GO:0010524	positive regulation of calcium ion transport into cytosol	-	IEA	-
GO:0010629	negative regulation of gene expression	-	IEA	-
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0031018	endocrine pancreas development	-	IEA	-
GO:0031100	animal organ regeneration	-	IEA	-
GO:0032469	endoplasmic reticulum calcium ion homeostasis	-	TAS	18309324
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	-	IEA	-
GO:0033137	negative regulation of peptidyl-serine phosphorylation	-	IEA	-
GO:0034620	cellular response to unfolded protein	-	TAS	22013210
GO:0034644	cellular response to UV	-	IMP	15901672
GO:0034644	cellular response to UV	-	ISS	-
GO:0035108	limb morphogenesis	-	IEA	-
GO:0042542	response to hydrogen peroxide	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IMP	17289999
GO:0043065	positive regulation of apoptotic process	-	ISS	-
GO:0043496	regulation of protein homodimerization activity	-	IDA	9111042
GO:0043497	regulation of protein heterodimerization activity	-	IDA	9111042
GO:0044346	fibroblast apoptotic process	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-
GO:0045862	positive regulation of proteolysis	-	IDA	18387192
GO:0046902	regulation of mitochondrial membrane permeability	-	IDA	9843949 21041309
GO:0048597	post-embryonic camera-type eye morphogenesis	-	IEA	-
GO:0051726	regulation of cell cycle	-	IEA	-
GO:0051881	regulation of mitochondrial membrane potential	-	IDA	9843949
GO:0060068	vagina development	-	IEA	-
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	-	TAS	22934019
GO:0070242	thymocyte apoptotic process	-	IEA	-
GO:0071260	cellular response to mechanical stimulus	-	IEP	19593445
GO:0090200	positive regulation of release of cytochrome c from mitochondria	-	IEA	-
GO:0097190	apoptotic signaling pathway	-	IMP	15901672
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	-	IBA	21873635
GO:0097202	activation of cysteine-type endopeptidase activity	-	IDA	18387192
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	-	IMP	16645094
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	-	TAS	-
GO:1902262	apoptotic process involved in blood vessel morphogenesis	-	IEA	-
GO:1903896	positive regulation of IRE1-mediated unfolded protein response	-	TAS	22013210

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IDA	9843949
GO:0005741	mitochondrial outer membrane	-	IBA	21873635
GO:0005741	mitochondrial outer membrane	-	TAS	-
GO:0005783	endoplasmic reticulum	-	IEA	-
GO:0005829	cytosol	-	IEA	-
GO:0031307	integral component of mitochondrial outer membrane	-	ISS	-
GO:0046930	pore complex	-	IDA	9843949
GO:0097145	BAK complex	-	IDA	23028632

KEGG ID	KEGG Term
hsa04141	Protein processing in endoplasmic reticulum

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-109606	Intrinsic Pathway for Apoptosis	TAS
R-HSA-111452	Activation and oligomerization of BAK protein	TAS
R-HSA-111457	Release of apoptotic factors from the mitochondria	TAS
R-HSA-5357801	Programmed Cell Death	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24790730	Apoptosis-Related Single Nucleotide Polymorphisms and the Risk of Non-Small Cell Lung Cancer in Women. (2014)	Pathak A	J Cancer Ther Res