Gene: POLD4

57804
POLDS|p12
DNA polymerase delta 4, accessory subunit
protein-coding
11q13.2
Ensembl:ENSG00000175482 MIM:611525 Vega:OTTHUMG00000167135 UniprotKB:Q9HCU8
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.759e-1 (AD)  5.505e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSENEN0.88
HSD17B100.873
PFN10.871
PGLS0.861
RNF1810.858
MYL60.851
ATRAID0.849
SEC61B0.847
GSTP10.846
RBM420.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.7
OR4F29-0.67
HS6ST3-0.192
IL1RAPL2-0.187
SIGLEC6-0.184
CDKL5-0.184
GRM5-0.181
TRPC5-0.173
CNTNAP5-0.171
OPRD1-0.169

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of POLD4 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of POLD4 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of POLD4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of POLD4 mRNA21641981|2715375
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of POLD4 mRNA24449571
D001151ArsenicArsenic results in increased methylation of POLD4 promoter21291286
C006632arsenic trioxidearsenic trioxide results in increased expression of POLD4 mRNA22521957
D001379AzathioprineAzathioprine results in increased expression of POLD4 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of POLD4 mRNA20106945|2062499
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of POLD4 mRNA21632981|2231617
D004958EstradiolEstradiol results in decreased expression of POLD4 mRNA16474171|2301914
C006780bisphenol Abisphenol A results in decreased expression of POLD4 mRNA16474171
C006780bisphenol Abisphenol A results in increased expression of POLD4 mRNA25181051
D002065BuspironeBuspirone results in increased expression of POLD4 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of POLD4 mRNA23410634
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of POLD4 mRNA15003993
D002101Cacodylic AcidCacodylic Acid results in increased expression of POLD4 mRNA17441966
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of POLD4 mRNA23650126
D002746ChlorpromazineChlorpromazine analog results in increased expression of POLD4 mRNA15924885
D002994ClofibrateClofibrate results in decreased expression of POLD4 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of POLD4 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of POLD4 mRNA24386269
D003300CopperCopper results in decreased expression of POLD4 mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of POLD4 mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of POLD4 mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of POLD4 mRNA20106945
D016572CyclosporineCyclosporine results in decreased methylation of POLD4 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of POLD4 mRNA25562108
D003976DiazinonDiazinon results in increased methylation of POLD4 gene22964155
C000944dicrotophosdicrotophos results in decreased expression of POLD4 mRNA28302478
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of POLD4 mRNA17490981
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of POLD4 mRNA24535843
D004317DoxorubicinDoxorubicin results in increased expression of POLD4 mRNA16404146
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of POLD4 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of POLD4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD4 mRNA17942748
D019833GenisteinGenistein results in decreased expression of POLD4 mRNA16474171
D005839GentamicinsGentamicins results in increased expression of POLD4 mRNA22061828
D006147GuanineGuanine metabolite results in decreased activity of [POLD1 protein binds to POLD2 protein binds to POLD3 protein binds to POLD4 protein]26010525
D006147GuanineGuanine metabolite results in decreased activity of [POLD1 protein binds to POLD2 protein binds to POLD4 protein]26010525
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of POLD4 mRNA23410634
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of POLD4 mRNA25613284
C410337K 7174K 7174 results in increased expression of POLD4 mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of POLD4 mRNA16807920
C045463leflunomideleflunomide results in increased expression of POLD4 mRNA24136188
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of POLD4 mRNA"20188158
D008825MiconazoleMiconazole results in decreased expression of POLD4 mRNA22262564
C523799MRK 003POLD4 results in increased susceptibility to MRK 00319903844
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of POLD4 mRNA19812364
C051752nefazodonenefazodone results in increased expression of POLD4 mRNA24136188
C012655nimesulidenimesulide results in increased expression of POLD4 mRNA24136188
C025589ochratoxin Aochratoxin A results in decreased expression of POLD4 mRNA18417182|2335814
D010634PhenobarbitalPhenobarbital affects the expression of POLD4 mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of POLD4 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of POLD4 mRNA23811191
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in decreased expression of POLD4 mRNA16474171
D054328Proton Pump InhibitorsProton Pump Inhibitors results in increased expression of POLD4 mRNA25626140
D011794QuercetinQuercetin results in increased expression of POLD4 mRNA21632981
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of POLD4 mRNA"26680231
C061133tamibarotenetamibarotene results in increased expression of POLD4 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of POLD4 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POLD4 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POLD4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POLD4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POLD4 mRNA18796159
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of POLD4 mRNA25613284
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of POLD4 mRNA"17951470
D014212TretinoinTretinoin results in increased expression of POLD4 mRNA15498508|1605412
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of POLD4 mRNA19042947
D014638VanadatesVanadates results in increased expression of POLD4 mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of POLD4 mRNA22570695
C029297vinylidene chloridevinylidene chloride results in increased expression of POLD4 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of POLD4 mRNA23410634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003887DNA-directed DNA polymerase activityCONTRIBUTES_TOIBA21873635  
GO:0003887DNA-directed DNA polymerase activity-TAS-  
GO:0005515protein binding-IPI12403614  15670210  16510448  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-TAS-  
GO:0000731DNA synthesis involved in DNA repair-IBA21873635  
GO:0006261DNA-dependent DNA replication-IBA21873635  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0006297nucleotide-excision repair, DNA gap filling-TAS-  
GO:0019985translesion synthesis-TAS-  
GO:0032201telomere maintenance via semi-conservative replication-TAS-  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0042769DNA damage response, detection of DNA damage-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-IDA-  
GO:0043625delta DNA polymerase complex-IBA21873635  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
hsa01100Metabolic pathways
hsa03030DNA replication
hsa03410Base excision repair
hsa03420Nucleotide excision repair
hsa03430Mismatch repair
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence
R-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateTAS
R-HSA-110314Recognition of DNA damage by PCNA-containing replication complexTAS
R-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathwayTAS
R-HSA-157579Telomere MaintenanceTAS
R-HSA-1640170Cell CycleTAS
R-HSA-174411Polymerase switching on the C-strand of the telomereTAS
R-HSA-174414Processive synthesis on the C-strand of the telomereTAS
R-HSA-174417Telomere C-strand (Lagging Strand) SynthesisTAS
R-HSA-174437Removal of the Flap Intermediate from the C-strandTAS
R-HSA-180786Extension of TelomeresTAS
R-HSA-5358508Mismatch RepairTAS
R-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)TAS
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)TAS
R-HSA-5651801PCNA-Dependent Long Patch Base Excision RepairTAS
R-HSA-5656169Termination of translesion DNA synthesisTAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-69091Polymerase switchingTAS
R-HSA-69109Leading Strand SynthesisTAS
R-HSA-69166Removal of the Flap IntermediateTAS
R-HSA-69183Processive synthesis on the lagging strandTAS
R-HSA-69186Lagging Strand SynthesisTAS
R-HSA-69190DNA strand elongationTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-73893DNA Damage BypassTAS
R-HSA-73894DNA RepairTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
269982734-Nitroquinoline-1-oxide effects human lung adenocarcinoma A549 cells by regulating the expression of POLD4. (2016 Mar)Huang QMBiomed Rep