Gene: CCAR2

57805
DBC-1|DBC1|KIAA1967|NET35|p30 DBC|p30DBC
cell cycle and apoptosis regulator 2
protein-coding
8p21.3
Ensembl:ENSG00000158941 MIM:607359 Vega:OTTHUMG00000162249 UniprotKB:Q8N163
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.830e-1 (AD)  7.765e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1545837chr8:22620294 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMD30.979
DHX300.968
COPG10.966
RNPS10.966
PRPF190.965
GPI0.965
TCF250.965
LRRC470.965
SCYL10.965
AP1M10.964

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.736
OR4F29-0.686
MTRNR2L9-0.365
MTRNR2L6-0.362
MTRNR2L10-0.331
TFPI2-0.324
CXCR2-0.319
KLRB1-0.316
EBF1-0.312
C9orf153-0.308

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of CCAR2 protein26194647
C004456beauvericinbeauvericin results in decreased expression of CCAR2 mRNA29203277
D003471CuprizoneCuprizone results in increased expression of CCAR2 mRNA26577399
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CCAR2 protein23301498
C042720mercuric bromidemercuric bromide results in decreased expression of CCAR2 mRNA26272509
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CCAR2 mRNA28001369
D009151Mustard GasMustard Gas results in increased phosphorylation of CCAR2 protein19845377
C059514resveratrolCCAR2 protein affects the susceptibility to resveratrol24252177
C059514resveratrolresveratrol inhibits the reaction [CCAR2 protein binds to and results in decreased activity of SIRT1 protein]24252177
C059514resveratrol[resveratrol inhibits the reaction [CCAR2 protein binds to and results in decreased activity of SIRT1 protein]] which results in increased activity of SIRT1 protein24252177
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CCAR2 mRNA27914987
D014635Valproic AcidValproic Acid results in decreased expression of CCAR2 mRNA23179753|2438349
D024483Vitamin K 3Vitamin K 3 affects the expression of CCAR2 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000993RNA polymerase II core binding-IDA22446626  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0004857enzyme inhibitor activity-IDA18235501  18235502  
GO:0004857enzyme inhibitor activity-IMP19218236  
GO:0005515protein binding-IPI17314511  17353931  18235501  18235502  20074560  20160719  
21030595  22190034  22446626  23398316  24824780  25661920  
GO:0019899enzyme binding-IPI18235501  19218236  23382074  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006397mRNA processing-IEA-  
GO:0006974cellular response to DNA damage stimulus-IEA-  
GO:0007049cell cycle-IEA-  
GO:0008380RNA splicing-IMP22446626  
GO:0009411response to UV-IMP23352644  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030308negative regulation of cell growth-IMP25661920  
GO:0031647regulation of protein stability-IDA23398316  
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process-IDA23398316  
GO:0032784regulation of DNA-templated transcription, elongation-IMP22446626  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043065positive regulation of apoptotic process-IMP18235501  18235502  
GO:0043086negative regulation of catalytic activity-IMP21030595  
GO:0043653mitochondrial fragmentation involved in apoptotic process-IDA15824730  
GO:0045892negative regulation of transcription, DNA-templated-IDA20160719  
GO:0045892negative regulation of transcription, DNA-templated-IMP20074560  25661920  
GO:0048511rhythmic process-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP24824780  
GO:0090311regulation of protein deacetylation-IDA21030595  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage-IMP23352644  
GO:2000003positive regulation of DNA damage checkpoint-IMP23352644  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA23352644  
GO:0005634nucleus-IDA15824730  20074560  20160719  24824780  25661920  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complexcolocalizes_withIDA22446626  
GO:0005737cytoplasm-IDA15824730  20160719  24824780  
GO:0005759mitochondrial matrix-IDA15824730  
GO:0044609DBIRD complex-IDA22446626  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal